Morphofunctional Lung Analysis by PET and CT After Lung Transplantation
Morphofunctional Lung Analysis by Positron Emission Tomography and Computed Tomography After Lung Transplantation
72 hours after lung transplantation, patients undergo a positron emission tomography (PET) scan and a computed tomography (CT) scan in order to analyse lung function and morphology.
Aim of the study is to analyse complications onset (in particular primary graft dysfunction), and evaluate 90 days mortality after lung transplantation.
研究概览
地位
条件
详细说明
Pulmonary transplantation is considered as a lifesaving procedure in end-stage pulmonary disease. However morbidity and mortality after lung transplantation are still significant.
Primary graft dysfunction (PGD) is the main cause of early death. PGD is similar to acute lung injury (ALI)/ acute respiratory distress syndrome (ARDS): oxygenation is compromised, pulmonary compliance is decreased, chest Rx shows several infiltrates, and alveolar damage is present.
25% of patients develops PGD within 72 hours from transplantation and 30 days mortality is eight times higher in patients who develop PGD.
72 hours after lung transplantation, patients, whose clinical condition allow to bring them to nuclear medicine department, will undergo pulmonary computed tomography (CT) to study lung morphology and measure lung recruitability and positron emission tomography (PET) to study lung functionality and estimate lung inflammation.
Aim of this study is to investigate the onset of PGD and other complications and to determine 72 hours and 90 days mortality after lung transplantation.
研究类型
注册 (实际的)
联系人和位置
学习地点
-
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Milan
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Milano、Milan、意大利、20122
- Fondazione Irccs Ca' Granda Ospedale Maggiore Policlinico
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion Criteria:
- lung transplantation
- ≥ 18 years
Exclusion Criteria:
- < 18 years
- patient' s clinical conditions not allowing patient transport from ICU to Nuclear Medicine Unit
学习计划
研究是如何设计的？
设计细节
队列和干预
团体/队列 |
|---|
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Lung transplantated patients
Patients undergone lung transplantation
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研究衡量的是什么？
主要结果指标
结果测量 |
大体时间 |
|---|---|
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Number of patients alive
大体时间：up to 90 days from transplantation
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up to 90 days from transplantation
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次要结果测量
结果测量 |
大体时间 |
|---|---|
|
incidence of complications other than primary graft dysfunction
大体时间：72 hours and 90 days
|
72 hours and 90 days
|
|
incidence of primary graft dysfunction
大体时间：72 hours and 90 days after transplantation
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72 hours and 90 days after transplantation
|
合作者和调查者
调查人员
- 首席研究员：davide chiumello, md、Policlinico Hospital
- 首席研究员：Franco Valenza, MD、Policlinico Hospital
研究记录日期
研究主要日期
学习开始
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (估计)
上次提交的符合 QC 标准的更新
最后验证
更多信息
与本研究相关的术语
其他研究编号
- 201212
计划个人参与者数据 (IPD)
计划共享个人参与者数据 (IPD)？
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