Peripheral Insulin Uptake in Type 2 Diabetes Mellitus and in Non-Diabetic Individuals (PEAKS)
Impaired uptake of glucose by skeletal muscle is a key feature of type 2 diabetes mellitus. It is unclear to what extent impaired insulin uptake from capillaries into skeletal muscle interstitium plays a role in this process.
We hypothesize that impaired uptake of insulin from capillaries into skeletal muscle interstitium is involved in impaired glucose uptake by skeletal muscle in type 2 diabetes mellitus.
研究概览
地位
条件
研究类型
注册 (预期的)
联系人和位置
学习地点
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Haarlem、荷兰、2023 KT
- Kennemer Gasthuis
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion criteria for all participants:
- written informed consent
- hemodynamically stable with a systolic blood pressure > 100 mmHg
- medical need to undergo a CAG procedure as determined by cardiologist
Exclusion criteria for all participants:
- ongoing myocardial infarction as determined from elevated cardiac markers
- participation in an investigational trial within 90 days prior to present study
- donation of blood (> 100 mL) within 90 days prior to present study
- serious mental impairment or language problems i.e. preventing to understand the study protocol/aim
- Use or recent use (within 3 months of study participation) of oral glucocorticoids
Inclusion criteria for non-diabetic individuals:
- 30 years ≤ age ≤ 80 years (extremes included)
- fasting glucose level of < 7.0 mmol/L and HbA1C < 6.5% (= < 48 mmol/mol)
Exclusion criteria for non-diabetic individuals:
- known T2DM/use of glucose-lowering medication
Inclusion criteria for T2DM patients:
- 30 years ≤ age ≤ 80 years (extremes included)
- fasting glucose level of > 7.0 mmol/L, or HbA1C > 6.5 (= > 48 mmol/mol) or known T2DM
Exclusion criteria for T2DM patients:
- treatment with insulin preparations
学习计划
研究是如何设计的?
设计细节
队列和干预
团体/队列 |
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Patients with type 2 diabetes mellitus
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Normoglycemic individuals
Control group
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研究衡量的是什么?
主要结果指标
结果测量 |
措施说明 |
大体时间 |
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Fore-arm insulin uptake measured as ([A]-[V]) x F in pmol/min where A = arterial insulin concentrations, V= venous insulin concentrations, F = fore arm plasma flow;
大体时间:Baseline
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During a single measure (thus cross-sectional) the primary endpoint will be measured.
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Baseline
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合作者和调查者
研究记录日期
研究主要日期
学习开始
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (估计)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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