Sperm Banking Among Adolescents Newly Diagnosed With Cancer: Development of a Profiling and Referral Tool
Predictors of Adolescent Sperm Banking: Development of a Profiling and Referral Tool
Despite the known adverse effects of specific cancer treatments on fertility, only 18-26% of at-risk adolescents and young men cryopreserve sperm prior to cancer treatment in the US: These already less than optimal rates of sperm banking are even lower among adolescents who have increased anxiety at cancer diagnosis, are lower in age and socioeconomic status, of Evangelical religious orientation, or are diagnosed with leukemia/lymphoma: It is not clear why sperm banking is underutilized, particularly in light of the high priority that survivors of childhood cancer place on fertility and the high psychological distress associated with fertility loss. Studies addressing sperm banking among adults with cancer suggest that factors such as poor physician communication and the resulting lack of fertility-risk knowledge by patients contributes to the low frequency of sperm cryopreservation. No well-designed studies have examined risk factors associated with failure to bank sperm among adolescents with cancer, a developmentally distinct population ripe for intervention.
This study plans to enroll 206 adolescent males and 412 parents/guardians.
研究概览
地位
条件
详细说明
研究类型
注册 (实际的)
联系人和位置
学习地点
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Ontario
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Toronto、Ontario、加拿大、M5G1X8
- The Hospital for Sick Children
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California
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Duarte、California、美国、91010
- City of Hope
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Los Angeles、California、美国、90095
- Mattel Children's Hospital
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Georgia
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Atlanta、Georgia、美国、30342
- Children's Healthcare of Atlanta
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Massachusetts
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Boston、Massachusetts、美国、02115
- Dana-Farber Cancer Institute/Children's Hospital Boston
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Michigan
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Ann Arbor、Michigan、美国、48109
- The University of Michigan
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Tennessee
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Memphis、Tennessee、美国、38105
- St. Jude Children's Research Hospital
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Texas
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Fort Worth、Texas、美国、76104
- Cook Children's Medical Center
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Utah
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Salt Lake City、Utah、美国、84113
- Primary Children's Medical Center
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion Criteria:
- Male participants newly diagnosed with cancer.
- Patients must be between 13 years of age (≥ 13 years) and 21 years of age (< 22 years) at time of study enrollment.
- Participant Identified as Tanner stage III or higher.
- Participant identified by his oncologist (or designee) as being at risk for treatment-related infertility.
- Proficiency speaking and reading English or Spanish.
- Cognitive capacity to complete study questionnaires.
Exclusion Criteria:
- Participant previously treated for cancer.
- History of mental retardation or severe cognitive or learning impairment.
学习计划
研究是如何设计的?
设计细节
队列和干预
团体/队列 |
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Adolescent Male Participants
Self-report questionnaire data will be collected one time, between Days 1-7 post initiation of cancer therapy(e.g.
Days 2-8 of being "on-treatment" for cancer) among eligible participants and their families who enroll on the study.
Patients who agree to participate will be asked to complete a battery of paper and pencil questionnaires (which will also be available on-line if preferred) that assess risk/protective factors for sperm banking.
When the banking recommendation is "Yes" or "further assessment required," the profiling and referral tool will be given to the family and instructions for completion will be provided.
The tool will include a list of key items which will be based on the most influential barriers to banking sperm.
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研究衡量的是什么?
主要结果指标
结果测量 |
措施说明 |
大体时间 |
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Investigation of factors predictive of sperm banking outcome
大体时间:3 years
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Investigate factors predictive of banking sperm/not banking sperm among at-risk adolescents newly diagnosed with cancer.
Psychological, health belief, demographic, developmental, parental/guardian, provider, and medical factors will be tested in models of sperm banking outcome.
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3 years
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次要结果测量
结果测量 |
措施说明 |
大体时间 |
---|---|---|
Develop and evaluate a Profiling and Referral Tool designed to increase clinical referrals and decrease barriers to sperm banking.
大体时间:3 years
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To utilize factors most predictive of sperm banking outcome to develop a brief Profiling and Referral Tool designed to increase sperm banking among teens newly diagnosed with cancer.
Implementation of the developed Profiling and Referral Tool will be feasible based on provider and family report.
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3 years
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合作者和调查者
合作者
调查人员
- 首席研究员:James Klosky, Ph.D、St. Jude Children's Research Hospital
出版物和有用的链接
研究记录日期
研究主要日期
学习开始
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (估计)
上次提交的符合 QC 标准的更新
最后验证
更多信息
与本研究相关的术语
其他研究编号
- SBANK10
- R21HD061296-01A2 (美国 NIH 拨款/合同)
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