Retrospective Evaluation of Ketamine Effectiveness for the Treatment of Acute Battlefield Related Pain
A Retrospective Evaluation of Ketamine Effectiveness for the Treatment of Acute Battlefield Related Pain
研究概览
详细说明
This is a retrospective study to determine if there is a relationship between intravenous infusion of ketamine given for analgesia and the use of additional opioid pain medications and patient reported pain levels before and during ketamine usage. The investigator anticipates that records of up to 700 subjects will be reviewed for eligibility. The time period 24 hours before the initial ketamine therapy is initiated along with 24 & 48 hours after the start of ketamine therapy will be the time periods examined. The average/minimum/maximum pain scores during these time periods will be used. Medication usage will be calculated over the 24 hour time periods.
This protocol is presented as an initial step in exploring the possible relationship between the administration of ketamine as an analgesic agent, the potential reduction in pain medications, and the potential reduction of pain levels. With this the goals/objectives are as follows:
Objectives
- To compare morphine consumption in battlefield injured patients with acute pain 24 hours before the initiation of a ketamine infusion to the subsequent 48 hours following the start of infusion.
- To compare average/minimum/maximum pain scores in battlefield injured patients with acute pain 24 hours before the initiation of a ketamine infusion to the subsequent 48 hours following the start of infusion.
- To describe the pain trajectory in battlefield injured patients with acute pain after the initiation of ketamine infusions.
- To measure the absolute and proportional incidence of ketamine associated side effects in battlefield injured patients with acute pain following the initiation of ketamine infusions.
研究类型
注册 (实际的)
联系人和位置
学习地点
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Maryland
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Bethesda、Maryland、美国、20889
- Walter Reed National Military Medical Center
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion Criteria:
- Battlefield injured from January 2007 to December 2013
- Prescribed a ketamine infusion for acute pain
- Awake, alert (non intubated/sedated), and able to report pain scores 24 hours prior to the start of infusion and up to 48 hours following infusion
Exclusion Criteria:
- Patients who did not receive an injury in theater and did not receive ketamine while being treated by the APS or WRNMMC/WRAMC hospital staff
- No continuous perineural catheter or epidural placement while on ketamine infusion
- Less than 18 years old
学习计划
研究是如何设计的?
设计细节
队列和干预
团体/队列 |
干预/治疗 |
---|---|
Battlefield Injury with ketamine treatment
Patients who received ketamine infusions to treat pain from January 2007 to December 2013.
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研究衡量的是什么?
主要结果指标
结果测量 |
措施说明 |
大体时间 |
---|---|---|
Opioid consumption measured in morphine equivalents
大体时间:24 hours before ketamine infusion
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Amount of opioids consumed within time frame
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24 hours before ketamine infusion
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Opioid consumption measured in morphine equivalents
大体时间:24 hours after ketamine infusion
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Amount of opioids consumed within time frame
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24 hours after ketamine infusion
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Opioid consumption measured in morphine equivalents
大体时间:48 hours after ketamine infusion
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Amount of opioids consumed within time frame
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48 hours after ketamine infusion
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Pain scores
大体时间:24 hours before ketamine infusion
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Defense and Veterans Pain Rating Scale Pain scores recorded based on the Defense and Veterans Pain Rating Scale Rate the severity of your CURRENT pain: 0 - No Pain
Circle the number that describes how, during the past 24 hours, pain has interfered with your usual activity: 0 - 10 (0=does not interfere, 10=completely interferes) Circle the number that describes how, during the past 24 hours, pain has interfered with sleep: 0 - 10 (0=does not interfere, 10=completely interferes) Circle the number that describes how, during the past 24 hours, pain has affected your mood: 0-10 |
24 hours before ketamine infusion
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Pain scores
大体时间:24 hours after ketamine infusion
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Defense and Veterans Pain Rating Scale Pain scores recorded based on the Defense and Veterans Pain Rating Scale Rate the severity of your CURRENT pain: 0 - No Pain
Circle the number that describes how, during the past 24 hours, pain has interfered with your usual activity: 0 - 10 (0=does not interfere, 10=completely interferes) Circle the number that describes how, during the past 24 hours, pain has interfered with sleep: 0 - 10 (0=does not interfere, 10=completely interferes) Circle the number that describes how, during the past 24 hours, pain has affected your mood: 0-10 |
24 hours after ketamine infusion
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Pain scores
大体时间:48 hours after ketamine infusion
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Defense and Veterans Pain Rating Scale Pain scores recorded based on the Defense and Veterans Pain Rating Scale Rate the severity of your CURRENT pain: 0 - No Pain
Circle the number that describes how, during the past 24 hours, pain has interfered with your usual activity: 0 - 10 (0=does not interfere, 10=completely interferes) Circle the number that describes how, during the past 24 hours, pain has interfered with sleep: 0 - 10 (0=does not interfere, 10=completely interferes) Circle the number that describes how, during the past 24 hours, pain has affected your mood: 0-10 |
48 hours after ketamine infusion
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Number of ketamine side effects
大体时间:24 hours before ketamine infusion
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Recorded side effects after ketamine infusion
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24 hours before ketamine infusion
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Number of ketamine side effects
大体时间:24 after ketamine infusion
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Recorded side effects after ketamine infusion
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24 after ketamine infusion
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Number of ketamine side effects
大体时间:48 hours after ketamine infusion
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Recorded side effects after ketamine infusion
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48 hours after ketamine infusion
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合作者和调查者
调查人员
- 首席研究员:Michael Kent, MD、Walter Reed National Military Medical Center
研究记录日期
研究主要日期
学习开始
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (实际的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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