Venous Thromboembolic Complications in Ovarian Cancer
Venous Thromboembolic Complications in Patients With Ovarian Cancer Compared to Patients With Benign Ovarian Tumours
研究概览
详细说明
Venous thromboembolism (VTE) is a common complication after surgery. Deep-vein thrombosis (DVT) and pulmonary embolism (PE) constitute VTE. PE is often a consequence of DVT and it is a feared complication and the most common preventable cause of hospital death. VTE can be asymptomatic and can be detected by a compression ultrasound scan (CUS) of the legs and a Computer Tomography (CT) of the lungs. It is wellknown that cancer patients are at higher risk of developing VTE, the risk is approximately seven times higher than in the background population. A Danish study showed a significantly higher risk of death when VTE was diagnosed at the same time as the cancer diagnosis with a 12 % one year survival compared to 36 % in cancer patients without a history of VTE.
Approximately 600 women in Denmark are diagnosed with ovarian cancer every year and it is the forth most common cause of cancer death among Danish women. Earlier studies have found that up to 31 % of ovarian cancer women develop VTE as a consequence of the disease and/or the treatment. Very few studies have examined the incidence of VTE before treatment.
Methods: A Pulmonary CT-angiography is included in the routinely performed Fluorodeoxyglucose Positron Emission Tomography - Computer Tomography (FDG PET-CT) to reveal pulmonary embolism at time of first referral. Compressive ultrasound scan including Doppler flow of the lower extremities is performed four times from first referral and during a one-year follow up period to detect clinical or subclinical deep vein thrombosis (DVT) before and after initiation of treatment.
Blood and tissue samples are taken, prepared and stored at -80 degrees in the Danish Cancer-Biobank for later analyzes of coagulation markers.
Immune histochemical techniques will be use to demonstrate tissue factor (TF) in tumor tissue.
The objectives of the study are:
- In a prospective study at Aalborg University Hospital to estimate the incidence of clinical and subclinical venous thromboembolism (VTE) in patients with suspected ovarian cancer before and after initiation of treatment. The impact of VTE on survival will be evaluated.
- In the same prospective cohort the correlation between markers of coagulation and fibrinolysis and subclinical VTE, tumour burden and overall survival will be evaluated.
- Evaluate the correlation between immunohistochemical demonstrated tissue factor (TF) in tumour tissue and circulating TF in peripheral blood and the relation to VTE and tumour burden.
研究类型
注册 (实际的)
联系人和位置
学习地点
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Aalborg、丹麦、9000
- Department of Gynecology and Obstetrics, Aalborg University Hospital
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion Criteria:
Women referred to the Department of Gynaecology and Obstetrics, Aalborg University Hospital on suspicion of ovarian cancer can be included if they present with a RMI ≥ 200.
Exclusion Criteria:
- Previous cancer (within previous 3 years) or concomitant cancer of any origin.
- Known immunological connective tissue disease.
- Treatment with heparin, low molecular weight heparin (LMWH) or vitamin K antagonist at the time of inclusion.
- Lack of informed consent.
学习计划
研究是如何设计的?
设计细节
队列和干预
团体/队列 |
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Patients with malignant disease
Patients with ovarian, tubar or primary peritoneal cancer
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Patients with benign disease
Patients with suspected ovarian cancer where the final pathologic diagnosis is benign
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研究衡量的是什么?
主要结果指标
结果测量 |
措施说明 |
大体时间 |
---|---|---|
Venous thromboembolism due to ovarian cancer
大体时间:one year
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Compressive ultrasound scan of lower extremities and pulmonary CT-angiography
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one year
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次要结果测量
结果测量 |
措施说明 |
大体时间 |
---|---|---|
Changes in the coagulation system in case of ovarian cancer
大体时间:one year
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Analysis of blood samples
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one year
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Impact of changes in the coagulation system on disease prognosis in ovarian cancer
大体时间:one year
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Evaluation of classic and novel coagulation markers and their relation to prognosis
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one year
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合作者和调查者
调查人员
- 首席研究员:Ole Thorlacius-Ussing, MD, DMSc、Department of Gastrointestinal Surgery, Aalborg University Hospital
研究记录日期
研究主要日期
学习开始 (实际的)
初级完成 (实际的)
研究完成 (预期的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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