E²-RADIatE: EORTC-ESTRO RADiotherapy InfrAstrucTure for Europe (E²-RADIatE)

March 20, 2025 updated by: European Organisation for Research and Treatment of Cancer - EORTC
The primary objective is the collection of real-world data of cancer patients treated with radiotherapy, to support radiotherapy research and to provide evidence of the role of radiation oncology in a multidisciplinary approach. This is an open ended prospective non-interventional non-therapeutic multi-cohort study.

Study Overview

Status

Status

Indicates the current recruitment status or the expanded access status.
Recruiting

Conditions

Conditions

The disease, disorder, syndrome, illness, or injury that is being studied. On ClinicalTrials.gov, conditions may also include other health-related issues, such as lifespan, quality of life, and health risks.

Study Type

Study Type

Describes the nature of a clinical study. Study types include interventional studies (also called clinical trials), observational studies (including patient registries), and expanded access.
Observational

Enrollment (Estimated)

Enrollment

The number of participants in a clinical study. The "anticipated" enrollment is the target number of participants that the researchers need for the study.
2000

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Contact

The name and contact information for the person who can answer enrollment questions for a clinical study. Each location where the study is being conducted may also have a specific contact, who may be better able to answer those questions.

Study Locations

  • Austria
      • Graz, Austria, AT 8036
        • Recruiting
        • Medical University of Graz - Radio-oncology
        • Contact:
          • Tanja Langsenlehner
      • Linz, Austria, AT 4010
        • Recruiting
        • Ordensklinikum Linz-Barmherzige Schwestern
        • Contact:
          • Hans Geinitz
      • Vienna, Austria, AT 1090
        • Recruiting
        • Universitaetskliniken der Uni Wien - Universitaetsklinikum Wien - AKH unikliniken
        • Contact:
          • Joachim Widder
  • Belgium
      • Aalst, Belgium, 9300
        • Suspended
        • Onze Lieve Vrouw Ziekenhuis
      • Brussels, Belgium, 1200
        • Recruiting
        • Cliniques universitaires Saint-Luc
        • Contact:
          • Xavier Geets
      • Brussels, Belgium, BE 1070
        • Recruiting
        • Institut Jules Bordet
      • Gent, Belgium, 9000
        • Recruiting
        • Universitair Ziekenhuis Gent
        • Contact:
          • Yolande Lievens
      • Gent, Belgium, BE 9000
        • Recruiting
        • AZ Sint-Lucas & Volkskliniek
      • Kortrijk, Belgium, 8500
        • Recruiting
        • AZ Groeninge Kortrijk - Campus Kennedylaan
        • Contact:
          • Karin Stellamans
      • Leuven, Belgium, BE 3000
        • Suspended
        • U.Z. Leuven - Campus Gasthuisberg
      • Liege, Belgium, 4000
        • Suspended
        • C.H.U. Sart-Tilman
      • Namur, Belgium, 5000
        • Suspended
        • CHU Site Sainte-Elisabeth-UCL Namur
      • Turnhout, Belgium, BE 2300
        • Recruiting
        • AZ Turnhout - Campus Sint Elisabeth
        • Contact:
          • Katrien Geboers
      • Wilrijk, Belgium, BE 2610
        • Recruiting
        • GasthuisZusters Antwerpen - Sint-Augustinus
        • Contact:
          • Piet Dirix
  • Czechia
      • Hradec Kralove, Czechia, CZ 500 05
        • Recruiting
        • University Hospital Hradec Kralove
        • Contact:
          • Igor Sirak
  • France
      • Brest, France, 29200
        • Suspended
        • Clinique Pasteur-Lanroze (1174)
  • Germany
      • Aachen, Germany, DE 52074
        • Suspended
        • Universitaetsklinikum Aachen AOR - Medizinische Fakultaet der RWTH
      • Bayreuth, Germany, DE 95448
        • Suspended
        • Klinikum Bayreuth GmbH
      • Dresden, Germany, DE 01307
        • Recruiting
        • Universitaetsklinikum Carl Gustav Carus
        • Contact:
          • Fabian Lohaus
      • Moenchengladbach, Germany, DE 41063
        • Recruiting
        • Kliniken Maria Hilf GmbH
      • Muenchen, Germany, DE 81377
        • Recruiting
        • Ludwig-Maximilians-Universitaet Muenchen - Campus Grosshadern
  • Ireland
      • Dublin, Ireland, IE 06
        • Recruiting
        • St Luke Hospital & SLRON - SLRON - St. Luke'S Hospital Rathgar
      • Dublin, Ireland, IE D18 AK68
        • Recruiting
        • Beacon Hospital
      • Galway, Ireland, IE H91 YR71
        • Recruiting
        • University Hospital Galway
  • Israel
      • Ramat Gan, Israel, IL 52621 60
        • Recruiting
        • Sheba Medical Center Tel Hashomer
  • Italy
      • Acquaviva delle Fonti, Italy, IT 70021
        • Recruiting
        • Ente Ecclesiastico Ospedale Generale Regionale "F. Miulli"
      • Arezzo, Italy, IT 52100
        • Suspended
        • USL Toscana South East, Ospedale S. Donato
      • Brescia, Italy, 25123
        • Recruiting
        • Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
      • Firenze, Italy, IT 50134
        • Recruiting
        • Univ. of Florence -Azienda Ospedaliero-Universitaria Careggi
      • Milan, Italy, 20089
        • Recruiting
        • Istituto Clinico Humanitas
        • Contact:
          • Marta Scorsetti
      • Milano, Italy, IT 20132
        • Recruiting
        • IRCCS Ospedale San Raffaele
        • Contact:
          • Nadia Gisella Di Muzio
      • Milano, Italy, IT 20141
        • Recruiting
        • Istituto Europeo Di Oncologia
        • Contact:
          • Barbara Jereczek-Fossa
      • Negrar, Italy, 37024
        • Recruiting
        • Sacro Cuore Hospital
        • Contact:
          • Filippo Alongi
      • Negrar, Italy, IT 37024
        • Recruiting
        • IRCCS Ospedale Sacro Cuore Don Calabria
      • Pavia, Italy, 27100
        • Suspended
        • Istituti Clinici Scientifici Maugeri
      • Pavia, Italy, IT 27100
        • Suspended
        • Centro Nazionale di Adroterapia Oncoloica par il trattamento dei tumori
      • Perugia, Italy, 06129
        • Recruiting
        • San Maria della Misericordia Hospital
      • Roma, Italy, IT 00128
        • Recruiting
        • Policlinico Universitario Campus Bio-Medico- Oncology Center
        • Contact:
          • Sara Ramella
      • Roma, Italy, IT 00168
        • Recruiting
        • Fondazione Policlinico Universitario A. Gemelli - Fondazione Policlinico Universitario Agostino Gemelli IRCCS
      • Terni, Italy, IT 05100
        • Recruiting
        • Azienda Ospedaliera Santa Maria di Terni
      • Torino, Italy, 10126
        • Recruiting
        • Azienda Ospedaliera Citta della Salute e della Scienza di Torino - Universita Di Torino - San Giovanni Battista
  • Netherlands
      • Eindhoven, Netherlands, NL 5623
        • Recruiting
        • Stichting Catharina Ziekenhuis
        • Contact:
          • Heike Peulen
      • Groningen, Netherlands, NL 9713 GZ
        • Recruiting
        • University Medical Center Groningen
      • Nijmegen, Netherlands, 6525
        • Recruiting
        • Radboudumc - Radboud University Medical Center Nijmegen
        • Contact:
          • Petra Braam
      • Nijmegen, Netherlands, NL 6525 GA
        • Recruiting
        • Radiotherapiegroep Arnhem
        • Contact:
          • Petra Braam
  • Poland
      • Lodz, Poland, PL 93-513
        • Recruiting
        • Wojewodzkie Wielospecjalistyczne Centrum Onkologii I Traumatologii Im. M. Kopernika W Lodzi
      • Radom, Poland, PL 26-600
        • Recruiting
        • Kliniki Neuroradiochirurgii Sp. z o.o.-Radomskie Centrum Onkologii
      • Warsaw, Poland, 02781
        • Suspended
        • Maria Sklodowska-Curie Memorial Cancer Centre - Maria Sklodowska-Curie National Research Institute of Oncology
  • Slovenia
      • Ljubljana, Slovenia, SI 1000
        • Recruiting
        • The Institute Of Oncology
        • Contact:
          • Ivica Ratosa
  • Spain
      • Badalona, Spain, ES 08916
        • Recruiting
        • ICO Badalona - Hospital Germans Trias i Pujol (Institut Catala D'Oncologia)
        • Contact:
          • Josep Jove i Teixido
      • Barcelona, Spain, ES 08035
        • Recruiting
        • Hospital Universitari Vall d'Hebron -Vall d'Hebron Institut Oncologia
        • Contact:
          • Sergi Benavente
      • Barcelona, Spain, ES 08041
        • Recruiting
        • Hospital de la Santa Creu i Sant Pau
        • Contact:
          • Gemma Sancho-Pardo
      • Cartagena, Spain, ES 30202
        • Recruiting
        • Hospital General Universitario Santa Lucía
        • Contact:
          • Juan Salinas Ramos
      • Cordoba, Spain, ES 14004
        • Recruiting
        • Hospital Universitario Reina Sofía
        • Contact:
          • Amalia Palacios Eito
      • Madrid, Spain, 28034
        • Recruiting
        • Hospital Universitario Ramón y Cajal
      • Madrid, Spain, 28046
        • Recruiting
        • Hospital Universitario La Paz
      • Madrid, Spain, ES 28006
        • Recruiting
        • Hospital Universitario de la Princesa
        • Contact:
          • Pablo Castro
      • Madrid, Spain, 28050
        • Recruiting
        • Hospitales HM Sanchinarro-CIOCC
      • Madrid, Spain, ES 28040
        • Suspended
        • Hospital Universitario San Carlos
      • Pamplona, Spain, ES 31008
        • Suspended
        • Hospital Universitario de Navarra
      • Salamanca, Spain, ES 37007
        • Recruiting
        • Hospital Universitario de Salamanca (430)
        • Contact:
          • Luis Perez-Romasanta
      • Terrassa, Spain, ES 08227
        • Recruiting
        • Hospital Consorci Sanitari De Terrassa
      • Valencia, Spain, ES 46026
        • Recruiting
        • Hospital Universitario la Fe
        • Contact:
          • Jose Antonio Conde Moreno
      • Valencia, Spain, ES 46010
        • Recruiting
        • Hospital Clínico Universitario de Valencia
  • Switzerland
      • Bern, Switzerland, 3010
        • Recruiting
        • Inselspital
        • Contact:
          • Hossein Hemmatazad
      • Chur, Switzerland, CH 7000
        • Recruiting
        • Kantonsspital Graubuenden
      • Geneve, Switzerland, 1211
        • Recruiting
        • Hôpitaux universitaires de Genève - HUG - site de Cluse-Roseraie
        • Contact:
          • Thomas Zilli
      • La Chaux-de-Fonds, Switzerland, CH 2303
        • Suspended
        • Reseau Hospitalier Neuchatelois - RHNe - La Chaux de Fonds
      • Sion, Switzerland, 1951
        • Recruiting
        • Hopital du Valais - Hopital de Sion
        • Contact:
          • Kaouthar Khanfir
      • Zürich, Switzerland, 8091
        • Recruiting
        • Universitaetsspital Zürich
        • Contact:
          • Matthias Guckenberger
  • United Kingdom
      • Aberdeen, United Kingdom, AB25 2ZD
        • Recruiting
        • NHS Grampian - Aberdeen Royal Infirmary
        • Contact:
          • Adnan Shaukat
      • Cardiff, United Kingdom, CF14 2TL
        • Recruiting
        • Velindre NHS Trust - Velindre Cancer Centre
      • Glasgow, United Kingdom, GB G12 0YN
        • Recruiting
        • NHS Greater Glasgow and Clyde - Beatson West of Scotland Cancer Centre - Gartnavel General Hospital
      • Manchester, United Kingdom, M20 4BX
        • Recruiting
        • The Christie NHS Foundation trust - The Christie NHS Foundation Trust
        • Contact:
          • Corinne Faivre-Finn
      • Sheffield, United Kingdom, S10 2SJ
        • Recruiting
        • Sheffield Teaching Hospitals Nhs Foundation Trust - Weston Park Hospital
        • Contact:
          • Matthew Hatton
      • Taunton, United Kingdom, TA1 5DA
        • Recruiting
        • Somerset NHS Foundation Trust-Musgrove Park Hospital
      • Wirral, United Kingdom, GB CH63 4JY
        • Recruiting
        • The Clatterbridge cancer Center NHS foundation Trust - Clatterbridge Cancer Center - Wirral

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Eligibility Criteria

The key requirements that people who want to participate in a clinical study must meet or the characteristics they must have. Eligibility criteria consist of both inclusion criteria (which are required for a person to participate in the study) and exclusion criteria (which prevent a person from participating). Types of eligibility criteria include whether a study accepts healthy volunteers, has age or age group requirements, or is limited by sex.

Ages Eligible for Study

12 years and older (Child, Adult, Older Adult)

Accepts Healthy Volunteers

N/A

Sampling Method

Non-Probability Sample

Study Population

Patient with various tumor types planned to be treated with radiation therapy

Description

Inclusion Criteria:

  • Pathologically confirmed cancer.
  • Written informed consent for E²-RADIatE according to applicable legal and ethical requirements
  • Planned use of radiotherapy
  • Eligibility of the patient confirmed for at least one cohort confirmed
  • Patients of 12 years and older

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort

Group / Cohort

A group or subgroup of participants in an observational study that is assessed for biomedical or health outcomes.
OligoCare
Patients with oligometastatic disease treated with radical radiotherapy
ReCare
Patients treated with high-dose Re-irradiation

What is the study measuring?

Primary Outcome Measures

Primary Outcome Measures

In a clinical study's protocol, the planned outcome measure that is the most important for evaluating the effect of an intervention/treatment. Most clinical studies have one primary outcome measure, but some have more than one.
Outcome Measure
Time Frame
Number of patients treated with radiotherapy enrolled in the program
Time Frame: 5 years
5 years

Secondary Outcome Measures

Secondary Outcome Measures

In a clinical study's protocol, a planned outcome measure that is not as important as the primary outcome measure for evaluating the effect of an intervention but is still of interest. Most clinical studies have more than one secondary outcome measure.
Outcome Measure
Time Frame
Overall survival
Time Frame: 5 years
5 years
Disease free survival
Time Frame: 5 years
5 years
Loco-regional control
Time Frame: 5 years
5 years
Distant metastasis free survival
Time Frame: 5 years
5 years
Incidence of adverse events related to radiotherapy
Time Frame: 5 years
5 years

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Sponsor

The organization or person who initiates the study and who has authority and control over the study.
European Organisation for Research and Treatment of Cancer - EORTC

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

Study Start

The actual date on which the first participant was enrolled in a clinical study. The "anticipated" study start date is the date that the researchers think will be the study start date.
June 24, 2019

Primary Completion (Estimated)

Primary Completion

The date on which the last participant in a clinical study was examined or received an intervention to collect final data for the primary outcome measure. Whether the clinical study ended according to the protocol or was terminated does not affect this date. For clinical studies with more than one primary outcome measure with different completion dates, this term refers to the date on which data collection is completed for all the primary outcome measures. The "anticipated" primary completion date is the date that the researchers think will be the primary completion date for the study.
April 30, 2026

Study Completion (Estimated)

Study Completion

The date on which the last participant in a clinical study was examined or received an intervention/treatment to collect final data for the primary outcome measures, secondary outcome measures, and adverse events (that is, the last participant's last visit). The "anticipated" study completion date is the date that the researchers think will be the study completion date.
April 30, 2026

Study Registration Dates

First Submitted

First Submitted

The date on which the study sponsor or investigator first submitted a study record to ClinicalTrials.gov. There is typically a delay of a few days between the first submitted date and the record's availability on ClinicalTrials.gov (the first posted date).
January 17, 2019

First Submitted That Met QC Criteria

First Submitted That Met QC Criteria

The date on which the study sponsor or investigator first submits a study record that is consistent with National Library of Medicine (NLM) quality control (QC) review criteria. The sponsor or investigator may need to revise and submit a study record one or more times before NLM's QC review criteria are met. It is the responsibility of the sponsor or investigator to ensure that the study record is consistent with the NLM QC review criteria.
January 24, 2019

First Posted (Actual)

First Posted

The date on which the study record was first available on ClinicalTrials.gov after National Library of Medicine (NLM) quality control (QC) review has concluded. There is typically a delay of a few days between the date the study sponsor or investigator submitted the study record and the first posted date.
January 28, 2019

Study Record Updates

Last Update Posted (Actual)

Last Update Posted

The most recent date on which changes to a study record were made available on ClinicalTrials.gov. There may be a delay between when the changes were submitted to ClinicalTrials.gov by the study's sponsor or investigator (the last update submitted date) and the last update posted date.
March 25, 2025

Last Update Submitted That Met QC Criteria

Last Update Submitted That Met QC Criteria

The most recent date on which the study sponsor or investigator submitted changes to a study record that are consistent with National Library of Medicine (NLM) quality control (QC) review criteria. It is the responsibility of the sponsor or investigator to ensure that the study record is consistent with the NLM QC review criteria.
March 20, 2025

Last Verified

Last Verified

The most recent date on which the study sponsor or investigator confirmed the information about a clinical study on ClinicalTrials.gov as accurate and current. If a study with a recruitment status of recruiting; not yet recruiting; or active, not recruiting has not been confirmed within the past 2 years, the study's recruitment status is shown as unknown.
March 1, 2025

More Information

Terms related to this study

Other Study ID Numbers

Other Study ID Numbers

Identifiers or ID numbers other than the NCT number that are assigned to a clinical study by the study's sponsor, funders, or others. These numbers may include unique identifiers from other trial registries and National Institutes of Health grant numbers.
  • EORTC-1811

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

UNDECIDED

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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