E²-RADIatE: EORTC-ESTRO RADiotherapy InfrAstrucTure for Europe (E²-RADIatE)

December 27, 2023 updated by: European Organisation for Research and Treatment of Cancer - EORTC
The primary objective is the collection of real-world data of cancer patients treated with radiotherapy, to support radiotherapy research and to provide evidence of the role of radiation oncology in a multidisciplinary approach. This is an open ended prospective non-interventional non-therapeutic multi-cohort study.

Study Overview

Status

Recruiting

Conditions

Study Type

Observational

Enrollment (Estimated)

2000

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Locations

  • Austria
      • Graz, Austria, AT 8036
        • Recruiting
        • Medical University of Graz - Radio-oncology
        • Contact:
          • Tanja Langsenlehner
      • Linz, Austria, AT 4010
        • Recruiting
        • Ordensklinikum Linz-Barmherzige Schwestern
        • Contact:
          • Hans Geinitz
      • Vienna, Austria, AT 1090
        • Recruiting
        • Universitaetskliniken der Uni Wien - Universitaetsklinikum Wien - AKH unikliniken
        • Contact:
          • Joachim Widder
  • Belgium
      • Aalst, Belgium, 9300
        • Recruiting
        • Onze Lieve Vrouw Ziekenhuis
        • Contact:
          • Luc Verbeke
      • Brussels, Belgium, 1200
        • Recruiting
        • Cliniques Universitaires Saint-Luc
        • Contact:
          • Xavier Geets
      • Gent, Belgium, 9000
        • Recruiting
        • Universitair Ziekenhuis Gent
        • Contact:
          • Yolande Lievens
      • Kortrijk, Belgium, 8500
        • Recruiting
        • AZ Groeninge Kortrijk - Campus Kennedylaan
        • Contact:
          • Karin Stellamans
      • Leuven, Belgium, BE 3000
        • Recruiting
        • U.Z. Leuven - Campus Gasthuisberg
        • Contact:
          • Jean-François Daisne
      • Namur, Belgium, 5000
        • Recruiting
        • CHU Site Sainte-Elisabeth-UCL Namur
        • Contact:
          • Vincent Remouchamps
      • Turnhout, Belgium, BE 2300
        • Recruiting
        • AZ Turnhout - Campus Sint Elisabeth
        • Contact:
          • Katrien Geboers
      • Wilrijk, Belgium, BE 2610
        • Recruiting
        • GasthuisZusters Antwerpen - Sint-Augustinus
        • Contact:
          • Piet Dirix
  • Czechia
      • Hradec Kralove, Czechia, CZ 500 05
        • Recruiting
        • University hospital Hradec Králové
        • Contact:
          • Igor Sirak
  • France
      • Brest, France, 29200
        • Recruiting
        • Clinique Pasteur-Lanroze (1174)
        • Contact:
          • Ali Hasbini
  • Germany
      • Aachen, Germany, DE 52074
        • Recruiting
        • Universitaetsklinikum Aachen AOR - Medizinische Fakultaet der RWTH
        • Contact:
          • Michael Eble
      • Bayreuth, Germany, DE 95448
        • Recruiting
        • Klinikum Bayreuth GmbH
        • Contact:
          • Jochen Willner
      • Dresden, Germany, DE 01307
        • Recruiting
        • Universitaetsklinikum Carl Gustav Carus
        • Contact:
          • Fabian Lohaus
  • Italy
      • Arezzo, Italy, IT 52100
        • Recruiting
        • Ospedale S. Donato, USL -8
        • Contact:
          • Simona Borghesi
      • Firenze, Italy, IT 50134
        • Recruiting
        • Azienda Ospedaliero-Universitaria Careggi
        • Contact:
          • Lorenzo Livi
      • Milan, Italy, 20089
        • Recruiting
        • Istituto Clinico Humanitas
        • Contact:
          • Marta Scorsetti
      • Milano, Italy, IT 20132
        • Recruiting
        • IRCCS Ospedale San Raffaele
        • Contact:
          • Nadia Gisella Di Muzio
      • Milano, Italy, IT 20141
        • Recruiting
        • Istituto Europeo Di Oncologia
        • Contact:
          • Barbara Jereczek-Fossa
      • Negrar, Italy, 37024
        • Recruiting
        • Sacro Cuore Hospital
        • Contact:
          • Filippo Alongi
      • Pavia, Italy, 27100
        • Recruiting
        • Istituti Clinici Scientifici Maugeri
        • Contact:
          • Giovanni Battista Ivaldi
      • Pavia, Italy, IT 27100
        • Recruiting
        • Centro Nazionale di Adroterapia Oncoloica par il trattamento dei tumori
        • Contact:
          • Ester Orlandi
      • Roma, Italy, IT 00128
        • Recruiting
        • Policlinico Universitario Campus Bio-Medico- Oncology Center
        • Contact:
          • Sara Ramella
      • Torino, Italy, 10126
        • Recruiting
        • Università di Torino
        • Contact:
          • Umberto Ricardi
  • Netherlands
      • Eindhoven, Netherlands, NL 5623
        • Recruiting
        • Stichting Catharina Ziekenhuis
        • Contact:
          • Heike Peulen
      • Nijmegen, Netherlands, 6525
        • Recruiting
        • Radboudumc - Radboud University Medical Center Nijmegen
        • Contact:
          • Petra Braam
      • Nijmegen, Netherlands, NL 6525 GA
        • Recruiting
        • Radiotherapiegroep Arnhem
        • Contact:
          • Petra Braam
  • Slovenia
      • Ljubljana, Slovenia, SI 1000
        • Recruiting
        • The Institute Of Oncology
        • Contact:
          • Ivica Ratosa
  • Spain
      • Badalona, Spain, ES 08916
        • Recruiting
        • ICO Badalona - Hospital Germans Trias i Pujol (Institut Catala D'Oncologia)
        • Contact:
          • Josep Jove i Teixido
      • Barcelona, Spain, ES 08035
        • Recruiting
        • Hospital Universitari Vall d'Hebron -Vall d'Hebron Institut Oncologia
        • Contact:
          • Sergi Benavente
      • Barcelona, Spain, ES 08041
        • Recruiting
        • Hospital de la Santa Creu i Sant Pau
        • Contact:
          • Gemma Sancho-Pardo
      • Cartagena, Spain, ES 30202
        • Recruiting
        • Hospital General Universitario Santa Lucia
        • Contact:
          • Juan Salinas Ramos
      • Cordoba, Spain, ES 14004
        • Recruiting
        • Hospital Universitario Reina Sofia
        • Contact:
          • Amalia Palacios Eito
      • Madrid, Spain, ES 28006
        • Recruiting
        • Hospital Universitario de la Princesa
        • Contact:
          • Pablo Castro
      • Madrid, Spain, ES 28040
        • Recruiting
        • Hospital Universitario San Carlos
        • Contact:
          • Miren Gaztanaga
      • Pamplona, Spain, ES 31008
        • Recruiting
        • Complejo Hospitalario de Navarra
        • Contact:
          • Mikel Rico
      • Salamanca, Spain, ES 37007
        • Recruiting
        • Hospital Universitario de Salamanca (430)
        • Contact:
          • Luis Perez-Romasanta
      • Valencia, Spain, ES 46026
        • Recruiting
        • Hospital Universitario La Fe
        • Contact:
          • Jose Antonio Conde Moreno
  • Switzerland
      • Bern, Switzerland, 3010
        • Recruiting
        • Inselspital
        • Contact:
          • Hossein Hemmatazad
      • Geneve, Switzerland, 1211
        • Recruiting
        • Hôpitaux universitaires de Genève - HUG - site de Cluse-Roseraie
        • Contact:
          • Thomas Zilli
      • La Chaux-de-Fonds, Switzerland, CH 2303
        • Recruiting
        • Reseau Hospitalier Neuchatelois - RHNe - La Chaux de Fonds
        • Contact:
          • Olalla Santa Cruz
      • Sion, Switzerland, 1951
        • Recruiting
        • Hopital du Valais - Hopital de Sion
        • Contact:
          • Kaouthar Khanfir
      • Zürich, Switzerland, 8091
        • Recruiting
        • UniversitaetsSpital Zurich
        • Contact:
          • Matthias Guckenberger
  • United Kingdom
      • Aberdeen, United Kingdom, AB25 2ZD
        • Recruiting
        • NHS Grampian - Aberdeen Royal Infirmary
        • Contact:
          • Adnan Shaukat
      • Manchester, United Kingdom, M20 4BX
        • Recruiting
        • The Christie NHS Foundation trust - The Christie NHS Foundation Trust
        • Contact:
          • Corinne Faivre-Finn
      • Sheffield, United Kingdom, S10 2SJ
        • Recruiting
        • Sheffield Teaching Hospitals NHS Foundation Trust - Weston Park Hospital
        • Contact:
          • Matthew Hatton

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

12 years and older (Child, Adult, Older Adult)

Accepts Healthy Volunteers

N/A

Sampling Method

Non-Probability Sample

Study Population

Patient with various tumor types planned to be treated with radiation therapy

Description

Inclusion Criteria:

  • Pathologically confirmed cancer.
  • Written informed consent for E²-RADIatE according to applicable legal and ethical requirements
  • Planned use of radiotherapy
  • Eligibility of the patient confirmed for at least one cohort confirmed
  • Patients of 12 years and older

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
OligoCare
Patients with oligometastatic disease treated with radical radiotherapy
ReCare
Patients treated with high-dose Re-irradiation

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
Number of patients treated with radiotherapy enrolled in the program
Time Frame: 5 years
5 years

Secondary Outcome Measures

Outcome Measure
Time Frame
Overall survival
Time Frame: 5 years
5 years
Disease free survival
Time Frame: 5 years
5 years
Loco-regional control
Time Frame: 5 years
5 years
Distant metastasis free survival
Time Frame: 5 years
5 years
Incidence of adverse events related to radiotherapy
Time Frame: 5 years
5 years

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

European Organisation for Research and Treatment of Cancer - EORTC

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

June 24, 2019

Primary Completion (Estimated)

April 30, 2024

Study Completion (Estimated)

April 30, 2024

Study Registration Dates

First Submitted

January 17, 2019

First Submitted That Met QC Criteria

January 24, 2019

First Posted (Actual)

January 28, 2019

Study Record Updates

Last Update Posted (Actual)

December 28, 2023

Last Update Submitted That Met QC Criteria

December 27, 2023

Last Verified

April 1, 2023

More Information

Terms related to this study

Other Study ID Numbers

  • EORTC-1811

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

UNDECIDED

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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