Switching to Low Oxidant Content Cigarettes in Adult Smokers

Inclusion Criteria:

• Age 21-65
• Smoke 10 cigarettes per day or more for at least one year
• Read and write in English
• Menthol and nonmenthol smokers
• Able to understand and provide consent to study procedures
• Plan to live in the local area for the next 3 months
• Women not pregnant or nursing and taking steps to avoid pregnancy
• No quit attempt in the last one months and not planning to quit in the next 3 months (ensuring stability of smoking)

Exclusion Criteria:

• Currently pregnant or nursing
• Unstable or significant medical conditions that affect oxidative stress, such as COPD, kidney failure, heart disease, stroke, cancer, tumors, lung or respiratory disease, diabetes, liver disease, autoimmune disorder, rheumatoid arthritis, infectious disease or fibromyalgia.
• Use of non-cigarette nicotine delivery
• History of difficulties providing blood samples: fainting, poor veins, anxiety, etc.
• Current or recent history of substance or alcohol abuse
• No more than seven alcoholic drinks a week, and/ or >two drinks a day
• Use of a high dose antioxidant supplement prior to 1 month
• Currently smoking cigarettes that will be used for the study (Pall Mall Red or American Spirit Dark Green)