High-dose Cytarabine and Survival in AML
Role of Consolidation With High-dose Cytarabine in Overall Survival of Adults With Acute Myeloid Leukemia
研究概览
地位
条件
详细说明
Background In adults with acute myeloid leukemia, especially those < 60 years of age, high-dose cytarabine consolidation therapy has been shown to influence survival. However, the appropriate dose has not been defined. We evaluated survival after cytarabine consolidation therapy at three different doses.
Design and Methods We conducted a single-center, retrospective study involving 499 acute myeloid leukemia patients, aged 18-92 years, all evaluated between 1978 and 2007. Of those 499 patients, 400 received curative treatment and 203 received cytarabine consolidation. The latter were divided into three groups: low-dose (receiving < 1.5 g/m2 of i.v. cytarabine, every 12 h, on 3 alternate days, for up to 4 cycles); medium-high-dose (< 45.45 g-the median dose-by the end of the cycles); and very-high-dose (≥ 45.45 g by the end of the cycles).
Results Among the 400 patients receiving curative treatment, five-year survival was 22.8% (91 patients). Cytarabine consolidation dose was an independent determinant of survival (significant differences were found among the groups), whereas age, karyotype, induction protocol, French-American-British classification and etiology were not. In comparison with the very-high-dose group, the risk of death was 3.871 times (95% CI, 1.043 to 14.370 times) higher in the high-dose group (p=0.043) and 9.775 times (95% CI, 2.493 to 38.320 times) higher in the low-dose group (p=0.001), assuming, in both cases, that age, karyotype, French-American-British classification and etiology of acute myeloid leukemia were constant.
Conclusions Consolidation therapy with high-dose cytarabine appears to improve survival in patients with acute myeloid leukemia.
研究类型
注册 (实际的)
联系人和位置
学习地点
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Sao Paulo、巴西、05430010
- University of Sao Paulo
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion Criteria:
- clinical diagnosis of acute myeloid leukemia
- age 18 years or above
- must have been treated with potentially curative therapy
Exclusion Criteria:
- children or age less than 18 years
- palliative therapy
学习计划
研究是如何设计的?
设计细节
- 观测模型:队列
- 时间观点:追溯
队列和干预
团体/队列 |
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acute myeloid leukemia, adults
Adults treated for acute myeloid leukemia in our hospital between 1978 and 2007
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研究衡量的是什么?
主要结果指标
结果测量 |
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总生存期
大体时间:5年
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5年
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合作者和调查者
调查人员
- 研究主任:Pedro ED Llacer, MD, PhD、University of Sao Paulo
研究记录日期
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学习开始
初级完成 (实际的)
研究完成 (实际的)
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首次提交
首先提交符合 QC 标准的
首次发布 (估计)
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最后更新发布 (估计)
上次提交的符合 QC 标准的更新
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急性髓性白血病的临床试验
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Shenzhen Second People's Hospital招聘中白血病 | 骨髓的 | 慢性的 | BCR-ABL (Breakpoint Cluster Region-abelson Murine Leukemia) | 积极的中国