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The Effect of Intravitreal Ranibizumab on Visual Acuity and Hard Exudate Resolution in the Treatment of Diabetic Macular Edema With Center Involved Edema and Lipid Exudates

2021年7月6日 更新者：Julie Gasperini, M.D.、South Coast Retina Center; Carson, McBeath, Boswell, Inc.

The Effect of Intravitreal Ranibizumab on Visual Acuity and Hard Exudate Resolution in the Treatment of Diabetic Macular Edema With Foveal Involving Edema and Lipid Exudates

This is an open-label, Phase I/II study of intravitreally administered 0.3mg ranibizumab in subjects with diabetic macular edema and lipid exudates in the central subfield.

研究概览

地位

完全的

条件

干预/治疗

详细说明

This is an open-label, Phase I/II study of intravitreally administered 0.3mg ranibizumab in subjects with diabetic macular edema and lipid exudates in the central subfield.

Consented, enrolled subjects will receive multiple open-label intravitreal injections on 0.3mg ranibizumab administered every 30 days for 12 months per the treatment algorithm.

The patients will be randomized to 1 of 2 treatment groups. Group 1: Treatment algorithm based on the Diabetic Retinopathy Clinical Research (DRCR) protocol I 4:2:7 strategy based on the presence of macular edema.

Group 2: Continue treatment until not only the macular edema is resolved but also until the lipid exudate is resolved.

Sample size: 30 eyes Follow-up Schedule: Every 4 weeks throughout the study.

研究类型

介入性

注册 (实际的)

25

阶段

  • 阶段2
  • 阶段1

联系人和位置

本节提供了进行研究的人员的详细联系信息，以及有关进行该研究的地点的信息。

学习地点

  • 美国
    • California
      • Huntington Beach、California、美国、92647
        • South Coast Retina Center; Carson, McBeath, Boswell, Inc
      • Long Beach、California、美国、90505
        • South Coast Retina Center; Carson, McBeath, and Boswell, Inc
      • Santa Monica、California、美国、90404
        • Retina Partners
      • Torrance、California、美国、90505
        • South Coast Retina Center; Carson, McBeath, Boswell, Inc

参与标准

研究人员寻找符合特定描述的人，称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。

资格标准

适合学习的年龄

18年 及以上 (成人、年长者)

接受健康志愿者

是的

有资格学习的性别

全部

描述

Subjects will be eligible if the following criteria are met:

Inclusion Criteria

  • Ability to provide written informed consent and comply with study assessments for the full duration of the study
  • Age ≥ 18 years
  • Type 1 or Type 2 Diabetes mellitus
  • Best corrected ETDRS visual acuity (20/32-20/320) or letter score 78 to 24
  • Diabetic macular edema on clinical examination involving the center of the macula assessed to be the main cause of visual loss
  • Retinal thickness measured on spectral domain optical coherence tomography (OCT). Zeiss Cirrus: ≥290μm in women and ≥305 μm in men in the central subfield. Heidelberg Spectralis: ≥305μm in women and ≥320 μm in men in the central subfield
  • Lipid exudates involving the central subfield on spectral domain OCT.

Exclusion Criteria

Subjects who meet any of the following criteria will be excluded from this study:

  • Treatment for diabetic macular edema within the prior 4 months.
  • Panretinal photocoagulation within the prior 4 months or anticipated need for panretinal photocoagulation within the next 6 months
  • major ocular surgery within the prior 4 months
  • myocardial infarction, other cardiac event requiring hospitalization, cerebrovascular accident, transient ischemic attack, or treatment for acute congestive heart failure occurred within 4 months before randomization
  • Pregnancy (positive pregnancy test) or lactation
  • Premenopausal women not using adequate contraception. The following are considered effective means of contraception: surgical sterilization or use of oral contraceptives, barrier contraception with either a condom or diaphragm in conjunction with spermicidal gel, an intrauterine device (IUD), or contraceptive hormone implant or patch.
  • Any other condition that the investigator believes would pose a significant hazard to the subject if the investigational therapy were initiated
  • Participation in another simultaneous medical investigation or trial

学习计划

本节提供研究计划的详细信息，包括研究的设计方式和研究的衡量标准。

研究是如何设计的？

设计细节

  • 主要用途：治疗
  • 分配：随机化
  • 介入模型：并行分配
  • 屏蔽：无（打开标签）

武器和干预

参与者组/臂
干预/治疗
有源比较器：Diabetic macular edema treatment group (Group 1)
Treatment using intravitreal ranibizumab 0.3mg based on the DRCR protocol I 4:2:7 strategy based on the presence of macular edema.
药品：ranibizumab 0.3mg
intravitreally administered
其他名称：
  • Lucentis
有源比较器：Diabetic macular edema and lipid treatment group (Group 2)
Continued treatment with intravitreal ranibizumab 0.3mg until, not only the macular edema is resolved, but also until the lipid exudate is resolved.
药品：ranibizumab 0.3mg
intravitreally administered
其他名称：
  • Lucentis

研究衡量的是什么？

主要结果指标

结果测量
措施说明
大体时间
Best Corrected Visual Acuity as Measured by ETDRS at 6 and 12 Months
大体时间：6-12 months
Compare Group 1 and Group 2 for best correct visual acuity (BCVA), as assessed by the number of letters read correctly on the ETDRS eye chart at a starting test distance of 4 meters.
6-12 months

次要结果测量

结果测量
大体时间
Percentage of Eyes With Improvement of Lipid Deposits in the Central Subfield as Measured on OCT and Fundus Photography
大体时间：12 months
12 months
Percentage of Eyes With Complete Resolution of Lipid Deposits in the Central Subfield as Measured on OCT and Fundus Photography
大体时间：12 months
12 months
Number of Eyes With Complete Resolution in the Central Subfield as Measured on OCT and Fundus Photography
大体时间：12 months
12 months
Percentage of Eyes With Improvement in Lipid Deposits Throughout the Macular Grid as Measured by OCT and Fundus Photography
大体时间：12 months
12 months
Percentage of Patients With Complete Resolution of Lipid Deposits Throughout the Macular Grid as Measured on OCT and Fundus Photography
大体时间：12 months
12 months
Number of Eyes With Complete Resolution of Lipid Deposits Throughout the Macular Grid as Measured by OCT and Fundus Photography
大体时间：12 months
12 months
Incidence and Severity of Ocular Adverse Events as a Measure of Safety and Tolerability
大体时间：12 months
12 months
Incidence and Severity of Other Adverse Events as a Measure of Safety and Tolerability
大体时间：12 months
12 months

合作者和调查者

在这里您可以找到参与这项研究的人员和组织。

赞助

South Coast Retina Center; Carson, McBeath, Boswell, Inc.

合作者

Genentech, Inc.
Doheny Image Reading Center
Retina Partners

研究记录日期

这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查，以确保它们在发布到公共网站之前符合特定的质量控制标准。

研究主要日期

学习开始

2015年8月1日

初级完成 (实际的)

2018年5月1日

研究完成 (实际的)

2018年5月1日

研究注册日期

首次提交

2015年3月5日

首先提交符合 QC 标准的

2015年5月14日

首次发布 (估计)

2015年5月19日

研究记录更新

最后更新发布 (实际的)

2021年7月8日

上次提交的符合 QC 标准的更新

2021年7月6日

最后验证

2021年7月1日

更多信息

与本研究相关的术语

其他相关的 MeSH 术语

其他研究编号

  • ML259577

此信息直接从 clinicaltrials.gov 网站检索，没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求，请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改，我们的网站上也会自动更新.

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