Hemodynamic Effects of Dexmedetomidine in Septic Shock
Effects of Dexmedetomidine on Pressor Response to Norepinephrine in Patients With Septic Shock
研究概览
详细说明
The present study was designed as a prospective study. All patients enrolled in the study will require norepinephrine to maintain MAP between 65 and 75 mmHg despite adequate volume resuscitation and will be sedated according to istitutional guidelines with propofol and remifentanyl. After 8 h had elapsed during stable hemodynamic conditions, an initial set of measurements will be obtained during the sedation with propofol and remifentanyl. This set of measurements will be considered as baseline. In the patients in which conventional sedation will be replaced by dexmedetomidine and remifentanyl, a second set of measurements will be obtained after 4 h had elapsed during stable conditions. A final set of mesurements will be obtained after another 8-h period in stable conditions after switcheing back again to propofol and remifentanyl, .
During the observational period the dosage rate of norepinephrine will be adjusted to maintain the same threshold MAP of 65-75 mmHg All other medications were held constant.
研究类型
注册 (实际的)
阶段
- 第三阶段
联系人和位置
学习地点
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Rome、意大利、00161
- Departement of Anesthesiology and Intensive Care of the University of Rome La Sapienza
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
描述
Inclusion Criteria:
- septic shock
- need for sedation
Exclusion Criteria:
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学习计划
研究是如何设计的?
设计细节
- 主要用途:治疗
- 分配:不适用
- 介入模型:单组作业
- 屏蔽:无(打开标签)
武器和干预
参与者组/臂 |
干预/治疗 |
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实验性的:右美托咪定
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Sedation with propofol and remifentanyl will be replaced by a sedation with dexmedetomidine and remifentanyl
其他名称:
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研究衡量的是什么?
主要结果指标
结果测量 |
大体时间 |
---|---|
norepinephrine dose
大体时间:4 hours
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4 hours
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次要结果测量
结果测量 |
大体时间 |
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cardiac output
大体时间:4 hours
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4 hours
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mean arterial pressure
大体时间:4 hours
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4 hours
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heart rate
大体时间:4 hours
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4 hours
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合作者和调查者
研究记录日期
研究主要日期
学习开始 (实际的)
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (估计)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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