Further Cardiovascular Outcomes Research With PCSK9 Inhibition in Subjects With Elevated Risk (FOURIER)

May 10, 2024 updated by: Amgen

A Double-blind, Randomized, Placebo-controlled, Multicenter Study Assessing the Impact of Additional LDL-Cholesterol Reduction on Major Cardiovascular Events When Evolocumab (AMG 145) is Used in Combination With Statin Therapy In Patients With Clinically Evident Cardiovascular Disease

The primary objective was to evaluate the effect of treatment with evolocumab, compared with placebo, on the risk for cardiovascular death, myocardial infarction, stroke, hospitalization for unstable angina, or coronary revascularization, whichever occurs first, in patients with clinically evident cardiovascular disease.

Study Overview

Status

Completed

Conditions

Dyslipidemia

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

27564

Phase

Phase 3

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

Argentina
- - Corrientes, Argentina, W3400AMZ
    - Research Site
  - Córdoba, Argentina, X5003DCE
    - Research Site
  - Salta, Argentina, A4400ANG
    - Research Site
  - Salta, Argentina, A4400CRC
    - Research Site
- Buenos Aires
  - Bahia Blanca, Buenos Aires, Argentina, B8000FTD
    - Research Site
  - Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina, C1128AAF
    - Research Site
  - Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina, C1430CKE
    - Research Site
  - Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina, 1209
    - Research Site
  - Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina, C1093AAS
    - Research Site
  - Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina, C1426EGR
    - Research Site
  - Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina, C1428AQK
    - Research Site
  - La Plata, Buenos Aires, Argentina, B1902AGY
    - Research Site
  - La Plata, Buenos Aires, Argentina, B1902COS
    - Research Site
  - Mar del Plata, Buenos Aires, Argentina, B7600FZN
    - Research Site
  - Mar del Plata, Buenos Aires, Argentina, B7602CBM
    - Research Site
  - Quilmes, Buenos Aires, Argentina, B1878GEG
    - Research Site
- Córdoba
  - Cordoba, Córdoba, Argentina, X5016KEH
    - Research Site
  - Cordoba, Córdoba, Argentina, X5000BNB
    - Research Site
  - Cordoba, Córdoba, Argentina, X5000EPU
    - Research Site
  - Cordoba, Córdoba, Argentina, X5002AOQ
    - Research Site
- Santa Fe
  - Rosario, Santa Fe, Argentina, S2000CVD
    - Research Site
- Tucuman
  - San Miguel de Tucuman, Tucuman, Argentina, T4000ICL
    - Research Site
  - San Miguel de Tucuman, Tucuman, Argentina, T4000IAF
    - Research Site
Australia
- Australian Capital Territory
  - Woden, Australian Capital Territory, Australia, 2605
    - Research Site
- New South Wales
  - Camperdown, New South Wales, Australia, 2050
    - Research Site
  - Concord, New South Wales, Australia, 2139
    - Research Site
  - Kogarah, New South Wales, Australia, 2217
    - Research Site
  - Liverpool, New South Wales, Australia, 2170
    - Research Site
  - Woolloongabba, New South Wales, Australia, 4102
    - Research Site
- Queensland
  - Auchenflower, Queensland, Australia, 4066
    - Research Site
  - Herston, Queensland, Australia, 4029
    - Research Site
  - Woolloongabba, Queensland, Australia, 4102
    - Research Site
- South Australia
  - Adelaide, South Australia, Australia, 5000
    - Research Site
  - Ashford, South Australia, Australia, 5035
    - Research Site
  - Ashford, South Australia, Australia, 5036
    - Research Site
  - Fullarton, South Australia, Australia, 5063
    - Research Site
  - Woodville South, South Australia, Australia, 5011
    - Research Site
- Tasmania
  - Hobart, Tasmania, Australia, 7000
    - Research Site
- Victoria
  - Box Hill, Victoria, Australia, 3128
    - Research Site
  - Epping, Victoria, Australia, 3076
    - Research Site
  - Footscray, Victoria, Australia, 3011
    - Research Site
  - Geelong, Victoria, Australia, 3220
    - Research Site
  - Heidelberg, Victoria, Australia, 3084
    - Research Site
- Western Australia
  - Nedlands, Western Australia, Australia, 6009
    - Research Site
Austria
- - Graz, Austria, 8036
    - Research Site
  - Innsbruck, Austria, 6020
    - Research Site
  - Linz, Austria, 4010
    - Research Site
  - Salzburg, Austria, 5020
    - Research Site
  - Wels, Austria, 4600
    - Research Site
  - Wien, Austria, 1130
    - Research Site
  - Wien, Austria, 1090
    - Research Site
  - Wien, Austria, 1160
    - Research Site
  - Wien, Austria, 1060
    - Research Site
  - Wien, Austria, 1190
    - Research Site
Belgium
- - Aalst, Belgium, 9300
    - Research Site
  - Antwerpen, Belgium, 2060
    - Research Site
  - Antwerpen, Belgium, 2020
    - Research Site
  - Blankenberge, Belgium, 8370
    - Research Site
  - Bonheiden, Belgium, 2820
    - Research Site
  - Brussels, Belgium, 1070
    - Research Site
  - Brussels, Belgium, 1020
    - Research Site
  - Bruxelles, Belgium, 1200
    - Research Site
  - Gent, Belgium, 9000
    - Research Site
  - Gozee, Belgium, 6534
    - Research Site
  - Ieper, Belgium, 8900
    - Research Site
  - La Louviere, Belgium, 7100
    - Research Site
  - La Louvière, Belgium, 7100
    - Research Site
  - Liege, Belgium, 4000
    - Research Site
  - Liège, Belgium, 4000
    - Research Site
  - Lodelinsart, Belgium, 6042
    - Research Site
  - Natoye, Belgium, 5360
    - Research Site
  - Turnhout, Belgium, 2300
    - Research Site
Brazil
- - Rio De Janeiro, Brazil, 22271-100
    - Research Site
  - São Paulo, Brazil, 04266-010
    - Research Site
  - São Paulo, Brazil, 05403-000
    - Research Site
  - São Paulo, Brazil, 04040-000
    - Research Site
- Ceará
  - Fortaleza, Ceará, Brazil, 60430-350
    - Research Site
- Distrito Federal
  - Brasília, Distrito Federal, Brazil, 71625-009
    - Research Site
- Espírito Santo
  - Vitória, Espírito Santo, Brazil, 29042-751
    - Research Site
- Goiás
  - Goiania, Goiás, Brazil, 74223-130
    - Research Site
- Minas Gerais
  - Belo Horizonte, Minas Gerais, Brazil, 30150-240
    - Research Site
- Paraná
  - Campina Grande do Sul, Paraná, Brazil, 83430-000
    - Research Site
  - Curitiba, Paraná, Brazil, 80010-030
    - Research Site
  - Curitiba, Paraná, Brazil, 80730-150
    - Research Site
- Rio Grande Do Sul
  - Canoas, Rio Grande Do Sul, Brazil, 92425-900
    - Research Site
  - Passo Fundo, Rio Grande Do Sul, Brazil, 99010-080
    - Research Site
  - Porto Alegre, Rio Grande Do Sul, Brazil, 90610-000
    - Research Site
  - Porto Alegre, Rio Grande Do Sul, Brazil, 90035-903
    - Research Site
  - Porto Alegre, Rio Grande Do Sul, Brazil, 90035-001
    - Research Site
  - Porto Alegre, Rio Grande Do Sul, Brazil, 90020-090
    - Research Site
  - Porto Alegre, Rio Grande Do Sul, Brazil, 91350-200
    - Research Site
  - Porto Alegre, Rio Grande Do Sul, Brazil, 90620-001
    - Research Site
  - Porto Alegre, Rio Grande Do Sul, Brazil, 90880-480
    - Research Site
- São Paulo
  - Campinas, São Paulo, Brazil, 13010-001
    - Research Site
  - Campinas, São Paulo, Brazil, 13059-740
    - Research Site
  - Sao Jose do Rio Preto, São Paulo, Brazil, 15015-210
    - Research Site
  - Sao Paulo, São Paulo, Brazil, 01244-030
    - Research Site
  - Sao Paulo, São Paulo, Brazil, 04004-030
    - Research Site
Bulgaria
- - Haskovo, Bulgaria, 6300
    - Research Site
  - Kazanlak, Bulgaria, 6100
    - Research Site
  - Pazardzhik, Bulgaria, 4700
    - Research Site
  - Pleven, Bulgaria, 5800
    - Research Site
  - Plovdiv, Bulgaria, 4002
    - Research Site
  - Sofia, Bulgaria, 1431
    - Research Site
  - Sofia, Bulgaria, 1784
    - Research Site
  - Sofia, Bulgaria, 1407
    - Research Site
  - Sofia, Bulgaria, 1527
    - Research Site
  - Sofia, Bulgaria, 1309
    - Research Site
  - Sofia, Bulgaria, 1606
    - Research Site
  - Varna, Bulgaria, 9010
    - Research Site
Canada
- - Quebec, Canada, G1V 4W2
    - Research Site
- Alberta
  - Calgary, Alberta, Canada, T2N 4Z6
    - Research Site
- British Columbia
  - Kelowna, British Columbia, Canada, V1Y 1V6
    - Research Site
  - New Westminster, British Columbia, Canada, V3L 3W4
    - Research Site
  - Vancouver, British Columbia, Canada, V6Z 1Y6
    - Research Site
- Newfoundland and Labrador
  - St. John's, Newfoundland and Labrador, Canada, A1A 3R5
    - Research Site
  - St. Johns, Newfoundland and Labrador, Canada, A1B 3V6
    - Research Site
- Nova Scotia
  - Halifax, Nova Scotia, Canada, B3H 3A7
    - Research Site
- Ontario
  - Brampton, Ontario, Canada, L6Z 4N5
    - Research Site
  - Cambridge, Ontario, Canada, N1R 6V6
    - Research Site
  - Hamilton, Ontario, Canada, L8L 2X2
    - Research Site
  - London, Ontario, Canada, N6A 5K8
    - Research Site
  - London, Ontario, Canada, N6C 0A7
    - Research Site
  - Newmarket, Ontario, Canada, L3Y 5G8
    - Research Site
  - Newmarket, Ontario, Canada, L3Y 8C3
    - Research Site
  - Oshawa, Ontario, Canada, L1J 2K1
    - Research Site
  - Oshawa, Ontario, Canada, L1J 2J9
    - Research Site
  - Ottawa, Ontario, Canada, K1Y 4W7
    - Research Site
  - Peterborough, Ontario, Canada, K9J 0B2
    - Research Site
  - Sarnia, Ontario, Canada, N7T 4X3
    - Research Site
  - Scarborough, Ontario, Canada, M1E 5E9
    - Research Site
  - Scarborough, Ontario, Canada, M1P 2T7
    - Research Site
  - Strathroy, Ontario, Canada, N7G 1Y7
    - Research Site
  - Thunder Bay, Ontario, Canada, P7B 6V4
    - Research Site
  - Toronto, Ontario, Canada, M5T 3A9
    - Research Site
  - Toronto, Ontario, Canada, M5C 2T2
    - Research Site
- Quebec
  - Chicoutimi, Quebec, Canada, G7H 7K9
    - Research Site
  - Gatineau, Quebec, Canada, J8Y 6S8
    - Research Site
  - Granby, Quebec, Canada, J2G 8Z9
    - Research Site
  - Greenfield Park, Quebec, Canada, J4V 2G8
    - Research Site
  - Lachine, Quebec, Canada, H8S 2E4
    - Research Site
  - Longueuil, Quebec, Canada, J4M 2X1
    - Research Site
  - Montreal, Quebec, Canada, H4A 3J1
    - Research Site
  - Montreal, Quebec, Canada, H3G 1A4
    - Research Site
  - Montreal, Quebec, Canada, H1T 3Y7
    - Research Site
  - Montreal, Quebec, Canada, H2W 1T8
    - Research Site
  - Montreal, Quebec, Canada, H1Y 3L1
    - Research Site
  - Montreal, Quebec, Canada, H2W 1R7
    - Research Site
  - Pointe-Claire, Quebec, Canada, H9R 3J1
    - Research Site
  - Québec, Quebec, Canada, G1V 4G5
    - Research Site
  - St Jean sur Richelieu, Quebec, Canada, J3A 1C3
    - Research Site
  - St-Charles-Borromee, Quebec, Canada, J6E 6J2
    - Research Site
  - St-Jérôme, Quebec, Canada, J7Z 5T3
    - Research Site
  - Terrebonne, Quebec, Canada, J6V 2H2
    - Research Site
  - Westmout, Quebec, Canada, H3Z 1E5
    - Research Site
- Saskatchewan
  - Regina, Saskatchewan, Canada, S4P 0W5
    - Research Site
Chile
- - Osorno, Chile, 5311092
    - Research Site
  - Santiago, Chile
    - Research Site
  - Santiago, Chile, 8350595
    - Research Site
  - Santiago, Chile, 7650018
    - Research Site
  - Santiago, Chile, 7500520
    - Research Site
- Cautín
  - Temuco, Cautín, Chile, 4781156
    - Research Site
  - Temuco, Cautín, Chile, 4813299
    - Research Site
China
- - Beijing, China, 100020
    - Research Site
  - Tianjin, China, 300211
    - Research Site
- Beijing
  - Beijing, Beijing, China, 100191
    - Research Site
  - Beijing, Beijing, China, 100037
    - Research Site
- Guangdong
  - Guangzhou, Guangdong, China, 510080
    - Research Site
- Heilongjiang
  - Harbin, Heilongjiang, China, 150001
    - Research Site
- Henan
  - Zhengzhou, Henan, China, 450052
    - Research Site
- Hubei
  - Wuhan, Hubei, China, 430030
    - Research Site
  - Wuhan, Hubei, China, 430014
    - Research Site
- Hunan
  - Changde, Hunan, China, 415003
    - Research Site
  - Changsha, Hunan, China, 410008
    - Research Site
  - Changsha, Hunan, China, 410013
    - Research Site
  - Changsha, Hunan, China, 410004
    - Research Site
  - Changsha, Hunan, China, 410005
    - Research Site
  - Xiangtan, Hunan, China, 411100
    - Research Site
  - Zhuzhou, Hunan, China, 412000
    - Research Site
- Inner Mongolia
  - Baotou, Inner Mongolia, China, 014010
    - Research Site
  - Hohhot, Inner Mongolia, China, 010020
    - Research Site
- Jiangsu
  - Suzhou, Jiangsu, China, 215000
    - Research Site
  - Wuxi, Jiangsu, China, 214023
    - Research Site
  - Xuzhou, Jiangsu, China, 221006
    - Research Site
- Jilin
  - Changchun, Jilin, China, 130021
    - Research Site
  - Changchun, Jilin, China, 130033
    - Research Site
  - Changchun, Jilin, China, 130011
    - Research Site
  - Siping, Jilin, China, 136000
    - Research Site
- Liaoning
  - Dalian, Liaoning, China, 116027
    - Research Site
  - Shenyang, Liaoning, China, 110016
    - Research Site
- Ningxia
  - Yinchuan, Ningxia, China, 750004
    - Research Site
- Shandong
  - Qingdao, Shandong, China, 266003
    - Research Site
- Shanxi
  - Taiyuan, Shanxi, China, 030009
    - Research Site
- Tianjin
  - Tianjin, Tianjin, China, 300052
    - Research Site
  - Tianjin, Tianjin, China, 300120
    - Research Site
- Xinjiang
  - Urumqi, Xinjiang, China, 830054
    - Research Site
- Zhejiang
  - Hangzhou, Zhejiang, China, 310013
    - Research Site
  - Linhai, Zhejiang, China, 317000
    - Research Site
  - Ningbo, Zhejiang, China, 315010
    - Research Site
  - Wenzhou, Zhejiang, China, 325000
    - Research Site
Colombia
- Antioquia
  - Medellin, Antioquia, Colombia, 050021
    - Research Site
  - Medellin, Antioquia, Colombia, 050012
    - Research Site
- Atlántico
  - Barranquilla, Atlántico, Colombia, 08001000
    - Research Site
  - Barranquilla, Atlántico, Colombia, 080020
    - Research Site
- Bolívar
  - Cartagena, Bolívar, Colombia, 130010
    - Research Site
- Caldas
  - Manizales, Caldas, Colombia
    - Research Site
- Cundinamarca
  - Bogota, Cundinamarca, Colombia, 11001000
    - Research Site
  - Bogota, Cundinamarca, Colombia
    - Research Site
  - Bogota, Cundinamarca, Colombia, 110221
    - Research Site
- Quindío
  - Armenia, Quindío, Colombia
    - Research Site
- Santander
  - Floridablanca, Santander, Colombia
    - Research Site
- Valle Del Cauca
  - Santiago de Cali, Valle Del Cauca, Colombia, 760032
    - Research Site
Czechia
- - Benatky nad Jizerou, Czechia, 294 71
    - Research Site
  - Benesov, Czechia, 256 01
    - Research Site
  - Beroun, Czechia, 266 01
    - Research Site
  - Bilovec, Czechia, 743 01
    - Research Site
  - Brandys nad Labem, Czechia, 250 01
    - Research Site
  - Brno, Czechia, 602 00
    - Research Site
  - Brno, Czechia, 625 00
    - Research Site
  - Brno, Czechia, 656 91
    - Research Site
  - Brno, Czechia, 636 00
    - Research Site
  - Brno, Czechia, 603 00
    - Research Site
  - Brno, Czechia, 638 00
    - Research Site
  - Ceske Budejovice, Czechia, 370 04
    - Research Site
  - Cesky Krumlov, Czechia, 381 01
    - Research Site
  - Chomutov, Czechia, 430 02
    - Research Site
  - Havlickuv Brod, Czechia, 580 22
    - Research Site
  - Hodonin, Czechia, 695 01
    - Research Site
  - Hradec Kralove, Czechia, 500 02
    - Research Site
  - Hranice na Morave, Czechia, 753 22
    - Research Site
  - Jihlava, Czechia, 586 01
    - Research Site
  - Kladno, Czechia, 272 59
    - Research Site
  - Klatovy IV, Czechia, 339 01
    - Research Site
  - Kutna Hora, Czechia, 284 01
    - Research Site
  - Liberec, Czechia, 460 63
    - Research Site
  - Litomerice, Czechia, 412 01
    - Research Site
  - Litomysl, Czechia, 570 14
    - Research Site
  - Milevsko, Czechia, 399 01
    - Research Site
  - Mlada Boleslav, Czechia, 293 01
    - Research Site
  - Mohelnice, Czechia, 789 85
    - Research Site
  - Moravske Budejovice, Czechia, 676 02
    - Research Site
  - Nymburk, Czechia, 288 01
    - Research Site
  - Olomouc, Czechia, 779 00
    - Research Site
  - Ostrava, Czechia, 728 80
    - Research Site
  - Ostrava - Zabreh, Czechia, 700 30
    - Research Site
  - Ostrava-Poruba, Czechia, 708 00
    - Research Site
  - Pardubice, Czechia, 530 02
    - Research Site
  - Plzen, Czechia, 305 99
    - Research Site
  - Policka, Czechia, 572 01
    - Research Site
  - Prachatice, Czechia, 383 01
    - Research Site
  - Praha 10, Czechia, 101 00
    - Research Site
  - Praha 2, Czechia, 128 08
    - Research Site
  - Praha 3, Czechia, 130 00
    - Research Site
  - Praha 4, Czechia, 140 21
    - Research Site
  - Praha 4, Czechia, 140 59
    - Research Site
  - Praha 5, Czechia, 150 06
    - Research Site
  - Praha 5, Czechia, 158 00
    - Research Site
  - Praha 5 - Smichov, Czechia, 150 00
    - Research Site
  - Prerov, Czechia, 750 02
    - Research Site
  - Pribram VIII, Czechia, 261 01
    - Research Site
  - Svitavy, Czechia, 568 25
    - Research Site
  - Teplice, Czechia, 415 01
    - Research Site
  - Uherske Hradiste, Czechia, 686 01
    - Research Site
  - Znojmo, Czechia, 669 02
    - Research Site
Denmark
- - Aalborg, Denmark, 9000
    - Research Site
  - Aarhus N, Denmark, 8200
    - Research Site
  - Ballerup, Denmark, 2750
    - Research Site
  - Esbjerg, Denmark, 6700
    - Research Site
  - Glostrup, Denmark, 2600
    - Research Site
  - Hvidovre, Denmark, 2650
    - Research Site
  - København, Denmark, 2400
    - Research Site
  - København S, Denmark, 2300
    - Research Site
  - Køge, Denmark, 4600
    - Research Site
  - Odense, Denmark, 5000
    - Research Site
  - Roskilde, Denmark, 4000
    - Research Site
  - Svendborg, Denmark, 5700
    - Research Site
  - Vejle, Denmark, 7100
    - Research Site
  - Viborg, Denmark, 8800
    - Research Site
Estonia
- - Harjumaa, Estonia, 74001
    - Research Site
  - Paide, Estonia, 72713
    - Research Site
  - Tallinn, Estonia, 13419
    - Research Site
  - Tallinn, Estonia, 10128
    - Research Site
  - Tallinn, Estonia, 10138
    - Research Site
Finland
- - Helsinki, Finland, 00290
    - Research Site
  - Helsinki, Finland, 00180
    - Research Site
  - Hämeenlinna, Finland, 13100
    - Research Site
  - Jyväskylä, Finland, 40100
    - Research Site
  - Kokkola, Finland, 67100
    - Research Site
  - Kuopio, Finland, 70100
    - Research Site
  - Oulo, Finland, 90029
    - Research Site
  - Oulu, Finland, 90100
    - Research Site
  - Tampere, Finland, 33521
    - Research Site
  - Tampere, Finland, 33100
    - Research Site
  - Turku, Finland, 20100
    - Research Site
France
- - Besançon Cedex, France, 25030
    - Research Site
  - Brest Cedex 2, France, 29200
    - Research Site
  - Chambray les Tours, France, 37170
    - Research Site
  - Clermont Ferrand, France, 63000
    - Research Site
  - Créteil, France, 94010
    - Research Site
  - Dijon cedex, France, 21079
    - Research Site
  - Le Coudray, France, 28630
    - Research Site
  - Lille Cedex, France, 59037
    - Research Site
  - Lyon, France, 69007
    - Research Site
  - Marseille Cedex 08, France, 13285
    - Research Site
  - Metz cedex 03, France, 57085
    - Research Site
  - Montpellier cedex 05, France, 34295
    - Research Site
  - Montpellier cedex 5, France, 34094
    - Research Site
  - Nantes Cedex 1, France, 44093
    - Research Site
  - Nantes Cedex 2, France, 44202
    - Research Site
  - Nice, France, 06000
    - Research Site
  - Nimes, France, 30029
    - Research Site
  - Orleans, France, 45067
    - Research Site
  - Paris, France, 75010
    - Research Site
  - Paris, France, 75015
    - Research Site
  - Paris, France, 75013
    - Research Site
  - Pau, France, 64000
    - Research Site
  - Perpignan Cedex, France, 66046
    - Research Site
  - Pessac Cedex, France, 33604
    - Research Site
  - Poitiers, France, 86000
    - Research Site
  - Reims cedex, France, 51092
    - Research Site
  - Rennes, France, 35033
    - Research Site
  - Saint Priest en Jarez, France, 42270
    - Research Site
  - Strasbourg, France, 67091
    - Research Site
  - Toulouse Cedex 9, France, 31059
    - Research Site
  - Vandoeuvre les Nancy, France, 54511
    - Research Site
  - Vesoul, France, 70014
    - Research Site
Germany
- - Bad Krozingen, Germany, 79189
    - Research Site
  - Berlin, Germany, 12351
    - Research Site
  - Berlin, Germany, 10787
    - Research Site
  - Berlin, Germany, 13353
    - Research Site
  - Berlin, Germany, 12559
    - Research Site
  - Bochum, Germany, 44787
    - Research Site
  - Demmin, Germany, 17109
    - Research Site
  - Dortmund, Germany, 44137
    - Research Site
  - Dresden, Germany, 01307
    - Research Site
  - Düsseldorf, Germany, 40210
    - Research Site
  - Frankfurt am Main, Germany, 60596
    - Research Site
  - Giessen, Germany, 35392
    - Research Site
  - Hamburg, Germany, 20246
    - Research Site
  - Hamburg, Germany, 20099
    - Research Site
  - Hannover, Germany, 30159
    - Research Site
  - Heidelberg, Germany, 69120
    - Research Site
  - Ingelheim, Germany, 55218
    - Research Site
  - Kassel, Germany, 34121
    - Research Site
  - Köln, Germany, 50937
    - Research Site
  - Lahr, Germany, 77933
    - Research Site
  - Leipzig, Germany, 04103
    - Research Site
  - Limburg, Germany, 65549
    - Research Site
  - Magdeburg, Germany, 39120
    - Research Site
  - Mainz, Germany, 55131
    - Research Site
  - Mannheim, Germany, 68165
    - Research Site
  - Marburg, Germany, 35043
    - Research Site
  - München, Germany, 80638
    - Research Site
  - München, Germany, 80636
    - Research Site
  - Regensburg, Germany, 93053
    - Research Site
  - Stuttgart, Germany, 70376
    - Research Site
  - Ulm, Germany, 89081
    - Research Site
  - Witten, Germany, 58455
    - Research Site
  - Wuppertal, Germany, 42117
    - Research Site
Greece
- - Alexandroupoli, Greece, 68100
    - Research Site
  - Athens, Greece, 11527
    - Research Site
  - Athens, Greece, 16673
    - Research Site
  - Athens, Greece, 12462
    - Research Site
  - Athens, Greece, 14233
    - Research Site
  - Athens, Greece, 10676
    - Research Site
  - Athens, Greece, 11521
    - Research Site
  - Athens, Greece, 14561
    - Research Site
  - Athens, Greece, 17674
    - Research Site
  - Athens, Greece, 15123
    - Research Site
  - Chalkida, Greece, 34100
    - Research Site
  - Heraklion, Greece, 71110
    - Research Site
  - Ioannina, Greece, 45500
    - Research Site
  - Larissa, Greece, 41110
    - Research Site
  - Nikaia, Piraeus, Greece, 18454
    - Research Site
  - Piraeus, Greece, 18536
    - Research Site
  - Rhodes, Greece, 85100
    - Research Site
  - Thessaloniki, Greece, 54636
    - Research Site
  - Thessaloniki, Greece, 54642
    - Research Site
Hong Kong
- - Hong Kong, Hong Kong
    - Research Site
  - New Territories, Hong Kong
    - Research Site
Hungary
- - Balatonfured, Hungary, 8230
    - Research Site
  - Bekescsaba, Hungary, 5600
    - Research Site
  - Berettyoujfalu, Hungary, 4100
    - Research Site
  - Budapest, Hungary, 1085
    - Research Site
  - Budapest, Hungary, 1125
    - Research Site
  - Budapest, Hungary, 1122
    - Research Site
  - Budapest, Hungary, 1134
    - Research Site
  - Budapest, Hungary, 1096
    - Research Site
  - Budapest, Hungary, 1036
    - Research Site
  - Budapest, Hungary, 1027
    - Research Site
  - Cegled, Hungary, 2700
    - Research Site
  - Debrecen, Hungary, 4032
    - Research Site
  - Gyongyos, Hungary, 3200
    - Research Site
  - Gyula, Hungary, 5700
    - Research Site
  - Kaposvar, Hungary, 7400
    - Research Site
  - Kecskemet, Hungary, 6000
    - Research Site
  - Komarom, Hungary, 2921
    - Research Site
  - Miskolc, Hungary, 3529
    - Research Site
  - Nyiregyhaza, Hungary, 4400
    - Research Site
  - Pecs, Hungary, 7624
    - Research Site
  - Szeged, Hungary, 6725
    - Research Site
  - Szekszard, Hungary, 7100
    - Research Site
  - Szolnok, Hungary, 5004
    - Research Site
  - Zalaegerszeg, Hungary, 8900
    - Research Site
Iceland
- - Kopavogur, Iceland, 201
    - Research Site
  - Reykjavik, Iceland, 101
    - Research Site
India
- Andhra Pradesh
  - Vijayawada, Andhra Pradesh, India, 520 008
    - Research Site
- Delhi
  - New Delhi, Delhi, India, 110 002
    - Research Site
- Gujarat
  - Ahmedabad, Gujarat, India, 380 060
    - Research Site
  - Ahmedabad, Gujarat, India, 380 008
    - Research Site
  - Ahmedabad, Gujarat, India, 380 016
    - Research Site
  - Ahmedabad, Gujarat, India, 380 054
    - Research Site
  - Vadodara, Gujarat, India, 390 001
    - Research Site
- Haryana
  - Gurgaon, Haryana, India, 122 001
    - Research Site
- Karnataka
  - Belgaum, Karnataka, India, 590 010
    - Research Site
  - Mysore, Karnataka, India, 570 001
    - Research Site
- Maharashtra
  - Mumbai, Maharashtra, India, 400 022
    - Research Site
  - Mumbai, Maharashtra, India, 400 007
    - Research Site
  - Mumbai, Maharashtra, India, 400 008
    - Research Site
  - Nagpur, Maharashtra, India, 440 003
    - Research Site
  - Pune, Maharashtra, India, 411 005
    - Research Site
  - Pune, Maharashtra, India, 411 006
    - Research Site
  - Pune, Maharashtra, India, 411 019
    - Research Site
- Uttar Pradesh
  - Lucknow, Uttar Pradesh, India, 226 003
    - Research Site
- West Bengal
  - Kolkata, West Bengal, India, 700 020
    - Research Site
Ireland
- - Ballinasloe, Ireland
    - Research Site
  - Dublin, Ireland, 8
    - Research Site
  - Dublin, Ireland, 9
    - Research Site
  - Galway, Ireland
    - Research Site
Israel
- - Hadera, Israel, 38100
    - Research Site
  - Haifa, Israel, 34362
    - Research Site
  - Haifa, Israel, 31048
    - Research Site
  - Herzliya-on-sea, Israel, 46851
    - Research Site
  - Holon, Israel, 58100
    - Research Site
  - Jerusalem, Israel, 91031
    - Research Site
  - Nahariya, Israel, 22100
    - Research Site
  - Netanya, Israel, 42470
    - Research Site
  - Rehovot, Israel, 76100
    - Research Site
  - Tel Aviv, Israel, 64239
    - Research Site
  - Tel Hashomer, Israel, 52621
    - Research Site
Italy
- - Ascoli Piceno, Italy, 63100
    - Research Site
  - Bergamo, Italy, 24127
    - Research Site
  - Bologna, Italy, 40138
    - Research Site
  - Chieti, Italy, 66100
    - Research Site
  - Colleferro RM, Italy, 00034
    - Research Site
  - Cortona AR, Italy, 52044
    - Research Site
  - Firenze, Italy, 50139
    - Research Site
  - L' Aquila, Italy, 67100
    - Research Site
  - Milano, Italy, 20162
    - Research Site
  - Milano, Italy, 20138
    - Research Site
  - Napoli, Italy, 80131
    - Research Site
  - Palermo, Italy, 90126
    - Research Site
  - Parma, Italy, 43100
    - Research Site
  - Pavia, Italy, 27100
    - Research Site
  - Perugia, Italy, 06129
    - Research Site
  - Pisa, Italy, 56124
    - Research Site
  - Roma, Italy, 00168
    - Research Site
  - Roma, Italy, 00161
    - Research Site
  - Sanremo (IM), Italy, 18038
    - Research Site
  - Siena, Italy, 53100
    - Research Site
Japan
- Aichi
  - Ichinomiya-shi, Aichi, Japan, 491-8551
    - Research Site
  - Kasugai-shi, Aichi, Japan, 487-0031
    - Research Site
  - Nagoya-shi, Aichi, Japan, 460-0001
    - Research Site
  - Nagoya-shi, Aichi, Japan, 451-8511
    - Research Site
  - Nagoya-shi, Aichi, Japan, 455-8530
    - Research Site
  - Nagoya-shi, Aichi, Japan, 457-8511
    - Research Site
  - Toyohashi-shi, Aichi, Japan, 440-8510
    - Research Site
- Chiba
  - Chiba-shi, Chiba, Japan, 260-8606
    - Research Site
  - Matsudo-shi, Chiba, Japan, 271-0077
    - Research Site
- Ehime
  - Niihama-shi, Ehime, Japan, 792-8586
    - Research Site
  - Saijo-shi, Ehime, Japan, 793-0030
    - Research Site
- Fukuoka
  - Chikushi-gun, Fukuoka, Japan, 811-1244
    - Research Site
  - Chikushino-shi, Fukuoka, Japan, 818-8516
    - Research Site
  - Fukuoka-shi, Fukuoka, Japan, 814-0180
    - Research Site
  - Fukuoka-shi, Fukuoka, Japan, 814-8522
    - Research Site
  - Itoshima-shi, Fukuoka, Japan, 819-1104
    - Research Site
  - Koga-shi, Fukuoka, Japan, 811-3195
    - Research Site
  - Kurume-shi, Fukuoka, Japan, 830-8577
    - Research Site
  - Kurume-shi, Fukuoka, Japan, 830-0011
    - Research Site
  - Okawa-shi, Fukuoka, Japan, 831-0016
    - Research Site
- Fukushima
  - Koriyama-shi, Fukushima, Japan, 963-8052
    - Research Site
- Hiroshima
  - Kure-shi, Hiroshima, Japan, 737-0023
    - Research Site
  - Otake-shi, Hiroshima, Japan, 739-0651
    - Research Site
- Hokkaido
  - Asahikawa-shi, Hokkaido, Japan, 070-0054
    - Research Site
  - Sapporo-shi, Hokkaido, Japan, 060-0031
    - Research Site
- Hyogo
  - Himeji-shi, Hyogo, Japan, 672-8043
    - Research Site
  - Kobe-shi, Hyogo, Japan, 654-0155
    - Research Site
- Ibaraki
  - Toride-shi, Ibaraki, Japan, 302-0022
    - Research Site
  - Tsukuba-city, Ibaraki, Japan, 305-8558
    - Research Site
- Ishikawa
  - Kanazawa-shi, Ishikawa, Japan, 920-8650
    - Research Site
- Kagawa
  - Sanuki-shi, Kagawa, Japan, 769-2393
    - Research Site
- Kanagawa
  - Fujisawa-shi, Kanagawa, Japan, 251-8550
    - Research Site
  - Odawara-shi, Kanagawa, Japan, 250-8558
    - Research Site
  - Sagamihara-shi, Kanagawa, Japan, 252-0375
    - Research Site
  - Yokohama-shi, Kanagawa, Japan, 245-8575
    - Research Site
- Kumamoto
  - Kumamoto-shi, Kumamoto, Japan, 860-8556
    - Research Site
- Kyoto
  - Kyoto-shi, Kyoto, Japan, 615-0035
    - Research Site
- Miyagi
  - Sendai-shi, Miyagi, Japan, 983-8520
    - Research Site
- Nagasaki
  - Higashisonogi-gun, Nagasaki, Japan, 859-3615
    - Research Site
  - Nagasaki-shi, Nagasaki, Japan, 850-8555
    - Research Site
  - Omura-shi, Nagasaki, Japan, 856-8562
    - Research Site
- Oita
  - Oita-shi, Oita, Japan, 870-0263
    - Research Site
- Okayama
  - Okayama-shi, Okayama, Japan, 702-8055
    - Research Site
- Okinawa
  - Okinawa-shi, Okinawa, Japan, 904-8585
    - Research Site
  - Shimajiri-gun, Okinawa, Japan, 901-0493
    - Research Site
  - Urasoe-shi, Okinawa, Japan, 901-2132
    - Research Site
- Osaka
  - Osaka-shi, Osaka, Japan, 530-0001
    - Research Site
  - Osaka-shi, Osaka, Japan, 530-8480
    - Research Site
  - Osaka-shi, Osaka, Japan, 543-0035
    - Research Site
  - Osaka-shi, Osaka, Japan, 550-0022
    - Research Site
- Saga
  - Saga-shi, Saga, Japan, 840-8571
    - Research Site
  - Saga-shi, Saga, Japan, 849-0917
    - Research Site
- Saitama
  - Kawaguchi-shi, Saitama, Japan, 332-8558
    - Research Site
- Shiga
  - Kusatsu-shi, Shiga, Japan, 525-8585
    - Research Site
- Shimane
  - Hamada-shi, Shimane, Japan, 697-8511
    - Research Site
- Shizuoka
  - Sunto-gun, Shizuoka, Japan, 411-8611
    - Research Site
- Tokushima
  - Komatsushima-shi, Tokushima, Japan, 773-8502
    - Research Site
- Tokyo
  - Bunkyo-ku, Tokyo, Japan, 113-8431
    - Research Site
  - Chuo-ku, Tokyo, Japan, 103-0027
    - Research Site
  - Hachioji-shi, Tokyo, Japan, 192-0918
    - Research Site
  - Itabashi-ku, Tokyo, Japan, 173-8610
    - Research Site
  - Itabashi-ku, Tokyo, Japan, 173-8606
    - Research Site
  - Musashimurayama-shi, Tokyo, Japan, 208-0011
    - Research Site
  - Tachikawa-shi, Tokyo, Japan, 190-0014
    - Research Site
- Yamanashi
  - Chuo-shi, Yamanashi, Japan, 409-3898
    - Research Site
Korea, Republic of
- - Busan, Seo-gu, Korea, Republic of, 602-715
    - Research Site
  - Daejeon, Korea, Republic of, 301-723
    - Research Site
  - Daejeon, Korea, Republic of, 371-718
    - Research Site
  - Goyang-si, Gyeonggi-do, Korea, Republic of, 411-706
    - Research Site
  - Gwangju, Korea, Republic of, 501-757
    - Research Site
  - Seongnam-si, Korea, Republic of, 463-707
    - Research Site
  - Seoul, Korea, Republic of, 135-710
    - Research Site
  - Seoul, Korea, Republic of, 156-707
    - Research Site
  - Seoul, Korea, Republic of, 158-710
    - Research Site
  - Seoul, Korea, Republic of, 120-752
    - Research Site
  - Seoul, Korea, Republic of, 138-736
    - Research Site
  - Seoul, Korea, Republic of, 137-701
    - Research Site
  - Seoul, Korea, Republic of, 152-703
    - Research Site
  - Seoul, Korea, Republic of, 130-872
    - Research Site
  - Seoul, Korea, Republic of, 110-746
    - Research Site
  - Seoul, Korea, Republic of, 135-700
    - Research Site
  - Suwon-si, Korea, Republic of, 443-380
    - Research Site
Latvia
- - Daugavpils, Latvia, 5417
    - Research Site
  - Daugavpils, Latvia, LV-5410
    - Research Site
  - Kuldiga, Latvia, LV-3301
    - Research Site
  - Liepaja, Latvia, LV-3414
    - Research Site
  - Ogre, Latvia, 5001
    - Research Site
  - Ogre, Latvia, LV-5003
    - Research Site
  - Riga, Latvia, 1002
    - Research Site
  - Riga, Latvia, 1012
    - Research Site
  - Riga, Latvia, LV-1001
    - Research Site
Lithuania
- - Kaunas, Lithuania, 50009
    - Research Site
  - Kaunas, Lithuania, 48259
    - Research Site
  - Klaipeda, Lithuania, 94231
    - Research Site
  - Vilnius, Lithuania, 08661
    - Research Site
  - Vilnius, Lithuania, 10323
    - Research Site
Malaysia
- - Georgetown, Malaysia, 10400
    - Research Site
  - Kuala Lumpur, Malaysia, 59100
    - Research Site
  - Melaka, Malaysia, 75400
    - Research Site
  - Penang, Malaysia, 10050
    - Research Site
- Johor
  - Johor Bahru, Johor, Malaysia, 80100
    - Research Site
- Perak
  - Taiping, Perak, Malaysia, 34000
    - Research Site
- Sabah
  - Kota Kinabalu, Sabah, Malaysia, 88300
    - Research Site
- Wilayah Persekutuan
  - Kuala Lumpur, Wilayah Persekutuan, Malaysia, 56000
    - Research Site
  - Kuala Lumpur, Wilayah Persekutuan, Malaysia, 50400
    - Research Site
Mexico
- - Aguascalientes, Mexico, 20230
    - Research Site
  - Chihuahua, Mexico, 31217
    - Research Site
- Coahuila
  - Torreon, Coahuila, Mexico, 27000
    - Research Site
- Distrito Federal
  - Mexico, Distrito Federal, Mexico, 03800
    - Research Site
  - Mexico, Distrito Federal, Mexico, 14380
    - Research Site
- Guanajuato
  - Leon, Guanajuato, Mexico, 37520
    - Research Site
- Jalisco
  - Guadalajara, Jalisco, Mexico, 44340
    - Research Site
  - Guadalajara, Jalisco, Mexico, 44380
    - Research Site
  - Guadalajara, Jalisco, Mexico, 44600
    - Research Site
  - Guadalajara, Jalisco, Mexico, 44150
    - Research Site
  - Guadalajara, Jalisco, Mexico, 44210
    - Research Site
- Nuevo León
  - Monterrey, Nuevo León, Mexico, 64718
    - Research Site
- Querétaro
  - Queretaro, Querétaro, Mexico, 76000
    - Research Site
- San Luis Potosí
  - San Luis Potosi, San Luis Potosí, Mexico, 78240
    - Research Site
- Sinaloa
  - Culiacan, Sinaloa, Mexico, 80230
    - Research Site
- Tamaulipas
  - Tampico, Tamaulipas, Mexico, 89000
    - Research Site
- Veracruz
  - Xalapa, Veracruz, Mexico, 91193
    - Research Site
Netherlands
- - Alkmaar, Netherlands, 1815 JD
    - Research Site
  - Almelo, Netherlands, 7609 PP
    - Research Site
  - Amstelveen, Netherlands, 1186 AM
    - Research Site
  - Amsterdam, Netherlands, 1091 AC
    - Research Site
  - Amsterdam, Netherlands, 1061 AE
    - Research Site
  - Arnhem, Netherlands, 6815 AD
    - Research Site
  - Beverwijk, Netherlands, 1942 LE
    - Research Site
  - Den Helder, Netherlands, 1782 GZ
    - Research Site
  - Deventer, Netherlands, 7416 SE
    - Research Site
  - Doetinchem, Netherlands, 7009 BL
    - Research Site
  - Ede, Netherlands, 6716 RP
    - Research Site
  - Eindhoven, Netherlands, 5631 BM
    - Research Site
  - Eindhoven, Netherlands, 5623 EJ
    - Research Site
  - Goes, Netherlands, 4462 RA
    - Research Site
  - Gorinchem, Netherlands, 4204 AA
    - Research Site
  - Gouda, Netherlands, 2803 HH
    - Research Site
  - Harderwijk, Netherlands, 3844 DG
    - Research Site
  - Helmond, Netherlands, 5707 HA
    - Research Site
  - Hoogeveen, Netherlands, 7909 AA
    - Research Site
  - Hoorn, Netherlands, 1624 NP
    - Research Site
  - Leiden, Netherlands, 2333 ZA
    - Research Site
  - Leiden, Netherlands, 2334 CK
    - Research Site
  - Nieuwegein, Netherlands, 3435 CM
    - Research Site
  - Nijmegen, Netherlands, 6532 SZ
    - Research Site
  - Purmerend, Netherlands, 1440 AG
    - Research Site
  - Rotterdam, Netherlands, 3079 DZ
    - Research Site
  - Rotterdam, Netherlands, 3045 PM
    - Research Site
  - Sneek, Netherlands, 8601 ZK
    - Research Site
  - Tiel, Netherlands, 4002 WP
    - Research Site
  - Tilburg, Netherlands, 5042 AD
    - Research Site
  - Uden, Netherlands, 5406 PT
    - Research Site
  - Veldhoven, Netherlands, 5504 DB
    - Research Site
  - Venlo, Netherlands, 5912 BL
    - Research Site
New Zealand
- - Christchurch, New Zealand, 8011
    - Research Site
  - Papatoetoe, Auckland, New Zealand, 2025
    - Research Site
  - Tauranga, New Zealand, 3143
    - Research Site
Norway
- - Bekkestua, Norway, 1357
    - Research Site
  - Bodø, Norway, 8092
    - Research Site
  - Hamar, Norway, 2317
    - Research Site
  - Lierskogen, Norway, 3420
    - Research Site
  - Oslo, Norway, 0450
    - Research Site
  - Skedsmokorset, Norway, 2020
    - Research Site
  - Skien, Norway, 3710
    - Research Site
  - Stavanger, Norway, 4005
    - Research Site
  - Ålesund, Norway, 6003
    - Research Site
Philippines
- - Angeles, Philippines, 2009
    - Research Site
  - Baguio City, Philippines, 2600
    - Research Site
  - Dasmariñas Cavite, Philippines, 4114
    - Research Site
  - Iloilo, Philippines, 5000
    - Research Site
  - Makati City, Philippines, 1218
    - Research Site
  - Manila, Philippines, 1113
    - Research Site
  - Marikiina, Philippines, 1800
    - Research Site
  - Quezon City, Philippines, 1100
    - Research Site
  - Quezon City, Philippines, 1102
    - Research Site
- Davao
  - Davao City, Davao, Philippines, 8000
    - Research Site
Poland
- - Bielsko-Biala, Poland, 43-316
    - Research Site
  - Bydgoszcz, Poland, 85-094
    - Research Site
  - Gdansk, Poland, 80-952
    - Research Site
  - Gdansk, Poland, 80-542
    - Research Site
  - Gdynia, Poland, 81-384
    - Research Site
  - Gdynia, Poland, 81-402
    - Research Site
  - Gdynia, Poland, 81-472
    - Research Site
  - Gizycko, Poland, 11-500
    - Research Site
  - Jelenia Gora, Poland, 58-506
    - Research Site
  - Katowice, Poland, 40-040
    - Research Site
  - Katowice, Poland, 40-084
    - Research Site
  - Katowice, Poland, 40-018
    - Research Site
  - Kielce, Poland, 25-020
    - Research Site
  - Krakow, Poland, 31-202
    - Research Site
  - Krakow, Poland, 31-315
    - Research Site
  - Krakow, Poland, 31-216
    - Research Site
  - Krakow, Poland, 30-001
    - Research Site
  - Krakow, Poland, 30-347
    - Research Site
  - Krakow, Poland, 32-082
    - Research Site
  - Lodz, Poland, 90-549
    - Research Site
  - Lodz, Poland, 91-347
    - Research Site
  - Lodz, Poland, 90-368
    - Research Site
  - Lodz, Poland, 93-530
    - Research Site
  - Lublin, Poland, 20-857
    - Research Site
  - Lublin, Poland, 20-080
    - Research Site
  - Lublin, Poland, 20-045
    - Research Site
  - Nowa Sol, Poland, 67-100
    - Research Site
  - Nysa, Poland, 48-300
    - Research Site
  - Olsztyn, Poland, 10-010
    - Research Site
  - Plock, Poland, 09-402
    - Research Site
  - Poznan, Poland, 61-853
    - Research Site
  - Poznan, Poland, 61-113
    - Research Site
  - Poznan, Poland, 60-702
    - Research Site
  - Pszczyna, Poland, 43-200
    - Research Site
  - Pulawy, Poland, 24-100
    - Research Site
  - Ruda Slaska, Poland, 41-709
    - Research Site
  - Skierniewice, Poland, 96-100
    - Research Site
  - Starogard Gdanski, Poland, 83-200
    - Research Site
  - Staszow, Poland, 28-200
    - Research Site
  - Swidnik, Poland, 21-040
    - Research Site
  - Tarnow, Poland, 33-100
    - Research Site
  - Torun, Poland, 87-100
    - Research Site
  - Warszawa, Poland, 01-192
    - Research Site
  - Warszawa, Poland, 02-097
    - Research Site
  - Warszawa, Poland, 02-507
    - Research Site
  - Warszawa, Poland, 04-730
    - Research Site
  - Warszawa, Poland, 04-749
    - Research Site
  - Warszawa, Poland, 04-628
    - Research Site
  - Warszawa, Poland, 01-809
    - Research Site
  - Wloclawek, Poland, 87-800
    - Research Site
  - Wroclaw, Poland, 50-088
    - Research Site
  - Wroclaw, Poland, 50-349
    - Research Site
  - Wroclaw, Poland, 51-685
    - Research Site
  - Zamosc, Poland, 22-400
    - Research Site
Portugal
- - Almada, Portugal, 2801-951
    - Research Site
  - Amadora, Portugal, 2720-276
    - Research Site
  - Carnaxide, Portugal, 2790-134
    - Research Site
  - Coimbra, Portugal, 3000-075
    - Research Site
  - Covilha, Portugal, 6200-251
    - Research Site
  - Lisboa, Portugal, 1449-005
    - Research Site
  - Lisboa, Portugal, 1169-024
    - Research Site
  - Lisboa, Portugal, 1350-070
    - Research Site
  - Porto, Portugal, 4100-180
    - Research Site
  - Setubal, Portugal, 2910-446
    - Research Site
Romania
- - Bucharest, Romania, 011601
    - Research Site
  - Bucharest, Romania, 020125
    - Research Site
  - Bucharest, Romania, 010242
    - Research Site
  - Bucuresti, Romania, 042122
    - Research Site
  - Bucuresti, Romania, 021659
    - Research Site
  - Bucuresti, Romania, 020054
    - Research Site
  - Bucuresti, Romania, 030463
    - Research Site
  - Cluj-Napoca, Romania, 400347
    - Research Site
  - Craiova, Romania, 200147
    - Research Site
  - Iasi, Romania, 700661
    - Research Site
  - Iasi, Romania, 700503
    - Research Site
  - Iasi, Romania, 700547
    - Research Site
  - Oradea, Romania, 410169
    - Research Site
  - Timisoara, Romania, 300736
    - Research Site
  - Timisoara, Romania, 300079
    - Research Site
  - Timisoara, Romania, 300158
    - Research Site
Russian Federation
- - Barnaul, Russian Federation, 656055
    - Research Site
  - Barnaul, Russian Federation, 656038
    - Research Site
  - Ekaterinburg, Russian Federation, 620102
    - Research Site
  - Ekaterinburg, Russian Federation, 620144
    - Research Site
  - Ivanovo, Russian Federation, 153012
    - Research Site
  - Izhevsk, Russian Federation, 426063
    - Research Site
  - Kemerovo, Russian Federation, 650002
    - Research Site
  - Kemerovo, Russian Federation, 650099
    - Research Site
  - Kirov, Russian Federation, 610014
    - Research Site
  - Moscow, Russian Federation, 101990
    - Research Site
  - Moscow, Russian Federation, 129090
    - Research Site
  - Moscow, Russian Federation, 121552
    - Research Site
  - Moscow, Russian Federation, 111539
    - Research Site
  - Moscow, Russian Federation, 117292
    - Research Site
  - Moscow, Russian Federation, 119620
    - Research Site
  - Moscow, Russian Federation, 111020
    - Research Site
  - Moscow, Russian Federation, 117342
    - Research Site
  - Nizhniy Novgorod, Russian Federation, 603076
    - Research Site
  - Novosibirsk, Russian Federation, 630047
    - Research Site
  - Novosibirsk, Russian Federation, 630089
    - Research Site
  - Omsk, Russian Federation, 644018
    - Research Site
  - Pushkin, Russian Federation, 196601
    - Research Site
  - Saint Petersburg, Russian Federation, 197341
    - Research Site
  - Saint Petersburg, Russian Federation, 198205
    - Research Site
  - Saint Petersburg, Russian Federation, 197022
    - Research Site
  - Saint Petersburg, Russian Federation, 195112
    - Research Site
  - Saint Petersburg, Russian Federation, 192289
    - Research Site
  - Saint-Petersburg, Russian Federation, 197022
    - Research Site
  - Saint-Petersburg, Russian Federation, 199106
    - Research Site
  - Saint-Petersburg, Russian Federation, 194156
    - Research Site
  - Saratov, Russian Federation, 410054
    - Research Site
  - St. Petersburg, Russian Federation, 191015
    - Research Site
  - Tomsk, Russian Federation, 634012
    - Research Site
  - Tyumen, Russian Federation, 625000
    - Research Site
Singapore
- - Singapore, Singapore, 169609
    - Research Site
  - Singapore, Singapore, 529889
    - Research Site
  - Singapore, Singapore, 768828
    - Research Site
Slovakia
- - Banovce nad Bebravou, Slovakia, 957 01
    - Research Site
  - Bardejov, Slovakia, 085 01
    - Research Site
  - Bratislava, Slovakia, 811 08
    - Research Site
  - Bratislava, Slovakia, 833 48
    - Research Site
  - Bratislava, Slovakia, 811 04
    - Research Site
  - Brezno, Slovakia, 977 42
    - Research Site
  - Dolny Kubin, Slovakia, 026 01
    - Research Site
  - Kosice, Slovakia, 040 01
    - Research Site
  - Kosice, Slovakia, 040 22
    - Research Site
  - Lucenec, Slovakia, 984 01
    - Research Site
  - Martin, Slovakia, 036 59
    - Research Site
  - Moldava nad Bodvou, Slovakia, 045 01
    - Research Site
  - Nitra, Slovakia, 949 01
    - Research Site
  - Nove Zamky, Slovakia, 940 01
    - Research Site
  - Presov, Slovakia, 080 01
    - Research Site
  - Rimavska Sobota, Slovakia, 979 01
    - Research Site
  - Roznava, Slovakia, 048 01
    - Research Site
  - Snina, Slovakia, 069 01
    - Research Site
  - Svidnik, Slovakia, 089 01
    - Research Site
  - Trencin, Slovakia, 911 01
    - Research Site
  - Trnava, Slovakia, 917 01
    - Research Site
South Africa
- - Cape Town, South Africa, 7530
    - Research Site
  - Cape Town, South Africa, 7405
    - Research Site
  - Kempton Park, South Africa, 1619
    - Research Site
- Eastern Cape
  - Port Elizabeth, Eastern Cape, South Africa, 6001
    - Research Site
- Free State
  - Bloemfontein, Free State, South Africa, 9301
    - Research Site
- Gauteng
  - Alberton, Gauteng, South Africa, 1449
    - Research Site
  - Alberton, Gauteng, South Africa, 1450
    - Research Site
  - Boksburg, Gauteng, South Africa, 1459
    - Research Site
  - Centurion, Gauteng, South Africa, 0157
    - Research Site
  - Johannesburg, Gauteng, South Africa, 2196
    - Research Site
  - Johannesburg, Gauteng, South Africa, 1724
    - Research Site
  - Midrand, Gauteng, South Africa, 1685
    - Research Site
  - Pretoria, Gauteng, South Africa, 0184
    - Research Site
  - Pretoria, Gauteng, South Africa, 0087
    - Research Site
  - Pretoria, Gauteng, South Africa, 0040
    - Research Site
  - Pretoria, Gauteng, South Africa, 0158
    - Research Site
  - Pretoria west, Gauteng, South Africa, 0183
    - Research Site
  - Soweto, Gauteng, South Africa, 2013
    - Research Site
  - Sunninghill, Gauteng, South Africa, 2157
    - Research Site
- KwaZulu-Natal
  - Amanzimtoti, KwaZulu-Natal, South Africa, 4126
    - Research Site
  - Durban, KwaZulu-Natal, South Africa, 4001
    - Research Site
  - Durban, KwaZulu-Natal, South Africa, 4321
    - Research Site
  - Tongaat, KwaZulu-Natal, South Africa, 4400
    - Research Site
- Western Cape
  - Kuils River, Western Cape, South Africa, 7580
    - Research Site
  - Paarl, Western Cape, South Africa, 7646
    - Research Site
  - Parow, Western Cape, South Africa, 7505
    - Research Site
  - Somerset West, Western Cape, South Africa, 7130
    - Research Site
  - Worcester, Western Cape, South Africa, 6850
    - Research Site
Spain
- - Madrid, Spain, 28034
    - Research Site
  - Madrid, Spain, 28007
    - Research Site
- Andalucía
  - Almeria, Andalucía, Spain, 04120
    - Research Site
  - Cordoba, Andalucía, Spain, 14004
    - Research Site
- Aragón
  - Zaragoza, Aragón, Spain, 50009
    - Research Site
- Cataluña
  - L'Hospitalet de Llobregat, Cataluña, Spain, 08907
    - Research Site
- Comunidad Valenciana
  - San Juan de Alicante, Comunidad Valenciana, Spain, 03550
    - Research Site
  - Valencia, Comunidad Valenciana, Spain, 46010
    - Research Site
- Galicia
  - Santiago de Compostela, Galicia, Spain, 15706
    - Research Site
  - Vigo, Galicia, Spain, 36312
    - Research Site
- Murcia
  - El Palmar, Murcia, Spain, 30120
    - Research Site
- País Vasco
  - Galdakao, País Vasco, Spain, 48960
    - Research Site
Sweden
- - Bollnäs, Sweden, 821 81
    - Research Site
  - Eksjö, Sweden, 575 81
    - Research Site
  - Eskilstuna, Sweden, 631 88
    - Research Site
  - Falun, Sweden, 791 82
    - Research Site
  - Helsingborg, Sweden, 251 87
    - Research Site
  - Jönköping, Sweden, 551 85
    - Research Site
  - Linköping, Sweden, 581 85
    - Research Site
  - Luleå, Sweden, 971 80
    - Research Site
  - Lund, Sweden, 221 85
    - Research Site
  - Lund, Sweden, 222 21
    - Research Site
  - Stockholm, Sweden, 141 86
    - Research Site
  - Stockholm, Sweden, 118 83
    - Research Site
  - Stockholm, Sweden, 171 76
    - Research Site
  - Stockholm, Sweden, 111 57
    - Research Site
  - Uddevalla, Sweden, 451 50
    - Research Site
  - Umeå, Sweden, 901 85
    - Research Site
  - Västerås, Sweden, 721 89
    - Research Site
  - Örebro, Sweden, 701 85
    - Research Site
  - Östersund, Sweden, 831 83
    - Research Site
Switzerland
- - Baden, Switzerland, 5404
    - Research Site
  - Basel, Switzerland, 4031
    - Research Site
  - Bern, Switzerland, 3010
    - Research Site
  - Geneva 14, Switzerland, 1211
    - Research Site
  - Lausanne, Switzerland, 1011
    - Research Site
  - Lugano, Switzerland, 6900
    - Research Site
  - Sion, Switzerland, 1950
    - Research Site
  - Winterthur, Switzerland, 8401
    - Research Site
  - Zurich, Switzerland, 8063
    - Research Site
Taiwan
- - Changhua, Taiwan, 50006
    - Research Site
  - Kaohsiung, Taiwan, 807
    - Research Site
  - Kaohsiung, Taiwan, 83301
    - Research Site
  - Taichung City, Taiwan, 402
    - Research Site
  - Tainan, Taiwan, 710
    - Research Site
  - Taipei, Taiwan, 100
    - Research Site
  - Taipei, Taiwan, 11217
    - Research Site
  - Taipei, Taiwan, 10630
    - Research Site
  - Taoyuan, Taiwan, 33305
    - Research Site
- Taipei
  - New Taipei City, Taipei, Taiwan, 251
    - Research Site
Turkey
- - Adana, Turkey, 01330
    - Research Site
  - Ankara, Turkey, 06490
    - Research Site
  - Ankara, Turkey, 06100
    - Research Site
  - Istanbul, Turkey, 34096
    - Research Site
  - Istanbul, Turkey, 34865
    - Research Site
  - Izmir, Turkey, 35100
    - Research Site
  - Izmir, Turkey, 35000
    - Research Site
  - Kocaeli, Turkey, 41380
    - Research Site
  - Konya, Turkey, 42080
    - Research Site
  - Sivas, Turkey, 58140
    - Research Site
Ukraine
- - Cherkasy, Ukraine, 18009
    - Research Site
  - Ivano-Frankivsk, Ukraine, 76018
    - Research Site
  - Kharkiv, Ukraine, 61002
    - Research Site
  - Kharkiv, Ukraine, 61039
    - Research Site
  - Kharkiv, Ukraine, 61176
    - Research Site
  - Kharkiv, Ukraine, 61018
    - Research Site
  - Kharkiv, Ukraine, 61106
    - Research Site
  - Kyiv, Ukraine, 04114
    - Research Site
  - Kyiv, Ukraine, 02002
    - Research Site
  - Kyiv, Ukraine, 02091
    - Research Site
  - Kyiv, Ukraine, 02232
    - Research Site
  - Kyiv, Ukraine, 02660
    - Research Site
  - Kyiv, Ukraine, 03049
    - Research Site
  - Kyiv, Ukraine, 03680
    - Research Site
  - Kyiv, Ukraine, 01023
    - Research Site
  - Lugansk, Ukraine, 91045
    - Research Site
  - Uzhgorod, Ukraine, 88000
    - Research Site
  - Vinnytsia, Ukraine, 21029
    - Research Site
  - Vinnytsia, Ukraine, 21018
    - Research Site
  - Zaporizhzhia, Ukraine, 69035
    - Research Site
  - Zaporizhzhia, Ukraine, 69000
    - Research Site
  - Zaporizhzhya, Ukraine, 69600
    - Research Site
United Kingdom
- - Aberdeen, United Kingdom, AB25 2ZN
    - Research Site
  - Addlestone, United Kingdom, KT15 2BH
    - Research Site
  - Arnsley, United Kingdom, S75 2EP
    - Research Site
  - Basildon, United Kingdom, SS16 5NL
    - Research Site
  - Belfast, United Kingdom, BT16 1RH
    - Research Site
  - Belfast, United Kingdom, BT12 6BA
    - Research Site
  - Belfast, United Kingdom, BT13 3BW
    - Research Site
  - Belfast, United Kingdom, BT7 2EB
    - Research Site
  - Birmingham, United Kingdom, B18 7QH
    - Research Site
  - Birmingham, United Kingdom, B15 2SQ
    - Research Site
  - Blackpool, United Kingdom, FY3 8NR
    - Research Site
  - Bournemouth, United Kingdom, BH7 7DW
    - Research Site
  - Bury St Edmunds, United Kingdom, IP33 2QZ
    - Research Site
  - Canterbury, United Kingdom, CT1 3NG
    - Research Site
  - Cardiff, United Kingdom, CF14 5GJ
    - Research Site
  - Cardiff, United Kingdom, CF4 4XW
    - Research Site
  - Chesterfield, United Kingdom, S40 4AA
    - Research Site
  - Chippenham, United Kingdom, SN15 2SB
    - Research Site
  - Chorley, United Kingdom, PR7 7NA
    - Research Site
  - Colchester, United Kingdom, CO4 5JL
    - Research Site
  - Cottingham, United Kingdom, HU16 5JQ
    - Research Site
  - Coventry, United Kingdom, CV4 7AL
    - Research Site
  - Dundee, United Kingdom, DD1 9SY
    - Research Site
  - Edinburgh, United Kingdom, EH16 4SB
    - Research Site
  - Glasgow, United Kingdom, G51 4TF
    - Research Site
  - Glasgow, United Kingdom, G20 0SP
    - Research Site
  - Glasgow, United Kingdom, G45 9AW
    - Research Site
  - Harrow, United Kingdom, HA1 3UJ
    - Research Site
  - Haxey, Doncaster, United Kingdom, DN9 2HY
    - Research Site
  - Hayle, United Kingdom, TR27 5DT
    - Research Site
  - Hexham, United Kingdom, NE46 1QJ
    - Research Site
  - Hitchin, United Kingdom, SG4 9TH
    - Research Site
  - Inverness, United Kingdom, IV2 3JH
    - Research Site
  - Leamington Spa, United Kingdom, CV34 4RA
    - Research Site
  - Leeds, United Kingdom, LS1 3EX
    - Research Site
  - Leicester, United Kingdom, LE3 9QP
    - Research Site
  - Liverpool, United Kingdom, L7 8XP
    - Research Site
  - Liverpool, United Kingdom, L22 0LG
    - Research Site
  - Liverpool, United Kingdom, L9 7AL
    - Research Site
  - London, United Kingdom, SE1 7EH
    - Research Site
  - London, United Kingdom, EC1M 6BQ
    - Research Site
  - London, United Kingdom, W12 0HS
    - Research Site
  - Luton, United Kingdom, LU4 0DZ
    - Research Site
  - Manchester, United Kingdom, M15 6SX
    - Research Site
  - Manchester, United Kingdom, M23 9LT
    - Research Site
  - Middlesbrough, United Kingdom, TS4 3BW
    - Research Site
  - Newport, United Kingdom, PO30 5TG
    - Research Site
  - Northampton, United Kingdom, NN1 5BD
    - Research Site
  - Nottingham, United Kingdom, NG5 1PB
    - Research Site
  - Nuneaton, United Kingdom, CV10 7DJ
    - Research Site
  - Penzance, United Kingdom, TR18 2RE
    - Research Site
  - Penzance, United Kingdom, TR18 4EL
    - Research Site
  - Penzance, United Kingdom, TR19 7HX
    - Research Site
  - Plymouth, United Kingdom, PL6 8DH
    - Research Site
  - Portsmouth, United Kingdom, PO6 3LY
    - Research Site
  - Reading, United Kingdom, RG2 0TF
    - Research Site
  - Rotherham, United Kingdom, S60 2UD
    - Research Site
  - Rugby, United Kingdom, CV22 5PX
    - Research Site
  - Sandbach, United Kingdom, CW11 1EQ
    - Research Site
  - Sheffield, United Kingdom, S5 7AU
    - Research Site
  - St Austell, United Kingdom, PL26 7RL
    - Research Site
  - St. Leonards-on-Sea, United Kingdom, TN37 7RD
    - Research Site
  - Stevenage, United Kingdom, SG1 4AB
    - Research Site
  - Stoke-on-Trent, United Kingdom, ST4 6DG
    - Research Site
  - Swansea, United Kingdom, SA2 8PP
    - Research Site
  - Telford, United Kingdom, TF1 6TF
    - Research Site
  - Torquay, United Kingdom, TQ2 7AA
    - Research Site
  - Welwyn Garden City, United Kingdom, AL7 4HQ
    - Research Site
  - West Bromwich, United Kingdom, B71 4HJ
    - Research Site
  - Whitby, United Kingdom, YO21 1SD
    - Research Site
  - Wiltshire, United Kingdom, BA15 1DQ
    - Research Site
  - Wirral, United Kingdom, CH49 5PE
    - Research Site
  - Wolverhampton, United Kingdom, WV10 0QP
    - Research Site
  - Worcester, United Kingdom, WR5 1DD
    - Research Site
  - Wrexham, United Kingdom, LL13 7TD
    - Research Site
  - York, United Kingdom, YO31 8HE
    - Research Site
United States
- Alabama
  - Birmingham, Alabama, United States, 35294
    - Research Site
  - Birmingham, Alabama, United States, 35235
    - Research Site
  - Huntsville, Alabama, United States, 35801
    - Research Site
  - Mobile, Alabama, United States, 36608
    - Research Site
- Alaska
  - Anchorage, Alaska, United States, 99508
    - Research Site
- Arizona
  - Glendale, Arizona, United States, 85306
    - Research Site
  - Phoenix, Arizona, United States, 85054
    - Research Site
  - Phoenix, Arizona, United States, 85018
    - Research Site
  - Phoenix, Arizona, United States, 85015
    - Research Site
  - Tucson, Arizona, United States, 85712
    - Research Site
  - Tucson, Arizona, United States, 85723
    - Research Site
- California
  - Alhambra, California, United States, 91801
    - Research Site
  - Banning, California, United States, 92220
    - Research Site
  - Beverly Hills, California, United States, 90211
    - Research Site
  - Encino, California, United States, 91436
    - Research Site
  - Escondido, California, United States, 92029
    - Research Site
  - Glendale, California, United States, 91204
    - Research Site
  - Harbor City, California, United States, 90710
    - Research Site
  - Huntington Beach, California, United States, 92646
    - Research Site
  - Laguna Hills, California, United States, 92653
    - Research Site
  - Long Beach, California, United States, 90807
    - Research Site
  - Long Beach, California, United States, 90822
    - Research Site
  - Los Alamitos, California, United States, 90720
    - Research Site
  - Los Angeles, California, United States, 90048
    - Research Site
  - Los Angeles, California, United States, 90033
    - Research Site
  - Newport Beach, California, United States, 92663
    - Research Site
  - Oceanside, California, United States, 92056
    - Research Site
  - Oxnard, California, United States, 93030
    - Research Site
  - Palm Springs, California, United States, 92262
    - Research Site
  - Roseville, California, United States, 95661
    - Research Site
  - Sacramento, California, United States, 95816
    - Research Site
  - San Diego, California, United States, 92103
    - Research Site
  - San Diego, California, United States, 92161
    - Research Site
  - San Pedro, California, United States, 90732
    - Research Site
  - Santa Ana, California, United States, 92704
    - Research Site
  - Tarzana, California, United States, 91356
    - Research Site
  - Thousand Oaks, California, United States, 91360
    - Research Site
  - Torrance, California, United States, 90502
    - Research Site
  - Torrance, California, United States, 90503
    - Research Site
  - Valley Village, California, United States, 91607
    - Research Site
- Colorado
  - Aurora, Colorado, United States, 80012
    - Research Site
  - Colorado Springs, Colorado, United States, 80907
    - Research Site
  - Colorado Springs, Colorado, United States, 80909
    - Research Site
  - Denver, Colorado, United States, 80218
    - Research Site
  - Greeley, Colorado, United States, 80631
    - Research Site
  - Littleton, Colorado, United States, 80120
    - Research Site
  - Longmont, Colorado, United States, 80501
    - Research Site
- Connecticut
  - Bridgeport, Connecticut, United States, 06610
    - Research Site
- Delaware
  - Newark, Delaware, United States, 19718
    - Research Site
  - Seaford, Delaware, United States, 19973
    - Research Site
  - Wilmington, Delaware, United States, 19803
    - Research Site
- District of Columbia
  - Washington, District of Columbia, United States, 20037
    - Research Site
- Florida
  - Atlantis, Florida, United States, 33462
    - Research Site
  - Aventura, Florida, United States, 33180
    - Research Site
  - Bay Pines, Florida, United States, 33744
    - Research Site
  - Boynton Beach, Florida, United States, 33472
    - Research Site
  - Bradenton, Florida, United States, 34205
    - Research Site
  - Clearwater, Florida, United States, 33756
    - Research Site
  - Crystal River, Florida, United States, 34429
    - Research Site
  - Daytona Beach, Florida, United States, 32117
    - Research Site
  - Deerfield Beach, Florida, United States, 33442
    - Research Site
  - Delray Beach, Florida, United States, 33484
    - Research Site
  - Edgewater, Florida, United States, 32141
    - Research Site
  - Fleming Island, Florida, United States, 32003
    - Research Site
  - Fort Lauderdale, Florida, United States, 33308
    - Research Site
  - Hollywood, Florida, United States, 33021
    - Research Site
  - Jacksonville, Florida, United States, 32216
    - Research Site
  - Jacksonville Beach, Florida, United States, 32250
    - Research Site
  - Lakeland, Florida, United States, 33805
    - Research Site
  - Largo, Florida, United States, 33777
    - Research Site
  - Melbourne, Florida, United States, 32901
    - Research Site
  - Miami, Florida, United States, 33173
    - Research Site
  - Miami, Florida, United States, 33144
    - Research Site
  - Miami, Florida, United States, 33155
    - Research Site
  - New Port Richey, Florida, United States, 34653
    - Research Site
  - Orlando, Florida, United States, 32806
    - Research Site
  - Palm Harbor, Florida, United States, 34684
    - Research Site
  - Pembroke Pines, Florida, United States, 33024
    - Research Site
  - Pembroke Pines, Florida, United States, 33028
    - Research Site
  - Pensacola, Florida, United States, 32501
    - Research Site
  - Ponte Vedra, Florida, United States, 32081
    - Research Site
  - Port Charlotte, Florida, United States, 33952
    - Research Site
  - Safety Harbor, Florida, United States, 34695
    - Research Site
  - Saint Petersburg, Florida, United States, 33713
    - Research Site
  - Saint Petersburg, Florida, United States, 33709
    - Research Site
  - Sanford, Florida, United States, 32771
    - Research Site
  - Sarasota, Florida, United States, 34232
    - Research Site
  - Sarasota, Florida, United States, 34239
    - Research Site
  - Tampa, Florida, United States, 33614
    - Research Site
  - Wellington, Florida, United States, 33449
    - Research Site
  - West Palm Beach, Florida, United States, 33401
    - Research Site
- Georgia
  - Athens, Georgia, United States, 30606
    - Research Site
  - Atlanta, Georgia, United States, 30342
    - Research Site
  - Augusta, Georgia, United States, 30909
    - Research Site
  - Dunwoody, Georgia, United States, 30338
    - Research Site
  - East Point, Georgia, United States, 30344
    - Research Site
  - Eatonton, Georgia, United States, 31024
    - Research Site
  - Gainesville, Georgia, United States, 30501
    - Research Site
  - Macon, Georgia, United States, 31201
    - Research Site
  - Savannah, Georgia, United States, 31406
    - Research Site
  - Suwanee, Georgia, United States, 30024
    - Research Site
- Idaho
  - Boise, Idaho, United States, 83706
    - Research Site
  - Boise, Idaho, United States, 83704
    - Research Site
  - Coeur d'Alene, Idaho, United States, 83814
    - Research Site
  - Meridian, Idaho, United States, 83642
    - Research Site
  - Nampa, Idaho, United States, 83686
    - Research Site
- Illinois
  - Addison, Illinois, United States, 60101
    - Research Site
  - Belleville, Illinois, United States, 62220
    - Research Site
  - Chicago, Illinois, United States, 60616
    - Research Site
  - Hazel Crest, Illinois, United States, 60429
    - Research Site
  - Jerseyville, Illinois, United States, 62052
    - Research Site
  - Quincy, Illinois, United States, 62301
    - Research Site
- Indiana
  - Evansville, Indiana, United States, 47714
    - Research Site
  - Indianapolis, Indiana, United States, 46237
    - Research Site
  - Indianapolis, Indiana, United States, 46260
    - Research Site
  - Indianapolis, Indiana, United States, 46227
    - Research Site
  - Munster, Indiana, United States, 46321
    - Research Site
  - Valparaiso, Indiana, United States, 46383
    - Research Site
- Iowa
  - Ames, Iowa, United States, 50010
    - Research Site
  - Des Moines, Iowa, United States, 50266
    - Research Site
  - Iowa City, Iowa, United States, 52242
    - Research Site
  - Waterloo, Iowa, United States, 50702
    - Research Site
- Kansas
  - Hutchinson, Kansas, United States, 67502
    - Research Site
  - Kansas City, Kansas, United States, 66160
    - Research Site
  - Overland Park, Kansas, United States, 66210
    - Research Site
  - Wichita, Kansas, United States, 67214
    - Research Site
  - Wichita, Kansas, United States, 67203
    - Research Site
- Kentucky
  - Lexington, Kentucky, United States, 40504
    - Research Site
  - Owensboro, Kentucky, United States, 42303
    - Research Site
- Louisiana
  - Baton Rouge, Louisiana, United States, 70808
    - Research Site
  - Covington, Louisiana, United States, 70433
    - Research Site
  - Hammond, Louisiana, United States, 70403
    - Research Site
  - Lafayette, Louisiana, United States, 70508
    - Research Site
  - Metairie, Louisiana, United States, 70006
    - Research Site
  - Monroe, Louisiana, United States, 71203
    - Research Site
  - Natchitoches, Louisiana, United States, 71457
    - Research Site
  - Slidell, Louisiana, United States, 70458
    - Research Site
- Maine
  - Auburn, Maine, United States, 04210
    - Research Site
  - Bangor, Maine, United States, 04401
    - Research Site
  - Biddeford, Maine, United States, 04005
    - Research Site
  - Portland, Maine, United States, 04101
    - Research Site
- Maryland
  - Annapolis, Maryland, United States, 21401
    - Research Site
  - Baltimore, Maryland, United States, 21204
    - Research Site
  - Baltimore, Maryland, United States, 21237
    - Research Site
  - Baltimore, Maryland, United States, 21201
    - Research Site
  - Baltimore, Maryland, United States, 21236
    - Research Site
  - Charlotte Hall, Maryland, United States, 20622
    - Research Site
  - Columbia, Maryland, United States, 21045
    - Research Site
  - Columbia, Maryland, United States, 21044
    - Research Site
  - Hollywood, Maryland, United States, 20636
    - Research Site
  - Salisbury, Maryland, United States, 21804
    - Research Site
  - Towson, Maryland, United States, 21204
    - Research Site
- Massachusetts
  - Ayer, Massachusetts, United States, 01432
    - Research Site
  - Billerica, Massachusetts, United States, 01821
    - Research Site
  - Fall River, Massachusetts, United States, 02720
    - Research Site
  - Haverhill, Massachusetts, United States, 01830
    - Research Site
  - Hyannis, Massachusetts, United States, 02601
    - Research Site
  - Newton, Massachusetts, United States, 02459
    - Research Site
  - Quincy, Massachusetts, United States, 02169
    - Research Site
  - Springfield, Massachusetts, United States, 01199
    - Research Site
  - Watertown, Massachusetts, United States, 02472
    - Research Site
- Michigan
  - Ann Arbor, Michigan, United States, 48106
    - Research Site
  - Dearborn, Michigan, United States, 48124
    - Research Site
  - Flint, Michigan, United States, 48532
    - Research Site
  - Grandville, Michigan, United States, 49418
    - Research Site
  - Lansing, Michigan, United States, 48912
    - Research Site
  - Muskegon, Michigan, United States, 49444
    - Research Site
  - Novi, Michigan, United States, 48374
    - Research Site
  - Saginaw, Michigan, United States, 48601
    - Research Site
  - Saginaw, Michigan, United States, 48604
    - Research Site
  - Traverse City, Michigan, United States, 49684
    - Research Site
- Minnesota
  - Minneapolis, Minnesota, United States, 55417
    - Research Site
  - Saint Cloud, Minnesota, United States, 56303
    - Research Site
  - Saint Paul, Minnesota, United States, 55102
    - Research Site
- Mississippi
  - Olive Branch, Mississippi, United States, 38654
    - Research Site
  - Tupelo, Mississippi, United States, 38801
    - Research Site
- Missouri
  - Columbia, Missouri, United States, 65212
    - Research Site
  - Jefferson City, Missouri, United States, 65109
    - Research Site
  - Kansas City, Missouri, United States, 64128
    - Research Site
  - Saint Louis, Missouri, United States, 63117
    - Research Site
  - Saint Louis, Missouri, United States, 63128
    - Research Site
- Montana
  - Billings, Montana, United States, 59101
    - Research Site
  - Billings, Montana, United States, 59102
    - Research Site
  - Great Falls, Montana, United States, 59405
    - Research Site
  - Kalispell, Montana, United States, 59901
    - Research Site
  - Missoula, Montana, United States, 59802
    - Research Site
- Nebraska
  - Lincoln, Nebraska, United States, 68506
    - Research Site
  - Omaha, Nebraska, United States, 68131
    - Research Site
- Nevada
  - Las Vegas, Nevada, United States, 89128
    - Research Site
- New Jersey
  - Elizabeth, New Jersey, United States, 07202
    - Research Site
  - Voorhees, New Jersey, United States, 08043
    - Research Site
  - Westwood, New Jersey, United States, 07675
    - Research Site
- New York
  - Albany, New York, United States, 12208
    - Research Site
  - Buffalo, New York, United States, 14215
    - Research Site
  - Buffalo, New York, United States, 14203
    - Research Site
  - Cortlandt Manor, New York, United States, 10567
    - Research Site
  - Kingston, New York, United States, 12401
    - Research Site
  - New Hyde Park, New York, United States, 11042
    - Research Site
  - New Windsor, New York, United States, 12553
    - Research Site
  - New York, New York, United States, 10021
    - Research Site
  - New York, New York, United States, 10029
    - Research Site
  - New York, New York, United States, 10033
    - Research Site
  - New York, New York, United States, 10036
    - Research Site
  - Rochester, New York, United States, 14609
    - Research Site
  - Stony Brook, New York, United States, 11794
    - Research Site
  - Syracuse, New York, United States, 13202
    - Research Site
  - Troy, New York, United States, 12180
    - Research Site
  - West Seneca, New York, United States, 14224
    - Research Site
  - Williamsville, New York, United States, 14221
    - Research Site
- North Carolina
  - Asheville, North Carolina, United States, 28801
    - Research Site
  - Asheville, North Carolina, United States, 28805
    - Research Site
  - Calabash, North Carolina, United States, 28467
    - Research Site
  - Cary, North Carolina, United States, 27518
    - Research Site
  - Charlotte, North Carolina, United States, 28277
    - Research Site
  - Charlotte, North Carolina, United States, 28204
    - Research Site
  - Durham, North Carolina, United States, 27710
    - Research Site
  - Greensboro, North Carolina, United States, 27408
    - Research Site
  - Hickory, North Carolina, United States, 28601
    - Research Site
  - High Point, North Carolina, United States, 27262
    - Research Site
  - Lenoir, North Carolina, United States, 28645
    - Research Site
  - Mooresville, North Carolina, United States, 28117
    - Research Site
  - Raleigh, North Carolina, United States, 27609
    - Research Site
  - Statesville, North Carolina, United States, 28625
    - Research Site
  - Tabor City, North Carolina, United States, 28463
    - Research Site
  - Wilmington, North Carolina, United States, 28401
    - Research Site
  - Winston-Salem, North Carolina, United States, 27103
    - Research Site
  - Winston-Salem, North Carolina, United States, 27127
    - Research Site
- North Dakota
  - Fargo, North Dakota, United States, 58122
    - Research Site
  - Grand Forks, North Dakota, United States, 58201
    - Research Site
- Ohio
  - Canton, Ohio, United States, 44710
    - Research Site
  - Cincinnati, Ohio, United States, 45219
    - Research Site
  - Cincinnati, Ohio, United States, 45224
    - Research Site
  - Cleveland, Ohio, United States, 44195
    - Research Site
  - Columbus, Ohio, United States, 43215
    - Research Site
  - Columbus, Ohio, United States, 43201
    - Research Site
  - Dayton, Ohio, United States, 45414
    - Research Site
  - Elyria, Ohio, United States, 44035
    - Research Site
  - Garfield Heights, Ohio, United States, 44125
    - Research Site
  - Marion, Ohio, United States, 43302
    - Research Site
  - Sandusky, Ohio, United States, 44870
    - Research Site
  - Springfield, Ohio, United States, 45505
    - Research Site
  - Toledo, Ohio, United States, 43608
    - Research Site
  - Toledo, Ohio, United States, 43623
    - Research Site
  - Toledo, Ohio, United States, 43615
    - Research Site
  - Westlake, Ohio, United States, 44145
    - Research Site
  - Willoughby, Ohio, United States, 44094
    - Research Site
- Oklahoma
  - Oklahoma City, Oklahoma, United States, 73135
    - Research Site
  - Pryor, Oklahoma, United States, 74362
    - Research Site
  - Tulsa, Oklahoma, United States, 74133
    - Research Site
- Oregon
  - Bend, Oregon, United States, 97701
    - Research Site
  - Portland, Oregon, United States, 97239
    - Research Site
  - Portland, Oregon, United States, 97225
    - Research Site
- Pennsylvania
  - Abington, Pennsylvania, United States, 19001
    - Research Site
  - Altoona, Pennsylvania, United States, 16602
    - Research Site
  - Camp Hill, Pennsylvania, United States, 17011
    - Research Site
  - Chambersburg, Pennsylvania, United States, 17201
    - Research Site
  - Feasterville, Pennsylvania, United States, 19053
    - Research Site
  - Indiana, Pennsylvania, United States, 15701
    - Research Site
  - Jersey Shore, Pennsylvania, United States, 17740
    - Research Site
  - Norristown, Pennsylvania, United States, 19401
    - Research Site
  - Philadelphia, Pennsylvania, United States, 19107
    - Research Site
  - Philadelphia, Pennsylvania, United States, 19104
    - Research Site
  - Philadelphia, Pennsylvania, United States, 19152
    - Research Site
  - Pittsburgh, Pennsylvania, United States, 15206
    - Research Site
  - Sellersville, Pennsylvania, United States, 18960
    - Research Site
  - Uniontown, Pennsylvania, United States, 15401
    - Research Site
  - York, Pennsylvania, United States, 17405
    - Research Site
- Rhode Island
  - Cranston, Rhode Island, United States, 02920
    - Research Site
  - Cumberland, Rhode Island, United States, 02864
    - Research Site
  - Johnston, Rhode Island, United States, 02919
    - Research Site
  - Pawtucket, Rhode Island, United States, 02860
    - Research Site
- South Carolina
  - Anderson, South Carolina, United States, 29621
    - Research Site
  - Charleston, South Carolina, United States, 29425
    - Research Site
  - Charleston, South Carolina, United States, 29407
    - Research Site
  - Columbia, South Carolina, United States, 29204
    - Research Site
  - Fountain Inn, South Carolina, United States, 29644
    - Research Site
  - Indian Land, South Carolina, United States, 29707
    - Research Site
  - Moncks Corner, South Carolina, United States, 29461
    - Research Site
  - Mount Pleasant, South Carolina, United States, 29464
    - Research Site
  - North Myrtle Beach, South Carolina, United States, 29582
    - Research Site
  - Orangeburg, South Carolina, United States, 29118
    - Research Site
- South Dakota
  - Rapid City, South Dakota, United States, 57701
    - Research Site
- Tennessee
  - Germantown, Tennessee, United States, 38138
    - Research Site
  - Jackson, Tennessee, United States, 38305
    - Research Site
  - Memphis, Tennessee, United States, 38112
    - Research Site
  - Nashville, Tennessee, United States, 37203
    - Research Site
  - Nashville, Tennessee, United States, 37205
    - Research Site
  - Nashville, Tennessee, United States, 37208
    - Research Site
  - Tullahoma, Tennessee, United States, 37388
    - Research Site
- Texas
  - Arlington, Texas, United States, 76012
    - Research Site
  - Austin, Texas, United States, 78758
    - Research Site
  - Dallas, Texas, United States, 75216
    - Research Site
  - Grapevine, Texas, United States, 76051
    - Research Site
  - Houston, Texas, United States, 77030
    - Research Site
  - Houston, Texas, United States, 77074
    - Research Site
  - Houston, Texas, United States, 77070
    - Research Site
  - Houston, Texas, United States, 77025
    - Research Site
  - Kerrville, Texas, United States, 78028
    - Research Site
  - Longview, Texas, United States, 75605
    - Research Site
  - Odessa, Texas, United States, 79761
    - Research Site
  - Plano, Texas, United States, 75024
    - Research Site
  - Plano, Texas, United States, 75023
    - Research Site
  - San Antonio, Texas, United States, 78229
    - Research Site
  - Sugar Land, Texas, United States, 77478
    - Research Site
  - Tomball, Texas, United States, 77375
    - Research Site
  - Wichita Falls, Texas, United States, 76301
    - Research Site
- Utah
  - Layton, Utah, United States, 84041
    - Research Site
  - Murray, Utah, United States, 84107
    - Research Site
  - West Jordan, Utah, United States, 84088
    - Research Site
- Vermont
  - White River Junction, Vermont, United States, 05009
    - Research Site
- Virginia
  - Burke, Virginia, United States, 22015
    - Research Site
  - Danville, Virginia, United States, 24541
    - Research Site
  - Falls Church, Virginia, United States, 22042
    - Research Site
  - Hopewell, Virginia, United States, 23860
    - Research Site
  - Richmond, Virginia, United States, 23294
    - Research Site
  - Richmond, Virginia, United States, 23219
    - Research Site
  - Roanoke, Virginia, United States, 24014
    - Research Site
  - Suffolk, Virginia, United States, 23435
    - Research Site
  - Virginia Beach, Virginia, United States, 23455
    - Research Site
- Washington
  - Federal Way, Washington, United States, 98003
    - Research Site
  - Seattle, Washington, United States, 98104
    - Research Site
  - Seattle, Washington, United States, 98195
    - Research Site
  - Selah, Washington, United States, 98942
    - Research Site
- Wisconsin
  - Green Bay, Wisconsin, United States, 54301
    - Research Site
  - Madison, Wisconsin, United States, 53713
    - Research Site
  - Marshfield, Wisconsin, United States, 54449
    - Research Site

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

40 years to 85 years (Adult, Older Adult)

Accepts Healthy Volunteers

Description

Inclusion Criteria:

Male or female ≥ 40 to ≤ 85 years of age
History of clinically evident cardiovascular disease at high risk for a recurrent event
Fasting low-density lipoprotein cholesterol (LDL-C) ≥ 70 mg/dL (≥ 1.8 mmol/L) ) or non-high-density lipoprotein cholesterol (non-HDL-C) ≥ 100 mg/dL (> 2.6 mmol/L)
Fasting triglycerides ≤ 400 mg/dL (4.5 mmol/L)

Exclusion Criteria:

New York Heart Association (NYHA) class III or IV, or last known left ventricular ejection fraction < 30%
Uncontrolled hypertension
Uncontrolled or recurrent ventricular tachycardia
Untreated hyperthyroidism or hypothyroidism
Homozygous familial hypercholesterolemia
LDL or plasma apheresis

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Interventional Model: Parallel Assignment
Masking: Quadruple

Arms and Interventions

Participant Group / Arm Participant Group / Arm A group or subgroup of participants in a clinical trial that receives a specific intervention/treatment, or no intervention, according to the trial's protocol.	Intervention / Treatment Intervention / Treatment A process or action that is the focus of a clinical study. Interventions include drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available. Interventions can also include noninvasive approaches, such as education or modifying diet and exercise.
Placebo Comparator: Placebo Participants received placebo subcutaneous injections either once every 2 weeks (Q2W) or once a month (QM) according to their own preference.	Drug: Placebo Administered subcutaneously using a spring-based prefilled 1.0 mL autoinjector/pen.
Experimental: Evolocumab Participants received evolocumab 140 mg Q2W or 420 mg QM subcutaneous injections according to their own preference.	Biological: Evolocumab Administered subcutaneously using a spring-based prefilled 1.0 mL autoinjector/pen. Other Names: Repatha AMG 145

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Time to Cardiovascular Death, Myocardial Infarction, Hospitalization for Unstable Angina, Stroke, or Coronary Revascularization Time Frame: Events that occurred from randomization to the last confirmed survival status date; the median duration of follow-up was 26 months. KM estimates at 6, 12, 18, 24, 30 and 36 months are reported.	All deaths and potential endpoint events were adjudicated by an independent external Clinical Events Committee (CEC) led by the Thrombolysis in Myocardial Infarction (TIMI) Study Group, using standardized definitions based on the "Standardized Definitions for Cardiovascular and Stroke End Point Events in Clinical Trials and the Third Universal Definition of Myocardial Infarction". Time to cardiovascular death, myocardial infarction, stroke, hospitalization for unstable angina, or coronary revascularization was defined as the time from randomization to the first occurrence of any component of the composite endpoint and was analyzed using Kaplan-Meier (KM) survival analysis. KM estimates of the percentage of participants with an event are reported. Participants with no event were censored based on last non-fatal potential endpoint collection date.	Events that occurred from randomization to the last confirmed survival status date; the median duration of follow-up was 26 months. KM estimates at 6, 12, 18, 24, 30 and 36 months are reported.

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Time to Cardiovascular Death, Myocardial Infarction, or Stroke Time Frame: Events that occurred from randomization to the last confirmed survival status date; the median duration of follow-up was 26 months. KM estimates at 6, 12, 18, 24, 30 and 36 months are reported.	All deaths and potential endpoint events were adjudicated by an independent external CEC led by the TIMI Study Group, using standardized definitions based on the "Standardized Definitions for Cardiovascular and Stroke End Point Events in Clinical Trials and the Third Universal Definition of Myocardial Infarction". Time to cardiovascular death, myocardial infarction, or stroke was defined as the time from randomization to the first occurrence of any component of the composite endpoint and was analyzed using Kaplan-Meier (KM) survival analysis. KM estimates of the percentage of participants with an event are reported. Participants with no event were censored based on last non-fatal potential endpoint collection date.	Events that occurred from randomization to the last confirmed survival status date; the median duration of follow-up was 26 months. KM estimates at 6, 12, 18, 24, 30 and 36 months are reported.
Time to Cardiovascular Death Time Frame: Events that occurred from randomization to the last confirmed survival status date; the median duration of follow-up was 26 months. KM estimates at 6, 12, 18, 24, 30 and 36 months are reported.	All deaths and potential endpoint events were adjudicated by an independent external CEC led by the TIMI Study Group, using standardized definitions based on the "Standardized Definitions for Cardiovascular and Stroke End Point Events in Clinical Trials and the Third Universal Definition of Myocardial Infarction". Cardiovascular death includes death resulting from an acute myocardial infarction (MI), sudden cardiac death, death due to heart failure (HF), death due to stroke, death due to cardiovascular (CV) procedures, death due to CV hemorrhage, and death due to other CV causes. Time to cardiovascular death was defined as the time from randomization to the date of cardiovascular death and was analyzed using Kaplan-Meier (KM) survival analysis. KM estimates of the percentage of participants with an event are reported. Participants with no event were censored based on the last confirmed survival status date.	Events that occurred from randomization to the last confirmed survival status date; the median duration of follow-up was 26 months. KM estimates at 6, 12, 18, 24, 30 and 36 months are reported.
Time to All Cause Death Time Frame: Events that occurred from randomization to the last confirmed survival status date; the median duration of follow-up was 26 months. KM estimates at 6, 12, 18, 24, 30 and 36 months are reported.	Time to all-cause death was defined as the time from randomization to the date of death and was analyzed using Kaplan-Meier (KM) survival analysis. KM estimates of the percentage of participants with an event are reported. Participants with no event were censored based on the last confirmed survival status date.	Events that occurred from randomization to the last confirmed survival status date; the median duration of follow-up was 26 months. KM estimates at 6, 12, 18, 24, 30 and 36 months are reported.
Time to First Myocardial Infarction Time Frame: Events that occurred from randomization to the last confirmed survival status date; the median duration of follow-up was 26 months. KM estimates at 6, 12, 18, 24, 30 and 36 months are reported.	All deaths and potential endpoint events were adjudicated by an independent external CEC led by the TIMI Study Group, using standardized definitions based on the "Standardized Definitions for Cardiovascular and Stroke End Point Events in Clinical Trials and the Third Universal Definition of Myocardial Infarction". The diagnosis of myocardial infarction required the combination of: Evidence of myocardial necrosis (either changes in cardiac biomarkers or post-mortem pathological findings); and Supporting information derived from the clinical presentation, electrocardiographic changes, or the results of myocardial or coronary artery Imaging. Time to first myocardial infarction was defined as the time from randomization to the date of the first MI and was analyzed using Kaplan-Meier survival analysis. KM estimates of the percentage of participants with an event are reported. Participants with no event were censored based on last non-fatal potential endpoint collection date.	Events that occurred from randomization to the last confirmed survival status date; the median duration of follow-up was 26 months. KM estimates at 6, 12, 18, 24, 30 and 36 months are reported.
Time to First Stroke Time Frame: Events that occurred from randomization to the last confirmed survival status date; the median duration of follow-up was 26 months. KM estimates at 6, 12, 18, 24, 30 and 36 months are reported.	All deaths and potential endpoint events were adjudicated by an independent external CEC led by the TIMI Study Group, using standardized definitions based on the "Standardized Definitions for Cardiovascular and Stroke End Point Events in Clinical Trials and the Third Universal Definition of Myocardial Infarction". Stroke was defined as an acute episode of focal or global neurological dysfunction caused by brain, spinal cord, or retinal vascular injury as a result of hemorrhage or infarction. Time to first stroke was defined as the time from randomization to the date of the stroke and was analyzed using Kaplan-Meier (KM) survival analysis. KM estimates of the percentage of participants with an event are reported. Participants with no event were censored based on last non-fatal potential endpoint collection date.	Events that occurred from randomization to the last confirmed survival status date; the median duration of follow-up was 26 months. KM estimates at 6, 12, 18, 24, 30 and 36 months are reported.
Time to First Coronary Revascularization Time Frame: Events that occurred from randomization to the last confirmed survival status date; the median duration of follow-up was 26 months. KM estimates at 6, 12, 18, 24, 30 and 36 months are reported.	All deaths and potential endpoint events were adjudicated by an independent external CEC led by the TIMI Study Group, using standardized definitions based on the "Standardized Definitions for Cardiovascular and Stroke End Point Events in Clinical Trials and the Third Universal Definition of Myocardial Infarction". Time to first coronary revascularization was defined as the time from randomization to the date of the coronary revascularization and was analyzed using Kaplan-Meier (KM) survival analysis. KM estimates of the percentage of participants with an event are reported. Participants with no event were censored based on last non-fatal potential endpoint collection date.	Events that occurred from randomization to the last confirmed survival status date; the median duration of follow-up was 26 months. KM estimates at 6, 12, 18, 24, 30 and 36 months are reported.
Time to Cardiovascular Death or First Hospitalization for Worsening Heart Failure Time Frame: Events that occurred from randomization to the last confirmed survival status date; the median duration of follow-up was 26 months. KM estimates at 6, 12, 18, 24, 30 and 36 months are reported.	All events were adjudicated by an independent external CEC led by the TIMI Study Group, using standardized definitions. HF hospitalization was defined as an event that met all of the following criteria: Admitted to hospital with a primary diagnosis of HF In hospital for at least 24 hours Documented new or worsening symptoms due to HF, including at least 1 of the following: Dyspnea Decreased exercise tolerance Fatigue Other symptoms of worsened end-organ perfusion or volume overload Evidence of new or worsening HF consisting of at least 2 physical exam findings or 1 physical exam finding and at least 1 laboratory criterion Received new or increased treatment for HF. Time to CV death or first hospitalization for worsening HF was defined as the time from randomization to the first occurrence of any component of the endpoint analyzed using KM survival analysis. Participants with no event were censored based on last non-fatal potential endpoint collection date.	Events that occurred from randomization to the last confirmed survival status date; the median duration of follow-up was 26 months. KM estimates at 6, 12, 18, 24, 30 and 36 months are reported.
Time to First Ischemic Fatal or Non-Fatal Stroke or Transient Ischemic Attack Time Frame: Events that occurred from randomization to the last confirmed survival status date; the median duration of follow-up was 26 months. KM estimates at 6, 12, 18, 24, 30 and 36 months are reported.	All deaths and potential endpoint events were adjudicated by an independent external CEC led by the TIMI Study Group, using standardized definitions. Ischemic stroke was defined as an acute episode of focal cerebral, spinal, or retinal dysfunction caused by infarction of central nervous system tissue. Transient ischemic attack (TIA) was defined as a transient episode of focal neurological dysfunction caused by brain, spinal cord, or retinal ischemia, without acute infarction. Time to first ischemic fatal or non-fatal stroke or TIA was defined as the time from randomization to the first occurrence of any component of the composite endpoint and was analyzed using KM analysis. KM estimates of the percentage of participants with an event are reported. Participants with no event were censored based on last non-fatal potential endpoint collection date.	Events that occurred from randomization to the last confirmed survival status date; the median duration of follow-up was 26 months. KM estimates at 6, 12, 18, 24, 30 and 36 months are reported.

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Amgen

Investigators

Study Director: MD, Amgen

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Helpful Links

AmgenTrials clinical trials website

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

February 8, 2013

Primary Completion (Actual)

November 11, 2016

Study Completion (Actual)

November 11, 2016

Study Registration Dates

First Submitted

January 8, 2013

First Submitted That Met QC Criteria

January 8, 2013

First Posted (Estimated)

January 9, 2013

Study Record Updates

Last Update Posted (Actual)

May 28, 2024

Last Update Submitted That Met QC Criteria

May 10, 2024

Last Verified

May 1, 2024

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

20110118
2014/01/004324 (Registry Identifier: Clinical Trials Registry- India (CTRI))
2012-001398-97 (EudraCT Number)

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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Study Overview

Status

Conditions

Intervention / Treatment

Study Type

Enrollment (Actual)

Phase

Contacts and Locations

Study Locations

Participation Criteria

Eligibility Criteria

Ages Eligible for Study

Accepts Healthy Volunteers

Description

Study Plan

How is the study designed?

Design Details

Number of Arms

Arms and Interventions

Participant Group / Arm

Intervention / Treatment

What is the study measuring?

Primary Outcome Measures

Outcome Measure

Measure Description

Time Frame

Secondary Outcome Measures

Outcome Measure

Measure Description

Time Frame

Collaborators and Investigators

Sponsor

Investigators

Publications and helpful links

General Publications

Helpful Links

Study record dates

Study Major Dates

Study Start (Actual)

Primary Completion (Actual)

Study Completion (Actual)

Study Registration Dates

First Submitted

First Submitted That Met QC Criteria

First Posted (Estimated)

Study Record Updates

Last Update Posted (Actual)

Last Update Submitted That Met QC Criteria

Last Verified

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

Clinical Trials on Dyslipidemia

Clinical Trials on Evolocumab

Search Similar Trials

Sponsors and Collaborators

Medical Conditions

Drug Interventions

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations