Effect of Genes on Rosuvastatin Therapy for Hyperlipidemia

December 20, 2012 updated by: National Taiwan University Hospital
Previous studies indicate that the variant status of detoxification proteins is different among Taiwanese and other ethnic groups. For example, in Taiwanese, the major SNPs of CYP2C9 are CYP2C9*2 (430C>T) and CYP2C9*3 (1075A>C) and their frequencies are different from that in Caucasians [11]. The second example is that the frequency of the A(TA)7TAA allele in the promoter area of the UGT1A1 gene is substantially lower, while for the rate of variation within the coding region is much higher in Taiwanese than that in Caucasians (14.3% vs. 35.7- 41.5% and 29.3% vs. 0.1%, respectively) [12]. The third example is that the frequency of 388A>G of the OATP2 gene in Taiwanese (0.68) [13] is in between that in European Americans (0.30) and African Americans (0.74) [14]. Therefore, the investigators hypothesize that, in Taiwanese the SNPs of detoxification proteins modulate the lipid-lowing effects of RVA and fenofibrate may be different from those for Caucasians.

Study Overview

Status

Status

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Available

Conditions

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Intervention / Treatment

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Detailed Description

Since April 2008, we have started to run a multicenter, prospective, randomized, open-label, blinded end-point classification trial to test the hypothesis in Taiwan that the addition of fibrate on statin would provide a further reduction in the major coronary events in the patients with diabetes or atherosclerotic vascular diseases with metabolic syndrome. With the advantage of this large-scaled prospective trial, it is also a good opportunity to identify simultaneously the genetic determinants of wide range of interindividual variability in phenotypic and clinical response to two major lipid-lowering drug classes, rosuvastatin and fenofibrate. The aim of this proposal is to find which SNPs influence the therapeutic effectiveness of lipid lowering therapy in Taiwanese hyperlipidemic patients. A key feature is the use of multiple drug-treated population samples to get the findings derived from both candidate gene and genome-wide searches for SNP associations with markers of drug efficacy as well as side effects. Thus the promise of pharmacogenomics and metabolomics-- "individualized medicine" will come true in treating hyperlipidemia in Taiwanese.

Study Type

Study Type

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Expanded Access

Participation Criteria

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Eligibility Criteria

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Ages Eligible for Study

20 years to 79 years (ADULT, OLDER_ADULT)

Accepts Healthy Volunteers

N/A

Genders Eligible for Study

All

Description

Inclusion Criteria:

  • Men or women aged 20-79 years with definite DM or atherosclerotic vascular diseases with metabolic syndrome, defined as the presence of three or more of the following risk factors:

    • abdominal obesity (waist circumference > 90 cm in men or > 80 cm in women),
    • triglycerides > 150 mg/dL, HDL-cholesterol < 40 mg/dL in men or < 50 mg/dL in women,
    • blood pressure > 130/85 mm Hg, or
    • fasting glucose > 100 mg/dL).
  • Those who are qualified for lipid lowering therapy according to the Taiwanese national guidelines (LDL-C 130-190 mg/dL or TG 200-500 mg/dL with HDL-C < 40 mg/dL or TC/HDL-C > 5).

Exclusion Criteria:

  • Any known contraindications to statin or fibrate therapy,
  • Previous intolerance to statin or fibrate in low or high doses,
  • Liver enzyme levels more than 3 times the upper limit of normal,
  • Pregnancy or breastfeeding,
  • Nephrotic syndrome,
  • Uncontrolled diabetes mellitus (HbA1c > 9),
  • Uncontrolled hypothyroidism,
  • Plasma LDL-C level higher than 190 mg/dL or triglyceride level higher than 500 mg/dL,
  • Coronary heart disease event or revascularisation within a month,
  • Congestive heart failure (New York Heart Association classification IIIb or IV),
  • Hemodynamically important valvular heart disease,
  • Gastrointestinal conditions affecting absorption of drugs,
  • Treatment with other drugs that seriously affect the pharmacokinetics of statins or fibrate,
  • Unexplained creatine phosphokinase concentrations six or more times the upper limit of normal,
  • Life-threatening malignancy,
  • Treatment with immuno suppressive or other lipid lowering drugs.
  • Patients previously treated with monotherapy with statins or fibrates will be qualified if they have not already had titration to a dose higher than the equivalent of 5 mg/d of rosuvastatin or 160 mg/d of SFC fenofibrate.

Study Plan

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How is the study designed?

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Sponsor

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National Taiwan University Hospital

Study record dates

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Study Registration Dates

First Submitted

First Submitted

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July 6, 2009

First Submitted That Met QC Criteria

First Submitted That Met QC Criteria

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July 7, 2009

First Posted (ESTIMATE)

First Posted

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July 8, 2009

Study Record Updates

Last Update Posted (ESTIMATE)

Last Update Posted

The most recent date on which changes to a study record were made available on ClinicalTrials.gov. There may be a delay between when the changes were submitted to ClinicalTrials.gov by the study's sponsor or investigator (the last update submitted date) and the last update posted date.
December 21, 2012

Last Update Submitted That Met QC Criteria

Last Update Submitted That Met QC Criteria

The most recent date on which the study sponsor or investigator submitted changes to a study record that are consistent with National Library of Medicine (NLM) quality control (QC) review criteria. It is the responsibility of the sponsor or investigator to ensure that the study record is consistent with the NLM QC review criteria.
December 20, 2012

Last Verified

Last Verified

The most recent date on which the study sponsor or investigator confirmed the information about a clinical study on ClinicalTrials.gov as accurate and current. If a study with a recruitment status of recruiting; not yet recruiting; or active, not recruiting has not been confirmed within the past 2 years, the study's recruitment status is shown as unknown.
November 1, 2012

More Information

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Other Study ID Numbers

Other Study ID Numbers

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  • 200812111R

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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