Study of Human Adipose Tissue (LOSHAT) (LOSHAT)
Longitudinal Observational Study of Human Adipose Tissue (LOSHAT)
研究概览
详细说明
The investigators will ask all subjects that have previously been examined at the investigators laboratory (from 1992 and forward) in studies of adipose tissue function if they are interested to participate in a new study.
Previously obtained results from examinations of adipose tissue, anthropometric measurements and blood samples will be used as baseline. In addition, saved blood samples and samples from old fat biopsies can be re-investigated in some cases.
The new investigation includes a questionnaire that the subjects can answer by mail or email. In addition, anthropometric measurements and blood pressure determination will be performed at a primary health care center and blood samples will be collected for analysis of fasting glucose, HbA1C and lipids.
Information regarding all previously investigated subjects will also be collected from several Swedish national patient registries such as the Patient Register, Prescribed Drug register and Cause-of Death register.
研究类型
注册 (预期的)
联系人和位置
学习联系方式
- 姓名:Peter Arner, MD, PhD
- 电话号码:+468 58582342
- 邮箱:peter.arner@ki.se
研究联系人备份
- 姓名:Daniel P Andersson, MD, PhD
- 电话号码:+468 58580000
- 邮箱:daniel.p.andersson@ki.se
学习地点
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Stockholm、瑞典、14186
- 招聘中
- Karolinska University Hospital
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接触:
- Daniel P Andersson, MD, PhD
- 邮箱:daniel.p.andersson@ki.se
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion Criteria:
- Previously participated in examinations at the investigators laboratory and donated adipose tissue.
- Previously participated in examinations at the investigators laboratory and donated blood samples that can be used to estimate lipolysis with a formula.
Exclusion Criteria:
- Decline to participate after invitation.
- Severe Psychiatric disease.
- Type 1 Diabetes
- Participants that have undergone bariatric surgery will be exluded in the primary analysis but will be analyzed separately in a secondary analysis for all above mentioned outcomes.
学习计划
研究是如何设计的?
设计细节
研究衡量的是什么?
主要结果指标
结果测量 |
措施说明 |
大体时间 |
---|---|---|
Body mass index
大体时间:2018 to 2022
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Body weight (in kilogram) will be assessed with a regular scale.
Height will be measured with a tape measure (in centimeters).
Body mass index (BMI) will be calculated with the formula weight (kg) divided by height^2 (in meter).
Changes in BMI from baseline values will be analysed.
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2018 to 2022
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Fasting glucose
大体时间:2018 to 2022
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Fasting plasma glucose will be assessed and divided into normal glucose (glucose < 6.1 mmol/L), impaired fasting glucose (glucose 6.1-6.9 mmol/L) or type 2 diabetes (glucose > 6.9 mmol/L).
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2018 to 2022
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Number of participants with metabolic syndrome
大体时间:2018 to 2022
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Metabolic syndrome is defined according to International Diabetes Federation, Waist circumference ≥102 cm for men or ≥88 cm for women.
In addition to this 2 of the following; Raised triglycerides: > 150 mg/dL (1.7 mmol/L), or specific treatment for this lipid abnormality; Reduced HDL cholesterol: < 40 mg/dL (1.03 mmol/L) in males, < 50 mg/dL (1.29 mmol/L) in females, or specific treatment for this lipid abnormality; Raised blood pressure (BP): systolic BP > 130 or diastolic BP >85 mm Hg, or treatment of previously diagnosed hypertension; Raised fasting plasma glucose (FPG): >100 mg/dL (5.6 mmol/L), or previously diagnosed type 2 diabetes.
Scores are 0-5.
≥ 3 is defined as metabolic syndrome.
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2018 to 2022
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Number of participants with type 2 Diabetes
大体时间:2018 to 2022
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Based on a diagnosis in the Swedish National Patient Register, or prescribed drugs for Type 2 diabetes in the Swedish National Prescribed Drug Register or direct information from the subject.
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2018 to 2022
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Number of participants with dyslipidemia
大体时间:2018 to 2022
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Based on a diagnosis in the Swedish National Patient Register, or prescribed drugs for dyslipidemia in the Swedish National Prescribed Drug Register, or direct information from the subject.
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2018 to 2022
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Number of participants with Hypertension
大体时间:2018 to 2022
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Based on a diagnosis in the Swedish National Patient Register, or prescribed drugs for hypertension in the Swedish National Prescribed Drug Register, or direct information from the subject.
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2018 to 2022
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次要结果测量
结果测量 |
措施说明 |
大体时间 |
---|---|---|
Genetic variations linked to lipolysis
大体时间:2018 to 2022
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Genome-wide association study (GWAS) with focus on genes related to lipolysis and analysis of single nucleotide polymorphisms (SNPs).
Samples from baseline examination will be used in the analysis.
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2018 to 2022
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合作者和调查者
调查人员
- 首席研究员:Peter Arner, MD, PhD、Karolinska University Hospital
- 研究主任:Daniel P Andersson, MD, PhD、Karolinska University Hospital
- 学习椅:Mikael Rydén, Md, PhD、Karolinska University Hospital
研究记录日期
研究主要日期
学习开始 (实际的)
初级完成 (预期的)
研究完成 (预期的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (实际的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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