Fructose Extra-splanchnic Metabolism and Its Effects on Systemic Flux of Substrates (FruPP) (FruPP)
In parallel to the dramatic rise in metabolic diseases and diabetes observed over the past fifty years, the generalization of added sugar in processed food led to a marked increase in fructose consumption in almost all countries, and epidemiological studies demonstrated that the consumption of sugar-sweetened beverage (containing at least 50% of fructose) is associated with the development of diabetes, hepatic steatosis, dyslipidemia and obesity.
The objective of the study is to measure the amount of fructose that escape first-pass hepatic extraction after oral ingestion (fructose+glucose), and gain insights into its metabolic fates with the use of tracers.
研究概览
研究类型
注册 (实际的)
阶段
- 不适用
联系人和位置
学习地点
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Lausanne、瑞士、1005
- University of Lausanne
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
描述
Inclusion Criteria:
- Aged from 18 to 40 years
- Body Mass Index of 18.5 to 25 kg/m²
- Sex male of female
Exclusion Criteria:
- Fructose intolerance
- Antidiabetic and hypolipemic drugs
- Alcohol consumption >10g/day
- Severe eating disorders
- Severe psychological problems
- Vegetarian diet or other specific diet
- Consumption of illicit substances
- Pregnancy
- Weight gain or weight loss > 3 kg in the last 3 months
学习计划
研究是如何设计的？
设计细节
- 主要用途：基础科学
- 分配：不适用
- 介入模型：单组作业
- 屏蔽：无（打开标签）
武器和干预
参与者组/臂 |
干预/治疗 |
|---|---|
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实验性的：Test meal
The subjects will receive a liquid test meal containing glucose and fructose with 13C fructose.
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Liquid test meal (fructose+glucose)
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研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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Measurement of the amount of fructose that escape first-pass hepatic extraction after oral ingestion.
大体时间：The quantity of 13C fructose will be calculated, during the post prandial period, until 240 min.
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Calculation with 13C fructose enrichment in blood samples at T0; 30; 60; 90; 120; 150; 180; 210 and 240 min.
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The quantity of 13C fructose will be calculated, during the post prandial period, until 240 min.
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合作者和调查者
研究记录日期
研究主要日期
学习开始 (实际的)
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (实际的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
与本研究相关的术语
关键字
其他研究编号
- 2016-01828
计划个人参与者数据 (IPD)
计划共享个人参与者数据 (IPD)？
药物和器械信息、研究文件
研究美国 FDA 监管的药品
研究美国 FDA 监管的设备产品
此信息直接从 clinicaltrials.gov 网站检索，没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求，请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改，我们的网站上也会自动更新.
Test meal的临床试验
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University of North Carolina, Chapel HillEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD); National... 和其他合作者完全的
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National University of Ireland, Galway, IrelandHealth Research Board, Ireland完全的
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PATHUnited States Agency for International Development (USAID); Kintampo Health Research Centre,...完全的
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University Hospital, Limoges完全的