Effects of Single Plasma Exchange and Double Filtration Plasmapheresis (DFPP) on Peripheral Lymphocyte Phenotypes in Patients With Chronic Inflammatory Demyelinating Polyradiculoneuropathy (LYMPHOARESIS)

December 3, 2025 updated by: Centre Hospitalier Universitaire de Nīmes

Comparison of the Effects of 2 Therapeutic Plasmapheresis Techniques: Single Plasma Exchange and Double Filtration Plasmapheresis (DFPP) on Peripheral Lymphocyte Phenotypes in Patients With Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP). A Monocentric Prospective Study With a Single-Case Experimental Design

CIDP, a rare disorder affecting young adults, causes gradual weakness of the limbs, areflexia and impaired sensory function. New CIDP phenotypes without antibodies but with modified cell profiles have been described. Treatments include corticotherapy, IVIg and plasmapheresis but the latter's action mechanisms remain unclear. Plasmapheresis supposedly removes toxic agents like antibodies from plasma but it is uncertain whether it has an immune-modulating effect. Also, the refining mechanisms of the two main plasmapheresis techniques - single plasma exchange and double filtration plasmapheresis (DFPP) - are different and unclear. This study aims to compare the evolution of peripheral lymphocyte profiles in patients with CIDP according to their treatment (single centrifugation plasmapheresis or DFPP) to better grasp the action mechanisms of both techniques.

Study Overview

Status

Status

Indicates the current recruitment status or the expanded access status.
Completed

Conditions

Conditions

The disease, disorder, syndrome, illness, or injury that is being studied. On ClinicalTrials.gov, conditions may also include other health-related issues, such as lifespan, quality of life, and health risks.

Intervention / Treatment

Intervention / Treatment

A process or action that is the focus of a clinical study. Interventions include drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available. Interventions can also include noninvasive approaches, such as education or modifying diet and exercise.

Study Type

Study Type

Describes the nature of a clinical study. Study types include interventional studies (also called clinical trials), observational studies (including patient registries), and expanded access.
Interventional

Enrollment (Actual)

Enrollment

The number of participants in a clinical study. The "anticipated" enrollment is the target number of participants that the researchers need for the study.
8

Phase

Phase

The stage of a clinical trial studying a drug or biological product, based on definitions developed by the U.S. Food and Drug Administration (FDA). The phase is based on the study's objective, the number of participants, and other characteristics. There are five phases: Early Phase 1 (formerly listed as Phase 0), Phase 1, Phase 2, Phase 3, and Phase 4. Not Applicable is used to describe trials without FDA-defined phases, including trials of devices or behavioral interventions.
  • Early Phase 1

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • France
      • Nîmes, France
        • Olivier MORANNE

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Eligibility Criteria

The key requirements that people who want to participate in a clinical study must meet or the characteristics they must have. Eligibility criteria consist of both inclusion criteria (which are required for a person to participate in the study) and exclusion criteria (which prevent a person from participating). Types of eligibility criteria include whether a study accepts healthy volunteers, has age or age group requirements, or is limited by sex.

Ages Eligible for Study

14 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

  • Patients with confirmed Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) without pathogenic antibodies and stable under therapeutic plasmapheresis with one session every 2-3 weeks for at least two months.
  • Patients who have given free written informed consent.
  • Patients who have signed the consent form.
  • Patients affiliated to or beneficiaries of a health insurance scheme.
  • Adult patients (≥18 ans).
  • Healthy subjects of the same age and sex

Exclusion Criteria:

  • Patients Under the age of 18.
  • Patients under immunosuppressive treatment for less than 3 months.
  • Patients participating in Category 1 research involving human subjects.
  • Patients in an exclusion period determined by another study.
  • Patients under legal protection, guardianship or curatorship.
  • Patients unable to express consent.
  • Patients for whom it is impossible to give informed information.
  • Pregnant, parturient or breastfeeding patients.
  • Healthy subject with chronic pathology or drug treatment

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Crossover Assignment
  • Masking: Single

Arms and Interventions

Participant Group / Arm

Participant Group / Arm

A group or subgroup of participants in a clinical trial that receives a specific intervention/treatment, or no intervention, according to the trial's protocol.
Intervention / Treatment

Intervention / Treatment

A process or action that is the focus of a clinical study. Interventions include drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available. Interventions can also include noninvasive approaches, such as education or modifying diet and exercise.
Experimental: Group A
Patients alternating single plasma exchange followed by double filtration plasmapheresis etc.
Biological: Blood sampling
Blood sampling before and after each type of cycle, Single Plasma Exchange or Double Filtration Plasmapheresis
Experimental: Group B
Patients alternating double filtration plasmapheresis followed by single plasma exchange etc.
Biological: Blood sampling
Blood sampling before and after each type of cycle, Single Plasma Exchange or Double Filtration Plasmapheresis

What is the study measuring?

Primary Outcome Measures

Primary Outcome Measures

In a clinical study's protocol, the planned outcome measure that is the most important for evaluating the effect of an intervention/treatment. Most clinical studies have one primary outcome measure, but some have more than one.
Outcome Measure
Measure Description
Time Frame
Cycle 1, Group A : TH1 cells BEFORE single plasma exchange
Time Frame: Day 0, Time 0
5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and the number of TH1 peripheral lymphocyte cells will be measured in %.
Day 0, Time 0
Cycle 1, Group A : TH1 cells AFTER single plasma exchange
Time Frame: Day 0, Hour 3
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH1 peripheral lymphocyte cells will be measured in %.
Day 0, Hour 3
Cycle 1, Group A : TH1 cells 7-10 days AFTER single plasma exchange
Time Frame: Day 7 -10
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH1 peripheral lymphocyte cells will be measured in %.
Day 7 -10
Cycle 1, Group A : TH17 cells BEFORE first single plasma exchange
Time Frame: Day 0, Time 0
5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and the number of TH17 peripheral lymphocyte cells will be measured in %.
Day 0, Time 0
Cycle 1, Group A : TH17 cells AFTER single plasma exchange
Time Frame: Day 0, Hour 3
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH17 peripheral lymphocyte cells will be measured in %.
Day 0, Hour 3
Cycle 1, Group A : TH17 cells 7 - 10 days AFTER single plasma exchange
Time Frame: Day 7 - 10
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH17 peripheral lymphocyte cells will be measured in %.
Day 7 - 10
Cycle 1, Group A : T-reg cells BEFORE first single plasma exchange
Time Frame: Day 0, Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and the number of T-reg cells will be measured in %.
Day 0, Hour 0
Cycle 1, Group A : T-reg cells AFTER single plasma exchange
Time Frame: Day 0, Hour 3
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of T-reg cells will be measured in %.
Day 0, Hour 3
Cycle 1, Group A : T-reg cells 7 - 10 days AFTER single plasma exchange
Time Frame: Day 7 - 10
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of T-reg cells will be measured in %.
Day 7 - 10
Cycle 1, Group B : TH1 cells BEFORE first double filtration plasmapheresis
Time Frame: Day 0, Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and the number of TH1 peripheral lymphocyte cells will be measured in %.
Day 0, Hour 0
Cycle 1, Group B : TH1 cells AFTER the first double filtration plasmapheresis
Time Frame: Day 0, Hour 3
5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH1 peripheral lymphocyte cells will be measured in %.
Day 0, Hour 3
Cycle 1, Group B : TH1 cells 7-10 days AFTER the first double filtration plasmapheresis
Time Frame: Day 7 - 10
5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH1 peripheral lymphocyte cells will be measured in %.
Day 7 - 10
Cycle 1, Group B : TH17 cells BEFORE the first double filtration plasmapheresis
Time Frame: Day0, Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and the number of TH17 cells will be measured in %.
Day0, Hour 0
Cycle 1, Group B : TH17 cells AFTER the first double filtration plasmapheresis
Time Frame: Day 0, Hour 3
5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH17 cells will be measured in %.
Day 0, Hour 3
Cycle 1, Group B : T17 cells 7-10 days AFTER double filtration plasmapheresis
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH17 cells will be measured in %.
Day 7-10
Cycle 1, Group B : T-reg cells BEFORE double filtration plasmapheresis
Time Frame: Day 0, Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and the number of T-reg cells will be measured in %.
Day 0, Hour 0
Cycle 1, Group B : T-reg cells AFTER double filtration plasmapheresis
Time Frame: Day 0, Hour 3
5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of T-reg cells will be measured in %.
Day 0, Hour 3
Cycle 1, Group B : T-reg cells 7-10 days AFTER double filtration plasmapheresis
Time Frame: Day 7 - 10
5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of T-reg cells will be measured in %.
Day 7 - 10
Cycle 2, Group A: TH1 cells BEFORE double filtration plasmapheresis
Time Frame: Day 0, Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and the number of TH1 cells will be measured in %.
Day 0, Hour 0
Cycle 2, Group A: TH1 cells AFTER double filtration plasmapheresis
Time Frame: Day 0, Hour 3
5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH1 cells will be measured in %.
Day 0, Hour 3
Cycle 2, Group A: TH1 cells 7-10 days AFTER double filtration plasmapheresis
Time Frame: Day 7 - 10
5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH1 cells will be measured in %.
Day 7 - 10
Cycle 2, Group A: TH17 cells BEFORE double filtration plasmapheresis
Time Frame: Day 0, Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and the number of TH17 cells will be measured in %.
Day 0, Hour 0
Cycle 2, Group A: TH17 cells AFTER double filtration plasmapheresis
Time Frame: Day 0, Hour 3
5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH17 cells will be measured in %.
Day 0, Hour 3
Cycle 2, Group A: TH17 cells 7-10 days AFTER double filtration plasmapheresis
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH17 cells will be measured in %.
Day 7-10
Cycle 2, Group A: T-reg cells BEFORE double filtration plasmapheresis
Time Frame: Day 0, Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and the number of T-reg cells will be measured in %.
Day 0, Hour 0
Cycle 2, Group A: T-reg cells AFTER double filtration plasmapheresis
Time Frame: Day 0, Hour 3
5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of T-reg cells will be measured in %.
Day 0, Hour 3
Cycle 2, Group A: T-reg cells 7-10 days AFTER double filtration plasmapheresis
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of T-reg cells will be measured in %.
Day 7-10
Cycle 2, Group B: TH1 cells BEFORE single plasma exchange
Time Frame: Day 0, Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and the number of TH1 cells will be measured in %.
Day 0, Hour 0
Cycle 2, Group B: TH1 cells AFTER single plasma exchange
Time Frame: Day 0, Hour 3
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH1 cells will be measured in %.
Day 0, Hour 3
Cycle 2, Group B: TH1 cells 7-10 days AFTER single plasma exchange
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH1 cells will be measured in %.
Day 7-10
Cycle 2, Group B: T17 cells BEFORE single plasma exchange
Time Frame: Day 0, Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and the number of T17 cells will be measured in %.
Day 0, Hour 0
Cycle 2, Group B: TH17 cells AFTER single plasma exchange
Time Frame: Day 0, Hour 3
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of T17 cells will be measured in %.
Day 0, Hour 3
Cycle 2, Group B: TH17 cells 7-10 days AFTER single plasma exchange
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH17 cells will be measured in %.
Day 7-10
Cycle 2, Group B: T-reg cells BEFORE single plasma exchange
Time Frame: Day 0, Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and the number of T-reg cells will be measured in %.
Day 0, Hour 0
Cycle 2, Group B: T-reg cells AFTER single plasma exchange
Time Frame: Day 0, Hour 3
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of T-reg cells will be measured in %.
Day 0, Hour 3
Cycle 2, Group B: T-reg cells 7-10 days AFTER single plasma exchange
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of T-reg cells will be measured in %.
Day 7-10
Cycle 3, Group A: TH1 cells BEFORE single plasma exchange
Time Frame: Day 1, Hour 1
5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and the number of TH1 peripheral lymphocyte cells will be measured in %.
Day 1, Hour 1
Cycle 3, Group A: TH1 cells AFTER single plasma exchange
Time Frame: Day 1, Hour 3
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH1 peripheral lymphocyte cells will be measured in %.
Day 1, Hour 3
Cycle 3, Group A: T1 cells 7-10 days AFTER single plasma exchange
Time Frame: Day 7 - 10
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH1 peripheral lymphocyte cells will be measured in %.
Day 7 - 10
Cycle 3, Group A: TH17 cells BEFORE single plasma exchange
Time Frame: Day 1, Hour 1
5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and the number of TH17 cells will be measured in %.
Day 1, Hour 1
Cycle 3, Group A: TH17 cells AFTER single plasma exchange
Time Frame: Day 1, Hour 3
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH17 cells will be measured in %.
Day 1, Hour 3
Cycle 3, Group A: TH17 cells 7-10 days AFTER single plasma exchange
Time Frame: Day 7 - 10
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH17 cells will be measured in %.
Day 7 - 10
Cycle 3, Group A: T-reg cells BEFORE single plasma exchange
Time Frame: Day 0, Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and the number of T-reg cells will be measured in %.
Day 0, Hour 0
Cycle 3, Group A: T-reg cells AFTER single plasma exchange
Time Frame: Day 0, Hour 3
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of T-reg cells will be measured in %.
Day 0, Hour 3
Cycle 3, Group A: T-reg cells 7-10 days AFTER single plasma exchange
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of T-reg cells will be measured in %.
Day 7-10
Cycle 3, Group B: TH1 cells BEFORE double filtration plasmapheresis
Time Frame: Day 0, Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and the number of TH1 peripheral lymphocyte cells will be measured in %.
Day 0, Hour 0
Cycle 3, Group B: TH1 cells AFTER double filtration plasmapheresis
Time Frame: Day 0, Hour 3
5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH1 peripheral lymphocyte cells will be measured in %.
Day 0, Hour 3
Cycle 3, Group B: TH1 cells 7-10 days AFTER double filtration plasmapheresis
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH1 peripheral lymphocyte cells will be measured in %.
Day 7-10
Cycle 3, Group B: TH17 cells BEFORE double filtration plasmapheresis
Time Frame: Day 0, Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and the number of TH17 cells will be measured in %.
Day 0, Hour 0
Cycle 3, Group B: TH17 cells AFTER double filtration plasmapheresis
Time Frame: Day 0, Hour 3
5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH17 cells will be measured in %.
Day 0, Hour 3
Cycle 3, Group B: TH17 cells 7-10 days AFTER double filtration plasmapheresis
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH17 cells will be measured in %.
Day 7-10
Cycle 3, Group B: T-reg cells BEFORE double filtration plasmapheresis
Time Frame: Day 0, Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and the number of T-reg cells will be measured in %.
Day 0, Hour 0
Cycle 3, Group B: T-reg cells AFTER double filtration plasmapheresis
Time Frame: Day 0, Hour 3
5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of T-reg cells will be measured in %.
Day 0, Hour 3
Cycle 3, Group B: T-reg cells 7-10 days AFTER double filtration plasmapheresis
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of T-reg cells will be measured in %.
Day 7-10
Cycle 4, Group A: T1 cells BEFORE double filtration plasmapheresis
Time Frame: Day 0, Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and the number of T1 peripheral lymphocyte cells will be measured in %.
Day 0, Hour 0
Cycle 4, Group A: T1 cells AFTER double filtration plasmapheresis
Time Frame: Day 0, Hour 3
5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of T1 peripheral lymphocyte cells will be measured in %.
Day 0, Hour 3
Cycle 4, Group A: TH1 cells 7-10 days AFTER double filtration plasmapheresis
Time Frame: Day 7 - 10
5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH1 peripheral lymphocyte cells will be measured in %.
Day 7 - 10
Cycle 4, Group A: TH17 cells BEFORE double filtration plasmapheresis
Time Frame: Day 0, Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and the number of TH17 cells will be measured in %.
Day 0, Hour 0
Cycle 4, Group A: TH17 cells AFTER double filtration plasmapheresis
Time Frame: Day 0, Hour 3
5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH17 cells will be measured in %.
Day 0, Hour 3
Cycle 4, Group A: TH17 cells 7-10 days AFTER double filtration plasmapheresis
Time Frame: Day 7 - 10
5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH17 peripheral lymphocyte cells will be measured in %.
Day 7 - 10
Cycle 4, Group A: T-reg cells BEFORE double filtration plasmapheresis
Time Frame: Day 0, Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and the number of T-reg cells will be measured in %.
Day 0, Hour 0
Cycle 4, Group A: T-reg cells AFTER double filtration plasmapheresis
Time Frame: Day 0, Hour 3
5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of T-reg cells will be measured in %.
Day 0, Hour 3
Cycle 4, Group A: T-reg cells 7-10 days AFTER double filtration plasmapheresis
Time Frame: Day 7 - 10
5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of T-reg peripheral lymphocyte cells will be measured in %.
Day 7 - 10
Cycle 4, Group B : TH1 cells BEFORE single plasma exchange
Time Frame: Day 0, Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and the number of TH1 peripheral lymphocyte cells will be measured in %.
Day 0, Hour 0
Cycle 4, Group B : TH1 cells AFTER single plasma exchange
Time Frame: Day 0, Hour 3
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH1 peripheral lymphocyte cells will be measured in %.
Day 0, Hour 3
Cycle 4, Group B : TH1 cells 7-10 days AFTER single plasma exchange
Time Frame: Day 7 -10
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH1 peripheral lymphocyte cells will be measured in %.
Day 7 -10
Cycle 4, Group B : TH17 cells BEFORE single plasma exchange
Time Frame: Day 0, Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and the number of TH17 cells will be measured in %.
Day 0, Hour 0
Cycle 4, Group B : TH17 cells AFTER single plasma exchange
Time Frame: Day 0, Hour 3
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH17 cells will be measured in %.
Day 0, Hour 3
Cycle 4, Group B : T17 cells 7-10 days AFTER single plasma exchange
Time Frame: Day 7 -10
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of T1 peripheral lymphocyte cells will be measured in %.
Day 7 -10
Cycle 4, Group B : T-reg cells BEFORE single plasma exchange
Time Frame: Day 0, Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and the number of T-reg cells will be measured in %.
Day 0, Hour 0
Cycle 4, Group B : T-reg cells AFTER single plasma exchange
Time Frame: Day 0, Hour 3
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of T-reg cells will be measured in %.
Day 0, Hour 3
Cycle 4, Group B : T-reg cells 7-10 days AFTER single plasma exchange
Time Frame: Day 7 - 10
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of T-reg cells will be measured in %.
Day 7 - 10
Cycle 5, Group A : TH1 cells BEFORE single plasma exchange
Time Frame: Day 0, Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and the number of TH1 peripheral lymphocyte cells will be measured in %.
Day 0, Hour 0
Cycle 5, Group A : TH1 cells AFTER single plasma exchange
Time Frame: Day 0, Hour 3
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH1 peripheral lymphocyte cells will be measured in %.
Day 0, Hour 3
Cycle 5, Group A : TH1 cells 7-10 days AFTER single plasma exchange
Time Frame: Day 7 - 10
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH1 cells will be measured in %.
Day 7 - 10
Cycle 5, Group A : TH17 cells BEFORE single plasma exchange
Time Frame: Day 0, Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and the number of TH17 cells will be measured in %.
Day 0, Hour 0
Cycle 5, Group A : TH17 cells AFTER single plasma exchange
Time Frame: Day 0, Hour 3
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH17 cells will be measured in %.
Day 0, Hour 3
Cycle 5, Group A : TH17 cells 7-10 days AFTER single plasma exchange
Time Frame: Day 7 - 10
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH17 cells will be measured in %.
Day 7 - 10
Cycle 5, Group A : T-reg cells BEFORE single plasma exchange
Time Frame: Day 0, Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and the number of T-reg cells will be measured in %.
Day 0, Hour 0
Cycle 5, Group A : T-reg cells AFTER single plasma exchange
Time Frame: Day 0, Hour 3
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of T-reg cells will be measured in %.
Day 0, Hour 3
Cycle 5, Group A : T-reg cells 7-10 days AFTER single plasma exchange
Time Frame: Day 7 - 10
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of T-reg cells will be measured in %.
Day 7 - 10
Cycle 5, Group B : TH1 cells BEFORE double filtration plasmapheresis
Time Frame: Day 0, Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and the number of TH1 peripheral lymphocyte cells will be measured in %.
Day 0, Hour 0
Cycle 5, Group B : TH1 cells AFTER double filtration plasmapheresis
Time Frame: Day 0, Hour 3
5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH1 peripheral lymphocyte cells will be measured in %.
Day 0, Hour 3
Cycle 5, Group B : TH1 cells 7-10 days AFTER double filtration plasmapheresis
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH1 peripheral lymphocyte cells will be measured in %.
Day 7-10
Cycle 5, Group B : TH17 cells BEFORE double filtration plasmapheresis
Time Frame: Day 0, Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and the number of TH17 cells will be measured in %.
Day 0, Hour 0
Cycle 5, Group B : TH17 cells AFTER double filtration plasmapheresis
Time Frame: Day 0, Hour 3
5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH17 cells will be measured in %.
Day 0, Hour 3
Cycle 5, Group B : TH17 cells 7-10 days AFTER double filtration plasmapheresis
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH17 cells will be measured in %.
Day 7-10
Cycle 5, Group B : T-reg cells BEFORE double filtration plasmapheresis
Time Frame: Day 0, Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and the number of T-reg cells will be measured in %.
Day 0, Hour 0
Cycle 5, Group B : T-reg cells AFTER double filtration plasmapheresis
Time Frame: Day 0, Hour 3
5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of T-reg cells will be measured in %.
Day 0, Hour 3
Cycle 5, Group B : T-reg cells 7-10 days AFTER double filtration plasmapheresis
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of T-reg cells will be measured in %.
Day 7-10
Cycle 6, Group A : TH1 cells BEFORE double filtration plasmapheresis
Time Frame: Day 0 Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and the number of TH1 peripheral lymphocyte cells will be measured in %.
Day 0 Hour 0
Cycle 6, Group A : TH1 cells AFTER double filtration plasmapheresis
Time Frame: Day 0 Hour 3
5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH1 peripheral lymphocyte cells will be measured in %.
Day 0 Hour 3
Cycle 6, Group A : TH1 cells 7-10 days AFTER double filtration plasmapheresis
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube 7-10 days AFTER double filtration plasmapheresis and the number of TH1 peripheral lymphocyte cells will be measured in %.
Day 7-10
Cycle 6, Group A : TH17 cells BEFORE double filtration plasmapheresis
Time Frame: Day 0 Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and the number of TH17 cells will be measured in %.
Day 0 Hour 0
Cycle 6, Group A : TH17 cells AFTER double filtration plasmapheresis
Time Frame: Day 0 Hour 3
5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH17 cells will be measured in %.
Day 0 Hour 3
Cycle 6, Group A : TH17 cells 7-10 days AFTER double filtration plasmapheresis
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube 7-10 days AFTER double filtration plasmapheresis and the number of TH17 cells will be measured in %.
Day 7-10
Cycle 6, Group A : T-reg cells BEFORE double filtration plasmapheresis
Time Frame: Day 0 Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and the number of T-reg cells will be measured in %.
Day 0 Hour 0
Cycle 6, Group A : T-reg cells AFTER double filtration plasmapheresis
Time Frame: Day 0 Hour 3
5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of T-reg cells will be measured in %.
Day 0 Hour 3
Cycle 6, Group A : T-reg cells 7-10 days AFTER double filtration plasmapheresis
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube 7-10 days AFTER double filtration plasmapheresis and the number of T-reg cells will be measured in %.
Day 7-10
Cycle 6, Group B : TH1 cells BEFORE single plasma exchange
Time Frame: Day 0 Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and the number of TH1 peripheral lymphocyte cells will be measured in %.
Day 0 Hour 0
Cycle 6, Group B : TH1 cells AFTER single plasma exchange
Time Frame: Day 0 Hour 3
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH1 peripheral lymphocyte cells will be measured in %.
Day 0 Hour 3
Cycle 6, Group B : TH1 cells 7-10 days AFTER single plasma exchange
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH1 peripheral lymphocyte cells will be measured in %.
Day 7-10
Cycle 6, Group B : TH17 cells BEFORE single plasma exchange
Time Frame: Day 0 Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and the number of TH17 cells will be measured in %.
Day 0 Hour 0
Cycle 6, Group B : TH17 cells AFTER single plasma exchange
Time Frame: Day 0 Hour 3
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH17 cells will be measured in %.
Day 0 Hour 3
Cycle 6, Group B : TH17 cells 7-10 days AFTER single plasma exchange
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH17 cells will be measured in %.
Day 7-10
Cycle 6, Group B : T-reg cells BEFORE single plasma exchange
Time Frame: Day 0 Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and the number of T-reg cells will be measured in %.
Day 0 Hour 0
Cycle 6, Group B : T-reg cells AFTER single plasma exchange
Time Frame: Day 0 Hour 3
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of T-reg cells will be measured in %.
Day 0 Hour 3
Cycle 6, Group B : T-reg cells 7-10 days AFTER single plasma exchange
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of T-reg cells will be measured in %.
Day 7-10

Secondary Outcome Measures

Secondary Outcome Measures

In a clinical study's protocol, a planned outcome measure that is not as important as the primary outcome measure for evaluating the effect of an intervention but is still of interest. Most clinical studies have more than one secondary outcome measure.
Outcome Measure
Measure Description
Time Frame
Cycle 1, Group A : T4 lymphocytes BEFORE single plasma exchange
Time Frame: Day 0 Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 0
Cycle 1, Group A : T4-DR+ lymphocytes BEFORE single plasma exchange
Time Frame: Day 0 Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 0
Cycle 1, Group A : T8 lymphocytes BEFORE single plasma exchange
Time Frame: Day 0 Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 0
Cycle 1, Group A : T8 DR+ lymphocytes BEFORE single plasma exchange
Time Frame: Day 0 Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 0
Cycle 1, Group A : B lymphocytes BEFORE single plasma exchange
Time Frame: Day 0 Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 0
Cycle 1, Group A : CD45RA+CCR7+ cells BEFORE single plasma exchange
Time Frame: Day 0 Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 0
Cycle 1, Group A : CD45RA-CCR7+ cells BEFORE single plasma exchange
Time Frame: Day 0 Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 0
Cycle 1, Group A : CD45RA-CCR7- cells BEFORE single plasma exchange
Time Frame: Day 0 Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 0
Cycle 1, Group A : CCR6-CXCR3- cells BEFORE single plasma exchange
Time Frame: Day 0 Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 0
Cycle 1, Group A : T4 lymphocytes AFTER single plasma exchange
Time Frame: Day 0 Hour 3
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 3
Cycle 1, Group A : T4-DR+ lymphocytes AFTER single plasma exchange
Time Frame: Day 0 Hour 3
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 3
Cycle 1, Group A : T8 lymphocytes AFTER single plasma exchange
Time Frame: Day 0 Hour 3
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 3
Cycle 1, Group A : T8 DR+ lymphocytes AFTER single plasma exchange
Time Frame: Day 0 Hour 3
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 3
Cycle 1, Group A : B lymphocytes AFTER single plasma exchange
Time Frame: Day 0 Hour 3
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 3
Cycle 1, Group A : CD45RA+CCR7+ cells AFTER single plasma exchange
Time Frame: Day 0 Hour 3
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 3
Cycle 1, Group A : CD45RA-CCR7+ cells AFTER single plasma exchange
Time Frame: Day 0 Hour 3
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 3
Cycle 1, Group A : CD45RA-CCR7- cells AFTER single plasma exchange
Time Frame: Day 0 Hour 3
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 3
Cycle 1, Group A : CR6-CXCR3- cells AFTER single plasma exchange
Time Frame: Day 0 Hour 3
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 3
Cycle 1, Group A : T4 lymphocytes 7-10 days AFTER single plasma exchange
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10
Cycle 1, Group A : T4-DR+ lymphocytes 7-10 days AFTER single plasma exchange
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10
Cycle 1, Group A : T8 lymphocytes 7-10 days AFTER single plasma exchange
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10
Cycle 1, Group A : T8 DR+ lymphocytes 7-10 days AFTER single plasma exchange
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10
Cycle 1, Group A : B lymphocytes 7-10 days AFTER single plasma exchange
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10
Cycle 1, Group A : CD45RA+CCR7+ cells 7-10 days AFTER single plasma exchange
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10
Cycle 1, Group A : CD45RA-CCR7+ cells 7-10 days AFTER single plasma exchange
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10
Cycle 1, Group A : CD45RA-CCR7- cells 7-10 days AFTER single plasma exchange
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10
Cycle 1, Group A : CCR6-CXCR3- cells 7-10 days AFTER single plasma exchange
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10
Cycle 1, Group B: T4 lymphocytes BEFORE double filtration plasmapheresis
Time Frame: Day 0 Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 0
Cycle 1, Group B: T4 DR+ lymphocytes BEFORE double filtration plasmapheresis
Time Frame: Day 0 Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 0
Cycle 1, Group B: T8 lymphocytes BEFORE double filtration plasmapheresis
Time Frame: Day 0 Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 0
Cycle 1, Group B: T8 DR+ lymphocytes BEFORE double filtration plasmapheresis
Time Frame: Day 0 Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 0
Cycle 1, Group B: B lymphocytes BEFORE double filtration plasmapheresis
Time Frame: Day 0 Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 0
Cycle 1, Group B: CD45RA+CCR7+ cells BEFORE double filtration plasmapheresis
Time Frame: Day 0 Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 0
Cycle 1, Group B: CD45RA-CCR7+ cells BEFORE double filtration plasmapheresis
Time Frame: Day 0 Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 0
Cycle 1, Group B: CD45RA-CCR7- cells BEFORE double filtration plasmapheresis
Time Frame: Day 0 Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 0
Cycle 1, Group B: CCR6-CXCR3- cells BEFORE double filtration plasmapheresis
Time Frame: Day 0 Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 0
Cycle 1, Group B:T4 lymphocytes AFTER double filtration plasmapheresis
Time Frame: Day 0 Hour 3
5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 3
Cycle 1, Group B:T4 DR+ lymphocytes AFTER double filtration plasmapheresis
Time Frame: Day 0 Hour 3
5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 3
Cycle 1, Group B:T8 lymphocytes AFTER double filtration plasmapheresis
Time Frame: Day 0 Hour 3
5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 3
Cycle 1, Group B:T8 DR+ lymphocytes AFTER double filtration plasmapheresis
Time Frame: Day 0 Hour 3
5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 3
Cycle 1, Group B: B lymphocytes AFTER double filtration plasmapheresis
Time Frame: Day 0 Hour 3
5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 3
Cycle 1, Group B: CD45RA+CCR7+ cells AFTER double filtration plasmapheresis
Time Frame: Day 0 Hour 3
5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 3
Cycle 1, Group B: CD45RA-CCR7+ cells AFTER double filtration plasmapheresis
Time Frame: Day 0 Hour 3
5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 3
Cycle 1, Group B: CD45RA-CCR7- cells AFTER double filtration plasmapheresis
Time Frame: Day 0 Hour 3
5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 3
Cycle 1, Group B: CCR6-CXCR3- cells AFTER double filtration plasmapheresis
Time Frame: Day 0 Hour 3
5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 3
Cycle 1, Group B: T4 lymphocytes 7-10 days AFTER double filtration plasmapheresis
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube 7-10 days AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10
Cycle 1, Group B: T4 DR+ lymphocytes 7-10 days AFTER double filtration plasmapheresis
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube 7-10 days AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10
Cycle 1, Group B: T8 lymphocytes 7-10 days AFTER double filtration plasmapheresis
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube 7-10 days AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10
Cycle 1, Group B: T8 DR+ lymphocytes 7-10 days AFTER double filtration plasmapheresis
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube 7-10 days AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10
Cycle 1, Group B: B lymphocytes 7-10 days AFTER double filtration plasmapheresis
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube 7-10 days AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10
Cycle 1, Group B: CD45RA+CCR7+ cells 7-10 days AFTER double filtration plasmapheresis
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube 7-10 days AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10
Cycle 1, Group B: CD45RA-CCR7+ cells 7-10 days AFTER double filtration plasmapheresis
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube 7-10 days AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10
Cycle 1, Group B: CD45RA-CCR7- cells 7-10 days AFTER double filtration plasmapheresis
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube 7-10 days AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10
Cycle 1, Group B: CCR6-CXCR3- cells 7-10 days AFTER double filtration plasmapheresis
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube 7-10 days AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10
Cycle 2, Group A : T4 lymphocytes BEFORE double filtration plasmapheresis
Time Frame: Day 0 Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 0
Cycle 2, Group A : T4 DR+ lymphocytes BEFORE double filtration plasmapheresis
Time Frame: Day 0 Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 0
Cycle 2, Group A : T8 lymphocytes BEFORE double filtration plasmapheresis
Time Frame: Day 0 Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 0
Cycle 2, Group A : T8 DR+ lymphocytes BEFORE double filtration plasmapheresis
Time Frame: Day 0 Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 0
Cycle 2, Group A : B lymphocytes BEFORE double filtration plasmapheresis
Time Frame: Day 0 Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) a,d measured as a percentage.
Day 0 Hour 0
Cycle 2, Group A : CD45RA+CCR7+ cells BEFORE double filtration plasmapheresis
Time Frame: Day 0 Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) a,d measured as a percentage.
Day 0 Hour 0
Cycle 2, Group A : CD45RA-CCR7+ cells BEFORE double filtration plasmapheresis
Time Frame: Day 0 Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) a,d measured as a percentage.
Day 0 Hour 0
Cycle 2, Group A : CD45RA-CCR7- cells BEFORE double filtration plasmapheresis
Time Frame: Day 0 Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) a,d measured as a percentage.
Day 0 Hour 0
Cycle 2, Group A : CCR6-CXCR3- cells BEFORE double filtration plasmapheresis
Time Frame: Day 0 Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) a,d measured as a percentage.
Day 0 Hour 0
Cycle 2, Group A : T4 lymphocytes AFTER double filtration plasmapheresis
Time Frame: Day 0 Hour 3
5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) a,d measured as a percentage.
Day 0 Hour 3
Cycle 2, Group A : T4 DR+ lymphocytes AFTER double filtration plasmapheresis
Time Frame: Day 0 Hour 3
5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 3
Cycle 2, Group A : T8 lymphocytes AFTER double filtration plasmapheresis
Time Frame: Day 0 Hour 3
5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 3
Cycle 2, Group A : T8 DR+ lymphocytes AFTER double filtration plasmapheresis
Time Frame: Day 0 Hour 3
5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 3
Cycle 2, Group A : B lymphocytes AFTER double filtration plasmapheresis
Time Frame: Day 0 Hour 3
5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 3
Cycle 2, Group A : CD45RA+CCR7+ cells AFTER double filtration plasmapheresis
Time Frame: Day 0 Hour 3
5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 3
Cycle 2, Group A : CD45RA-CCR7+ cells AFTER double filtration plasmapheresis
Time Frame: Day 0 Hour 3
5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 3
Cycle 2, Group A : CD45RA-CCR7- cells AFTER double filtration plasmapheresis
Time Frame: Day 0 Hour 3
5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 3
Cycle 2, Group A : CCR6-CXCR3- cells AFTER double filtration plasmapheresis
Time Frame: Day 0 Hour 3
5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 3
Cycle 2, Group A : T4 lymphocytes 7-10 days AFTER double filtration plasmapheresis
Time Frame: Day 7 - 10
5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7 - 10
Cycle 2, Group A : T4 DR+ lymphocytes 7-10 days AFTER double filtration plasmapheresis
Time Frame: Day 7 - 10
5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7 - 10
Cycle 2, Group A : T8 lymphocytes 7-10 days AFTER double filtration plasmapheresis
Time Frame: Day 7 - 10
5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7 - 10
Cycle 2, Group A : T8 DR+ lymphocytes 7-10 days AFTER double filtration plasmapheresis
Time Frame: Day 7 - 10
5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7 - 10
Cycle 2, Group A : B lymphocytes 7-10 days AFTER double filtration plasmapheresis
Time Frame: Day 7 - 10
5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7 - 10
Cycle 2, Group A : CD45RA+CCR7+ cells 7-10 days AFTER double filtration plasmapheresis
Time Frame: Day 7 - 10
5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7 - 10
Cycle 2, Group A : CD45RA-CCR7+ cells 7-10 days AFTER double filtration plasmapheresis
Time Frame: Day 7 - 10
5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7 - 10
Cycle 2, Group A : CD45RA-CCR7- cells 7-10 days AFTER double filtration plasmapheresis
Time Frame: Day 7 - 10
5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7 - 10
Cycle 2, Group A : CCR6-CXCR3- cells 7-10 days AFTER double filtration plasmapheresis
Time Frame: Day 7 - 10
5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7 - 10
Cycle 2, Group B : T4 lymphocytes BEFORE single plasma exchange
Time Frame: Day 0 Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 0
Cycle 2, Group B : T4 DR+ lymphocytes BEFORE single plasma exchange
Time Frame: Day 0 Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 0
Cycle 2, Group B : T8 lymphocytes BEFORE single plasma exchange
Time Frame: Day 0 Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 0
Cycle 2, Group B : T8 DR+ lymphocytes BEFORE single plasma exchange
Time Frame: Day 0 Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 0
Cycle 2, Group B : B lymphocytes BEFORE single plasma exchange
Time Frame: Day 0 Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 0
Cycle 2, Group B : CD45RA+CCR7+ cells BEFORE single plasma exchange
Time Frame: Day 0 Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 0
Cycle 2, Group B : CD45RA-CCR7+ cells BEFORE single plasma exchange
Time Frame: Day 0 Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 0
Cycle 2, Group B : CD45RA-CCR7- cells BEFORE single plasma exchange
Time Frame: Day 0 Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 0
Cycle 2, Group B : CCR6-CXCR3- cells BEFORE single plasma exchange
Time Frame: Day 0 Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 0
Cycle 2, Group B : T4 lymphocytes AFTER single plasma exchange
Time Frame: Day 0 Hour 3
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 3
Cycle 2, Group B : T4 DR+ lymphocytes AFTER single plasma exchange
Time Frame: Day 0 Hour 3
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 3
Cycle 2, Group B : T8 lymphocytes AFTER single plasma exchange
Time Frame: Day 0 Hour 3
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 3
Cycle 2, Group B : T8 DR+ lymphocytes AFTER single plasma exchange
Time Frame: Day 0 Hour 3
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 3
Cycle 2, Group B : B lymphocytes AFTER single plasma exchange
Time Frame: Day 0 Hour 3
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 3
Cycle 2, Group B : CD45RA+CCR7+ cells AFTER single plasma exchange
Time Frame: Day 0 Hour 3
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 3
Cycle 2, Group B : CD45RA-CCR7+ cells AFTER single plasma exchange
Time Frame: Day 0 Hour 3
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 3
Cycle 2, Group B : CD45RA-CCR7- cells AFTER single plasma exchange
Time Frame: Day 0 Hour 3
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 3
Cycle 2, Group B : CCR6-CXCR3- cells AFTER single plasma exchange
Time Frame: Day 0 Hour 3
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 3
Cycle 2, Group B : T4 lymphocytes 7-10 days AFTER single plasma exchange
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10
Cycle 2, Group B : T4 DR+ lymphocytes 7-10 days AFTER single plasma exchange
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10
Cycle 2, Group B : T8 lymphocytes 7-10 days AFTER single plasma exchange
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10
Cycle 2, Group B : T8 DR+ lymphocytes 7-10 days AFTER single plasma exchange
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10
Cycle 2, Group B : B lymphocytes 7-10 days AFTER single plasma exchange
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10
Cycle 2, Group B : CD45RA+CCR7+ cells 7-10 days AFTER single plasma exchange
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10
Cycle 2, Group B : CD45RA-CCR7+ cells 7-10 days AFTER single plasma exchange
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10
Cycle 2, Group B : CD45RA-CCR7- cells 7-10 days AFTER single plasma exchange
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured a percentage.
Day 7-10
Cycle 2, Group B : CCR6-CXCR3- cells 7-10 days AFTER single plasma exchange
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10
Cycle 3, Group A : T4 lymphocytes BEFORE single plasma exchange
Time Frame: Day 0 Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 0
Cycle 3, Group A : T4 DR+ lymphocytes BEFORE single plasma exchange
Time Frame: Day 0 Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 0
Cycle 3, Group A : T8 lymphocytes BEFORE single plasma exchange
Time Frame: Day 0 Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 0
Cycle 3, Group A : T8 DR+ lymphocytes BEFORE single plasma exchange
Time Frame: Day 0 Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 0
Cycle 3, Group A : B lymphocytes BEFORE single plasma exchange
Time Frame: Day 0 Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 0
Cycle 3, Group A : CC45RA+CCR7+ cells BEFORE single plasma exchange
Time Frame: Day 0 Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 0
Cycle 3, Group A : CC45RA-CCR7+ cells BEFORE single plasma exchange
Time Frame: Day 0 Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 0
Cycle 3, Group A : CC45RA-CCR7- cells BEFORE single plasma exchange
Time Frame: Day 0 Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 0
Cycle 3, Group A : CCR6-CXCR3- cells BEFORE single plasma exchange
Time Frame: Day 0 Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 0
Cycle 3, Group A : T4 lymphocytes AFTER single plasma exchange
Time Frame: Day 0 Hour 3
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 3
Cycle 3, Group A : T4 DR+ lymphocytes AFTER single plasma exchange
Time Frame: Day 0 Hour 3
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 3
Cycle 3, Group A : T8 lymphocytes AFTER single plasma exchange
Time Frame: Day 0 Hour 3
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 3
Cycle 3, Group A : T8 DR+ lymphocytes AFTER single plasma exchange
Time Frame: Day 0 Hour 3
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 3
Cycle 3, Group A : B lymphocytes AFTER single plasma exchange
Time Frame: Day 0 Hour 3
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 3
Cycle 3, Group A : CD45RA+CCR7+ cells AFTER single plasma exchange
Time Frame: Day 0 Hour 3
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 3
Cycle 3, Group A : CD45RA-CCR7+ cells AFTER single plasma exchange
Time Frame: Day 0 Hour 3
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 3
Cycle 3, Group A : CD45RA-CCR7- cells AFTER single plasma exchange
Time Frame: Day 0 Hour 3
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 3
Cycle 3, Group A : CCR6-CXCR3- cells AFTER single plasma exchange
Time Frame: Day 0 Hour 3
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 3
Cycle 3, Group A : T4 DR+ lymphocytes 7-10 days AFTER single plasma exchange
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10
Cycle 3, Group A : T4 lymphocytes 7 -10 days AFTER single plasma exchange
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10
Cycle 3, Group A : T8 lymphocytes 7-10 days AFTER single plasma exchange
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10
Cycle 3, Group A : T8 DR+ lymphocytes 7-10 days AFTER single plasma exchange
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10
Cycle 3, Group A : B lymphocytes 7-10 days AFTER single plasma exchange
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10
Cycle 3, Group A : CD45RA+CCR7+ cells 7-10 days AFTER single plasma exchange
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10
Cycle 3, Group A : CD45RA-CCR7+ cells 7-10 days AFTER single plasma exchange
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10
Cycle 3, Group A : CD45RA-CCR7- cells 7-10 days AFTER single plasma exchange
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10
Cycle 3, Group A : CCR6-CXCR3- cells 7-10 days AFTER single plasma exchange
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10
Cycle 3, Group B : T4 lymphocytes BEFORE double filtration plasmapheresis
Time Frame: Day 0 Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 0
Cycle 3, Group B : T4 DR+ lymphocytes BEFORE double filtration plasmapheresis
Time Frame: Day 0 Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 0
Cycle 3, Group B : T8 lymphocytes BEFORE double filtration plasmapheresis
Time Frame: Day 0 Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 0
Cycle 3, Group B : T8 DR+ lymphocytes BEFORE double filtration plasmapheresis
Time Frame: Day 0 Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 0
Cycle 3, Group B : B lymphocytes BEFORE double filtration plasmapheresis
Time Frame: Day 0 Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 0
Cycle 3, Group B : CD45RA+CCR7+ cells BEFORE double filtration plasmapheresis
Time Frame: Day 0 Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 0
Cycle 3, Group B : CD45RA-CCR7+ cells BEFORE double filtration plasmapheresis
Time Frame: Day 0 Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 0
Cycle 3, Group B : CD45RA-CCR7- cells BEFORE double filtration plasmapheresis
Time Frame: Day 0 Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 0
Cycle 3, Group B : CCR6-CXCR3- cells BEFORE double filtration plasmapheresis
Time Frame: Day 0 Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 0
Cycle 3, Group B : T4 lymphocytes AFTER double filtration plasmapheresis
Time Frame: Day 0 Hour 3
5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 3
Cycle 3, Group B : T4 DR+ lymphocytes AFTER double filtration plasmapheresis
Time Frame: Day 0 Hour 3
5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 3
Cycle 3, Group B : T8 lymphocytes AFTER double filtration plasmapheresis
Time Frame: Day 0 Hour 3
5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 3
Cycle 3, Group B : T8 DR+ lymphocytes AFTER double filtration plasmapheresis
Time Frame: Day 0 Hour 3
5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 3
Cycle 3, Group B : B lymphocytes AFTER double filtration plasmapheresis
Time Frame: Day 0 Hour 3
5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 3
Cycle 3, Group B : CD45RA+CCR7+ cells AFTER double filtration plasmapheresis
Time Frame: Day 0 Hour 3
5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 3
Cycle 3, Group B : CD45RA-CCR7+ cells AFTER double filtration plasmapheresis
Time Frame: Day 0 Hour 3
5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 3
Cycle 3, Group B : CD45RA-CCR7- cells AFTER double filtration plasmapheresis
Time Frame: Day 0 Hour 3
5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 3
Cycle 3, Group B : CCR6-CXCR3- cells AFTER double filtration plasmapheresis
Time Frame: Day 0 Hour 3
5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 3
Cycle 3, Group B : T4 lymphocytes 7-10 days AFTER double filtration plasmapheresis
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10
Cycle 3, Group B : T4 DR+ lymphocytes 7-10 days AFTER double filtration plasmapheresis
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10
Cycle 3, Group B : T8 lymphocytes 7-10 days AFTER double filtration plasmapheresis
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10
Cycle 3, Group B : T8 DR+ lymphocytes 7-10 days AFTER double filtration plasmapheresis
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10
Cycle 3, Group B : B lymphocytes 7-10 days AFTER double filtration plasmapheresis
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10
Cycle 3, Group B : CD45RA+CCR7+ cells 7-10 days AFTER double filtration plasmapheresis
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10
Cycle 3, Group B : CD45RA-CCR7+ cells 7-10 days AFTER double filtration plasmapheresis
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10
Cycle 3, Group B : CD45RA-CCR7- cells 7-10 days AFTER double filtration plasmapheresis
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10
Cycle 3, Group B : CCR6-CXCR3- cells 7-10 days AFTER double filtration plasmapheresis
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10
Cycle 4, Group A : T4 lymphocytes BEFORE double filtration plasmapheresis
Time Frame: Day 0 Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 0
Cycle 4, Group A : T4 DR+ lymphocytes BEFORE double filtration plasmapheresis
Time Frame: Day 0 Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 0
Cycle 4, Group A : T8 lymphocytes BEFORE double filtration plasmapheresis
Time Frame: Day 0 Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 0
Cycle 4, Group A : T8 DR+ lymphocytes BEFORE double filtration plasmapheresis
Time Frame: Day 0 Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 0
Cycle 4, Group A : B lymphocytes BEFORE double filtration plasmapheresis
Time Frame: Day 0 Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 0
Cycle 4, Group A : CD45RA+CCR7+ cells BEFORE double filtration plasmapheresis
Time Frame: Day 0 Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 0
Cycle 4, Group A : CD45RA-CCR7+ cells BEFORE double filtration plasmapheresis
Time Frame: Day 0 Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 0
Cycle 4, Group A : CD45RA-CCR7- cells BEFORE double filtration plasmapheresis
Time Frame: Day 0 Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 0
Cycle 4, Group A : CCR6-CXCR3- cells BEFORE double filtration plasmapheresis
Time Frame: Day 0 Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 0
Cycle 4, Group A : T4 lymphocytes AFTER double filtration plasmapheresis
Time Frame: Day 0 Hour 3
5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 3
Cycle 4, Group A : T4 DR+ lymphocytes AFTER double filtration plasmapheresis
Time Frame: Day 0 Hour 3
5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 3
Cycle 4, Group A : T8 lymphocytes AFTER double filtration plasmapheresis
Time Frame: Day 0 Hour 3
5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 3
Cycle 4, Group A : T8 DR+ lymphocytes AFTER double filtration plasmapheresis
Time Frame: Day 0 Hour 3
5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 3
Cycle 4, Group A : B lymphocytes AFTER double filtration plasmapheresis
Time Frame: Day 0 Hour 3
5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 3
Cycle 4, Group A : CD45RA+CCR7+ cells AFTER double filtration plasmapheresis
Time Frame: Day 0 Hour 3
5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 3
Cycle 4, Group A : CD45RA-CCR7+ cells AFTER double filtration plasmapheresis
Time Frame: Day 0 Hour 3
5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 3
Cycle 4, Group A : CD45RA-CCR7- cells AFTER double filtration plasmapheresis
Time Frame: Day 0 Hour 3
5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 3
Cycle 4, Group A : CCR6-CXCR3- cells AFTER double filtration plasmapheresis
Time Frame: Day 0 Hour 3
5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 3
Cycle 4, Group A : T4 lymphocytes 7-10 days AFTER double filtration plasmapheresis
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10
Cycle 4, Group A : T4 DR+ lymphocytes 7-10 days AFTER double filtration plasmapheresis
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10
Cycle 4, Group A : T8 lymphocytes 7-10 days AFTER double filtration plasmapheresis
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10
Cycle 4, Group A : T8 DR+ lymphocytes 7-10 days AFTER double filtration plasmapheresis
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10
Cycle 4, Group A : B lymphocytes 7-10 days AFTER double filtration plasmapheresis
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10
Cycle 4, Group A : CD45RA+CCR7+ cells 7-10 days AFTER double filtration plasmapheresis
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10
Cycle 4, Group A : CD45RA-CCR7+ cells 7-10 days AFTER double filtration plasmapheresis
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10
Cycle 4, Group A : CD45RA-CCR7- cells 7-10 days AFTER double filtration plasmapheresis
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10
Cycle 4, Group A : CCR6-CXCR3- cells 7-10 days AFTER double filtration plasmapheresis
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10
Cycle 4, Group B : T4 lymphocytes BEFORE plasma exchange
Time Frame: Day 0 Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 0
Cycle 4, Group B : T4 DR+ lymphocytes BEFORE plasma exchange
Time Frame: Day 0 Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 0
Cycle 4, Group B : T8 lymphocytes BEFORE plasma exchange
Time Frame: Day 0 Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 0
Cycle 4, Group B : T8 DR+ lymphocytes BEFORE single plasma exchange
Time Frame: Day 0 Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 0
Cycle 4, Group B : B lymphocytes BEFORE single plasma exchange
Time Frame: Day 0 Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 0
Cycle 4, Group B : CD45RA+CCR7+ cells BEFORE single plasma exchange
Time Frame: Day 0 Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 0
Cycle 4, Group B : CD45RA-CCR7+ cells BEFORE single plasma exchange
Time Frame: Day 0 Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 0
Cycle 4, Group B : CD45RA-CCR7- cells BEFORE single plasma exchange
Time Frame: Day 0 Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 0
Cycle 4, Group B : CCR6-CXCR3- cells BEFORE single plasma exchange
Time Frame: Day 0 Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 0
Cycle 4, Group B : T4 lymphocytes AFTER single plasma exchange
Time Frame: Day 0 Hour 3
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 3
Cycle 4, Group B : T4 DR+ lymphocytes AFTER single plasma exchange
Time Frame: Day 0 Hour 3
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 3
Cycle 4, Group B : T8 lymphocytes AFTER single plasma exchange
Time Frame: Day 0 Hour 3
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 3
Cycle 4, Group B : T8 DR+ lymphocytes AFTER single plasma exchange
Time Frame: Day 0 Hour 3
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 3
Cycle 4, Group B : B lymphocytes AFTER single plasma exchange
Time Frame: Day 0 Hour 3
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 3
Cycle 4, Group B : CD45RA+CCR7+ cells AFTER single plasma exchange
Time Frame: Day 0 Hour 3
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 3
Cycle 4, Group B : CD45RA-CCR7+ cells AFTER single plasma exchange
Time Frame: Day 0 Hour 3
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 3
Cycle 4, Group B : CD45RA-CCR7- cells AFTER single plasma exchange
Time Frame: Day 0 Hour 3
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 3
Cycle 4, Group B : CCR6-CXCR3- cells AFTER single plasma exchange
Time Frame: Day 0 Hour 3
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0 Hour 3
Cycle 4, Group B : T4 lymphocytes 7-10 days AFTER single plasma exchange
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10
Cycle 4, Group B : T4 DR+ lymphocytes 7-10 days AFTER single plasma exchange
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10
Cycle 4, Group B : T8 lymphocytes 7-10 days AFTER single plasma exchange
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10
Cycle 4, Group B : T8 DR+ lymphocytes 7-10 days AFTER single plasma exchange
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10
Cycle 4, Group B : B lymphocytes 7-10 days AFTER single plasma exchange
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10
Cycle 4, Group B : CD45RA+CCR7+ cells 7-10 days AFTER single plasma exchange
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10
Cycle 4, Group B : CD45RA-CCR7+ cells 7-10 days AFTER single plasma exchange
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10
Cycle 4, Group B : CD45RA-CCR7- cells 7-10 days AFTER single plasma exchange
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10
Cycle 4, Group B : CCR6-CXCR3- cells 7-10 days AFTER single plasma exchange
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10
Cycle 5, Group A : T4 lymphocytes BEFORE single plasma exchange
Time Frame: Day 0, Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0, Hour 0
Cycle 5, Group A : T4 DR+ lymphocytes BEFORE single plasma exchange
Time Frame: Day 0, Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0, Hour 0
Cycle 5, Group A : T8 lymphocytes BEFORE single plasma exchange
Time Frame: Day 0, Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0, Hour 0
Cycle 5, Group A : T8 DR+ lymphocytes BEFORE single plasma exchange
Time Frame: Day 0, Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0, Hour 0
Cycle 5, Group A : B lymphocytes BEFORE single plasma exchange
Time Frame: Day 0, Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0, Hour 0
Cycle 5, Group A : CD45RA+CCR7+ cells BEFORE single plasma exchange
Time Frame: Day 0, Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0, Hour 0
Cycle 5, Group A : CD45RA-CCR7+ cells BEFORE single plasma exchange
Time Frame: Day 0, Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0, Hour 0
Cycle 5, Group A : CD45RA-CCR7- cells BEFORE single plasma exchange
Time Frame: Day 0, Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0, Hour 0
Cycle 5, Group A : CCR6-CXCR3- cells BEFORE single plasma exchange
Time Frame: Day 0, Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0, Hour 0
Cycle 5, Group A : T4 lymphocytes AFTER single plasma exchange
Time Frame: Day 0, Hour 3
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0, Hour 3
Cycle 5, Group A : T4 DR+ lymphocytes AFTER single plasma exchange
Time Frame: Day 0, Hour 3
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0, Hour 3
Cycle 5, Group A : T8 lymphocytes AFTER single plasma exchange
Time Frame: Day 0, Hour 3
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0, Hour 3
Cycle 5, Group A : T8 DR+ lymphocytes AFTER single plasma exchange
Time Frame: Day 0, Hour 3
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0, Hour 3
Cycle 5, Group A : B lymphocytes AFTER single plasma exchange
Time Frame: Day 0, Hour 3
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0, Hour 3
Cycle 5, Group A : CD45RA+CCR7+ cells AFTER single plasma exchange
Time Frame: Day 0, Hour 3
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0, Hour 3
Cycle 5, Group A : CD45RA-CCR7+ cells AFTER single plasma exchange
Time Frame: Day 0, Hour 3
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0, Hour 3
Cycle 5, Group A : CD45RA-CCR7- cells AFTER single plasma exchange
Time Frame: Day 0, Hour 3
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0, Hour 3
Cycle 5, Group A : CCR6-CXCR3- cells AFTER single plasma exchange
Time Frame: Day 0, Hour 3
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0, Hour 3
Cycle 5, Group A : T4 lymphocytes 7-10 days AFTER single plasma exchange
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10
Cycle 5, Group A : T4 DR+ lymphocytes 7-10 days AFTER single plasma exchange
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10
Cycle 5, Group A : T8 lymphocytes 7-10 days AFTER single plasma exchange
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10
Cycle 5, Group A : T8 DR+ lymphocytes 7-10 days AFTER single plasma exchange
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10
Cycle 5, Group A : B lymphocytes 7-10 days AFTER single plasma exchange
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10
Cycle 5, Group A : CD45RA+CCR7+ cells 7-10 days AFTER single plasma exchange
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10
Cycle 5, Group A : CD45RA-CCR7+ cells 7-10 days AFTER single plasma exchange
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10
Cycle 5, Group A : CD45RA-CCR7- cells 7-10 days AFTER single plasma exchange
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10
Cycle 5, Group A : CCR6-CXCR3- cells 7-10 days AFTER single plasma exchange
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10
Cycle 5, Group B : T4 lymphocytes BEFORE double filtration plasmapheresis
Time Frame: Day 0, Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0, Hour 0
Cycle 5, Group B : T4 DR+ lymphocytes BEFORE double filtration plasmapheresis
Time Frame: Day 0, Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0, Hour 0
Cycle 5, Group B : T8 lymphocytes BEFORE double filtration plasmapheresis
Time Frame: Day 0, Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0, Hour 0
Cycle 5, Group B : T8 DR+ lymphocytes BEFORE double filtration plasmapheresis
Time Frame: Day 0, Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0, Hour 0
Cycle 5, Group B : B lymphocytes BEFORE double filtration plasmapheresis
Time Frame: Day 0, Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0, Hour 0
Cycle 5, Group B : CD45RA+CCR7+ cells BEFORE double filtration plasmapheresis
Time Frame: Day 0, Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0, Hour 0
Cycle 5, Group B : CD45RA-CCR7+ cells BEFORE double filtration plasmapheresis
Time Frame: Day 0, Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0, Hour 0
Cycle 5, Group B : CD45RA-CCR7- cells BEFORE double filtration plasmapheresis
Time Frame: Day 0, Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0, Hour 0
Cycle 5, Group B : CCR6-CXCR3- cells BEFORE double filtration plasmapheresis
Time Frame: Day 0, Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0, Hour 0
Cycle 5, Group B : T4 lymphocytes AFTER double filtration plasmapheresis
Time Frame: Day 0, Hour 3
5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0, Hour 3
Cycle 5, Group B : T4 DR+ lymphocytes AFTER double filtration plasmapheresis
Time Frame: Day 0, Hour 3
5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0, Hour 3
Cycle 5, Group B : T8 lymphocytes AFTER double filtration plasmapheresis
Time Frame: Day 0, Hour 3
5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0, Hour 3
Cycle 5, Group B : T8 DR+ lymphocytes AFTER double filtration plasmapheresis
Time Frame: Day 0, Hour 3
5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0, Hour 3
Cycle 5, Group B : B lymphocytes AFTER double filtration plasmapheresis
Time Frame: Day 0, Hour 3
5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0, Hour 3
Cycle 5, Group B : CD45RA+CCR7+ cells AFTER double filtration plasmapheresis
Time Frame: Day 0, Hour 3
5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0, Hour 3
Cycle 5, Group B : CD45RA-CCR7+ cells AFTER double filtration plasmapheresis
Time Frame: Day 0, Hour 3
5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0, Hour 3
Cycle 5, Group B : CD45RA-CCR7- cells AFTER double filtration plasmapheresis
Time Frame: Day 0, Hour 3
5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0, Hour 3
Cycle 5, Group B : CCR6-CXCR3- cells AFTER double filtration plasmapheresis
Time Frame: Day 0, Hour 3
5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0, Hour 3
Cycle 5, Group B : T4 lymphocytes 7-10 days AFTER double filtration plasmapheresis
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10
Cycle 5, Group B : T4 DR+ lymphocytes 7-10 days AFTER double filtration plasmapheresis
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10
Cycle 5, Group B : T8 lymphocytes 7-10 days AFTER double filtration plasmapheresis
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10
Cycle 5, Group B : T8 DR+ lymphocytes 7-10 days AFTER double filtration plasmapheresis
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10
Cycle 5, Group B : B lymphocytes 7-10 days AFTER double filtration plasmapheresis
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10
Cycle 5, Group B : CD45RA+CCR7+ cells 7-10 days AFTER double filtration plasmapheresis
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10
Cycle 5, Group B : CD45RA-CCR7+ cells 7-10 days AFTER double filtration plasmapheresis
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10
Cycle 5, Group B : CD45RA-CCR7- cells 7-10 days AFTER double filtration plasmapheresis
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10
Cycle 5, Group B : CCR6-CXCR3- cells 7-10 days AFTER double filtration plasmapheresis
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10
Cycle 6, Group A : T4 lymphocytes BEFORE double filtration plasmapheresis
Time Frame: Day 0, Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0, Hour 0
Cycle 6, Group A : T4 DR+ lymphocytes BEFORE double filtration plasmapheresis
Time Frame: Day 0, Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0, Hour 0
Cycle 6, Group A : T8 lymphocytes BEFORE double filtration plasmapheresis
Time Frame: Day 0, Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0, Hour 0
Cycle 6, Group A : T8 DR+ lymphocytes BEFORE double filtration plasmapheresis
Time Frame: Day 0, Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0, Hour 0
Cycle 6, Group A : B lymphocytes BEFORE double filtration plasmapheresis
Time Frame: Day 0, Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0, Hour 0
Cycle 6, Group A : CD45RA+CCR7+ cells BEFORE double filtration plasmapheresis
Time Frame: Day 0, Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0, Hour 0
Cycle 6, Group A : CD45RA-CCR7+ cells BEFORE double filtration plasmapheresis
Time Frame: Day 0, Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0, Hour 0
Cycle 6, Group A : CD45RA-CCR7- cells BEFORE double filtration plasmapheresis
Time Frame: Day 0, Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0, Hour 0
Cycle 6, Group A : CCR6-CXCR3- cells BEFORE double filtration plasmapheresis
Time Frame: Day 0, Hour 0
5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0, Hour 0
Cycle 6, Group A : T4 lymphocytes AFTER double filtration plasmapheresis
Time Frame: Day 0, Hour 3
5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0, Hour 3
Cycle 6, Group A : T4 DR+ lymphocytes AFTER double filtration plasmapheresis
Time Frame: Day 0, Hour 3
5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0, Hour 3
Cycle 6, Group A : T8 lymphocytes AFTER double filtration plasmapheresis
Time Frame: Day 0, Hour 3
5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0, Hour 3
Cycle 6, Group A : T8 DR+ lymphocytes AFTER double filtration plasmapheresis
Time Frame: Day 0, Hour 3
5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0, Hour 3
Cycle 6, Group A : B lymphocytes AFTER double filtration plasmapheresis
Time Frame: Day 0, Hour 3
5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0, Hour 3
Cycle 6, Group A : CD45RA+CCR7+ cells AFTER double filtration plasmapheresis
Time Frame: Day 0, Hour 3
5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0, Hour 3
Cycle 6, Group A : CD45RA-CCR7+ cells AFTER double filtration plasmapheresis
Time Frame: Day 0, Hour 3
5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0, Hour 3
Cycle 6, Group A : CD45RA-CCR7- cells AFTER double filtration plasmapheresis
Time Frame: Day 0, Hour 3
5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0, Hour 3
Cycle 6, Group A : CCR6-CXCR3- cells AFTER double filtration plasmapheresis
Time Frame: Day 0, Hour 3
5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0, Hour 3
Cycle 6, Group A : T4 lymphocytes 7-10 days AFTER double filtration plasmapheresis
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10
Cycle 6, Group A : T4 DR+ lymphocytes 7-10 days AFTER double filtration plasmapheresis
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10
Cycle 6, Group A : T8 lymphocytes 7-10 days AFTER double filtration plasmapheresis
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10
Cycle 6, Group A : T8 DR+ lymphocytes 7-10 days AFTER double filtration plasmapheresis
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10
Cycle 6, Group A : B lymphocytes 7-10 days AFTER double filtration plasmapheresis
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10
Cycle 6, Group A : CD45RA+CCR7+ cells 7-10 days AFTER double filtration plasmapheresis
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10
Cycle 6, Group A : CD45RA-CCR7+ cells 7-10 days AFTER double filtration plasmapheresis
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10
Cycle 6, Group A : CD45RA-CCR7- cells 7-10 days AFTER double filtration plasmapheresis
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10
Cycle 6, Group A : CCR6-CXCR3- cells 7-10 days AFTER double filtration plasmapheresis
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10
Cycle 6, Group B : T4 lymphocytes BEFORE single plasma exchange
Time Frame: Day 0, H0
5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0, H0
Cycle 6, Group B : T4 DR+ lymphocytes BEFORE single plasma exchange
Time Frame: Day 0, H0
5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0, H0
Cycle 6, Group B : T8 lymphocytes BEFORE single plasma exchange
Time Frame: Day 0, H0
5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0, H0
Cycle 6, Group B : T8 DR+ lymphocytes BEFORE single plasma exchange
Time Frame: Day 0, H0
5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0, H0
Cycle 6, Group B : B lymphocytes BEFORE single plasma exchange
Time Frame: Day 0, H0
5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0, H0
Cycle 6, Group B : CD45RA+CCR7+ cells BEFORE single plasma exchange
Time Frame: Day 0, H0
5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0, H0
Cycle 6, Group B : CD45RA-CCR7+ cells BEFORE single plasma exchange
Time Frame: Day 0, H0
5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0, H0
Cycle 6, Group B : CD45RA-CCR7- cells BEFORE single plasma exchange
Time Frame: Day 0, H0
5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0, H0
Cycle 6, Group B : CCR6-CXCR3- cells BEFORE single plasma exchange
Time Frame: Day 0, H0
5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0, H0
Cycle 6, Group B : T4 lymphocytes AFTER single plasma exchange
Time Frame: Day 0, H3
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0, H3
Cycle 6, Group B : T4 DR+ lymphocytes AFTER single plasma exchange
Time Frame: Day 0, H3
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0, H3
Cycle 6, Group B : T8 lymphocytes AFTER single plasma exchange
Time Frame: Day 0, H3
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0, H3
Cycle 6, Group B : T8 DR+ lymphocytes AFTER single plasma exchange
Time Frame: Day 0, H3
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0, H3
Cycle 6, Group B : B lymphocytes AFTER single plasma exchange
Time Frame: Day 0, H3
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0, H3
Cycle 6, Group B : CD45RA+CCR7+ cells AFTER single plasma exchange
Time Frame: Day 0, H3
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0, H3
Cycle 6, Group B : CD45RA-CCR7+ cells AFTER single plasma exchange
Time Frame: Day 0, H3
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0, H3
Cycle 6, Group B : CD45RA-CCR7- cells AFTER single plasma exchange
Time Frame: Day 0, H3
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0, H3
Cycle 6, Group B : CCR6-CXCR3- cells AFTER single plasma exchange
Time Frame: Day 0, H3
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 0, H3
Cycle 6, Group B : T4 lymphocytes 7-10 days AFTER single plasma exchange
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10
Cycle 6, Group B : T4 DR+ lymphocytes 7-10 days AFTER single plasma exchange
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10
Cycle 6, Group B : T8 lymphocytes 7-10 days AFTER single plasma exchange
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10
Cycle 6, Group B : T8 DR+ lymphocytes 7-10 days AFTER single plasma exchange
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10
Cycle 6, Group B : B lymphocytes 7-10 days AFTER single plasma exchange
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10
Cycle 6, Group B : CD45RA+CCR7+ cells 7-10 days AFTER single plasma exchange
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10
Cycle 6, Group B : CD45RA-CCR7+ cells 7-10 days AFTER single plasma exchange
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10
Cycle 6, Group B : CD45RA-CCR7- cells 7-10 days AFTER single plasma exchange
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10
Cycle 6, Group B : CCR6-CXCR3- cells 7-10 days AFTER single plasma exchange
Time Frame: Day 7-10
5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.
Day 7-10

Other Outcome Measures

Other Outcome Measures

For clinical trials, a planned measurement described in the protocol that is used to determine the effect of an intervention/treatment on participants. For observational studies, a measurement or observation that is used to describe patterns of diseases or traits, or associations with exposures, risk factors, or treatment. Types of outcome measures include primary outcome measure and secondary outcome measure.
Outcome Measure
Measure Description
Time Frame
Group A, Cycle 1 : Link between variations in lymphocyte sub-populations and the clinical evolution .
Time Frame: Day 7-10 after the end of Cycle 1 (each cycle lasts 3 hours)
All the above primary and secondary outcome measures will be compared with clinical information in the patient file in order to determine a link between these variations at the end of each treatment cycle.
Day 7-10 after the end of Cycle 1 (each cycle lasts 3 hours)
Group B, Cycle 1 : Link between variations in lymphocyte sub-populations and the clinical evolution .
Time Frame: Day 7-10 after the end of Cycle 1 (each cycle lasts 3 hours)
All the above primary and secondary outcome measures will be compared with clinical information in the patient file in order to determine a link between these variations at the end of each treatment cycle.
Day 7-10 after the end of Cycle 1 (each cycle lasts 3 hours)
Group A, Cycle 2 : Link between variations in lymphocyte sub-populations and the clinical evolution .
Time Frame: Day 7-10 after the end of Cycle 2 (each cycle lasts 3 hours)
All the above primary and secondary outcome measures will be compared with clinical information in the patient file in order to determine a link between these variations at the end of each treatment cycle.
Day 7-10 after the end of Cycle 2 (each cycle lasts 3 hours)
Group B, Cycle 2 : Link between variations in lymphocyte sub-populations and the clinical evolution .
Time Frame: Day 7-10 after the end of Cycle 2 (each cycle lasts 3 hours)
All the above primary and secondary outcome measures will be compared with clinical information in the patient file in order to determine a link between these variations at the end of each treatment cycle.
Day 7-10 after the end of Cycle 2 (each cycle lasts 3 hours)
Group A, Cycle 3 : Link between variations in lymphocyte sub-populations and the clinical evolution .
Time Frame: Day 7-10 after the end of Cycle 3 (each cycle lasts 3 hours)
All the above primary and secondary outcome measures will be compared with clinical information in the patient file in order to determine a link between these variations at the end of each treatment cycle.
Day 7-10 after the end of Cycle 3 (each cycle lasts 3 hours)
Group B, Cycle 3 : Link between variations in lymphocyte sub-populations and the clinical evolution .
Time Frame: Day 7-10 after the end of Cycle 3 (each cycle lasts 3 hours)
All the above primary and secondary outcome measures will be compared with clinical information in the patient file in order to determine a link between these variations at the end of each treatment cycle.
Day 7-10 after the end of Cycle 3 (each cycle lasts 3 hours)
Group A, Cycle 4 : Link between variations in lymphocyte sub-populations and the clinical evolution .
Time Frame: Day 7-10 after the end of Cycle 4 (each cycle lasts 3 hours)
All the above primary and secondary outcome measures will be compared with clinical information in the patient file in order to determine a link between these variations at the end of each treatment cycle.
Day 7-10 after the end of Cycle 4 (each cycle lasts 3 hours)
Group B, Cycle 4 : Link between variations in lymphocyte sub-populations and the clinical evolution .
Time Frame: Day 7-10 after the end of Cycle 4 (each cycle lasts 3 hours)
All the above primary and secondary outcome measures will be compared with clinical information in the patient file in order to determine a link between these variations at the end of each treatment cycle.
Day 7-10 after the end of Cycle 4 (each cycle lasts 3 hours)
Group A, Cycle 5 : Link between variations in lymphocyte sub-populations and the clinical evolution .
Time Frame: Day 7-10 after the end of Cycle 5 (each cycle lasts 3 hours)
All the above primary and secondary outcome measures will be compared with clinical information in the patient file in order to determine a link between these variations at the end of each treatment cycle.
Day 7-10 after the end of Cycle 5 (each cycle lasts 3 hours)
Group B, Cycle 5 : Link between variations in lymphocyte sub-populations and the clinical evolution .
Time Frame: Day 7-10 after the end of Cycle 5 (each cycle lasts 3 hours)
All the above primary and secondary outcome measures will be compared with clinical information in the patient file in order to determine a link between these variations at the end of each treatment cycle.
Day 7-10 after the end of Cycle 5 (each cycle lasts 3 hours)
Group A, Cycle 6 : Link between variations in lymphocyte sub-populations and the clinical evolution .
Time Frame: Day 7-10 after the end of Cycle 6 (each cycle lasts 3 hours)
All the above primary and secondary outcome measures will be compared with clinical information in the patient file in order to determine a link between these variations at the end of each treatment cycle.
Day 7-10 after the end of Cycle 6 (each cycle lasts 3 hours)
Group B, Cycle 6 : Link between variations in lymphocyte sub-populations and the clinical evolution .
Time Frame: Day 7-10 after the end of Cycle 6 (each cycle lasts 3 hours)
All the above primary and secondary outcome measures will be compared with clinical information in the patient file in order to determine a link between these variations at the end of each treatment cycle.
Day 7-10 after the end of Cycle 6 (each cycle lasts 3 hours)
Group A, Cycle 1 : Cost of single plasma exchange to the health institution.
Time Frame: Day 7-10 after the end of Cycle 1 (each cycle lasts 3 hours)
The cost of each cycle will be recorded in Euros in the electronic clinical research file and the average amount will be calculated from this information at the end of 6 cycles.
Day 7-10 after the end of Cycle 1 (each cycle lasts 3 hours)
Group B, Cycle 1 : Cost of double filtration plasmapheresis to the health institution.
Time Frame: Day 7-10 after the end of Cycle 1 (each cycle lasts 3 hours)
The cost of each cycle will be recorded in Euros in the electronic clinical research file and the average amount will be calculated from this information at the end of 6 cycles.
Day 7-10 after the end of Cycle 1 (each cycle lasts 3 hours)
Group A, Cycle 2 : Cost of double filtration plasmapheresis to the health institution.
Time Frame: Day 7-10 after the end of Cycle 2 (each cycle lasts 3 hours)
The cost of each cycle will be recorded in Euros in the electronic clinical research file and the average amount will be calculated from this information at the end of 6 cycles.
Day 7-10 after the end of Cycle 2 (each cycle lasts 3 hours)
Group B, Cycle 2 : Cost of single plasma exchange to the health institution.
Time Frame: Day 7-10 after the end of Cycle 2 (each cycle lasts 3 hours)
The cost of each cycle will be recorded in Euros in the electronic clinical research file and the average amount will be calculated from this information at the end of 6 cycles.
Day 7-10 after the end of Cycle 2 (each cycle lasts 3 hours)
Group A, Cycle 3 : Cost of single plasma exchange to the health institution.
Time Frame: Day 7-10 after the end of Cycle 3 (each cycle lasts 3 hours)
The cost of each cycle will be recorded in Euros in the electronic clinical research file and the average amount will be calculated from this information at the end of 6 cycles.
Day 7-10 after the end of Cycle 3 (each cycle lasts 3 hours)
Group B, Cycle 3 : Cost of double filtration plasmapheresis to the health institution.
Time Frame: Day 7-10 after the end of Cycle 3 (each cycle lasts 3 hours)
The cost of each cycle will be recorded in Euros in the electronic clinical research file and the average amount will be calculated from this information at the end of 6 cycles.
Day 7-10 after the end of Cycle 3 (each cycle lasts 3 hours)
Group A, Cycle 4 : Cost of double filtration plasmapheresis to the health institution.
Time Frame: Day 7-10 after the end of Cycle 4 (each cycle lasts 3 hours)
The cost of each cycle will be recorded in Euros in the electronic clinical research file and the average amount will be calculated from this information at the end of 6 cycles.
Day 7-10 after the end of Cycle 4 (each cycle lasts 3 hours)
Group B, Cycle 4 : Cost of single plasma exchange to the health institution.
Time Frame: Day 7-10 after the end of Cycle 4 (each cycle lasts 3 hours)
The cost of each cycle will be recorded in Euros in the electronic clinical research file and the average amount will be calculated from this information at the end of 6 cycles.
Day 7-10 after the end of Cycle 4 (each cycle lasts 3 hours)
Group A, Cycle 5 : Cost of single plasma exchange to the health institution.
Time Frame: Day 7-10 after the end of Cycle 5 (each cycle lasts 3 hours)
The cost of each cycle will be recorded in Euros in the electronic clinical research file and the average amount will be calculated from this information at the end of 6 cycles.
Day 7-10 after the end of Cycle 5 (each cycle lasts 3 hours)
Group B, Cycle 5 : Cost of double filtration to the health institution.
Time Frame: Day 7-10 after the end of Cycle 5 (each cycle lasts 3 hours)
The cost of each cycle will be recorded in Euros in the electronic clinical research file and the average amount will be calculated from this information at the end of 6 cycles.
Day 7-10 after the end of Cycle 5 (each cycle lasts 3 hours)
Group A, Cycle 6 : Cost of double filtration to the health institution.
Time Frame: Day 7-10 after the end of Cycle 6 (each cycle lasts 3 hours)
The cost of each cycle will be recorded in Euros in the electronic clinical research file and the average amount will be calculated from this information at the end of 6 cycles.
Day 7-10 after the end of Cycle 6 (each cycle lasts 3 hours)
Group B, Cycle 6 : Cost of double filtration to the health institution.
Time Frame: Day 7-10 after the end of Cycle 6 (each cycle lasts 3 hours)
The cost of each cycle will be recorded in Euros in the electronic clinical research file and the average amount will be calculated from this information at the end of 6 cycles.
Day 7-10 after the end of Cycle 6 (each cycle lasts 3 hours)
Constitution of a biological resource centre using the blood samples taken in view of future research, especially immunological phenotyping.
Time Frame: Day 0, Hour 0
After all the above analyses, the unused aliquots from the samples taken (bottom of tubes) will be conserved and indexed.
Day 0, Hour 0
Constitution of a biological resource centre using the blood samples taken in view of future research, especially immunological phenotyping.
Time Frame: Day 0, Hour 3
After all the above analyses, the unused aliquots from the samples taken (bottom of tubes) will be conserved and indexed.
Day 0, Hour 3
Constitution of a biological resource centre using the blood samples taken in view of future research, especially immunological phenotyping.
Time Frame: Day 7-10
After all the above analyses, the unused aliquots from the samples taken (bottom of tubes) will be conserved and indexed.
Day 7-10
Compare lymphocyte phenotype between patients with PIDC and control subjects.
Time Frame: Day 0
Significant difference in Th1/Th2 ratio between PIDC patients and control subjects.
Day 0

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Sponsor

The organization or person who initiates the study and who has authority and control over the study.
Centre Hospitalier Universitaire de Nīmes

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

Study Start

The actual date on which the first participant was enrolled in a clinical study. The "anticipated" study start date is the date that the researchers think will be the study start date.
March 12, 2021

Primary Completion (Actual)

Primary Completion

The date on which the last participant in a clinical study was examined or received an intervention to collect final data for the primary outcome measure. Whether the clinical study ended according to the protocol or was terminated does not affect this date. For clinical studies with more than one primary outcome measure with different completion dates, this term refers to the date on which data collection is completed for all the primary outcome measures. The "anticipated" primary completion date is the date that the researchers think will be the primary completion date for the study.
December 18, 2023

Study Completion (Actual)

Study Completion

The date on which the last participant in a clinical study was examined or received an intervention/treatment to collect final data for the primary outcome measures, secondary outcome measures, and adverse events (that is, the last participant's last visit). The "anticipated" study completion date is the date that the researchers think will be the study completion date.
December 18, 2023

Study Registration Dates

First Submitted

First Submitted

The date on which the study sponsor or investigator first submitted a study record to ClinicalTrials.gov. There is typically a delay of a few days between the first submitted date and the record's availability on ClinicalTrials.gov (the first posted date).
January 26, 2021

First Submitted That Met QC Criteria

First Submitted That Met QC Criteria

The date on which the study sponsor or investigator first submits a study record that is consistent with National Library of Medicine (NLM) quality control (QC) review criteria. The sponsor or investigator may need to revise and submit a study record one or more times before NLM's QC review criteria are met. It is the responsibility of the sponsor or investigator to ensure that the study record is consistent with the NLM QC review criteria.
February 3, 2021

First Posted (Actual)

First Posted

The date on which the study record was first available on ClinicalTrials.gov after National Library of Medicine (NLM) quality control (QC) review has concluded. There is typically a delay of a few days between the date the study sponsor or investigator submitted the study record and the first posted date.
February 8, 2021

Study Record Updates

Last Update Posted (Actual)

Last Update Posted

The most recent date on which changes to a study record were made available on ClinicalTrials.gov. There may be a delay between when the changes were submitted to ClinicalTrials.gov by the study's sponsor or investigator (the last update submitted date) and the last update posted date.
December 10, 2025

Last Update Submitted That Met QC Criteria

Last Update Submitted That Met QC Criteria

The most recent date on which the study sponsor or investigator submitted changes to a study record that are consistent with National Library of Medicine (NLM) quality control (QC) review criteria. It is the responsibility of the sponsor or investigator to ensure that the study record is consistent with the NLM QC review criteria.
December 3, 2025

Last Verified

Last Verified

The most recent date on which the study sponsor or investigator confirmed the information about a clinical study on ClinicalTrials.gov as accurate and current. If a study with a recruitment status of recruiting; not yet recruiting; or active, not recruiting has not been confirmed within the past 2 years, the study's recruitment status is shown as unknown.
December 1, 2025

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

Other Study ID Numbers

Identifiers or ID numbers other than the NCT number that are assigned to a clinical study by the study's sponsor, funders, or others. These numbers may include unique identifiers from other trial registries and National Institutes of Health grant numbers.
  • NIMAO/2020-01/OM001
  • 2020-A02879-30 (Other Identifier: ANSM)

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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Conditions

Rare Diseases

Drug Interventions

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