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VeClose Five Year Follow-Up Extension Study

2019年4月10日 更新者：Medtronic Endovascular

Follow-up of Patients Treated in VeClose Study (Five Years)

The VeClose Five Year Follow-up Extension Study will seek to gain additional follow-up data from the patients enrolled in the VeClose study (NCT01807585).

研究概览

地位

完全的

条件

干预/治疗

详细说明

The VeClose Five Year Follow-up Extension Study will continue to assess the safety and efficacy of the VenaSeal Closure System for the long term effect on closure of the great saphenous vein by conducting a follow-up visit at five years post index procedure/enrollment in the VeClose study.

研究类型

观察性的

注册 (实际的)

114

联系人和位置

本节提供了进行研究的人员的详细联系信息，以及有关进行该研究的地点的信息。

学习地点

  • 美国
    • Arizona
      • Scottsdale、Arizona、美国、85255
        • Morrison Vein Institute
    • California
      • San Diego、California、美国、92121
        • GBK Cosmetic Laser Dermatology
    • Colorado
      • Greenwood Village、Colorado、美国、80111
        • Radiology Imaging Associates (RIA)
    • Illinois
      • Springfield、Illinois、美国、62701
        • Prairie Education & Research Cooperative
    • Maryland
      • Hunt Valley、Maryland、美国、21030
        • MD Laser Skin & Vein Institute
    • New York
      • North Tonawanda、New York、美国、14120
        • Vein Institute of Buffalo
    • Oregon
      • Bend、Oregon、美国、97701
        • Inovia Vein Speciality Center
    • Virginia
      • Virginia Beach、Virginia、美国、23452
        • Sentara Vascular Specialists
    • Washington
      • Bellevue、Washington、美国、98004
        • Lake Washington Vascular

参与标准

研究人员寻找符合特定描述的人，称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。

资格标准

适合学习的年龄

21年 至 70年 (成人、年长者)

接受健康志愿者

不

有资格学习的性别

全部

取样方法

非概率样本

研究人群

Subjects currently enrolled in both arms of the VeClose Study (NCT01807585) will be assessed for eligibility to enroll in the VeClose Five Year Follow-up Extension Study. All subjects must meet the inclusion criteria and must not meet the exclusion criteria. Assessment of eligibility is based on data available to the investigator at the time of subject enrollment. The subject will be considered to be enrolled in the VeClose Five Year Follow-up Extension Study after the informed consent is signed/dated and all of the study eligibility criteria have been met.

描述

Inclusion Criteria:

  1. Enrolled in the VeClose study.
  2. Able and willing to complete the required 5 year study visit including Duplex ultrasound exam.
  3. Able and willing to provide written informed consent prior to study specific data collection.

Exclusion Criteria:

1. Withdrew consent from the VeClose study.

学习计划

本节提供研究计划的详细信息，包括研究的设计方式和研究的衡量标准。

研究是如何设计的？

设计细节

队列和干预

团体/队列
干预/治疗
Experimental: VenaSeal SCS
Endovenous delivery of VenaSeal Adhesive (VA) to a target site in diseased great saphenous veins (GSV). The VA is dispensed in small amounts with each pull of the trigger equaling 0.10 cc. Subjects were randomized in a 1:1 ratio to either VenaSeal SCS or to RFA at the time of enrollment into the VeClose study (NCT01807585).
设备：VenaSeal SCS
非肿胀、非热、非硬化程序，使用专有的医用粘合剂通过静脉内输送来闭合静脉。
其他名称：
  • VenaSeal Sapheon 封闭系统
  • VSCS
Active Comparator: RFA
Endovenous insertion of the ClosureFast radiofrequency ablation (RFA) catheter into a target site in diseased great saphenous veins (GSV). Heat is applied to the target vein using radiofrequency energy to ablate the target vein. Subjects were randomized in a 1:1 ratio to either VenaSeal SCS or to RFA at the time of enrollment into the VeClose study (NCT01807585).
设备：ClosureFast 射频消融 (RFA)
使用 Covidien ClosureFast 系统对 GSV 进行射频热消融。
其他名称：
  • 快速关闭
Experimental: Roll-in (VenaSeal SCS)
Prior to initiation of the randomized cohort at each site for the VeClose study (NCT01807585), a non-randomized cohort of 2 subjects per site (roll-in phase) were enrolled and treated with VenaSeal SCS with endovenous delivery of VenaSeal Adhesive (VA) to a target site in diseased great saphenous veins (GSV). The VA is dispensed in small amounts with each pull of the trigger equaling 0.10 cc.
设备：Roll-In (VenaSeal SCS)
Non-tumescent, non-thermal, non-sclerosant procedure that uses a proprietary medical adhesive delivered endovenously to close the vein.
其他名称：
  • VenaSeal Sapheon 封闭系统
  • VSCS
  • 滚入

研究衡量的是什么？

主要结果指标

结果测量
措施说明
大体时间
Complete Closure of the Target Vein at 5 years after index treatment in the VeClose study (NCT01807585).
大体时间：5 years
Complete closure is defined as Doppler ultrasound examination showing closure along entire treated target vein segment with no discrete segments of patency exceeding 5cm.
5 years

次要结果测量

结果测量
措施说明
大体时间
Venous Clinical Severity Score (VCSS)
大体时间：5 years
Change in Venous Clinical Severity Score (VCSS) at 5 years as compared to baseline data from the VeClose study (NCT01807585). The VCSS is an Investigator assessment of the severity of venous reflux disease, assessing signs and symptoms such as pain, varicose veins, venous edema, skin pigmentation, induration and inflammation. The VCSS score is the sum of responses to 10 questions. Each question has a total possible of 3 points, which are then added for each question. The overall VCSS scores can therefore range from 0 (no venous disease) to 30 (severe venous disease). High scores indicate worse outcomes and "0" is the best possible outcome.
5 years
Aberdeen Varicose Vein Questionnaire (AVVQ)
大体时间：5 years
Change in Aberdeen Varicose Vein Questionnaire (AVVQ) at 5 years as compared to baseline data from the VeClose study (NCT01807585). AVVQ is a disease-specific 13-item questionnaire used to assess the impact of varicose veins on the quality of life, such as pain caused by varicose veins, and need to take painkilling tablets for varicose veins as well as assessing the presence of signs/symptoms such as ankle swelling, purple discoloration and rash/eczema. The total score of AVVQ is the sum of all questions for each leg. Scores range from 0 (no disease) to 100 (maximal disease). High scores indicate worse outcomes and "0" is the best possible outcome.
5 years
Quality of Life survey (EQ-5D)
大体时间：5 years
Change in Quality of Life survey (EQ-5D) at 5 years as compared to baseline data from the VeClose study (NCT01807585). EQ-5D is a short generic quality of life survey that is commonly used outside of the United States for health technology assessments. The "health state today" question provides an overall assessment along a 20-cm visual analog scale (VAS) with a range from 0 ("worst imaginable health state") to 100 ("best imaginable health state").
5 years
CEAP classification ("clinical, etiology, assessment and pathophysiology")
大体时间：5 years
Standardized measure of the degree of venous insufficiency and secondary manifestations of venous disease as measured by the treating physician.
5 years
Satisfaction with Treatment
大体时间：5 years
Satisfaction with Treatment assessment consists of a brief 2-question patient survey rating satisfaction with treatment provided and whether the subject would undergo the assigned treatment again. The number (percent) of subjects on each level of satisfaction are summarized (Very satisfied, Somewhat satisfied, Somewhat dissatisfied, Very dissatisfied). The number (percent) of subjects for the second satisfaction question, "would undergo treatment again" were also summarized by response (Definitely have again, Might have again, Not have again).
5 years
Adverse events (AE) related to the target GSV
大体时间：5 years
AEs related to the GSV will be tabulated and reporting using the MedDRA dictionary, version 16.1.
5 years
Adjunctive procedures performed on the study limb
大体时间：5 years
Details of adjunctive procedures performed on the study limb will be captured on Case Report Forms (CRFs)
5 years

合作者和调查者

在这里您可以找到参与这项研究的人员和组织。

赞助

Medtronic Endovascular

调查人员

  • 首席研究员：Nick Morrison, MD、Morrison Vein Institute

出版物和有用的链接

负责输入研究信息的人员自愿提供这些出版物。这些可能与研究有关。

一般刊物

研究记录日期

这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查，以确保它们在发布到公共网站之前符合特定的质量控制标准。

研究主要日期

学习开始 (实际的)

2016年7月1日

初级完成 (实际的)

2019年1月1日

研究完成 (实际的)

2019年1月1日

研究注册日期

首次提交

2018年2月28日

首先提交符合 QC 标准的

2018年2月28日

首次发布 (实际的)

2018年3月6日

研究记录更新

最后更新发布 (实际的)

2019年4月12日

上次提交的符合 QC 标准的更新

2019年4月10日

最后验证

2019年4月1日

更多信息

与本研究相关的术语

关键字

其他相关的 MeSH 术语

其他研究编号

  • CP-1011

计划个人参与者数据 (IPD)

计划共享个人参与者数据 (IPD)？

不

此信息直接从 clinicaltrials.gov 网站检索，没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求，请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改，我们的网站上也会自动更新.

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条件

罕见疾病

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