Allogeneic Stem Cell Transplantation in Pediatric Patients With Malignant and Non-malignant High-risk Diseases

Inclusion Criteria:

• Patients aged 0 to 30 years
• Written informed consent from patient and/or parents or guardian
• Patients with Karnofsky Index > 60%

• Malignant disease:

  • acute lymphoblastic leukemia
  • acute myeloid leukemia
  • myelodysplastic syndrome
  • chronic myeloid leukemia according to the standard indications

  • solid tumors (e.g. neuroblastoma recurrence, soft-tissue sarcoma, Ewing's sarcoma, osteosarcoma, hepatoblastoma)

    . Non malignant disease:

  • acquired anemias (e.g. severe aplastic anemia, particularly severe Evans syndrome)
  • congenital anemias (e.g. thalassemia and sickle cell anemia)
• Women reliable contraception method when appropriate

Exclusion Criteria:

• Participation in other clinical trials
• Patients, parents, or guardians unable to understand the nature, the importance and the implications of the procedure
• Pregnant or nursing women
• Patients who underwent a stem cell transplantation in the last 250 days
• Patients with kidney, heart or liver insufficiency