A Study to Investigate the Effect of Lepodisiran on the Reduction of Major Adverse Cardiovascular Events in Adults With Elevated Lipoprotein(a) - ACCLAIM-Lp(a)

May 18, 2026 updated by: Eli Lilly and Company

A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Investigate the Effect of Lepodisiran on the Reduction of Major Adverse Cardiovascular Events in Adults With Elevated Lipoprotein(a) Who Have Established Atherosclerotic Cardiovascular Disease or Are at Risk for a First Cardiovascular Event - ACCLAIM-Lp(a)

The purpose of this study is to evaluate the efficacy of lepodisiran in reducing cardiovascular risk in participants with high lipoprotein(a) who have cardiovascular disease or are at risk of a heart attack or stroke. The study drug will be administered subcutaneously (SC) (under the skin). Approximately 1700 additional participants will be enrolled in an addendum to explore Lp(a) lowering with an alternative dosing schema.

Study Overview

Status

Active, not recruiting

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Estimated)

17300

Phase

Phase 3

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Name: Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or
Phone Number: 1-317-615-4559
Email: LillyTrials@Lilly.com

Study Contact Backup

Name: Physicians interested in becoming principal investigators please contact
Email: clinical_inquiry_hub@lilly.com

Study Locations

Argentina
- - Alberdi, Argentina, 5000
    - Clínica Privada del Prado SRL
  - Buenos Aires, Argentina, 1405
    - Instituto Médico Especializado (IME)
  - Buenos Aires, Argentina, C1426ABP
    - Fundación Respirar
  - Buenos Aires, Argentina, C1119ACN
    - CIPREC
  - Buenos Aires, Argentina, C1407GTN
    - CEMEDIC
  - Buenos Aires, Argentina, 1061
    - Buenos Aires Macula S.A
  - Buenos Aires, Argentina, C1023AAB
    - Stat Research S.A.
  - Buenos Aires, Argentina, C1061AAS
    - CIPREC
  - Buenos Aires, Argentina, C1056ABI
    - Centro de Investigaciones Metabólicas (CINME)
  - Buenos Aires, Argentina, C1425AGC
    - Centro Medico Dra. Laura Maffei- Investigacion Clinica Aplicada
  - Buenos Aires, Argentina, C1430CKE
    - Glenny Corp. S.A.
  - Buenos Aires, Argentina, C1056ABH
    - Investigaciones Medicas IMOBA SRL
  - Buenos Aires, Argentina, C1427CCL
    - Centro Medico Arsema
  - Buenos Aires, Argentina, 1426
    - Consultorio Medico Investigador Principal Dr Besada
  - Buenos Aires, Argentina, 1406
    - Consultorio Medico Dr Litvak Bruno
  - Buenos Aires, Argentina, C1093AAS
    - Fundación favaloro para la Docencia e Investigación Médica
  - CABA, Argentina, C1060ABN
    - CEDIC
  - Ciudad de Buenos Aires, Argentina, C1012AAR
    - IDIM - Instituto de Investigaciones Metabólicas
  - Corrientes, Argentina, 3400
    - Instituto de Cardiología "Juana F. Cabral"
  - Córdoba, Argentina, 5000
    - Instituto de Investigaciones Clínicas Córdoba
  - Córdoba, Argentina, X5000AVE
    - CIDIM-Centro Integral de Diagnostico por Imagenes Marchegiani
  - Córdoba, Argentina, 5002
    - Sanatorio Privado Duarte Quirós
  - Córdoba, Argentina, 5003
    - Centro Medico Colon
  - Del Viso, Argentina, 1669
    - MICA - Medicina e Investigación Cardiometabólica
  - Godoy Cruz, Argentina, 5501
    - CIPADI - Centro Integral de Prevención y Atención en Diabetes
  - Granadero Baigorria, Argentina, 2152
    - Centro de Investigaciones Clínicas Baigorria
  - La Plata, Argentina, 1900
    - Hospital Italiano de La Plata
  - Lanus, Argentina, B1824KAJ
    - CIMeL
  - Mar del Plata, Argentina, 7600
    - Centro de Investigaciones Medicas Mar del Plata
  - Mar del Plata, Argentina, B7600FZO
    - Instituto de Investigaciones Clinicas Mar del Plata
  - Mendoza, Argentina, 5500
    - Instituto de Cardiología Wolff
  - Munro, Argentina, 1605
    - Clinica Privada Independencia
  - Paraná, Argentina, 3100
    - Centro Privado de Medicina Respiratoria
  - Quilmes, Argentina, 1878
    - Instituto de Investigaciones Clinicas Quilmes
  - Quilmes, Argentina, 1878
    - CER medical Institute
  - Ramos Mejía, Argentina, B1704ETD
    - Dim Clinica Privada
  - Rosario, Argentina, S2002KDS
    - Hospital Provincial del Centenario
  - Rosario, Argentina, 2000
    - INECO Neurociencias Oroño
  - Rosario, Argentina, 2000
    - Instituto Médico Fundación Grupo Colaborativo Rosario Investigación y Prevención Medica
  - Rosario, Argentina, 2000
    - Instituto Medico Catamarca Imec
  - Rosario, Argentina, 2000
    - Instituto Especialidades de la Salud Rosario
  - Rosario, Argentina, S2000CVD
    - Instituto de Investigaciones Clinicas Rosario
  - Rosario, Argentina, 2000
    - Fundacion Estudios Clinicos
  - Rosario, Argentina, S2000DTB
    - Laboratorio de Hemostasia y Trombosis
  - Río Cuarto, Argentina, X5800AEV
    - Instituto Medico Rio Cuarto
  - Salta, Argentina, 4400
    - Centro Cardiovascular Salta
  - San Martin, Argentina, 1650
    - Corporación Médica San Martín
  - San Miguel de Tucumán, Argentina, 4000
    - Investigaciones Clinicas Tucuman
  - San Miguel de Tucumán, Argentina, 4000
    - Centro Modelo de Cardiologia
  - San Miguel de Tucumán, Argentina, 4000
    - Clínica Mayo de Urgencias Médicas Cruz Blanca S.R.L
  - San Nicolás, Argentina, 2900
    - Go Centro Medico San Nicolas
  - Santa Fe, Argentina, S3000FWO
    - Centro de Investigaciones Clinicas del Litoral
  - Santa Fe, Argentina, 3000
    - Clínica de Nefrología, Urología y Enfermedades Cardiovasculares
  - Santa Fe, Argentina, 3000
    - Centro de Diagnóstico y Rehabilitación (CEDIR)
  - Venado Tuerto, Argentina, 2600
    - Sanatorio San Martin
Australia
- - Adelaide, Australia, 5000
    - Nightingale Research
  - Adelaide, Australia, 5068
    - Advara HeartCare Leabrook
  - Blacktown, Australia, 2148
    - Paratus Clinical Research Western Sydney
  - Botany, Australia, 2019
    - Emeritus Research
  - Box Hill, Australia, 3128
    - Box Hill Hospital
  - Brisbane, Australia, 4029
    - Royal Brisbane and Women's Hospital
  - Brisbane, Australia, 4064
    - Core Research Group
  - Brisbane, Australia, 4068
    - Heart of Australia
  - Brisbane, Australia, 4102
    - Cholesterol Care
  - Bruce, Australia, 2617
    - Paratus Clinical Research Canberra
  - Camberwell, Australia, 3124
    - Emeritus Research
  - Clayton, Australia, 3168
    - Victorian Heart Hospital
  - Geelong, Australia, 3220
    - Barwon Health
  - Heidelberg West, Australia, 3081
    - Austin Health - Repatriation Hospital
  - Herston, Australia, 4010
    - Paratus Clinical Research Brisbane
  - Joondalup, Australia, 6027
    - Advara HeartCare Joondalup
  - Kanwal, Australia, 2259
    - Paratus Clinical Research Central Coast
  - Liverpool, Australia, 2170
    - Liverpool Hospital
  - Meadowbrook, Australia, 4131
    - Logan Hospital
  - Meadowbrook, Australia, 4131
    - University of the Sunshine Coast (UniSC) Clinical Trials - Meadowbrook
  - Melbourne, Australia, 3021
    - AusTrials - Sunshine
  - Merewether, Australia, 2291
    - The AIM Centre / Hunter Diabetes Centre
  - Morayfield, Australia, 4506
    - USC Clinical Trials Moreton Bay
  - Mulgrave, Australia, 3170
    - Advara HeartCare - Mulgrave
  - Noosaville, Australia, 4566
    - University of the Sunshine Coast (UniSC) Clinical Trials - Noosa
  - Norwood, Australia, 5067
    - Fusion Clinical Research
  - Perth, Australia, 6000
    - Royal Perth Hospital
  - Sippy Downs, Australia, 4556
    - USC Clinical Trials Sunshine Coast
  - South Brisbane, Australia, 4101
    - USC Clinical Trials Brisbane (South Bank)
  - Sydney, Australia, 2065
    - Momentum St. Leonards
  - Townsville, Australia, 4814
    - Townsville University Hospital
  - West Perth, Australia, 6005
    - Clinitrials
Austria
- - Braunau am Inn, Austria, 5280
    - Krankenhaus St. Josef Braunau
  - Feldkirch, Austria, 6800
    - VIVIT
  - Innsbruck, Austria, 6020
    - Medizinische Universitaet Innsbruck
  - Linz, Austria, 4020
    - Ordensklinikum Linz GmbH Elisabethinen
  - Linz, Austria, 4021
    - Konventhospital der Barmherzigen Brüder Linz
  - Mistelbach, Austria, 2130
    - Landesklinikum Mistelbach
  - Salzburg, Austria, 5020
    - Uniklinikum Salzburg
  - Sankt Pölten, Austria, 3100
    - Universitätsklinikum St. Pölten
  - Vienna, Austria, 1090
    - Medizinische Universität Wien
  - Vienna, Austria, 1030
    - Klinik Landstrasse
  - Vienna, Austria, 1210
    - Klinik Floridsdorf
  - Vienna, Austria, 1060
    - Zentrum für klinische Studien Dr Hanusch Gmbh
  - Vienna, Austria, 1090
    - Universitaetsklinikum Allgemeines Krankenhaus Wien
  - Vienna, Austria, 1130
    - Klinik Hietzing
  - Vienna, Austria, 1180
    - Herz Zentrum Währing - Innere Medizin und Kardiologie | Alle Kassen und Privat
Belgium
- - Antwerp, Belgium, 2020
    - ZAS Middelheim
  - Bonheiden, Belgium, 2820
    - Imelda General Hospital
  - Brasschaat, Belgium, 2930
    - Algemeen Ziekenhuis klina
  - Brussels, Belgium, 1200
    - Cliniques universitaires Saint-Luc
  - Brussels, Belgium, 1020
    - Centre Hospitalier Universitaire Brugmann
  - Brussels, Belgium, 1070
    - Université Libre de Bruxelles - Hôpital Erasme
  - Charleroi, Belgium, 6060
    - Grand Hôpital de Charleroi
  - Dendermonde, Belgium, 9200
    - AZ Sint-Blasius
  - Edegem, Belgium, 2650
    - Antwerp University Hospital
  - Genk, Belgium, 3600
    - Ziekenhuis Oost-Limburg, Campus St.-Jan
  - Ghent, Belgium, 9000
    - AZ Maria Middelares
  - Ghent, Belgium, 9000
    - UZ Gent
  - Hasselt, Belgium, 3500
    - Jessa Ziekenhuis
  - Kortrijk, Belgium, 8500
    - AZ Groeninge Campus Kennedylaan
  - Leuven, Belgium, 3000
    - UZ Leuven
  - Mechelen, Belgium, 2800
    - Az Sint-Maarten
  - Ostend, Belgium, 8400
    - AZ Oostende vzw
  - Roeselare, Belgium, 8800
    - AZ Delta VZW
Brazil
- - Aracaju, Brazil, 49055-530
    - Centro de Pesquisa Clínica do Coração
  - Asa Norte, Brazil, 70712-903
    - Instituto Aramari Apo
  - Belo Horizonte, Brazil, 30150-221
    - Santa Casa de Misericordia de Belo Horizonte
  - Belo Horizonte, Brazil, 30220-140
    - NUPEC - Cardio
  - Belo Horizonte, Brazil, 30150-320
    - Freire Pesquisa Clínica
  - Belém, Brazil, 66073-000
    - Hospital Universitário João de Barros Barreto
  - Blumenau, Brazil, 89020-430
    - AngioKormann Blumenau
  - Brasília, Brazil, 72145-450
    - Chronos Pesquisa Clinica
  - Brasília, Brazil, 70200730
    - L2IP - Instituto de Pesquisas Clínicas
  - Brasília, Brazil, 70390-140
    - Instituto D'Or de Pesquisa e Ensino (IDOR) - Filial Brasília
  - Campinas, Brazil, 13060-080
    - Instituto de Pesquisa clinica de Campinas
  - Campinas, Brazil, 13060-803
    - Centro de Pesquisa Sao Lucas
  - Curitiba, Brazil, 80040-110
    - Quanta Diagnóstico e Terapia
  - Curitiba, Brazil, 80230-130
    - PUC Trials- Nucleo de Pesquisa clinica da Escola de Medicina da PUCPR
  - Curitiba, Brazil, 80370-150
    - Nucleo de Pesquisa Clinica
  - Goiânia, Brazil, 74605-020
    - Universidade Federal de Goias
  - Maceió, Brazil, 57051-160
    - Centro de Pesquisas Clínicas Dr. Marco Mota
  - Marília, Brazil, 17515-000
    - Instituto do Coracao de Marilia
  - Niterói, Brazil, 24020-096
    - CHN - Complexo Hospitalar de Niterói
  - Passo Fundo, Brazil, 99010-120
    - Instituto Mederi de Pesquisa e Saude
  - Porto Alegre, Brazil, 90035-903
    - Hospital de Clínicas de Porto Alegre
  - Porto Alegre, Brazil, 90430-001
    - Nucleo de Pesquisa Clinica do Rio Grande do Sul
  - Porto Alegre, Brazil, 90035001
    - Hospital Moinhos de Vento
  - Porto Alegre, Brazil, 90610000
    - Hospital Sao Lucas Da Pucrs
  - Porto Alegre, Brazil, 91350-280
    - Hospital Nossa Senhora da Conceição
  - Ribeirão Preto, Brazil, 14026-020
    - CAPED Centro Avancado Pesquisa e Diagnostica
  - Rio de Janeiro, Brazil, 22270-060
    - Ruschel Medicina e Pesquisa Clínica
  - Rio de Janeiro, Brazil, 20241-180
    - IBPClin - Instituto Brasil de Pesquisa Clínica
  - Rio de Janeiro, Brazil, 22281-100
    - Instituto D'Or Pesquisa e Ensino
  - Salvador, Brazil, 41810-011
    - Hospital Da Bahia
  - Salvador, Brazil, 40320-010
    - Hospital Ana Nery (HAN) - Salvador
  - Salvador, Brazil, 40170-130
    - Instituto D'Or de Pesquisa e Ensino (IDOR) - Filial Salvador
  - Santo André, Brazil, 09060-870
    - Faculdade de Medicina do ABC
  - Santo André, Brazil, 09790790
    - Praxis Pesquisa Medica
  - São Bernardo do Campo, Brazil, 09715-090
    - Centro Multidisciplinar de Estudos Clinicos
  - São José do Rio Preto, Brazil, 15090000
    - Fundação Faculdade Regional de Medicina de São José do Rio Preto
  - São José dos Campos, Brazil, 12230-001
    - Centro Internacional de Pesquisa Clínica (CIPES)
  - São Paulo, Brazil, 01228-000
    - CPQuali Pesquisa Clínica
  - São Paulo, Brazil, 04266-010
    - CEPIC - Centro Paulista de Investigacao Clinica
  - São Paulo, Brazil, 01323-903
    - Hospital Alemao Oswaldo Cruz
  - São Paulo, Brazil, 01228-200
    - CPCLIN
  - São Paulo, Brazil, 04012-909
    - Instituto Dante Pazzanese de Cardiology
  - São Paulo, Brazil, 04014-002
    - IBCC - Núcleo de Pesquisa e Ensino
  - São Paulo, Brazil, 05403-900
    - Incor - Instituto do Coracao
  - São Paulo, Brazil, 01321-001
    - BP - A Beneficencia Portuguesa de São Paulo
  - São Paulo, Brazil, 04003-905
    - Hospital do Coracao
  - Tatuí, Brazil, 18270-170
    - Instituto de Molestias Cardiovasculares de Tatui
  - Uberlândia, Brazil, 38400-500
    - Eurolatino Pesquisas Medicas
  - Vitória, Brazil, 29055450
    - CEDOES
  - Votuporanga, Brazil, 15502-269
    - Integral Pesquisa e Ensino
Canada
- - Brampton, Canada, L6Y 6H4
    - Cardio Health Clinical Trial - Brampton
  - Chicoutimi, Canada, G7H 7K9
    - Ecogene-21
  - Hamilton, Canada, L8L5G4
    - Premier Clinical Trial Network
  - Joliette, Canada, J6E 6A9
    - Diex Recherche Inc. Division Joliette
  - London, Canada, N5W 6A2
    - Milestone Research Inc.
  - London, Canada, N6H 5L4
    - Cardio Health Clinical Trial - London
  - Longueuil, Canada, J4H 4B9
    - Viacar Recherche Clinique
  - Moncton, Canada, E1G 1A7
    - G A Research Associates
  - New Westminster, Canada, V3L 3W4
    - Fraser Clinical Trials Inc
  - North Vancouver, Canada, V7P 2T4
    - The Medical Arts Health Research Group
  - North York, Canada, M6B 3H7
    - North York Diagnostic and Cardiac Centre
  - Oakville, Canada, L6K 3W7
    - Oakville Cardiovascular Research LP
  - Penticton, Canada, V2A 5L5
    - Medical Arts Health Research Group
  - Québec, Canada, G3K 2P8
    - ALPHA Recherche Clinique
  - Québec, Canada, G1V 4W2
    - Clinique des maladies lipidiques de Quebec
  - Saint-Jérôme, Canada, J7Z 2V4
    - Unite de Recherche Clinique Du Cisss Des Laurentides
  - St. Thomas, Canada, N5R 2R4
    - Cardio Health Clinical Trial - St. Thomas
  - Surrey, Canada, V3V 0C6
    - SMH Cardiology Clinical Trials
  - Sydney, Canada, B1M 0A1
    - Care Access - Cape Breton
  - Terrebonne, Canada, J6X 4P7
    - Centre de Medecine Metabolique de Lanaudiere (CMML)
  - Toronto, Canada, M6G 1M2
    - Diabetes Heart Research Centre
  - Toronto, Canada, M1B 5N1
    - Corcare
  - Trois-Rivières, Canada, G9A 4P3
    - Diex Recherche Inc. Division Trois-Rivieres
  - Vancouver, Canada, V6Z 2H2
    - ARC Biosystems
  - Victoria, Canada, V8R 1B2
    - Victoria Heart Institute Foundation
  - Victoria, Canada, V8T 5G4
    - Discovery Clinical Services
  - Winnipeg, Canada, R3C 0N2
    - Winnipeg Clinic
China
- - Beijing, China, 100020
    - Beijing Chaoyang Hospital, Capital Medical University
  - Beijing, China, 100091
    - Peking University Third Hospital
  - Beijing, China, 100050
    - Beijing Friendship Hospital Affiliate of Capital University
  - Changchun, China, 130033
    - China-Japan Union Hospital
  - Changchun, China, 100012
    - The First Hospital of Jilin University
  - Changde, China, 415000
    - Changde First People's Hospital
  - Changsha, China, 410013
    - The third xiangya hospital of Central South University
  - Changzhou, China, 213000
    - Changzhou Second People's Hospital
  - Chengdu, China, 610041
    - West China Hospital Sichuan University
  - Chengdu, China, 610072
    - Sichuan Provincial People's Hospital
  - Chifeng, China, 024099
    - Chifeng Hospital
  - Chongqing, China, 400000
    - 2nd Affiliated Hospital Chongqing Medical Universi
  - Dalian, China, 116033
    - Dalian Municipal Central Hospital Affiliated of Dalian Medical University
  - Foshan, China, 528399
    - Shunde Hospital of Southern Medical Univesity
  - Guangzhou, China, 510000
    - Guangdong Provincial People's Hospital
  - Guangzhou, China, 510180
    - Guangzhou First People's Hospital
  - Hangzhou, China, 310014
    - Zhejiang provincial people's hospital
  - Harbin, China, 150001
    - The Fourth Affiliated Hospital of Harbin Medical University
  - Harbin, China, 150001
    - The First Hospital of Harbin Medical University
  - Hefei, China, 230011
    - The Second People's hospital of Hefei
  - Hohhot, China, 010017
    - Inner Mongolia People's Hospital
  - Huizhou, China, 516001
    - Huizhou Municipal Central Hospital
  - Jinan, China, 250013
    - Jinan Central Hospital
  - Jingzhou, China, 434020
    - Jingzhou Central Hospital
  - Lanzhou, China, 730000
    - The First Hospital of Lanzhou University
  - Lishui, China
    - Lishui Central Hospital
  - Luoyang, China, 471003
    - The First Affiliated Hospital of Henan University of Science &Technology
  - Luoyang, China, 471000
    - The First Affiliated Hospital of Henan University of Science &Technology
  - Nanchang, China, 330006
    - The Second Affiliated Hospital of Nanchang University
  - Nanchang, China, 330009
    - The Third Hospital of Nanchang
  - Nanjing, China, 210011
    - The Second Affiliated Hospital of Nanjing Medical University
  - Nanjing, China, 210000
    - Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School
  - Nanning, China, 530021
    - Guangxi People's Hospital
  - Nanyang, China
    - The First Affiliated Hospital of Nanyang Medical College
  - Nanyang, China, 473007
    - The First Affiliated Hospital of Nanyang Medical College
  - Nanyang, China, 473000
    - Nanyang Second General Hospital
  - Ningbo, China, 315010
    - Ningbo First Hospital
  - Shanghai, China, 200062
    - Shanghai Putuo District Center Hospital
  - Shanghai, China, 200032
    - Zhongshan Hospital,Fudan University
  - Shanghai, China, 200120
    - Shanghai East Hospital
  - Shanghai, China, 200001
    - Ruijin Hospital Shanghai Jiaotong University School of Medicine
  - Shanghai, China, 201500
    - Shanghai No. 6 People's Hospital - Jinshan Central Hospital
  - Shenyang, China, 110000
    - The People's Hospital of Liaoning Province
  - Shenzhen, China, 518057
    - Shenzhen Sun Yat-sen Cardiovascular Hospital
  - Siping, China, 136000
    - Siping Central People's Hospital
  - Suzhou, China, 215006
    - The First Affiliated Hospital of Soochow University
  - Tianjin, China, 300457
    - Teda International Cardiovascular Hospital
  - Tianjin, China, 300140
    - Tianjin Fourth Centre Hospital
  - Wanzhou, China, 404199
    - Chongqing Three Gorges Central Hospital
  - Wenzhou, China, 325000
    - The First Affiliated Hospital of Wenzhou Medical University
  - Wuhan, China, 430022
    - Wuhan Asia Heart Hospital
  - Wuhan, China, 430060
    - Renmin Hospital of Wuhan University
  - Wuhan, China, 430000
    - Wuhan University Medical College - Hubei Zhongshan Hospital
  - Wuxi, China, 214023
    - Wuxi People's Hospital
  - Xi'an, China, 710061
    - The First Affiliated Hospital of Xi'an Jiaotong University
  - Xi'an, China, 710068
    - Shaanxi Provincial People's Hospital
  - Xi'an, China, 710038
    - Tangdu Hospital of Fourth Military Medical University of Chinese People's Liberation Army
  - Xiamen, China, 361006
    - Xiamen Cardiovascular Hospital
  - Xuzhou, China, 221006
    - The Affiliated Hospital of Xuzhou Medical College
  - Yinchuan, China, 750001
    - General Hospital of Ningxia Medical University
  - Yueyang, China, 414000
    - The First People's Hospital of Yueyang
  - Zhengzhou, China, 450014
    - The Second Affiliated Hospital of Zhengzhou University
  - Zigong, China, 643000
    - Zigong First People's Hospital
  - Ürümqi, China, 830054
    - The First Affiliated Hospital of Xinjiang Medical University
Czechia
- - Brandýs nad Labem, Czechia, 250 01
    - MEDICUS SERVICES s.r.o., kardiologicka ambulance
  - Brno, Czechia, 656 91
    - Fakultni nemocnice u sv. Anny v Brne
  - Brno, Czechia, 636 00
    - Vojenska nemocnice Brno
  - Brno, Czechia, 60200
    - Fakultni nemocnice u sv. Anny v Brne
  - Brno, Czechia, 612 00
    - Kardiologická ambulance Brno
  - Brno, Czechia, 615 00
    - EFERTUS healthcare s.r.o.
  - Litovel, Czechia, 784 01
    - Kardiologicka ambulance
  - Náchod, Czechia, 547 01
    - EDUMED - Náchod
  - Olomouc, Czechia, 779 00
    - PreventaMed
  - Olomouc, Czechia, 779 00
    - Agentura Science Pro
  - Ostrava, Czechia, 702 00
    - Private Practice - Dr. Miroslav Koliba
  - Ostrava, Czechia, 700 30
    - Kardiologicka a Angiologicka Ambulance
  - Prague, Czechia, 149 00
    - Nefrologie
  - Prague, Czechia, 158 00
    - Poliklinika Lípa Centrum
  - Prague, Czechia, 169 00
    - Centrum Kardiovaskularni Mediciny
  - Prague, Czechia, 104 00
    - Kardio Uhrineves
  - Prague, Czechia, 120 00
    - Synexus Czech
  - Prague, Czechia, 143 00
    - Angiocentrum Komorany
  - Trutnov, Czechia, 541 01
    - Kardiologicka ambulance MUDr. Ferkl s.r.o.
  - Uherské Hradiště, Czechia, 686 01
    - Clinical Trials Service s.r.o.
  - Zlín, Czechia, 760 01
    - Cardio Research, s.r.o
  - Říčany, Czechia, 251 01
    - Nova kardiologie - Kardiologicka ambulance
Denmark
- - Aabenraa, Denmark, 6200
    - Sygehus Sønderjylland i Aabenraa
  - Aarhus, Denmark, 8200
    - Aarhus Universitetshospital, Skejby
  - Copenhagen, Denmark, 2100
    - Rigshospitalet
  - Esbjerg, Denmark, 6700
    - Esbjerg sygehus, Syddansk Universitetshospital
  - Gandrup, Denmark, 9362
    - Sanos Clinic - Nordjylland
  - Herlev, Denmark, 2730
    - Herlev and Gentofte Hospital
  - Herlev, Denmark, 2730
    - Sanos Clinic
  - Holbæk, Denmark, 4300
    - Holbæk Sygehus
  - Vejle, Denmark, 7100
    - Sanos Clinic - Syddanmark
France
- - Bobigny, France, 93000
    - Hôpital Avicenne
  - Bron, France, 69677
    - Hospices Civils de Lyon - Hôpital Louis Pradel
  - Chambray-lès-Tours, France, 37170
    - CHRU Troussau
  - Compiègne, France, 60200
    - Centre Hospitalier Compiègne-Noyon
  - Dijon, France, 21079
    - Centre Hospitalier Universitaire Dijon Bourgogne - Hôpital François Mitterrand
  - Le Coudray, France, 28630
    - Centre Hospitalier Louis Pasteur
  - Lille, France, 59037
    - Hopital Claude Huriez - CHU de Lille
  - Lyon, France, 69007
    - Centre Hospitalier Saint Joseph - Saint Luc
  - Marseille, France, 13005
    - Hôpital de La Conception
  - Marseille, France, 13285
    - Hopital Saint Joseph
  - Montpellier, France, 34295
    - CHU Montpellier Lapeyronie Hospital
  - Nantes, France, 44093
    - Hôpital Nord Guillaume-et-René-Laennec / CHU de Nantes
  - Nice, France, 06000
    - Centre Hospitalier Universitaire de Nice - Hopital Pasteur
  - Nîmes, France, 30029
    - Centre Hospitalier Universitaire de Nîmes - Hôpital Universitaire Carémeau
  - Paris, France, 75015
    - Hôpital Europeen Georges Pompidou
  - Paris, France, 75571
    - Hôpital Saint Antoine
  - Paris, France, 75018
    - Hôpital Bichat - Claude-Bernard
  - Paris, France, 75013
    - Pitie Salpetriere University Hospital
  - Pau, France, 64000
    - Centre Hospitalier De Pau
  - Pessac, France, 33600
    - CHU Bordeaux Haut-Leveque
  - Rennes, France, 35033
    - Centre Hospitalier Universitaire de Rennes - Hôpital Pontchaillou
  - Rouen, France, 76031
    - CHU Charles Nicolle
  - Strasbourg, France, 67098
    - CHU Strasbourg-Hautepierre
  - Toulouse, France, 31059
    - CHU Rangueil
  - Valenciennes, France, 59300
    - Polyclinique Vauban
Germany
- - Aachen, Germany, 52074
    - Universitätsklinikum Aachen
  - Bad Friedrichshall, Germany, 74177
    - Klinikum am Plattenwald
  - Bad Homburg, Germany, 61348
    - Zentrum für klinische Studien Bad Homburg
  - Berlin, Germany, 13353
    - Charité Campus Virchow-Klinikum
  - Berlin, Germany, 10789
    - Praxis Rankestrasse
  - Berlin, Germany, 10559
    - Kardiologische Praxen im Spreebogen
  - Berlin, Germany, 12559
    - DRK Kliniken Berlin - Köpenick
  - Bielefeld, Germany, 33604
    - Klinikum Bielefeld Mitte
  - Cologne, Germany, 50937
    - Universitaetsklinikum Koeln
  - Dresden, Germany, 01307
    - Herzzentrum Dresden GmbH Universitätsklinik
  - Dresden, Germany, 01307
    - Universitaetsklinikum Carl Gustav Carus Dresden
  - Dresden, Germany, 01277
    - Hausärztlich-Kardiologisches MVZ am Felsenkeller GmbH/Zentrum für klinische Studien
  - Essen, Germany, 45355
    - Medizentrum Essen Borbeck
  - Frankfurt, Germany, 60389
    - Cardioangiologisches Centrum Bethanien
  - Gelnhausen, Germany, 63571
    - BAG Diabeteszentrum Dr. Tews & Partner
  - Hamburg, Germany, 22041
    - Cardiologicum Hamburg
  - Heidelberg, Germany, 69120
    - Universitaetsklinikum Heidelberg
  - Jena, Germany, 07747
    - Universitätsklinikum Jena
  - Leipzig, Germany, 04103
    - Universitätsklinikum Leipzig
  - Leipzig, Germany, 04289
    - Herzzentrum Leipzig GmbH
  - Lüneburg, Germany, 21339
    - Praxis Oedeme
  - Magdeburg, Germany, 39120
    - Otto-von-Guericke-Universität Magdeburg
  - Mannheim, Germany, 68167
    - Universitätsmedizin Mannheim
  - Mannheim, Germany, 68165
    - Ze:ro Arztpraxen
  - Munich, Germany, 80636
    - Deutsches Herzzentrum München
  - Münster, Germany, 48145
    - Institut für Diabetesforschung GmbH Münster
  - Potsdam, Germany, 14471
    - Kardiologische Gemeinschaftspraxis am Park Sanssouci
  - Regensburg, Germany, 93053
    - Universitätsklinikum Regensburg
  - Remscheid, Germany, 42859
    - Universitaet zu Koeln - Sana-Klinikum Remscheid GmbH - Klinik fuer Kardiologie, Pneumologie und Internisti -T
  - Rüsselsheim am Main, Germany, 65428
    - GPR Gesundheits- und Pflegezentrum Rüsselsheim
  - Saint Ingbert, Germany, 66386
    - Zentrum für klinische Studien
  - Ulm, Germany, 89077
    - Studienzentrum Herzklinik Ulm MVZ
Greece
- - Athens, Greece, 11527
    - General Hospital of Athens Laiko
  - Athens, Greece, 11521
    - Athens Naval Hospital
  - Athens, Greece, 151 25
    - Athens Medical Center
  - Chaïdári, Greece, 12462
    - Attikon General University Hospital
  - Heraklion, Greece, 71110
    - University General Hospital of Heraklion
  - Ioannina, Greece, 45500
    - University Hospital of Ioannina
  - Palaió Fáliro, Greece, 17562
    - Iatriko Paleou Falirou Medical Center
  - Thessaloniki, Greece, 546 36
    - AHEPA University General Hospital of Thessaloniki
  - Thessaloniki, Greece, 564 03
    - Papageorgiou General Hospital of Thessaloniki
Hungary
- - Balatongyörök, Hungary, 8313
    - DRC Gyógyszervizsgáló Központ
  - Budapest, Hungary, 1122
    - Semmelweis University
  - Budapest, Hungary, 1062
    - Eszak-Pesti Centrumkorhaz-Honvedkorhaz
  - Budapest, Hungary, 1132
    - Privát Doktor Egészségügyi Zrt
  - Debrecen, Hungary, 4032
    - Debreceni Egyetem Klinikai Központ
  - Nyíregyháza, Hungary, 4400
    - Medifarma 98 Kft
  - Szeged, Hungary, 6725
    - Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont
  - Székesfehérvár, Hungary, 8000
    - Vita Verum Medical Egeszsegugyi Szolgaltato
India
- - Belagavi, India, 590010
    - KLES Dr. Prabhakar Kore Hospital & M.R.C
  - Bikaner, India, 334001
    - Sardar Patel Medical College
  - Dehradun, India, 248001
    - Shri Mahant Indiresh Hospital
  - Kanpur, India, 208001
    - K care Hospital
  - Kochi, India, 682018
    - Lisie Hospital
  - Kozhikode, India, 673008
    - Government Medical College - Kozhikode
  - Lucknow, India, 226003
    - King George's Medical University
  - Nashik, India, 422005
    - Vijan Hospital & Research Centre
  - New Delhi, India, 110002
    - G.B. Pant Institute of Postgraduate Medical Education & Research
  - Raipur, India, 492099
    - All India Institute of Medical Sciences
Israel
- - Afula, Israel, 1834111
    - Emek Medical Center
  - Beersheba, Israel, 8410101
    - Soroka Medical Center
  - Haifa, Israel, 3109601
    - Rambam Health Care Campus
  - Haifa, Israel, 3515209
    - Linn Medical Center
  - Haifa, Israel, 3436212
    - Carmel Hospital
  - Holon, Israel, 5810001
    - Edith Wolfson Medical Center
  - Jerusalem, Israel, 9112001
    - Hadassah Medical Center
  - Jerusalem, Israel, 9013102
    - Shaare Zedek Medical Center
  - Kfar Saba, Israel, 4428164
    - Meir Medical Center
  - Nahariya, Israel, 2210001
    - Galilee Medical Center
  - Petah Tikva, Israel, 4941492
    - Rabin Medical Center
  - Ramat Gan, Israel, 5262100
    - Sheba Medical Center
  - Ramat Gan, Israel, 5265601
    - Sheba Medical Center
  - Rehovot, Israel, 7610001
    - Kaplan Medical Center
  - Sakhnin, Israel, 3081000
    - Clalit Health Services - Sakhnin Community Clinic
  - Tel Aviv, Israel, 6423906
    - Sourasky Medical Center
Italy
- - Arzignano, Italy, 36071
    - Ospedale Cazzavillan di Arzignano
  - Baggiovara, Italy, 41126
    - Ospedale di Baggiovara
  - Bologna, Italy, 40138
    - IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola
  - Cinisello Balsamo, Italy, 20092
    - Ospedale Bassini
  - Ferrara, Italy, 44100
    - Azienda Ospedaliero Universitaria S.Anna
  - Florence, Italy, 50134
    - Azienda Ospedaliera Universitaria Careggi
  - Genova, Italy, 16132
    - Ospedale San Martino
  - Milan, Italy, 20132
    - Ospedale San Raffaele
  - Milan, Italy, 20138
    - Centro Cardiologico Monzino
  - Milan, Italy, 20162
    - ASST Grande Ospedale Metropolitano Niguarda
  - Padova, Italy, 35128
    - Azienda Ospedale - Università Padova
  - Perugia, Italy, 06156
    - Hospital Santa Maria della Misericordia in Perugia
  - Pisa, Italy, 56124
    - Fondazione G. Monasterio
  - Rome, Italy, 00161
    - AOU Policlinico Umberto I
Japan
- - Asahi, Japan, 289-2511
    - Asahi Hospital - Asahi
  - Asahikawa, Japan, 070-8610
    - Asahikawa City Hospital
  - Chikushino-shi, Japan, 818-8516
    - Saiseikai Futsukaichi Hospital
  - Chūō, Japan, 409-3898
    - University of Yamanashi Hospital
  - Chūōku, Japan, 103-0027
    - Tokyo-Eki Center-building Clinic
  - Chūōku, Japan, 104-0031
    - Fukuwa Clinic
  - Chūōku, Japan, 103-0002
    - The Institute of Medical Science, Asahi Life Foundation
  - Fukuoka, Japan, 811-0213
    - Fukuoka Wajiro Hospital
  - Hakodate, Japan, 041-8680
    - Hakodate Municipal Hospital
  - Hakusan, Japan, 924-0865
    - Public Matto Ishikawa Central Hospital
  - Himeji, Japan, 670-8560
    - Hyogo Prefectural Harima-Himeji General Medical Center
  - Isehara, Japan, 259-1193
    - Tokai University Hospital
  - Izumisano, Japan, 598-8577
    - Rinku General Medical Center
  - Kagoshima, Japan, 892-0822
    - Tenyoukai Central Clinic
  - Kamakura-shi, Japan, 247-0056
    - Takai Internal Medicine Clinic
  - Kanazawa, Japan, 920-8641
    - Kanazawa University Hospital
  - Kanazawa, Japan, 920-8650
    - National Hospital Organization Kanazawa Medical Center
  - Kanazawa, Japan, 920-8530
    - Ishikawa Prefectural Central Hospital
  - Kasugai, Japan, 486-8510
    - Kasugai Municipal Hospital
  - Kitakyushu, Japan, 802-8555
    - Kokura Memorial Hospital
  - Kobe, Japan, 650-0047
    - Kobe City Medical Center General Hospital
  - Komatsu, Japan, 923-8560
    - Komatsu Municipal Hospital
  - Kumamoto, Japan, 862-0976
    - Jinnouchi Hospital
  - Kurashiki, Japan, 710-8602
    - Kurashiki Central Hospital
  - Kure, Japan, 737-0193
    - Chugoku Rosai Hospital
  - Kyoto, Japan, 607-8062
    - Rakuwakai Otowa Hospital
  - Kyoto, Japan, 604-8401
    - Rakuwakai Marutamachi Hospital
  - Matsumoto, Japan, 390-8510
    - Aizawa Hospital
  - Meguro-ku, Japan, 152-8902
    - National Hospital Organization Tokyo Medical Center
  - Minatoku, Japan, 108-0073
    - Tokyo Saiseikai Central Hospital
  - Miyakonojō, Japan, 885-0002
    - Miyakonojo Medical Association Hospital - Tarobocho
  - Miyazaki, Japan, 880-2102
    - Miyazaki Medical Association Hospital
  - Morioka, Japan, 020-0066
    - Iwate Prefectural Central Hospital
  - Mukai-awagasaki, Japan, 920-0293
    - Kanazawa Medical University Hospital
  - Nagaoka, Japan, 940-8621
    - Tachikawa Medical Center
  - Nagoya, Japan, 467-8602
    - Nagoya City University Hospital
  - Naka-gun, Japan, 259-0114
    - Shonan Oiso Hospital
  - Nakano, Japan, 165-0027
    - Nogata Clinic
  - Okayama, Japan, 701-1192
    - National Hospital Organization Okayama Medical Center
  - Okayama, Japan, 700-8557
    - Okayama City General Medical Center Okayama City Hospital
  - Ootaku, Japan, 143-0015
    - Medical Corporation Sato Medical clinic
  - Osaka, Japan, 553-0003
    - Kansai Electric Power Hospital
  - Osaka, Japan, 558-8558
    - Osaka General Medical Center
  - Osaka, Japan, 540-0006
    - National Hospital Organization - Osaka National Hospital - Institute For Clinical Research
  - Osaka, Japan, 543-8922
    - Osaka Keisatsu Hospital
  - Saga, Japan, 849-8501
    - Saga University Hospital
  - Sagamihara, Japan, 252-0375
    - Kitasato University Hospital
  - Saitama, Japan, 338-0837
    - Sanai Hospital - Saitama
  - Sapporo, Japan, 060-8543
    - Sapporo Medical University Hospital
  - Sapporo, Japan, 060-0906
    - Tokeidai Memorial Hospital
  - Sapporo, Japan, 062-8618
    - Japan Community Healthcare Organization Hokkaido Hospital
  - Shinjuku-ku, Japan, 160-0008
    - Heishinkai Medical Group ToCROM Clinic
  - Shinjyuku-ku, Japan, 162-8655
    - National Center for Global Health and Medicine
  - Shūnan, Japan, 745-8522
    - Tokuyama Central Hospital
  - Suita, Japan, 564-8565
    - National Cerebral and Cardiovascular Center
  - Suita-shi, Japan, 565-0853
    - Medical Corporation Heishinkai OCROM Clinic
  - Sunto-gun, Japan, 411-8611
    - Shizuoka Medical Center
  - Takamatsu, Japan, 760-8557
    - Kagawa Prefectural Central Hospital
  - Takarazuka, Japan, 665-0873
    - Higashi Takarazuka Satoh Hospital
  - Takasago, Japan, 676-0812
    - Takasago Seibu Hospital
  - Takatsuki, Japan, 569-8686
    - Osaka Medical and Pharmaceutical University Hospital
  - Toshimaku, Japan, 171-0014
    - Sekino Hospital
  - Toyoma, Japan, 930-0194
    - Toyama University Hospital
  - Tsuchiura, Japan, 300-0028
    - Tsuchiura Kyodo General Hospital
  - Ueda, Japan, 386-8610
    - National Hospital Organization Shinshu Ueda Medical Center
  - Yokohama, Japan, 230-8765
    - Saiseikai Yokohamashi Tobu Hospital
  - Yokosuka, Japan, 238-8558
    - Yokosukakyosai
  - Ōsaki, Japan, 989-6183
    - Osaki Citizen Hospital - Furukawahonami
Mexico
- - Aguascalientes, Mexico, 20230
    - Hospital Cardiologica Aguescalientes
  - Aguascalientes, Mexico, 20230
    - Centro de Investigación Cardiometabólica de Aguascalientes
  - Aguascalientes, Mexico, 20230
    - Fundación Cardiovascular de Aguascalientes A.C.
  - Chihuahua City, Mexico, 31110
    - Enclifar Ensayos Clínicos Farmacológicos Sc
  - Cuernavaca, Mexico, 62250
    - Instituto de Diabetes, Obesidad y Nutricion
  - Culiacán, Mexico, 80230
    - Centro para el Desarrollo de la Medicina y de Asistencia Medica Especializada S.C.
  - Durango, Mexico, 34000
    - Lahoja. Asociacion Para La Investigacion Y La Farmacovigilancia
  - Guadalajara, Mexico, 44130
    - Diseno y Planeacion en Investigacion Medica
  - Guadalajara, Mexico, 04460
    - Instituto Jalisciense de Investigacion en Diabetes y Obesidad
  - Guadalajara, Mexico, 44160
    - Centro de Investigacion Medica Integral
  - Guadalajara, Mexico, 44670
    - Virgen Cardiovascular Research SC
  - Guadalajara, Mexico, 44670
    - Unidad de Investigación Clínica y Atención Médica HEPA S.C.
  - Guadalajara, Mexico, 44690
    - CINVEC Medica
  - Hermosillo, Mexico, 83270
    - Investigación Médica Sonora, S.C.
  - León, Mexico, 37520
    - Instituto Cardiovascular de León S.C.
  - Mexico City, Mexico, 14080
    - Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
  - Mexico City, Mexico, 06090
    - Hospital de Jésus, I.A.P.
  - Mexico City, Mexico, 06720
    - Centro Médico Nacional Siglo XXI
  - Mexico City, Mexico, 03310
    - Grupo Medico Camino Sc
  - Mexico City, Mexico, 11650
    - Centro Especializado En Diabetes, Obesidad Y Prevencion De Enfermedades Cardiovasculares
  - Mexico City, Mexico, 03100
    - RM Pharma Specialists
  - Mexico City, Mexico, 03300
    - Clínicos Asociados BOCM
  - Mexico City, Mexico, 06700
    - Clinica Omega
  - Mexico City, Mexico, 14050
    - ProcliniQ Investigación Clínica SA de CV
  - Monterrey, Mexico, 64460
    - UBAM Unidad Biomedica Avanzada Monterrey
  - Monterrey, Mexico, 64000
    - Accelerium Clinical Research
  - Monterrey, Mexico, 64460
    - Hospital Universitario "Dr. Jose Eleuterio Gonzalez"
  - Monterrey, Mexico, 64060
    - Cardiolink Clin Trials
  - Monterrey, Mexico, 64610
    - Clínica García Flores SC
  - Monterrey, Mexico, 66465
    - Centro de investigación y control metabólico
  - Monterrey, Mexico, 64060
    - CHRISTUS - LATAM HUB Center of excellence and innovation S.C.
  - Morelia, Mexico, 58249
    - Clinica de Enfermedades Crónicas y de Procedimientos Especiales
  - Mérida, Mexico, 97070
    - Medical Care and Research Sa de Cv
  - México, Mexico, 06700
    - Clinstile, S.A. de C.V.
  - Querétaro, Mexico, 76000
    - Centro de Estudios Clínicos de Querétaro (CECLIQ)
  - Querétaro, Mexico, 76100
    - PanAmerican Clinical Research - Querétaro - Avenida Antea
  - San Luis Potosí City, Mexico, 78200
    - Centro de Atención e Investigación Cardiovascular del Potosí
  - San Nicolás de los Garza, Mexico, 66450
    - Servicios Integrales Nova de Monterrey S.A. de C.V.
  - Tijuana, Mexico, 22500
    - Centro de Investigacion Cardiovascular y Metabólica
  - Tlalpan, Mexico, 14050
    - Medimanage Research
  - Veracruz, Mexico, 91851
    - Instituto Veracruzano en Investigación Clínica S.C.
  - Xalapa, Mexico, 91193
    - Hospital Angeles Xalapa
Netherlands
- - Amersfoort, Netherlands, 3813 TZ
    - Meander Medisch Centrum
  - Amsterdam, Netherlands, 1105 AZ
    - Amsterdam UMC, locatie AMC
  - Apeldoorn, Netherlands, 7334 DZ
    - Gelre Ziekenhuis
  - Beverwijk, Netherlands, 1942 LE
    - Rode Kruis Ziekenhuis
  - Delft, Netherlands, 2625 AD
    - Reinier de Graaf Ziekenhuis, locatie Delft
  - Deventer, Netherlands, 7416 SE
    - Deventer Ziekenhuis
  - Doetinchem, Netherlands, 7009 BL
    - Slingeland Ziekenhuis
  - Ede, Netherlands, 6716 RP
    - Ziekenhuis Gelderse Vallei
  - Eindhoven, Netherlands, 5623 EJ
    - Catharina Ziekenhuis
  - Goes, Netherlands, 4462 RA
    - Admiraal de Ruyter Ziekenhuis, locatie Goes
  - Gouda, Netherlands, 2803HH
    - Groene Hart Ziekenhuis
  - Groningen, Netherlands, 9728 NT
    - Martini Ziekenhuis
  - Groningen, Netherlands, 9713 GH
    - General Practitioners Research Institute (GPRI)
  - Haarlem, Netherlands, 2035 RC
    - Spaarne Gasthuis, Haarlem Zuid
  - Hardenberg, Netherlands, 7772 SE
    - Saxenburgh Medisch Centrum
  - Harderwijk, Netherlands, 3844 DG
    - Ziekenhuis St. Jansdal
  - Hilversum, Netherlands, 1212 VG
    - Tergooiziekenhuizen, locatie Hilversum
  - Leeuwarden, Netherlands, 8934 AD
    - Medische Centrum Leeuwarden
  - Leiden, Netherlands, 2333 ZA
    - Leids Universitair Medisch Centrum
  - Nijmegen, Netherlands, 6525 GA
    - Radboudumc
  - Roosendaal, Netherlands, 4708 AE
    - Bravis Ziekenhuis, locatie Roosendaal
  - Rotterdam, Netherlands, 3015 GD
    - Erasmus Medisch Centrum
  - Rotterdam, Netherlands, 3083 AN
    - Ikazia Ziekenhuis
  - Sneek, Netherlands, 8601 ZR
    - Antonius Ziekenhuis, locatie D&A Research and Genetics
  - The Hague, Netherlands, 2545 AA
    - Haga Ziekenhuis locatie Leyweg
  - Tilburg, Netherlands, 5042 AD
    - ETZ TweeSteden
  - Utrecht, Netherlands, 3584 CX
    - Universitair Medisch Centrum Utrecht
  - Veldhoven, Netherlands, 5504 DB
    - Maxima Medisch Centrum, locatie Veldhoven
  - Venlo, Netherlands, 5912 BL
    - VieCuri Medisch Centrum, locatie Venlo
  - Zaandam, Netherlands, 1502 DV
    - Zaans Medisch Centrum
Poland
- - Bialystok, Poland, 15-375
    - SPECDERM Poznanska sp.j.
  - Bydgoszcz, Poland, 85-231
    - NZOZ Centrum Medyczne KERmed
  - Bydgoszcz, Poland, 85-605
    - Centrum Medyczne Intercor Sp. z o.o.
  - Chrzanów, Poland, 32-500
    - Polsko-Amerykańskie Kliniki Serca PAKS Małopolskie Centrum Sercowo-Naczyniowe
  - Dąbrowa Górnicza, Poland, 41-300
    - Polsko-Amerykanskie Kliniki Serca
  - Elblag, Poland, 82-300
    - Centrum Kliniczno-Badawcze
  - Elblag, Poland, 82-300
    - NZOZ Twoje Zdrowie EL Sp. z o. o.
  - Gdansk, Poland, 80-952
    - Uniwersyteckie Centrum Kliniczne
  - Grudziądz, Poland, 86-300
    - Przychodnie Grudziądz
  - Katowice, Poland, 40-772
    - NZOZ Salvia CM
  - Krakow, Poland, 31-261
    - Medyczne Centrum Diabetologiczno Endokrynologiczno Metaboliczne DIAB-ENDO-MET
  - Krakow, Poland, 30-105
    - Centrum Medyczne Linden
  - Kędzierzyn-Koźle, Poland, 47-200
    - Polsko-Amerykanskie Kliniki Serca
  - Leszno, Poland, 64-100
    - Poliklinika Kardiologiczna Serce
  - Lodz, Poland, 93-338
    - Instytut Centrum Zdrowia Matki Polki
  - Lodz, Poland, 91-053
    - Centra Medyczne Medyceusz
  - Lodz, Poland, 91-473
    - Pro Salus Centrum Medyczne
  - Lublin, Poland, 20-011
    - Clinical Best Solutions
  - Lublin, Poland, 20-044
    - CenterMed Lublin NZOZ
  - Lublin, Poland, 20-043
    - 1 Wojskowy Szpital Kliniczny w Lublinie
  - Lublin, Poland, 20-068
    - Private Practice - Dr. Michał Tomaszewski
  - Nowa Sól, Poland, 67-100
    - Wielospecjalistyczny Szpital Samodzielny Publiczny Zakład Opieki Zdrowotnej w Nowej Soli
  - Przemyśl, Poland, 37-700
    - Wojewodzki Szpital im. Sw. Ojca Pio w Przemyslu
  - Ruda Śląska, Poland, 41-710
    - AKA-MED Centrum
  - Tarnów, Poland, 33-100
    - Centrum Szybkiej Diagnostyki Kardiologicznej "Kardiomed" M. Żabówka E. Żabówka
  - Tychy, Poland, 43-100
    - Polsko-Amerykanskie Kliniki Serca
  - Warsaw, Poland, 04-501
    - Medical Network Spółka z o.o. WIP Warsaw IBD Point Profesor Kierkuś
  - Warsaw, Poland, 00-710
    - Clinical Best Solutions
  - Warsaw, Poland, 01-249
    - Balsam Medica
  - Wroclaw, Poland, 50-981
    - 4 Wojskowy Szpital Kliniczny z Polikliniką SPZOZ
  - Żarów, Poland, 58-130
    - NZOZ Centurm Medyczne SERAFIN-MED
Puerto Rico
- - Bayamón, Puerto Rico, 00959
    - Advanced Clinical Research, LLC
  - San Juan, Puerto Rico, 00917
    - GCM Medical Group, PSC - Hato Rey Site
Romania
- - Baia Mare, Romania, 430222
    - CMI DNBM Dr. Pop Lavinia
  - Baia Mare, Romania, 430124
    - CMI Cardiologie - Dr. Mercea Corina Delia
  - Brasov, Romania, 500283
    - C.M.D.T.A. Neomed
  - Bucharest, Romania, 050098
    - Spitalul Universitar de Urgenta Bucuresti
  - Bucharest, Romania, 011053
    - Hightech Medical Services SRL-Centrul pentru Studiul Metabolismului
  - Bucharest, Romania, 010507
    - Nicodiab
  - Bucharest, Romania, 013764
    - Centrul Medical NutriLife
  - Bucharest, Romania, 50538
    - Centrul Medical Endocrinologie si Diabet Dr. Paveliu
  - Buzău, Romania
    - Mat Cord Biomedica S.R.L.
  - Craiova, Romania, 200642
    - Spitalul Clinic Județean de Urgență
  - Galați, Romania, 800291
    - Diamed Obesity
  - Galați, Romania, 800001
    - Milena Sante
  - Iași, Romania, 700547
    - Centrul Medical Consultmed
  - Iași, Romania, 700687
    - Cardiomed Iași
  - Satu Mare, Romania, 440055
    - Clinica Korall
  - Sibiu, Romania, 550371
    - Policlinica Astra Sibiu
  - Timișoara, Romania, 300288
    - Cabinet Medical Dr.Geru
  - Timișoara, Romania, 300310
    - Institutul de Boli Cardiovasculare Timișoara
  - Târgu Mureş, Romania, 540142
    - Centrul Medical Mediab
  - Târgu Mureş, Romania, 540143
    - Private Practice - Dr. Cristian Podoleanu
  - Târgu Mureş, Romania, 540098
    - SC Dentosim Queen SRL - Centrul Medical Diamed
  - Târgu Mureş, Romania, 540142
    - Mediab S.R.L.
  - Târgu Mureş, Romania, 540124
    - Cardiomed
Slovakia
- - Bratislava, Slovakia, 81109
    - Cliniq s.r.o.
  - Dolný Kubín, Slovakia, 02601
    - JM-Interna s.r.o
  - Dolný Kubín, Slovakia, 026 01
    - ENDIAMED s.r.o
  - Lučenec, Slovakia, 984 01
    - IN-DIA
  - Malacky, Slovakia, 901 01
    - Sin Azucar
  - Martin, Slovakia, 036 01
    - AMBORA s.r.o. Interna ambulancia
  - Nitra, Slovakia, 950 01
    - Fakultna nemocnica Nitra
  - Piešťany, Slovakia, 921 01
    - MEDIKALS
  - Prešov, Slovakia, 080 01
    - MEDISPOL
  - Rimavská Sobota, Slovakia, 979 01
    - ENRIN, s.r.o.
  - Rožňava, Slovakia, 04801
    - Tatratrial s.r.o.
  - Trebišov, Slovakia, 075 01
    - Areteus s.r.o.
  - Trstená, Slovakia, 028 01
    - MediPrax, s.r.o.
  - Ľubochňa, Slovakia, 034 91
    - NEDÚ - Národný endokrinologický a diabetologický ústav n.o.
South Korea
- - Bucheon-si, South Korea, 14647
    - The Catholic University of Korea, Bucheon St. Mary's Hospital
  - Daegu, South Korea, 42601
    - Keimyung University Dongsan Hospital
  - Daegu, South Korea, 42472
    - Daegu Catholic University Medical Center
  - Daejeon, South Korea, 01830
    - Eulji University Hospital
  - Dongjak-gu, South Korea, 07061
    - Boramae Medical Center
  - Gwangju, South Korea, 61469
    - Chonnam National University Hospital
  - Namdong-gu, South Korea, 21565
    - Gachon University Gil Medical Center
  - Seongnam, South Korea, 13620
    - Seoul National University Bundang Hospital
  - Seoul, South Korea, 03080
    - Seoul National University Hospital
  - Seoul, South Korea, 05505
    - Asan Medical Center
  - Seoul, South Korea, 03181
    - Kangbuk Samsung Hospital
  - Seoul, South Korea, 03722
    - Severance Hospital, Yonsei University Health System
  - Seoul, South Korea, 06591
    - The Catholic Univ. of Korea Seoul St. Mary's Hospital
  - Seoul, South Korea, 02841
    - Korea University Anam Hospital
  - Seoul, South Korea, 02447
    - Kyung Hee University Hospital
  - Seoul, South Korea, 08308
    - Korea University Guro Hospital
  - Seoul, South Korea, 134-090
    - Kyung Hee University Hospital at Gangdong
  - Sosa-gu, South Korea, 14754
    - Sejong General Hospital
  - Suwon, South Korea, 16247
    - The Catholic University of Korea St. Vincent's Hospital
  - Ulsan, South Korea, 44033
    - Ulsan University Hospital
Spain
- - A Coruña, Spain, 15001
    - CHUAC-Complejo Hospitalario Universitario A Coruña
  - Alcorcón, Spain, 28922
    - Hospital Universitario Fundacion Alcorcon
  - Badalona, Spain, 08916
    - Hospital Germans Trias I Pujol
  - Barcelona, Spain, 08036
    - Hospital Clinic De Barcelona
  - Barcelona, Spain, 08041
    - Hospital De La Santa Creu I Sant Pau
  - Barcelona, Spain, 08003
    - Parc de Salut Mar - Hospital del Mar
  - Córdoba, Spain, 14004
    - Hospital Universitario Reina Sofía
  - Denia, Spain, 03700
    - Hospital de Denia Marina Salud
  - El Palmar, Murcia, Spain, 30120
    - Hospital Clinico Universitario Virgen de la Arrixaca
  - Ferrol, Spain, 15405
    - Complejo Hospitalario Universitario de Ferrol (CHUF)- Hospital Naval
  - Gijón, Spain, 33394
    - Hospital de Cabuenes
  - Girona, Spain, 17007
    - Hospital Universitari de Girona Doctor Josep Trueta
  - Granada, Spain, 18014
    - Hospital Universitario Virgen Nieves
  - Huelva, Spain, 21007
    - Hospital Infanta Elena
  - Jaén, Spain, 23007
    - Hospital Universitario de Jaén
  - L'Hospitalet de Llobregat, Spain, 08907
    - Hospital Universitari de Bellvitge
  - Las Palmas de Gran Canaria, Spain, 35016
    - Hospital Insular de Gran Canaria
  - Lugo, Spain, 27003
    - Hospital Lucus Augusti
  - Madrid, Spain, 28034
    - Hospital Universitario Ramon y Cajal
  - Madrid, Spain, 28040
    - Hospital Clinico San Carlos
  - Madrid, Spain, 28041
    - Hospital Universitario 12 De Octubre
  - Madrid, Spain, 28029
    - Hospital Universitario La Paz
  - Madrid, Spain, 28003
    - FutureMeds - Madrid
  - Majadahonda, Spain, 28220
    - Hospital Universitario Puerta de Hierro Majadahonda
  - Málaga, Spain, 29010
    - Hospital Universitario Virgen de la Victoria
  - Palma, Spain, 07120
    - Hospital Universitari Son Espases
  - Pozuelo de Alarcón, Spain, 28223
    - Hospital Universitario Quirónsalud Madrid
  - Reus, Spain, 43204
    - Salut Sant Joan de Reus-Baix Camp (Edp)
  - Salamanca, Spain, 37007
    - Hospital Universitario de Salamanca - Complejo Asistencial Universitario de Salamanca
  - Sanlúcar de Barrameda, Spain, 11540
    - Hospital Virgen del Camino
  - Sant Joan Despí, Spain, 08970
    - Hospital de Sant Joan Despi Moises Broggi
  - Santander, Spain, 39008
    - Hospital Universitario Marqués de Valdecilla
  - Santiago de Compostela, Spain, 15706
    - CHUS - Hospital Clinico Universitario
  - Segovia, Spain, 40002
    - Hospital General de Segovia
  - Seville, Spain, 41013
    - Hospital Universitario Virgen del Rocio
  - Seville, Spain, 41009
    - Hospital Universitario Virgen Macarena
  - Seville, Spain, 41950
    - Vithas Hospital Sevilla
  - Seville, Spain, 41012
    - FutureMeds - Sevilla
  - Valencia, Spain, 46015
    - Hospital Arnau de Vilanova
  - Valencia, Spain, 46010
    - Hospital Clinico de Valencia
  - Valencia, Spain, 46014
    - Hospital General Universitario de Valencia
  - Villamartín, Spain, 11650
    - Hospital Virgen de las Montañas
  - Zaragoza, Spain, 50009
    - Hospital Universitario Miguel Servet
Taiwan
- - Changhua County, Taiwan, 50006
    - Changhua Christian Hospital
  - Kaohsiung City, Taiwan, 807
    - Kaohsiung Medical University Chung-Ho Memorial Hospital
  - Kaohsiung Niao Sung Dist, Taiwan, 83301
    - Chang Gung Memorial Hospital at Kaohsiung
  - New Taipei City, Taiwan, 24352
    - Fu Jen Catholic University Hospital
  - Taichung, Taiwan, 402
    - Chung Shan Medical University Hospital
  - Tainan, Taiwan, 704
    - National Cheng Kung University Hospital
  - Tainan, Taiwan, 71004
    - Chi Mei Medical Center
  - Taipei, Taiwan, 10002
    - National Taiwan University Hospital
  - Taipei, Taiwan, 11217
    - Taipei Veterans General Hospital
  - Taipei, Taiwan, 110
    - Taipei Medical University Hospital
  - Taipei, Taiwan, 114
    - Tri-Service General Hospital
  - Taipei, Taiwan, 111
    - Shin Kong Wu Ho-Su Memorial Hospital
  - Taipei, Taiwan, 106
    - Cathay General Hospital
  - Taoyuan, Taiwan, 333
    - Chang Gung Medical Foundation-Linkou Branch
  - Yilan, Taiwan, 260006
    - National Yang Ming Chiao Tung University Hospital
United Kingdom
- - Blackpool, United Kingdom, FY3 7EN
    - Layton Medical Centre
  - Bristol, United Kingdom, BS2 8HW
    - Bristol Royal Infirmary
  - Cheadle, United Kingdom, ST10 1NS
    - Cheadle Community Hospital
  - Enfield, United Kingdom, EN3 4GS
    - Panthera Biopartners - North London
  - Glasgow, United Kingdom, G51 4RY
    - Panthera Biopartners - Glasgow
  - Hull, United Kingdom, HU3 2JZ
    - Hull Royal Infirmary
  - London, United Kingdom, NW32QG
    - Royal Free Hospital
  - Newcastle upon Tyne, United Kingdom, NE1 4LP
    - Royal Victoria Infirmary
  - Preston, United Kingdom, PR2 9QB
    - Panthera Biopartners - Preston
  - Rochdale, United Kingdom, OL11 4AU
    - Panthera Biopartners - Manchester
  - Salford, United Kingdom, M6 8HD
    - Salford Royal Hospital
  - Sheffield, United Kingdom, S2 5FX
    - Panthera Biopartners - Sheffield
  - Stevenage, United Kingdom, SG1 4AB
    - Lister Hospital
  - Torquay, United Kingdom, TQ2 7AA
    - Torbay Hospital
  - Tyne and Wear, United Kingdom, SR4 7TP
    - Sunderland Royal Hospital
  - West Bromwich, United Kingdom, B71 4HJ
    - Sandwell General Hospital
  - York, United Kingdom, YO24 4LJ
    - Panthera Clinic - York
United States
- Alabama
  - Birmingham, Alabama, United States, 35209
    - Birmingham Clinical Research
  - Daphne, Alabama, United States, 36526
    - Alliance for Multispecialty Research, LLC
  - Dothan, Alabama, United States, 36305
    - SEC Clinical Research
  - Mobile, Alabama, United States, 36608
    - Alliance for Multispecialty Research, LLC
  - Mobile, Alabama, United States, 36608
    - Mobile Heart Specialists
- Arizona
  - Gilbert, Arizona, United States, 85297
    - Mercy Gilbert Medical Center
  - Gilbert, Arizona, United States, 85296
    - Prime Medical Group, LLC dba Gilbert Center for Family Medicine, LLC
  - Glendale, Arizona, United States, 85304
    - Sun City Clinical Research
  - Phoenix, Arizona, United States, 85018
    - Elite Clinical Studies, LLC
  - Phoenix, Arizona, United States, 85051
    - Absolute Clinical Research
  - Phoenix, Arizona, United States, 85028
    - Helios Clinical Research - Phoenix
  - Sun City West, Arizona, United States, 85375
    - Clinical Research Institute of Arizona (CRI) - Sun City West
  - Tucson, Arizona, United States, 85745
    - Eclipse Clinical Research
  - Tucson, Arizona, United States, 85741
    - Synexus Clinical Research US, Inc./Orange Grove Family Practice
  - Tucson, Arizona, United States, 85741
    - Pima Heart
- Arkansas
  - Little Rock, Arkansas, United States, 72204
    - Cardiology and Medicine Clinic
- California
  - Beverly Hills, California, United States, 90211
    - National Heart Institute
  - Covina, California, United States, 91723
    - Valley Clinical Trials, Inc.
  - Escondido, California, United States, 92025
    - Neighborhood Healthcare Institute of Health
  - Fountain Valley, California, United States, 92708
    - HB Clinical Trials - Fountain Valley
  - Huntington Beach, California, United States, 92648
    - Care Access - Huntington Beach
  - Inglewood, California, United States, 90301
    - 310 Clinical Research
  - La Jolla, California, United States, 92037
    - Scripps Whittier Diabetes Institute
  - La Jolla, California, United States, 92037-7410
    - UCSD - Altman Clinical and Translational Research Institute (ACTRI)
  - Lancaster, California, United States, 93534
    - First Valley Medical Group
  - Long Beach, California, United States, 90815
    - ARK Clinical Research
  - Long Beach, California, United States, 90806
    - MemorialCare Health System - Long Beach Medical Center
  - Los Angeles, California, United States, 90033
    - Keck School of Medicine of USC
  - Los Angeles, California, United States, 90210
    - Cardiovascular Research Foundation of Southern California
  - Northridge, California, United States, 91325
    - Valley Clinical Trials, Inc.
  - Palm Springs, California, United States, 92262
    - Desert Oasis Healthcare Medical Group
  - San Diego, California, United States, 92123
    - Artemis Institute for Clinical Research
  - Santa Clarita, California, United States, 91321
    - Care Access - Santa Clarita
  - Stanford, California, United States, 94305
    - Stanford University Medical Center
  - Sylmar, California, United States, 91342
    - Olive View-UCLA Medical Center
  - Thousand Oaks, California, United States, 91360
    - Care Access - Thousand Oaks
  - Toluca Lake, California, United States, 91602
    - Med Partners, Inc. dba Premiere Medical Center of Burbank, Inc.
  - Torrance, California, United States, 90502
    - Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
  - Torrance, California, United States, 90505
    - UCLA South Bay Endocrinology
  - Van Nuys, California, United States, 91405
    - InvivoCure
  - Vista, California, United States, 92083
    - Synexus Clinical Research US, Inc.
  - West Hills, California, United States, 91307
    - Interventional Cardiology Medical Group
  - Westlake Village, California, United States, 91361
    - Millennium Clinical Trials
- Colorado
  - Aurora, Colorado, United States, 80045
    - University of Colorado Anschutz Medical Campus
- Connecticut
  - Bridgeport, Connecticut, United States, 06610
    - Bridgeport Hospital
  - Hamden, Connecticut, United States, 06517
    - CMR of Greater New Haven, LLC
  - Hartford, Connecticut, United States, 06102
    - Hartford Hospital (HH)
  - Stamford, Connecticut, United States, 06905
    - Cardiology Associates of Fairfield County, P.C.
  - Waterbury, Connecticut, United States, 06708
    - Chase Medical Research, LLC
- District of Columbia
  - Washington D.C., District of Columbia, United States, 20010
    - Medstar Washington Hospital Center
- Florida
  - Boca Raton, Florida, United States, 33434
    - Excel Medical Clinical Trials
  - Clearwater, Florida, United States, 33765
    - Clinical Research of West Florida, Inc. (Clearwater)
  - Clearwater, Florida, United States, 33756
    - Clearwater Cardiovascular & Interventional Consultants M.D., P.A.
  - Fort Lauderdale, Florida, United States, 33312
    - Jellinger and Lerman, MD PA dba The Center for Diabetes and Endocrine Care
  - Hialeah, Florida, United States, 33013
    - Elite Cardiac Research Center
  - Jacksonville, Florida, United States, 32205
    - Westside Center for Clinical Research
  - Jacksonville, Florida, United States, 32216
    - Jacksonville Center for Clinical Research
  - Largo, Florida, United States, 33777
    - Clearwater Cardiovascular & Interventional Consultants M.D., P.A.
  - Maitland, Florida, United States, 32751
    - K2 Medical Research - Maitland
  - Margate, Florida, United States, 33063
    - South Florida Clinical Research Institute
  - Miami, Florida, United States, 33135
    - Flourish Research - Miami, LLC
  - Miami Lakes, Florida, United States, 33014
    - Inpatient Research Clinic
  - Naples, Florida, United States, 34102
    - Advanced Research for Health Improvement, LLC
  - Ocala, Florida, United States, 34470
    - Renstar Medical Research
  - Orlando, Florida, United States, 32825
    - Florida Institute For Clinical Research, LLC
  - Orlando, Florida, United States, 32806
    - CTR Oakwater, LLC
  - Port Charlotte, Florida, United States, 33952
    - Peace River Cardiovascular Center
  - Port Charlotte, Florida, United States, 33952
    - Innovative Research Institute - Port Charlotte
  - Port Orange, Florida, United States, 32127
    - Progressive Medical Research
  - Safety Harbor, Florida, United States, 34695
    - Clearwater Cardiovascular & Interventional Consultants M.D., P.A.
  - Tamarac, Florida, United States, 33321
    - Care Access - Tamarac
  - Tampa, Florida, United States, 33606
    - Clinical Research of West Florida
  - Tampa, Florida, United States, 33625
    - Care Access - Tampa
  - Wellington, Florida, United States, 33449
    - Cardiology Partners Clinical Research Institute - Wellington
- Georgia
  - Acworth, Georgia, United States, 30101
    - American Clinical Trials - Acworth
  - Atlanta, Georgia, United States, 30318
    - Atlanta Diabetes Associates
  - Atlanta, Georgia, United States, 30322
    - Emory University School of Medicine
  - Augusta, Georgia, United States, 30904
    - Southeastern Clinical Research Institute
  - Canton, Georgia, United States, 30114
    - East Coast Institute for Research - Canton
  - Douglasville, Georgia, United States, 30134
    - American Clinical Trials - Douglasville
  - Gainesville, Georgia, United States, 30501
    - Center for Advanced Research & Education
  - Lawrenceville, Georgia, United States, 30044
    - Georgia Clinical Research - Lawrenceville
  - Macon, Georgia, United States, 31210
    - The Jones Center Clinical Research
  - Woodstock, Georgia, United States, 30189
    - North Georgia Clinical Research
- Idaho
  - Meridian, Idaho, United States, 83642
    - CARE Institute
- Illinois
  - Chicago, Illinois, United States, 60607
    - Chicago Clinical Research Institute
  - Chicago, Illinois, United States, 60640
    - Great Lakes Clinical Trials - Ravenswood
  - Gurnee, Illinois, United States, 60031
    - Clinical Investigation Specialists
  - Niles, Illinois, United States, 60714
    - Alliance for Multispecialty Research, LLC
  - Springfield, Illinois, United States, 62711
    - Central Illinois Diabetes and Clinical Research a Division of Prairie Education and Research Cooperative
  - Winfield, Illinois, United States, 60190
    - Accellacare - DuPage
- Indiana
  - Avon, Indiana, United States, 46123
    - American Health Network of Indiana, LLC - Avon
  - Franklin, Indiana, United States, 46131
    - American Health Network of Indiana, LLC - Franklin
  - Indianapolis, Indiana, United States, 46202
    - Indiana University Health Methodist Hospital
  - Indianapolis, Indiana, United States, 46254
    - Care Access - South Indianapolis
- Iowa
  - West Des Moines, Iowa, United States, 50266
    - Iowa Diabetes and Endocrinology Research Center
- Kansas
  - Topeka, Kansas, United States, 66606
    - Cotton O'Neil Clinical Research Center
  - Wichita, Kansas, United States, 67226
    - AMR Clinical
- Kentucky
  - Bowling Green, Kentucky, United States, 42101
    - Qualmedica Research
  - Lexington, Kentucky, United States, 40509
    - Alliance for Multispecialty Research, LLC
- Louisiana
  - Bossier City, Louisiana, United States, 71111
    - Grace Research - Bossier
  - Lake Charles, Louisiana, United States, 70601
    - Care Access - Lake Charles
  - Monroe, Louisiana, United States, 71201
    - IMA Clinical Research
  - New Orleans, Louisiana, United States, 70119
    - Alliance for Multispecialty Research, LLC
  - Slidell, Louisiana, United States, 70458
    - Louisiana Heart Center - Slidell
- Maryland
  - Baltimore, Maryland, United States, 21239
    - MedStar Good Samaritan Hospital
  - Baltimore, Maryland, United States, 21209
    - Sinai Hospital of Baltimore
  - Baltimore, Maryland, United States, 21213
    - Care Access - Baltimore
  - Baltimore, Maryland, United States, 21229
    - Ascension Saint Agnes Heart Care
  - Beltsville, Maryland, United States, 20705
    - Jadestone Clinical Research
  - Bowie, Maryland, United States, 20715
    - Flourish Research - Bowie
  - Columbia, Maryland, United States, 21045
    - Kur Research - Columbia Medical
  - Ft. Washington, Maryland, United States, 20744
    - Anderson Medical Research
  - Hyattsville, Maryland, United States, 20782
    - MedStar Health Research Institute (MedStar Physician Based Research Network)
- Massachusetts
  - Boston, Massachusetts, United States, 02115
    - Brigham and Women's Hospital Diabetes Program
  - Fall River, Massachusetts, United States, 02721
    - NECCR PrimaCare Research
  - Quincy, Massachusetts, United States, 02169
    - Care Access - Quincy
- Michigan
  - Dearborn, Michigan, United States, 48126
    - Alliance for Multispecialty Research, LLC.
  - Dearborn, Michigan, United States, 48126
    - Revival Research Institute, LLC
  - Detroit, Michigan, United States, 48202
    - Henry Ford Hospital
  - Troy, Michigan, United States, 48098
    - Arcturus Healthcare , PLC, Troy Internal Medicine Research Division
  - Ypsilanti, Michigan, United States, 48197
    - Michigan Heart & Vascular Institute
- Mississippi
  - Diamondhead, Mississippi, United States, 39525
    - Memorial Hospital at Gulfport
- Missouri
  - City of Saint Peters, Missouri, United States, 63303
    - StudyMetrix Research
  - Springfield, Missouri, United States, 65807
    - Clinvest Headlands Llc
- Montana
  - Butte, Montana, United States, 59701
    - Mercury Street Medical Group, PLLC
- Nevada
  - Henderson, Nevada, United States, 89074
    - Las Vegas Endocrinology
  - Las Vegas, Nevada, United States, 89128
    - Palm Research Center Tenaya
  - Las Vegas, Nevada, United States, 89107
    - DaVita Clinical Research - Las Vegas
  - Las Vegas, Nevada, United States, 89128
    - Vector Clinical Trials
- New Jersey
  - Bridgeton, New Jersey, United States, 08302
    - Internal Medicine Associates
  - Somerset, New Jersey, United States, 08873
    - Cardio Metabolic Institute
  - Summit, New Jersey, United States, 07901
    - Atlantic Health System Overlook Medical Center
  - Warren Township, New Jersey, United States, 07059
    - IMA Clinical Research Warren
- New Mexico
  - Albuquerque, New Mexico, United States, 87109
    - IMA Clinical Research
- New York
  - Albany, New York, United States, 12203
    - Albany Medical College, Division of Community Endocrinology
  - New Hyde Park, New York, United States, 11576
    - St. Francis Hospital & Heart Center
  - New York, New York, United States, 10029
    - Icahn School of Medicine at Mount Sinai
  - New York, New York, United States, 10016
    - NYU Langone Health
  - New York, New York, United States, 10075
    - Lenox Hill Hospital
  - New York, New York, United States, 10036
    - Ima Clinical Research Manhattan
  - Riverhead, New York, United States, 11901
    - Northwell Health Physician Peconic
  - Rochester, New York, United States, 14642
    - University of Rochester Medical Center
  - Saratoga Springs, New York, United States, 12866
    - Saratoga Clinical Research
  - Stony Brook, New York, United States, 11794
    - Stony Brook University
- North Carolina
  - Fayetteville, North Carolina, United States, 28314
    - Care Access - Fayetteville
  - Greensboro, North Carolina, United States, 27410
    - Triad Clinical Trials
  - Greensboro, North Carolina, United States, 27405
    - Medication Management
  - Greenville, North Carolina, United States, 27834
    - Physician's East Endocrinology
  - Mount Airy, North Carolina, United States, 27030
    - IMA Clinical Research Mount Airy
  - Raleigh, North Carolina, United States, 27609
    - Accellacare - Raleigh
  - Wilmington, North Carolina, United States, 28401
    - Accellacare - Wilmington
  - Winston-Salem, North Carolina, United States, 27157
    - Wake Forest Baptist Health
- Ohio
  - Beachwood, Ohio, United States, 44122
    - Velocity Clinical Research, Cleveland
  - Cincinnati, Ohio, United States, 45219
    - Velocity Clinical Research, Mt. Auburn
  - Cincinnati, Ohio, United States, 45246
    - Velocity Clinical Research, Springdale
  - Cleveland, Ohio, United States, 44195
    - Cleveland Clinic
  - Columbus, Ohio, United States, 43210
    - Ohio State University
  - Columbus, Ohio, United States, 43213
    - Centricity Research Columbus Ohio Multispecialty
- Oregon
  - Corvallis, Oregon, United States, 97330
    - Good Samaritan Regional Medical Center
- Pennsylvania
  - Allentown, Pennsylvania, United States, 18103
    - Lehigh Valley Health Network
  - Beaver, Pennsylvania, United States, 15009
    - Heritage Valley Multispecialty Group, Inc
  - Camp Hill, Pennsylvania, United States, 17011
    - Capital Area Research, LLC
  - Horsham, Pennsylvania, United States, 19044
    - Abington Medical Specialists
  - Lancaster, Pennsylvania, United States, 17602
    - Lancaster General Hospital
  - Philadelphia, Pennsylvania, United States, 19104
    - Penn Medicine: University of Pennsylvania Health System
  - Philadelphia, Pennsylvania, United States, 19114
    - Clinical Research of Philadelphia
  - Pittsburgh, Pennsylvania, United States, 15212
    - AHN Allegheny General Hospital
  - Plymouth Meeting, Pennsylvania, United States, 19462
    - Keystone Clinical Studies
  - Uniontown, Pennsylvania, United States, 15401
    - Preferred Primary Care Physicians
  - Yardley, Pennsylvania, United States, 19067
    - Cardiology Consultants of Philadelphia Yardley
  - York, Pennsylvania, United States, 17403
    - Heart and Vascular Research at WellSpan Health
- South Carolina
  - Charleston, South Carolina, United States, 29456
    - Accellacare Trident Cardiology
  - Greenville, South Carolina, United States, 29607
    - Tribe Clinical Research, LLC
  - Little River, South Carolina, United States, 29566
    - Walker Family Care
  - Mauldin, South Carolina, United States, 29662
    - Care Access - Mauldin
  - Mt. Pleasant, South Carolina, United States, 29464
    - Accellacare - Mt Pleasant
- South Dakota
  - Rapid City, South Dakota, United States, 57701
    - Monument Health Rapid City Hospital
- Tennessee
  - Knoxville, Tennessee, United States, 37909
    - Alliance for Multispecialty Research, LLC
  - Memphis, Tennessee, United States, 38119
    - Care Access - Memphis 2
- Texas
  - Amarillo, Texas, United States, 79106
    - PharmaTex Research
  - Amarillo, Texas, United States, 79124
    - Amarillo Heart Clinical Research Institute Inc.
  - Austin, Texas, United States, 78759
    - Velocity Clinical Research, Austin
  - Austin, Texas, United States, 78745
    - IMA Clinical Research Austin
  - Brownsville, Texas, United States, 78526
    - Headlands Horizons LLC
  - Corpus Christi, Texas, United States, 78404
    - South Texas Clinical Research
  - Dallas, Texas, United States, 75390
    - UT Southwestern Medical Center
  - Dallas, Texas, United States, 75230
    - Zenos Clinical Research
  - Dallas, Texas, United States, 75251
    - Cedar Health Research
  - Dallas, Texas, United States, 75226
    - Baylor Soltero CV Research Center
  - Dallas, Texas, United States, 75224
    - Private Practice - Dr. James E. Race
  - Denison, Texas, United States, 75020
    - Cardio Voyage
  - Edinburg, Texas, United States, 78539
    - South Texas Research Institute
  - Fort Worth, Texas, United States, 76104
    - Texas Health Research & Education Institute - Fort Worth
  - Houston, Texas, United States, 77040
    - Juno Research
  - Houston, Texas, United States, 77043
    - Biopharma Informatic, LLC
  - Houston, Texas, United States, 77079
    - PlanIt Research, PLLC
  - Houston, Texas, United States, 77089
    - Research Physicians Network, LLC
  - Houston, Texas, United States, 77030
    - Center for Cardiometabolic Disease Prevention/Baylor College of Medicine
  - Humble, Texas, United States, 77338
    - Accurate Clinical Research - Humble
  - Lufkin, Texas, United States, 75904
    - The Heart Institute of East Texas
  - McAllen, Texas, United States, 78503
    - Biopharma Informatic, LLC
  - McKinney, Texas, United States, 75071
    - North Texas Research Associates
  - McKinney, Texas, United States, 75071
    - Texas Institute of Cardiology, PA
  - McKinney, Texas, United States, 75069
    - Wellness Clinical Research
  - McKinney, Texas, United States, 75071
    - Revival Research Institute, LLC
  - Mesquite, Texas, United States, 75149
    - Southern Endocrinology Associates
  - Mesquite, Texas, United States, 75149
    - PRX Research
  - San Antonio, Texas, United States, 78229
    - Clinical Trials of Texas, LLC
  - San Antonio, Texas, United States, 78212
    - Clinical Advancement Center
  - San Antonio, Texas, United States, 78229
    - IMA Clinical Research San Antonio
  - San Antonio, Texas, United States, 78240
    - Endeavor Clinical Trials
  - Shavano Park, Texas, United States, 78231
    - Consano Clinical Research, LLC
  - Shenandoah, Texas, United States, 77384
    - DaVita Clinical Research - North Houston
  - Sherman, Texas, United States, 75090
    - Sherman Clinical Research
- Utah
  - Clinton, Utah, United States, 84015
    - Alpine Research Organization
  - Murray, Utah, United States, 84107
    - Intermountain Medical Center
- Virginia
  - Falls Church, Virginia, United States, 22042
    - Virginia Heart
  - Norfolk, Virginia, United States, 23502
    - Alliance for Multispecialty Research, LLC
- Washington
  - Redmond, Washington, United States, 98052
    - Eastside Research Associates
- West Virginia
  - Morgantown, West Virginia, United States, 26505
    - IMA Clinical Research West Virginia
- Wisconsin
  - Kenosha, Wisconsin, United States, 53144
    - Clinical Investigation Specialists

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

Adult
Older Adult

Accepts Healthy Volunteers

Description

Inclusion Criteria:

Have Lipoprotein(a) [Lp(a)] ≥175 nanomoles per liter (nmol/L).
Meet criteria of either 2a or 2b:
2a: Individuals 18 years of age or older with established atherosclerotic cardiovascular disease (ASCVD) with an event or revascularization.
2b: Individuals 55 years of age or older who are at risk for a first cardiovascular (CV) event and either: Documented coronary artery disease (CAD), carotid stenosis, or peripheral artery disease (PAD) without history of event or revascularization; known familial hypercholesteremia; or a combination of high-risk factors.

Exclusion Criteria:

Have had a major cardiovascular event or surgery, such as myocardial infarction (MI), stroke or coronary or peripheral revascularization, < 60 days before screening
Have uncontrolled hypertension
Have New York Heart Association class IV heart failure.
Have lipoprotein apheresis within 90 days of screening, or planned lipoprotein apheresis during the study.
Have severe renal failure, defined as
- Estimated glomerular rate (eGFR) <15 milliliters per minute per 1.73 meters squared (mL/min/1.73m2) at screening Visit 1, or ongoing dialysis.
Have a diagnosis of active nephrotic syndrome, or urine albumin-creatinine ratio (UACR) of ≥5000 mg/g at screening Visit 1.
Have acute or chronic hepatitis, known cirrhosis, signs and symptoms of any other liver disease other than metabolic-associated steatotic liver disease, or exclusionary laboratory results as determined by the central laboratory during screening.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Interventional Model: Parallel Assignment
Masking: Double

Arms and Interventions

Participant Group / Arm Participant Group / Arm A group or subgroup of participants in a clinical trial that receives a specific intervention/treatment, or no intervention, according to the trial's protocol.	Intervention / Treatment Intervention / Treatment A process or action that is the focus of a clinical study. Interventions include drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available. Interventions can also include noninvasive approaches, such as education or modifying diet and exercise.
Placebo Comparator: Placebo Placebo administered SC.	Drug: Placebo Administered SC
Experimental: Lepodisiran Sodium Lepodisiran sodium administered subcutaneously (SC).	Drug: Lepodisiran Sodium Administered SC Other Names: LY3819469

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Time to First Occurrence of Any Component of the Major Adverse Cardiac Event (MACE)-4 Composite Endpoint Time Frame: Baseline up to End of Study (About 4.5 Years)	Time to first event in a MACE-4 composite endpoint, comprised of cardiovascular death, nonfatal myocardial infarction, nonfatal ischemic stroke, and urgent coronary revascularization.	Baseline up to End of Study (About 4.5 Years)

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Change from Baseline in Lipoprotein(a) [Lp(a)] at Week 4 Time Frame: Baseline, Week 4	Change from Baseline in Lp(a)	Baseline, Week 4
Time to First Occurrence of Any of the Component of MACE-3 Composite Endpoint Time Frame: Baseline up to End of Study (About 4.5 Years)	Time to first occurrence MACE-3	Baseline up to End of Study (About 4.5 Years)
Time to First Occurrence of Fatal or Non-Fatal Myocardial Infarction Time Frame: Baseline up to End of Study (About 4.5 Years)	Time to first occurrence of fatal or non-fatal myocardial infarction.	Baseline up to End of Study (About 4.5 Years)
Time to Cardiovascular Death Time Frame: Baseline up to End of Study (About 4.5 Years)	Time to cardiovascular death.	Baseline up to End of Study (About 4.5 Years)
Time to Occurrence of All-Cause Death Time Frame: Baseline up to End of Study (About 4.5 Years)	Time to occurrence of all-cause death	Baseline up to End of Study (About 4.5 Years)
Time to First Occurrence of Any Component of the MACE-4 Composite Endpoint (In the Population with Established ASCVD and CV Event, or Revascularization) Time Frame: Baseline up to End of Study (About 4.5 Years)	Time to first occurrence of any component of the MACE-4 composite endpoint.	Baseline up to End of Study (About 4.5 Years)
Time to First Occurrence of any Component of the MACE-4 Composite Endpoint (In the Population At Risk for First CV event) Time Frame: Baseline up to End of Study (About 4.5 Years)	Time to first occurrence of any component of the MACE-4 composite endpoint.	Baseline up to End of Study (About 4.5 Years)
Time to First Occurrence of any Component of the MACE-4 Composite Endpoint (In the Population with Lp(a) ≥ 200 nmol/L) Time Frame: Baseline up to End of Study (About 4.5 Years)	Time to first occurrence of any component of the MACE-4 composite endpoint.	Baseline up to End of Study (About 4.5 Years)
Time to First Occurrence of Any Component of MACE-3 + MALE Composite Endpoint Time Frame: Baseline up to End of Study (About 4.5 Years)	Time to first occurrence of any component of MACE-3 + MALE composite endpoint.	Baseline up to End of Study (About 4.5 Years)
Time to First Occurrence of Any Component of Coronary MACE-3 Composite Endpoint Time Frame: Baseline up to End of Study (About 4.5 Years)	Time to first Occurrence of any component of coronary MACE-3 composite endpoint.	Baseline up to End of Study (About 4.5 Years)

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Eli Lilly and Company

Investigators

Study Director: Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 8 AM - 8 PM Eastern time (UTC/GMT - 5 hours, EST), Eli Lilly and Company

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Helpful Links

Related Info

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

March 5, 2024

Primary Completion (Estimated)

March 1, 2029

Study Completion (Estimated)

March 1, 2029

Study Registration Dates

First Submitted

February 27, 2024

First Submitted That Met QC Criteria

March 1, 2024

First Posted (Actual)

March 4, 2024

Study Record Updates

Last Update Posted (Actual)

May 19, 2026

Last Update Submitted That Met QC Criteria

May 18, 2026

Last Verified

May 1, 2026

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

18812
J3L-MC-EZEF (Other Identifier: Eli Lilly and Company)
2023-509190-23 (EudraCT Number)

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

YES

IPD Plan Description

Anonymized individual patient level data will be provided in a secure access environment upon approval of a research proposal and a signed data sharing agreement.

IPD Sharing Time Frame

Data are available 6 months after the primary publication and approval of the indication studied in the US and EU, whichever is later. Data will be indefinitely available for requesting.

IPD Sharing Access Criteria

A research proposal must be approved by an independent review panel and researchers must sign a data sharing agreement.

IPD Sharing Supporting Information Type

STUDY_PROTOCOL
SAP
CSR

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

Yes

Studies a U.S. FDA-regulated device product

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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Study Overview

Status

Conditions

Intervention / Treatment

Study Type

Enrollment (Estimated)

Phase

Contacts and Locations

Study Contact

Study Contact Backup

Study Locations

Participation Criteria

Eligibility Criteria

Ages Eligible for Study

Accepts Healthy Volunteers

Description

Study Plan

How is the study designed?

Design Details

Number of Arms

Arms and Interventions

Participant Group / Arm

Intervention / Treatment

What is the study measuring?

Primary Outcome Measures

Outcome Measure

Measure Description

Time Frame

Secondary Outcome Measures

Outcome Measure

Measure Description

Time Frame

Collaborators and Investigators

Sponsor

Investigators

Publications and helpful links

General Publications

Helpful Links

Study record dates

Study Major Dates

Study Start (Actual)

Primary Completion (Estimated)

Study Completion (Estimated)

Study Registration Dates

First Submitted

First Submitted That Met QC Criteria

First Posted (Actual)

Study Record Updates

Last Update Posted (Actual)

Last Update Submitted That Met QC Criteria

Last Verified

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

IPD Plan Description

IPD Sharing Time Frame

IPD Sharing Access Criteria

IPD Sharing Supporting Information Type

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

Studies a U.S. FDA-regulated device product

Clinical Trials on Elevated Lp(a)

Clinical Trials on Placebo

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Sponsors and Collaborators

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Drug Interventions

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations