Validation of Structured Light Plethysmography - Health and Disease (SLP-RespDis)
Validation in Healthy Subjects and Different Diagnostic States
研究概览
地位
详细说明
The investigators hypothesize that SLP may be a useful tool to differentiate between different respiratory diseases. To further examine differences in disease and health, and between diseases SLP measurements will be recorded in a range of diagnostic conditions that effect breathing and in healthy normal subjects.
This is a non-randomised observational study to validate Structured Light Plethysmography in two groups of participants: those with Respiratory condition such as COPD and a normal healthy group. Neither group will receive any clinical intervention. SLP data capture and spirometry (as part of the patients clinical care) will be performed by the patients. The data collected from this study will allow examination of different breathing patterns between patients with different diseases, to compare breathing patterns in patients to those in healthy individuals, and to compare breathing patterns within a healthy population.
研究类型
注册 (预期的)
联系人和位置
学习地点
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Cambridgeshire
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Cambridge、Cambridgeshire、英国、CB2 0QQ
- 招聘中
- Cambridge University Hospitals Foundation Trust
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接触：
- Richard Iles, MB
- 电话号码：07736351424
- 邮箱：Richard.iles@doctors.org.uk
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首席研究员：
- Richard Iles, MB
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
A range of diagnostic conditions that effect breathing and healthy normal subjects. The study will aim to recruit:
200 patients from different diagnostic groups between the ages of 0 and 80 100 healthy participants with no diagnosis of respiratory disease, between the ages of 0 and 80
描述
Inclusion Criteria:
- Aged between 0 and 80 years
Exclusion Criteria:
- Any contraindication to spirometry (if performed) or a history of a myocardial infarction or chest surgery within 4 weeks
- Patient unable to sit in an upright (or supine in the case of infants) position for required period of time
- Patients with significant co morbidities (assessed by the clinician at screening only):
- Chest wall or spinal deformity e.g. scoliosis
- Obstructive Sleep Apnoea (OSA) Apnoea hypopnoea index > 30 (if known)
- An acute or chronic condition that, in the investigator's opinion, would limit the patient's ability to participate in the study
- BMI > 40
- Inability to consent/comply with trial protocol
学习计划
研究是如何设计的？
设计细节
队列和干预
团体/队列 |
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Normal
Participants with no diagnosis of respiratory disease between the ages of 0 and 80
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COPD
Patients from different diagnostic groups between the ages of 0 and 80
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研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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患者和健康受试者之间 SLP 衍生的相对贡献（以 % 衡量）的差异
大体时间：基线
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SLP 呼吸参数源自潮汐呼吸期间胸腹壁 (TA) 壁的运动，描述了胸腹壁区域对总位移的贡献
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基线
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患者和健康受试者之间 SLP 衍生相位（以度为单位）的差异
大体时间：基线
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SLP 呼吸参数源自潮汐呼吸期间胸腹壁 (TA) 壁的运动，描述了胸腹壁区域对总位移的贡献
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基线
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患者和健康受试者之间 SLP 衍生位移率衍生参数（以每秒距离测量）的差异
大体时间：基线
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SLP 呼吸参数源自潮汐呼吸期间胸腹壁 (TA) 壁随时间推移的位移率轨迹
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基线
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患者和健康受试者之间 SLP 位移率的差异（以每秒距离测量）患者和健康受试者之间
大体时间：基线
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SLP 呼吸参数比率源自潮汐呼吸期间胸腹壁 (TA) 壁的位移率随时间变化的轨迹
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基线
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Difference in SLP Breath Timing indices and measured in seconds and between Patients and Healthy Subjects
大体时间：Baseline
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SLP breathing parameters derived from the movement of the thoracoabdominal (TA) wall during tidal breathing
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Baseline
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Difference in SLP Breath Timing Ratios between Patients and Healthy Subjects
大体时间：Baseline
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SLP breathing parameters derived from the trace of movement over time of the thoracoabdominal (TA) wall during tidal breathing
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Baseline
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次要结果测量
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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Forced Expiratory Volume in 1 second (FEV1)
大体时间：Baseline
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Measurement of FEV1
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Baseline
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Forced Vital Capacity (FVC)
大体时间：Baseline
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Measurement of FVC
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Baseline
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合作者和调查者
出版物和有用的链接
一般刊物
- Miller MR, Crapo R, Hankinson J, Brusasco V, Burgos F, Casaburi R, Coates A, Enright P, van der Grinten CP, Gustafsson P, Jensen R, Johnson DC, MacIntyre N, McKay R, Navajas D, Pedersen OF, Pellegrino R, Viegi G, Wanger J; ATS/ERS Task Force. General considerations for lung function testing. Eur Respir J. 2005 Jul;26(1):153-61. doi: 10.1183/09031936.05.00034505. No abstract available.
- de Boer WH, Lasenby J, Cameron J, Wareham R, Ahmad S, Roach C, Hills W, Iles R. SLP: a zero-contact non-invasive method for pulmonary function testing. In: Labrosse F, Zwiggelaar R, Liu Y, Tiddeman B, eds, Proceedings of the British Machine Vision Conference. BMVA Press, 2010; pp 85.1-85.12
- Morgan MD, Gourlay AR, Denison DM. An optical method of studying the shape and movement of the chest wall in recumbent patients. Thorax. 1984 Feb;39(2):101-6. doi: 10.1136/thx.39.2.101.
研究记录日期
研究主要日期
学习开始
初级完成 (预期的)
研究完成 (预期的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
与本研究相关的术语
其他相关的 MeSH 术语
其他研究编号
- PMC-T3D-004
计划个人参与者数据 (IPD)
计划共享个人参与者数据 (IPD)？
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