EASi-KIDNEY™ (The Studies of Heart & Kidney Protection With BI 690517 in Combination With Empagliflozin)

October 27, 2026 updated by: Boehringer Ingelheim

A Multicenter, International, Randomized, Double-blind, Placebo-controlled Clinical Trial of the Aldosterone Synthase Inhibitor BI 690517 in Combination With Empagliflozin in Patients With Chronic Kidney Disease

This study is open to adults with chronic kidney disease at risk of progression. People with and without type 2 diabetes can take part in this study. The study is open to people who take other medicines called angiotensin converting enzyme inhibitors (ACEi) or angiotensin receptor blockers (ARB). People who already take empagliflozin or any other sodium-glucose cotransporter-2 inhibitor (SGLT2i) can also join. The study is also open to people who currently do not take any of these treatments. The purpose of this study is to find out whether a medicine called BI 690517 helps people with chronic kidney disease when taken in combination with a study medicine called empagliflozin. Worsening of kidney function increases the risk for kidney failure, cardiovascular disease, and heart failure hospitalisation.

After a run-in period, during which participants are confirmed to be receiving clinically appropriate renin-angiotensin system blockade and are established on empagliflozin, they are randomly assigned (by chance) to 1 of 2 groups. One group receives BI 690517 tablets, and the other group receives placebo tablets. Placebo tablets look like BI 690517 but do not contain any medicine. Participants take 1 study tablet once a day, in addition to empagliflozin, for the duration of the study.

The doctors document when participants experience worsening of their kidney disease, go to hospital due to heart failure, or die of cardiovascular problems during the study. The time to these events is compared between the 2 treatment groups to see whether the treatment works. The study continues until the required number of events have occurred which is about 3 to 4 years. During this time, participants visit the study site about 5 times within the first 6 months. Then they visit the study site every 6 months. At the visits, doctors regularly check participants' health, take blood and urine samples, measure blood pressure and weight, check kidney function, and take note of any unwanted effects.

Study Overview

Status

Status

Indicates the current recruitment status or the expanded access status.
Active, not recruiting

Conditions

Conditions

The disease, disorder, syndrome, illness, or injury that is being studied. On ClinicalTrials.gov, conditions may also include other health-related issues, such as lifespan, quality of life, and health risks.

Intervention / Treatment

Intervention / Treatment

A process or action that is the focus of a clinical study. Interventions include drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available. Interventions can also include noninvasive approaches, such as education or modifying diet and exercise.

Study Type

Study Type

Describes the nature of a clinical study. Study types include interventional studies (also called clinical trials), observational studies (including patient registries), and expanded access.
Interventional

Enrollment (Actual)

Enrollment

The number of participants in a clinical study. The "anticipated" enrollment is the target number of participants that the researchers need for the study.
8371

Phase

Phase

The stage of a clinical trial studying a drug or biological product, based on definitions developed by the U.S. Food and Drug Administration (FDA). The phase is based on the study's objective, the number of participants, and other characteristics. There are five phases: Early Phase 1 (formerly listed as Phase 0), Phase 1, Phase 2, Phase 3, and Phase 4. Not Applicable is used to describe trials without FDA-defined phases, including trials of devices or behavioral interventions.
  • Phase 3

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Argentina
      • Bariloche, Argentina, 8500
        • Fundacion INTECNUS
      • Buenos Aires, Argentina, 1407
        • Terapia Renal Domiciliaria
      • Buenos Aires, Argentina, B6000
        • Centro de Salud Renal Junin SRL
      • Buenos Aires, Argentina, C1061AAE
        • Dres. Iribarren & Asoc. Consultario
      • Buenos Aires, Argentina, C1430CKE
        • Glenny Corp - Centro Medico Saavedra
      • CABA, Argentina, 1425
        • CPSIC SRL - Cardiologia Palermo
      • Catamarca, Argentina, K4703AFI
        • Sanatorio Pasteur S.A
      • Ciudad Autonoma Buenos Aires, Argentina, C1431FWO
        • CEMIC
      • Lanús Este, Argentina, B1824KAJ
        • CIMEL Chahin - Chahin S.A.
      • Mar del Plata, Argentina, B7612
        • Centro Nefrologico del Mar
      • Rafaela, Argentina, S2300
        • Mains Bleues
      • Rosario, Argentina, S2000GAP
        • Hospital Privado de Rosario
      • Rosario, Argentina, S2013
        • Sanatorio Parque S.A.
      • Salta, Argentina, A4400
        • Instituto de Nefrourologia y Nutricion de Salta
      • San Juan, Argentina, J5400
        • Clinica El Castaño
      • San Miguel de Tucumán, Argentina, 4000
        • Centro de Investigaciones Medicas Tucuman
      • San Miguel de Tucumán, Argentina, 4000
        • Centro Integral de Medicina Respiratoria - CIMER
      • Santa Fe, Argentina, 2000
        • Instituto de Investigaciones Clinicas de Rosario
      • Villa Domínico, Argentina, B1872EEB
        • CEREHA S.A.- Centro de Estudios Renales e Hipertension Arterial
  • Australia
      • New South Wales, Australia, 2019
        • Macquarie University
      • New South Wales, Australia, 2145
        • Westmead Hospital
    • New South Wales
      • Concord, New South Wales, Australia, 2139
        • Concord Hospital
      • Gosford, New South Wales, Australia, 2250
        • Renal Research, Gosford
      • Kingswood, New South Wales, Australia, 2747
        • Nepean Hospital
      • Kogarah, New South Wales, Australia, 2217
        • St George Hospital
      • Liverpool, New South Wales, Australia, 2170
        • Liverpool Hospital
      • Port Macquarie, New South Wales, Australia, 2444
        • Port Macquarie Base Hospital (PMBH)
    • Queensland
      • Pialba, Queensland, Australia, 4655
        • Hervey Bay Hospital
      • Southport, Queensland, Australia, 4222
        • Griffith University
      • Southport, Queensland, Australia, 4215
        • AOVO Clinical Trials
      • Toowoomba, Queensland, Australia, 4350
        • Toowoomba Hospital
    • South Australia
      • Bedford Park, South Australia, Australia, 5042
        • Flinders Medical Centre
    • Victoria
      • Box Hill, Victoria, Australia, 3128
        • Eastern Health-Box Hill Hospital
      • Heidelberg Heights, Victoria, Australia, 3081
        • Austin Health
      • Melbourne, Victoria, Australia, 3004
        • The Alfred Hospital
      • Melbourne, Victoria, Australia, 3065
        • St Vincent's Hospital Melbourne
      • St Albans, Victoria, Australia, 3021
        • Sunshine Hospital
  • Belgium
      • Bruges, Belgium, 8000
        • AZ Sint-Jan Brugge
      • Genk, Belgium, 3600
        • Ziekenhuis Oost-Limburg
      • Jette, Belgium, 1090
        • UZ Brussel
      • Liège, Belgium, 4000
        • Centre Hospitalier Universitaire de Liège
  • Brazil
      • Aracaju, Brazil, 49055-530
        • Centro de Pesquisa Clínica do Coração
      • Belo Horizonte, Brazil, 30150-320
        • Santa Casa de Belo Horizonte
      • Belo Horizonte, Brazil, 30220-330
        • Centro de Pesquisa do Hospital Evangelico de Belo Horizonte
      • Botucatu, Brazil, 18618-686
        • Universidade Estadual Paulista "Julio De Mesquita Filho"
      • Bragança Paulista, Brazil, 1291-6542
        • Hospital Universitário São Francisco na Providência de Deus
      • Campinas, Brazil, 13073-350
        • CEG - Centro de Endocrinologia Geloneze
      • Centro Linhares, Brazil, 29900010
        • Instituto Cardiovascular de Linhares Ltda
      • Curitiba, Brazil, 80230-130
        • PUC Trials - Núcleo de Pesquisa Clínica da Escola de Medicina da PUC-PR
      • Fortaleza, Brazil, 60416-000
        • Hospital Universitário Walter Cantidio - UFC
      • Fortaleza, Brazil, 60430-350
        • Centro de Pesquisas em Diabetes e Doencas Metabolicas
      • Goiânia, Brazil, 74230-035
        • Clínica CENDI Endocrinologia e Diabetes
      • Goiânia, Brazil, 74453200
        • Hospital Ruy Azeredo
      • Joinville, Brazil, 89227-680
        • Fundação Pró-Rim Joinville
      • Juiz de Fora, Brazil, 36033-318
        • Galileo Medical Research Ltda
      • Maceió, Brazil, 57051-160
        • Centro de Pesquisas Clínicas Dr. Marco Mota
      • Natal, Brazil, 59012300
        • Hospital Universitário Onofre Lopes
      • Porto Alegre, Brazil, 90610-000
        • Hospital Sao Lucas da PUCRS
      • Porto Alegre, Brazil, 90035-903
        • Hospital de Clinicas de Porto Alegre
      • Porto Alegre, Brazil, 90560-032
        • Hospitalar Moinhos de Vento
      • Recife, Brazil, 50070902
        • IMIP Pernambuco
      • Recife, Brazil, 50720110
        • AME Saúde
      • Recife, Brazil, 50740900
        • Hospital das Clinicas da Universidade Federal de Pernambuco
      • Salvador, Brazil, 40110160
        • Fundação Bahiana de Infectologia
      • São Bernardo do Campo, Brazil, 09715-090
        • CEMEC - Centro Multidisciplinar de Estudos Clínicos
      • São José do Rio Preto, Brazil, 15090-000
        • Hospital de Base
      • São José dos Campos, Brazil, 12230-001
        • CIPES - Centro Internacional de Pesquisa Clínica
      • São Paulo, Brazil, 0402-9001
        • Instituto de Assistência Médica ao Servidor Público Estadual de São Paulo
      • São Paulo, Brazil, 04023900
        • Fundacao Oswaldo Ramos (Hospital do Rim)
      • São Paulo, Brazil, 05403-000
        • Hospital das Clinicas da Faculdade de Medicina da USP
      • Teresina, Brazil, 64049550
        • Hospital Universitário da Universidade Federal do Piauí
      • Vitória, Brazil, 29043-260
        • Hospital Universitário Cassiano Antônio Moraes
      • Votuporanga, Brazil, 15505-189
        • Clínica Cardiológica
  • Canada
      • Montreal, Canada, H2X 0A9
        • Centre hospitalier de l'Université de Montréal (CHUM)
      • Québec, Canada, G1V 4T3
        • Diex Recherche Québec
      • Québec, Canada, G1R 2J6
        • CHU de Quebec-Universite Laval Research Centre
    • Alberta
      • Edmonton, Alberta, Canada, T6G 2P4
        • University of Alberta Hospital (University of Alberta)
    • British Columbia
      • Kamloops, British Columbia, Canada, V2C 2T1
        • Royal Inland Hospital
      • Kelowna, British Columbia, Canada, V1Y 1T2
        • Kelowna General Hospital
      • Prince George, British Columbia, Canada, V2M 1S2
        • Northern Health
      • Surrey, British Columbia, Canada, V3W 1J8
        • Fraser Health
      • Vancouver, British Columbia, Canada, V5Z 1M9
        • Vancouver General Hospital
      • Vancouver, British Columbia, Canada, V1Y 1S1
        • St. Paul's Hospital (Vancouver)
    • Montréal
      • Québec, Montréal, Canada, H4J 1C5
        • CIUSSS Nord de l'île de Montreal
    • Nova Scotia
      • Halifax, Nova Scotia, Canada, B3H 1V7
        • Centre for Clinical Research
    • Ontario
      • Brampton, Ontario, Canada, L6S 0C6
        • Centricity Research (Brampton)
      • Concord, Ontario, Canada, L4K 4M2
        • Centricity Research (Vaughan)
      • Kingston, Ontario, Canada, K7L 3N6
        • Queen's University
      • London, Ontario, Canada, N6A 5W9
        • London Regional Cancer Program - London Health Sciences Ctr.
      • Oshawa, Ontario, Canada, L1G 2B9
        • Lakeridge Health Oshawa
      • Ottawa, Ontario, Canada, K1H 7W9
        • The Ottawa Hospital
      • Toronto, Ontario, Canada, M5G 2N2
        • Toronto General Hospital
      • Toronto, Ontario, Canada, M4G 3E8
        • Sunnybrook Health Sciences Centre
      • Toronto, Ontario, Canada, M5C2T2
        • St. Michael's Hospital
    • Quebec
      • Montreal, Quebec, Canada, H3G 1A4
        • McGill University Health Centre (MUHC)
      • Montreal, Quebec, Canada, H1T 2M4
        • CIUSSS de l'Est-de-l'Île-de-Montréal
      • Sherbrooke, Quebec, Canada, J1H 5N4
        • CIUSSS de l Estrie-CHUS
  • China
      • Anshan, China, 114000
        • Ansteel Group General Hospital
      • Beijing, China, 100029
        • Beijing AnZhen Hospital, Capital Medical University
      • Beijing, China, 100029
        • Peking University Third Hospital
      • Beijing, China, 100037
        • Fuwai Hospital, CAMS&PUMC
      • Changzhi, China, 046000
        • Heping Hospital Affiliated to Changzhi Medical College
      • Chaoyang, China, 122000
        • The Second Hospital of Chaoyang
      • Chengdu, China, 610041
        • Affiliated Hospital of Chengdu University
      • Chengdu, China, 610041
        • West China Fourth Hospital of Sichuan University
      • Chifeng, China, 024000
        • Affiliated Hospital of Chifeng University
      • Chongqing, China, 402160
        • The Affiliated Yongchuan Hospital of Chongqing Medical University
      • Foshan, China, 528500
        • Gaoming People's Hospital
      • Fuyang, China, 236400
        • Linquan County People's Hospital
      • Gaozhou, China, 525200
        • Gaozhou People's Hospital
      • Guangzhou, China, 510180
        • Guangzhou First People's Hospital
      • Guangzhou, China, 510240
        • Guangzhou Red Cross Hospital
      • Guangzhou, China, 510665
        • The Third Affiliated Hospital of Southern Medical University
      • Guangzhou, China, 510925
        • The Fifth Affiliated Hospital of Southern Medical University
      • Guangzhou, China, 528200
        • Guangdong Provincial Hospital of Chinese Medicine
      • Haikou, China, 570311
        • Hainan General Hospital
      • Hanghzhou, China, 310022
        • Shulan(Hanghzhou) Hospital
      • Hangzhou, China, 310030
        • Zhejiang Hospital
      • Harbin, China, 150001
        • The Second Affiliated Hospital of Heilongjiang University of Chinese Medicine
      • Harbin, China, 150066
        • The Second Affiliated Hospital of Heilongjiang University of Chinese Medicine
      • Hefei, China, 230011
        • The Second People's Hospital of Hefei
      • Hohot, China, 010010
        • International Mongolian Hospital of Inner Mongolia
      • Huangshi, China, 435000
        • Huangshi Central Hospital
      • Jingzhou, China, 434020
        • Jingzhou Central Hospital
      • Jiyuan, China, 454650
        • Henan Jiyuan People's Hospital
      • Liuzhou, China, 545006
        • Liuzhou People's Hospital
      • Luoyang, China, 471002
        • Luoyang Third People's Hospital
      • Luoyang, China, 471000
        • Oriental Hospital
      • Luoyang, China, 471009
        • Luoyang Central Hospital
      • Luoyang, China, 471900
        • Luoyang Yanshi People's Hospital
      • Meishan, China, 620010
        • Meishan People's Hospital
      • Nanchang, China, 330000
        • Jiangxi Branch Hospital of Xiangya Hospital of Central South University
      • Qingdao, China, 266034
        • Qingdao Cardiovascular Hospital
      • Shanghai, China, 200072
        • Shanghai Tenth People's Hospital
      • Shantou, China, 515041
        • Second Hospital Affiliated to Shantou Medical University
      • Shantou, China, 515031
        • Shantou Central Hospital
      • Shaoguan, China, 512000
        • Shaoguan First People's Hospital
      • Shaoxing, China, 312000
        • Shaoxing Second Hospital
      • Shenzhen, China, 518052
        • Shenzhen Nanshan People's Hospital
      • Shenzhen, China, 518107
        • The Seventh Affiliated Hospital, Sun Yat-sen University
      • Shijiazhuang, China, 050011
        • Shijiazhuang People's Hospital
      • Songyuan, China, 138000
        • Songyuan Jilin Oilfield Hospital
      • Taizhou, China, 317000
        • Taizhou Hospital of Zhejiang Province
      • Tianjin, China, 300140
        • The Fourth Central Hospital of Tianjin
      • Wuhan, China, 430000
        • Wuhan Fourth Hospital
      • Wuhan, China, 430015
        • Hubei Provincial Hospital of Integrated Traditional Chinese and Western Medicine
      • Xiamen, China, 361006
        • Xiamen Cardiovascular Hospital Xiamen University
      • Xinxiang, China, 453000
        • Xinxiang Central Hospital
      • Xinxiang, China, 453100
        • The First Affiliated Hospital of Xinxiang Medical University
      • Zhangjiakou, China, 075000
        • The First Affiliated Hospital of Hebei North University
      • Zhengzhou, China, 450053
        • The Ninth People's Hospital of Zhengzhou
      • Zhuhai, China, 519000
        • Zhuhai People's Hospital
      • Zhumadian, China, 463000
        • Zhumadian Central Hospital
      • Zhuzhou, China, 412000
        • Zhuzhou Central Hospital
      • Zhuzhou, China, 412007
        • Zhuzhou Central Hospital
      • Ürümqi, China, 830054
        • The First Affiliated Hospital of Xinjiang Medical University
  • Denmark
      • Aalborg, Denmark, 9000
        • Aalborg Universitetsshospital
      • Copenhagen, Denmark, 2100
        • Rigshospitalet, København
      • Herlev, Denmark, 2730
        • Herlev and Gentofte Hospital
      • Herlev, Denmark, 2730
        • Steno Diabetes Center Copenhagen
      • Kolding, Denmark, 6000
        • Kolding Hospital
      • Odense, Denmark, 5000
        • Odense University Hospital
      • Roskilde, Denmark, 4000
        • Zealand University Hospita; Roskilde
  • Germany
      • Aachen, Germany, 52074
        • Universitätsklinikum Aachen, AöR
      • Bad Kreuznach, Germany, 55543
        • KfH-Nierenzentrum Bad Kreuznach
      • Bad Nenndorf, Germany, 31542
        • Nephrologische Gemeinschaftspraxis Bad Nenndorf
      • Bad Oeynhausen, Germany, 32545
        • Herz- und Diabeteszentrum Nordrhein-Westfalen, Bad Oeynhausen
      • Berlin, Germany, 10249
        • Vivantes Klinikum im Friedrichshain
      • Berlin, Germany, 12627
        • Praxis für Nierenkrankheiten und Dialyse Helle Mitte
      • Bonn, Germany, 53127
        • Universitätsklinikum Bonn AöR
      • Braunschweig, Germany, 38126
        • Städtisches Klinikum Braunschweig gGmbH
      • Cloppenburg, Germany, 49661
        • St.-Josefs-Hospital Cloppenburg
      • Coburg, Germany, 96450
        • KfH Nierenzentrum Coburg
      • Dortmund, Germany, 44137
        • Klinikum Dortmund gGmbH
      • Düsseldorf, Germany, 40225
        • Universitätsklinikum Düsseldorf
      • Elsenfeld, Germany, 63820
        • Dialysezentrum Elsenfeld
      • Frankfurt, Germany, 60596
        • ClinPhenomics CVC GmbH
      • Frankfurt am Main, Germany, 60596
        • Universitätsklinikum Frankfurt
      • Frankfurt am Main, Germany, 60431
        • Agaplesion Markus Krankenhaus
      • Freiburg im Breisgau, Germany, 79100
        • Nierenzentrum Freiburg
      • Giessen, Germany, 35392
        • Universitätsklinikum Gießen und Marburg GmbH
      • Greifswald, Germany, 17489
        • Universitätsmedizin Greifswald
      • Halle, Germany, 06097
        • Universitätsklinikum Halle (Saale) AöR
      • Hamburg, Germany, 20246
        • Universitätsklinikum Hamburg, Eppendorf
      • Hanover, Germany, 30625
        • Medizinische Hochschule Hannover
      • Hanover, Germany, 30625
        • Zentrum Für Nieren Hochdruck und Stoffwechselerkrankungen
      • Heilbronn, Germany, 74076
        • BAG für Nephrologie und Dialyse
      • Herne, Germany, 44625
        • Ruhr-Universität Bochum
      • Homburg, Germany, 66421
        • Universität des Saarlandes
      • Jena, Germany, 07747
        • Universitätsklinikum Jena
      • Kiel, Germany, 24105
        • Universitätsklinikum Schleswig-Holstein, Campus Kiel
      • Konstanz, Germany, 78464
        • Klinikum Konstanz
      • Kronach, Germany, 96317
        • KfH-Nierenzentrum Kronach
      • Landshut, Germany, 84036
        • Dr. Vehling-Kaiser MVZ GmbH
      • Leipzig, Germany, 04129
        • KfH Nierenzentrum Leipzig
      • Lingen, Germany, 49808
        • Nephrologisches Zentrum Emsland
      • Magdeburg, Germany, 39120
        • Otto-von-Guericke-Universität Magdeburg
      • Mainz, Germany, 55131
        • Universitätsmedizin der Johannes Gutenberg-Universität Mainz
      • München, Germany, 81675
        • Klinikum rechts der Isar der Technischen Universität München
      • München, Germany, 80336
        • Klinikum der Universität München - Campus Innenstadt
      • Neckarsulm, Germany, 74172
        • Dialysezentrum Neckarsulm
      • Neuruppin, Germany, 16816
        • Universitätsklinikum Ruppin-Brandenburg
      • Nuremberg, Germany, 90471
        • Klinikum Nürnberg
      • Rostock, Germany, 18057
        • Universitätsmedizin Rostock
      • Rotenburg (Wümme), Germany, 27356
        • Dialysezentrum Rotenburg
      • Schweinfurt, Germany, 97421
        • MVZ Dialysezentrum Schweinfurt
      • Solingen, Germany, 42653
        • Städtisches Klinikum Solingen gGmbH
      • Springe, Germany, 31832
        • Nephrologische Gemeinschaftspraxis Springe
      • Stuttgart, Germany, 70376
        • Robert-Bosch-Krankenhaus GmbH
      • Traunstein, Germany, 83278
        • KfH-Nierenzentrum Traunstein
      • Trier, Germany, 54292
        • Medizinisches Versorgungszentrum der Barmherzigen Brüder Trier gGmbH
      • Villingen-Schwenningen, Germany, 78052
        • Nephrologisches Zentrum Villingen-Schwenningen
      • Wiesbaden, Germany, 65191
        • Nierenzentrum Wiesbaden
      • Wuppertal, Germany, 42283
        • Helios Universitätsklinikum Wuppertal
      • Würzburg, Germany, 97078
        • Universitätsklinikum Würzburg AÖR
  • India
      • Bangalore, India, 560034
        • St John's Medical College
      • Bangalore, India, 560017
        • Manipal Hospitals, Old Airport Road
      • Bangalore, India, 560076
        • Apollo Hospital - Bangalore
      • Bathinda, India, 151001
        • All India Institute of Medical Sciences, Bathinda
      • Bhubaneswar, India, 751005
        • Apollo Hospitals - Bhubaneswar
      • Bhubaneswar, India, 751019
        • All India Institute of Medical Sciences Bhubaneswar
      • Bilāspur, India, 174001
        • All India Institute of Medical Sciences, Bilaspur
      • Chandigarh, India, 160012
        • Post Graduate Institute of Medical Education and Research
      • Chennai, India, 600006
        • Apollo Hospital - Chennai
      • Chennai, India, 600095
        • Apollo Speciality Hospitals, Vanagaram
      • Dwārka, India, 110075
        • Aakash Healthcare Super Speciality Hospital
      • Faridabad, India, 121002
        • Accord Superspeciality Hospital
      • Faridabad, India, 121002
        • Amrita Hospital Faridabad
      • Guhugram, India, 122011
        • Marengo Asia Hospitals, Guhugram
      • Guntur, India, 522001
        • Vedenta Hospitals
      • Gurugram, India, 122001
        • Artemis Hospital
      • Hubli, India, 580021
        • Karnataka Institute of Medical Sciences, Hubli
      • Hyderabad, India, 500082
        • Nizam's Institute of Medical Sciences
      • Hyderabad, India, 500012
        • Osmania Medical College & Hospital
      • Hyderabad, India, 500033
        • Apollo Hospitals Jubilee Hills
      • Hyderabad, India, 500058
        • Apollo DRDO Hospital
      • Jalandhar, India, 144012
        • Fortis Hospital, Jalandhar
      • Jodhpur, India, 342005
        • All India Institute of Medical Sciences, Jodhpur
      • Kochi, India, 682041
        • Amrita Institute of Medical Sciences and Research Centre
      • Kolkata, India, 700014
        • Nil Ratan Sircar Medical College & Hospital
      • Kolkata, India
        • Manipal Hospitals, EM Bypass
      • Kozhikode, India, 673009
        • IQRAA International hospital & research centre.
      • Lucknow, India, 226003
        • King George's Medical University
      • Lucknow, India, 226014
        • Sanjay Gandhi Post Graduate Institute of Medical Sciences
      • Lucknow, India, 226010
        • Dr Ram Manohar Lohia Institute of Medical Sciences
      • Madurai, India, 625107
        • Meenakshi Mission Hospital & Research Centre
      • Madurai, K.K. Nagar, India, 625020
        • Apollo Speciality Hospital
      • Mangaluru, India, 575001
        • Kasturba Medical College and Hospital
      • Mysore, India, 570023
        • Apollo BGS Hospital
      • Mānesar, India, 122052
        • Fortis Hospital, Manesar
      • Nadiād, India, 387001
        • Muljibhai Patel Urological Hospital
      • New Delhi, India, 110029
        • All India Institute of Medical Sciences
      • New Delhi, India, 110026
        • Maharaja Agrasen Hospital
      • New Delhi, India, 110017
        • Max Super Specialty Hospital, Saket
      • New Delhi, India, 110025
        • Epitome Kidney Urology Institute and Lions Hospital
      • New Delhi, India, 110070
        • Fortis Flt. Lt. Rajan Dhall Hospital
      • New Delhi, India, 110075
        • Venkateshwar Hospital
      • Patna, India, 800014
        • Indira Gandhi Institute of Medical Sciences
      • Puducherry, India, 605006
        • Jawaharlal Institute of Postgraduate Medical Education
      • Raipur, India, 492099
        • All India Institute of Medical Sciences
      • Raipur, India, 492001
        • DKS Post Graduate Institute & Research Center, Raipur (C.G)
      • Ranchi, India, 834001
        • Raj Hospitals
      • Ranchi, India, 834004
        • Paras HEC, Ranchi
      • Rohtak, India, 124001
        • Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences
      • Secunderabad, India, 500003
        • Yashoda Hospitals - Secunderabad
      • Trivandrum, India, 695029
        • Kimshealth
      • Vadodara, India, 390021
        • Aman Hospital & Research Center
      • Vellore, India, 632517
        • Christian Medical College, Vellore
      • Visakhapatnam, India, 530040
        • Apollo Hospitals Health City
  • Italy
      • Alessandria, Italy, 15121
        • Ospedale SS. Antonio e Biagio e C. Arrigo - AOUAL
      • Asti, Italy, 14100
        • Asti-Ospedale Cardinal Massaia
      • Bari, Italy, 70124
        • Azienda Universitaria Ospedaliera Consorziale Policlinico Bari
      • Bergamo, Italy, 24127
        • ASST Papa Giovanni XXIII
      • Bologna, Italy, 40138
        • Policlinico S. Orsola-Malpighi
      • Cagliari, Italy, 09100
        • Azienda Ospedaliera ARNAS G. Brotzu
      • Chieri, Italy, 10023
        • Chieri-Ospedale Maggiore
      • Chieti, Italy, 66100
        • Ospedale SS Annunziata
      • Cuneo, Italy, 12100
        • A.S.O. S. Croce e Carle
      • Florence, Italy, 50134
        • A. O. Universitaria Careggi
      • Florence, Italy, 50124
        • Firenze-Ospedale San Giovanni di Dio
      • Genova, Italy, 16132
        • Azienda Ospedaliera San Martino
      • Imola, Italy, 40026
        • Ospedale di Imola S. Maria della Scaletta
      • Milan, Italy, 20132
        • Ospedale San Raffaele S.r.l.
      • Milan, Italy, 20142
        • Asst Santi Paolo E Carlo
      • Monza, Italy, 20900
        • Fondazione IRCCS San Gerardo dei Tintori
      • Novara, Italy, 28100
        • Ospedale Maggiore della Carità
      • Padova, Italy, 35128
        • Azienda Ospedaliera di Padova
      • Parma, Italy, 43126
        • Azienda Ospedaliera Unversitaria di Parma
      • Pavia, Italy, 27100
        • Fondazione Salvatore Maugeri
      • Perugia, Italy, 06129
        • Azienda Ospedaliera di Perugia
      • Pisa, Italy, 56126
        • Azienda Ospedaliera Universitaria Pisana
      • Prato, Italy, 59100
        • Prato-Ospedale Santo Stefano
      • Roma, Italy, 00189
        • Azienda Ospedaliera Sant'Andrea-Università di Roma La Sapienza
      • San Fermo della Battaglia, Italy, 22020
        • Azienda Socio Sanitaria Territoriale Lariana
      • San Giovanni Rotondo (Foggia), Italy, 71013
        • IRCCS Ospedale "Casa Sollievo della Sofferenza"
      • Savona, Italy, 17100
        • Azienda Socio Sanitaria Ligure 2
      • Sesto San Giovanni, Italy, 20099
        • IRCCS MultiMedica
      • Todi, Italy, 06059
        • Todi-Nuovo Ospedale Media Valle del Tevere
      • Turin, Italy, 0100
        • Torino-Ospedale Oftalmico
      • Verbania, Italy, 28922
        • Ospedale Castelli - Verbania
      • Vicenza, Italy, 36100
        • Ospedale San Bortolo
  • Japan
      • Asahikawa-Shi, Japan, 078-8510
        • Asahikawa Medical University Hospital
      • Chiba, Japan, 260-8677
        • Chiba University Hospital
      • Chuo-Shi, Japan, 409-3898
        • University of Yamanashi Hospital
      • Fukuoka, Japan, 812-8582
        • Kyushu University Hospital
      • Isehara, Japan, 259-1193
        • Tokai University Hospital
      • Izumo, Japan, 693-8501
        • Shimane University Hospital
      • Kurashiki-Shi, Japan, 701-0192
        • Kawasaki Medical School Hospital
      • Kurume, Japan, 830-0011
        • Kurume University Hospital
      • Kyoto, Japan, 606-8507
        • Kyoto University Hospital
      • Nagakute, Japan, 480-1195
        • Aichi Medical University Hospital
      • Nagoya, Japan, 466-8560
        • Nagoya University Hospital
      • Nagoya, Japan, 455-8530
        • Chubu Rosai Hospital
      • Okayama, Japan, 700-8558
        • Okayama University Hospital
      • Osaka, Japan, 553-0003
        • Kansai Electric Power Hospital
      • Sendai, Japan, 980-8547
        • Tohoku University Hospital
      • Tokyo, Japan, 160-8582
        • Keio University Hospital
      • Tokyo, Japan, 105-8470
        • Toranomon Hospital
      • Tokyo, Japan, 104-8560
        • St. Luke's International Hospital
      • Tokyo, Japan, 173-8606
        • Teikyo University Hospital
      • Tokyo, Japan, 113-8431
        • Juntendo University Hospital
      • Tokyo, Japan, 113-8655
        • The University of Tokyo Hospital
      • Tokyo, Japan, 162-8655
        • National Center for Global Health and Medicine
      • Tokyo, Chuo-ku, Japan, 103-0027
        • Tokyo-Eki Center-building Clinic
      • Yokohama, Japan, 236-0004
        • Yokohama City University Hospital
      • Ōtsu, Japan, 520-2192
        • Shiga University of Medical Science Hospital
  • Malaysia
      • Ampang, Malaysia, 68000
        • Hospital Ampang
      • Batu Caves, Malaysia, 68100
        • Hospital Selayang
      • Batu Pahat, Malaysia, 83000
        • Hospital Sultanah Nora Ismail
      • George Town, Malaysia, 10990
        • Hospital Pulau Pinang-Pulau Pinang-21953
      • Ipoh, Malaysia, 30450
        • Hospital Raja Permaisuri Bainun
      • Johor Bahru, Malaysia, 80100
        • Hospital Sultanah Aminah
      • Johor Bahru, Malaysia, 81100
        • Hospital Sultan Ismail
      • Kajang, Malaysia, 43000
        • Hospital Sultan Idris Shah Serdang
      • Kajang, Selangor, Malaysia, 43000
        • Hospital Kajang
      • Klang, Malaysia, 41200
        • Hospital Tengku Ampuan Rahimah
      • Kota Bharu, Malaysia, 15586
        • Hospital Raja Perempuan Zainab II
      • Kota Kinabalu, Malaysia, 88586
        • Hospital Queen Elizabeth
      • Kuala Lumpur, Malaysia, 50586
        • Hospital Kuala Lumpur
      • Kuala Lumpur, Malaysia, 59100
        • University Malaya Medical Centre
      • Kuala Pilah, Malaysia, 72000
        • Hospital Tuanku Ampuan Najihah
      • Kuantan, Malaysia, 25100
        • Hospital Tengku Ampuan Afzan
      • Kuching, Malaysia, 93586
        • Hospital Umum Sarawak
      • Kulim, Malaysia, 09090
        • Hospital Kulim
      • Malacca, Malaysia, 75400
        • Hospital Melaka
      • Muar town, Malaysia, 84000
        • Hospital Pakar Sultanah Fatimah
      • Perai, Malaysia, 13700
        • Hospital Seberang Jaya
      • Serdang, Malaysia, 43400
        • Hospital Sultan Abdul Aziz Shah
      • Seremban, Malaysia, 70300
        • Hospital Tuanku Ja'afar
      • Taiping, Malaysia
        • Hospital Taiping
      • Teluk Intan, Malaysia, 36000
        • Hospital Teluk Intan
      • Temerluh, Malaysia, 28000
        • Hospital Sultan Haji Ahmad Shah
  • Mexico
      • Aguascalientes, Mexico, 20259
        • Centenario Hospital Miguel Hidalgo
      • Cuernavaca, Mexico, 62250
        • Instituto de Diabetes, Obesidad y Nutrición S.C.
      • Culiacán, Mexico, CP 80020
        • Neurociencias Estudios Clinicos S.C.
      • Durango, Mexico, 34000
        • Instituto de investigación aplicado a la neurociencia
      • Guadalajara, Mexico, 44670
        • Unidad de Investigación Clinica y Atencion Medica HEPA SC
      • Guadalajara, Mexico, 44340
        • Centro de Investigacion Clinica y Medicina Traslacional (CIMeT)
      • Guadalajara, Mexico, 44340
        • Centro Medico Nacional de Occidente/ Centro De Investigacion Biomedica De Occidente
      • Mexico City, Mexico, 03100
        • Health Pharma Professional Research S.A. de C.V.
      • Mexico City, Mexico, 03650
        • Soluciones Terapéuticas Médico Quirúrgicas S. de R.L. de C.V.
      • Mexico City, Mexico, 07760
        • Hospital Juárez de México
      • Monterrey, Mexico, 64460
        • Hospital Universitario Dr Jose Eleuterio Gonzalez
      • Monterrey, Mexico, 64310
        • Iecsi S.C.
      • Monterrey, Mexico, CP 64040
        • Renall Monterrey
      • Morelia, Mexico, 58260
        • Centro de Investigación Clínica Chapultepec S.A. de C.V.
      • Mérida, Mexico, 97070
        • Medical Care & Research SA de CV
      • Mérida, Mexico, 97125
        • Merida Investigación Clínica
      • Tlajomulco de Zúñiga, Mexico, 45653
        • IMSS Regional General Hospital 180
      • Tlalpan, Mexico, 14080
        • Instituto Nacional de Cardiologia Ignacio Chavez
      • Veracruz, Mexico, 91900
        • FAICIC S de RL de C.V.
      • Veracruz, Mexico, 91910
        • Sociedad de Metabolismo y Corazón S.C.
  • New Zealand
      • Auckland, New Zealand, 1023
        • Auckland City Hospital
      • Auckland, New Zealand, 2025
        • Middlemore Hospital
      • Auckland, Takapuna, New Zealand, 0620
        • North Shore Hospital
      • New Plymouth, New Zealand, 4310
        • Taranaki Base Hospital
    • Northland
      • Whangarei, Northland, New Zealand, 0110
        • Whangarei Hospital
    • Otago
      • Dunedin, Otago, New Zealand, 9016
        • Dunedin Hospital
    • Waikato Region
      • Hamilton, Waikato Region, New Zealand, 3240
        • Waikato Hospital
  • Portugal
      • Aveiro, Portugal, 3814-501
        • ULS da Região de Aveiro
      • Braga, Portugal, 4710-243
        • Centro Clínico Académico de Braga (2CA-Braga)
      • Carnaxide, Portugal, 2790-134
        • CHLO, EPE - Hospital de Santa Cruz
      • Castelo Branco, Portugal, 6000-085
        • Unidade Local de Saúde de Castelo Branco, E.P.E
      • Coimbra, Portugal, 3004-561
        • CHUC - Centro Hospitalar e Universitario de Coimbra, EPE
      • Faro, Portugal, 8000-386
        • Unidade Local de Saúde do Algarve, E.P.E
      • Funchal, Portugal, 9004-514
        • SESARAM
      • Lisbon, Portugal, 1069-166
        • ULS de São José
      • Lisbon, Portugal, 1649-035
        • Unidade Local de Saúde Santa Maria
      • Loures, Portugal, 2674-514
        • Hospital Beatriz Ângelo
      • Porto, Portugal, 4200-319
        • Centro Hospitalar Universitário São João,EPE
      • Senhora da Hora, Portugal, 4464-513
        • Unidade Local de Saúde de Matosinhos
      • Setúbal, Portugal, 2910-549
        • Unidade Local De Saude Da Arrabida E.P.E.
      • Viseu, Portugal, 3504-509
        • Unidade Local De Saude De Viseu Dao-Lafoes E.P.E.
  • South Korea
      • Ansan-si, South Korea, 15355
        • Korea University Ansan Hospital
      • Busan, South Korea, 49241
        • Pusan National University Hospital
      • Cheonan-si, South Korea, 31151
        • Soon Chun Hyang University Hospital Cheonan
      • Cheongju-si, South Korea, 28644
        • Chungbuk National University Hospital
      • Daegu, South Korea, 41944
        • Kyungpook National University Hospital
      • Deagu, South Korea, 42601
        • Keimyung University Dongsan Hospital
      • Goyang-si, South Korea, 10380
        • Inje University Ilsan Paik Hospital
      • Guri-si, South Korea, 11923
        • Hanyang University Guri Hospital
      • Gwangmyeong, South Korea, 14353
        • Chung-Ang University Gwangmyeong Hospital
      • Incheon, South Korea, 21431
        • The Catholic University of Korea, Incheon St. Mary's Hospital
      • Seongnam-si, South Korea, 13496
        • CHA Bundang Medical Center
      • Seoul, South Korea, 03080
        • Seoul National University Hospital
      • Seoul, South Korea, 03722
        • Severance Hospital
      • Seoul, South Korea, 06273
        • Gangnam Severance Hospital
      • Seoul, South Korea, 08308
        • Korea University Guro Hospital
      • Seoul, South Korea, 07345
        • The Catholic University of Korea, Yeouido St.Mary's Hospital
      • Seoul, South Korea, 07061
        • SMG-SNU Boramae Medical Center
      • Wŏnju, South Korea, 26426
        • Yonsei University Wonju Severance Christian Hospital
  • Sweden
      • Danderyd, Sweden, 182 88
        • Danderyds Sjukhus AB
      • Gothenburg, Sweden, 413 46
        • Sahlgrenska Universitetsjukhuset
      • Linköping, Sweden, 581 85
        • Universitetssjukhuset Linköping
      • Lund, Sweden, 221 85
        • Skånes Universitetssjukhus, Lund
      • Stockholm, Sweden, 14157
        • Karolinska University Hospital
      • Sundsvall, Sweden, 856 43
        • Region Vaesternorrland
      • Uppsala, Sweden, 751 85
        • Akademiska sjukhuset
  • Taiwan
      • Kaohsiung City, Taiwan, 824005
        • E-Da Hospital
      • Luodong Township, Taiwan, 265
        • Lotung Poh-Ai Hospital
      • New Taipei City, Taiwan, 220
        • Far Eastern Memorial Hospital
      • New Taipei City, Taiwan, 23561
        • Taipei Medical University-Shuang Ho Hospital
      • New Taipei City, Taiwan, 23142
        • Taipei Tzu Chi Hospital
      • New Taipei City, Taiwan, 243089
        • Fu Jen Catholic University Hospital
      • Taichung, Taiwan, 404
        • China Medical University Hospital
      • Taichung, Taiwan, 402
        • Chung Shan Medical University Hospital
      • Taichung, Taiwan, 435
        • Tungs' Taichung MetroHarbor Hospital
      • Taichung, Taiwan, 407219
        • Taichung Veterans General Hospital
      • Tainan, Taiwan, 70403
        • National Cheng Kung University Hospital
      • Tainan, Taiwan, 736402
        • Chi Mei Hospital, Liouying
      • Taipei, Taiwan, 110
        • Taipei Medical University Hospital
      • Taipei, Taiwan, 10449
        • Mackay Memorial Hospital
      • Taipei, Taiwan, 112
        • Taipei Veterans General Hospital
      • Taipei, Taiwan, 106
        • Cathay General Hospital
      • Taipei, Taiwan, 11696
        • Taipei Municipal Wanfang Hospital
      • Taipei, Taiwan, 111045
        • Shin Kong Wu Ho-Su Memorial Hospital
      • Taoyuan City, Taiwan, 333
        • Chang Gung Memorial Hospital, Linkou
      • Taoyuan City, Taiwan, 330
        • TaoYuan General Hospital
  • United Kingdom
      • Antrim, United Kingdom, BT41 2RL
        • Antrim Area Hospital
      • Basildon, United Kingdom, SS16 5NL
        • Basildon Hospital
      • Belfast, United Kingdom, BT16 1RH
        • Ulster Hospital
      • Belfast, United Kingdom, BT9 7AB
        • Beltfast City Hospital
      • Birmingham, United Kingdom, B15 2WB
        • Queen Elizabeth Hospital Birmingham
      • Birmingham, United Kingdom, B11 4AN
        • Fernley Medical Centre
      • Birmingham, United Kingdom, B19 1TT
        • Burbury Medical Centre
      • Birmingham, United Kingdom, B31 3HB
        • West Heath Surgery
      • Birmingham, United Kingdom, B32 2TJ
        • Ridgacre House Surgery
      • Blackburn, United Kingdom, BB2 1AX
        • Oakenhurst Medical Practice
      • Brighton, United Kingdom, BN2 1ES
        • Royal County Sussex Hospital
      • Bristol, United Kingdom, BS10 5NB
        • Southmead Hospital
      • Bristol, United Kingdom, BS11 0QE
        • Pioneer Ridingleaze
      • Bristol, United Kingdom, BS2 0AN
        • Lawrence Hill Health Centre
      • Bristol, United Kingdom, BS34 5TF
        • Coniston Medical Practice
      • Bury St Edmunds, United Kingdom, IP33 2QZ
        • West Suffolk Hospital
      • Chelmsford, United Kingdom, CM1 7ET
        • Broomfield Hospital
      • Chippenham, United Kingdom, SN14 6GT
        • Hathaway Medical Centre
      • Clevedon, United Kingdom, BS21 6DG
        • Clevedon Medical Centre
      • Cosham, United Kingdom, PO6 3LY
        • Queen Alexandra Hospital
      • County Down, United Kingdom, BT35 8DR
        • Daisy Hill Hospital
      • Coventry, United Kingdom, CV2 2DX
        • University Hospital Coventry
      • Cramlington, United Kingdom, NE23 6US
        • The Village Surgery
      • Darlington, United Kingdom, DL3 6HZ
        • Orchard Court Surgery
      • Dartford, United Kingdom, DA2 8DA
        • Darent Valley Hospital
      • Dorchester, United Kingdom, DT1 2JY
        • Dorset County Hospital
      • Dudley, United Kingdom, DY1 2HQ
        • Russells Hall Hospital
      • Durham, United Kingdom, DH1 3JX
        • University Health Centre
      • Fulwood, United Kingdom, PR2 9HT
        • Highland Clinical Research Facility
      • Gillingham, United Kingdom, ME7 2BU
        • Woodlands Family Practice
      • Gloucester, United Kingdom, GL1 3NN
        • Gloucestershire Royal Hospital
      • Great Yarmouth, United Kingdom, NR31 6LA
        • James Paget University Hospital
      • Guisborough, United Kingdom, TS14 7DJ
        • The Garth Surgery
      • Hereford, United Kingdom, HR1 2BN
        • Hereford County Hospital
      • Ipswich, United Kingdom, IP4 5PD
        • Ipswich Hospital (UK)
      • Kings Lynn, United Kingdom, PE30 4ET
        • The Queen Elizabeth Hospital
      • Leeds, United Kingdom, LS26 9AA
        • Pinfold Surgery
      • Leominster, United Kingdom, HR6 8HD
        • Ryeland Surgery
      • Little Horton Lane, United Kingdom, BD5 0NA
        • St Luke's Hospital
      • Liverpool, United Kingdom, L9 7AL
        • Aintree University Hospital
      • London, United Kingdom, SE1 9RT
        • Guy's Hospital
      • London, United Kingdom, SE5 9RS
        • King's College Hospital
      • London, United Kingdom, SW17 0QT
        • St George's Hospital
      • London, United Kingdom, W12 0HS
        • Hammersmith Hospital
      • London, United Kingdom, N18 1QX
        • North Middlesex University Hospital
      • London, United Kingdom, W6 7HY
        • Richford Gate Medical Practice
      • Londonderry, United Kingdom, BT47 6SB
        • Altnagelvin Area Hospital
      • Metropolitan Borough of Wirral, United Kingdom, CH49 5PE
        • Arrowe Park Hospital
      • Middlesbrough, United Kingdom, TS5 6HA
        • Linthorpe Surgery
      • Norfolk, United Kingdom, NR4 7UY
        • Norfolk and Norwich University Hospital
      • Northampton, United Kingdom, NN1 5BD
        • Northampton General Hospital
      • Oxford, United Kingdom, OX3 7LE
        • Churchill Hospital
      • Oxford, United Kingdom, OX16 9AD
        • Banbury Cross Health Centre
      • Oxford, United Kingdom, OX4 1XB
        • St Bartholomews & Hollow Way Med Centre
      • Pickering, United Kingdom, YO18 8BL
        • Pickering Medical Practice
      • Poole, United Kingdom, BH14 8EE
        • Lilliput Surgery
      • Reading, United Kingdom, RG1 5AN
        • Royal Berkshire Hospital
      • Redditch, United Kingdom, B98 7UB
        • Alexandra Hospital
      • Salford, United Kingdom, M6 8HD
        • Salford Royal Hospital
      • Shrewsbury, United Kingdom, SY3 8XQ
        • Royal Shrewsbury Hospital
      • St Helens, United Kingdom, WA9 3DA
        • St Helens Hospital
      • Stevenage, United Kingdom, SG1 4AB
        • Lister Hospital
      • Swindon, United Kingdom, SN3 6BB
        • Great Western Hospital
      • Truro, United Kingdom, TR1 3LJ
        • Royal Cornwall Hospital
      • Wantage, United Kingdom, OX12 9BN
        • Church Street Practice
      • Westcliff-on-Sea, United Kingdom, SS0 0RY
        • Southend University Hospital
      • Weston-super-Mare, United Kingdom, BS24 7PR
        • 168 Parklands Medical Centre
      • Whitstable, United Kingdom, CT5 3SE
        • Estuary View Medical Centre
      • Witney, United Kingdom, OX28 6JS
        • Windrush Medical Practice
      • Witney, United Kingdom, OX29 4QB
        • Eynsham Medical Centre
      • York, United Kingdom, YO24 2RQ
        • Woodthorpe Surgery
  • United States
    • Alabama
      • Huntsville, Alabama, United States, 35805-4104
        • Apogee Clinical Research
    • Arizona
      • Surprise, Arizona, United States, 85374-4840
        • Southwest Kidney Institute
    • California
      • Beverly Hills, California, United States, 90211
        • National Heart Institute
      • Sylmar, California, United States, 91342
        • Olive View - UCLA Medical Cente
      • West Hills, California, United States, 91307
        • Interventional Cardiology Medical Group
    • Colorado
      • Littleton, Colorado, United States, 80120
        • South Denver Cardiology Associates
    • Florida
      • Boca Raton, Florida, United States, 33434
        • Flourish Research
      • Gainesville, Florida, United States, 32608
        • University of Florida Health Shands Hospital
      • Jacksonville Beach, Florida, United States, 32250-4303
        • Florida Kidney Physicians LLC
      • Miami, Florida, United States, 33126
        • Total Research Group, LLC
      • Miami, Florida, United States, 33127
        • Bioresearch Partner
    • Georgia
      • Atlanta, Georgia, United States, 30322
        • Emory University School of Medicine
      • Decatur, Georgia, United States, 30033-4004
        • Joseph Maxwell Cleland Atlanta VA Medical Center
      • Macon, Georgia, United States, 31210-1359
        • East Coast Institute For Research LLC
    • Idaho
      • Coeur d'Alene, Idaho, United States, 83814
        • Kootenai Research Services
    • Illinois
      • Chicago, Illinois, United States, 60611
        • Northwestern University
    • Kansas
      • Kansas City, Kansas, United States, 66160
        • University of Kansas Medical Center
      • Wichita, Kansas, United States, 67214
        • Kansas Nephrology Research Institute, LLC
    • Kentucky
      • Louisville, Kentucky, United States, 40202
        • University of Louisville
    • Maryland
      • Baltimore, Maryland, United States, 21239
        • Medstar Health Research Institute
    • Michigan
      • Saint Joseph, Michigan, United States, 49085-8511
        • Lake Michigan Nephrology
      • Shelby, Michigan, United States, 48315
        • St. Clair Nephrology Research, LLC
    • Minnesota
      • Minneapolis, Minnesota, United States, 55417
        • Minneapolis VA Health Care System
    • Mississippi
      • Brookhaven, Mississippi, United States, 39601-2326
        • Southwest Mississippi Nephrology, Pllc
    • Nebraska
      • North Platte, Nebraska, United States, 69101-0614
        • Great Plains Nephrology
    • Nevada
      • North Las Vegas, Nevada, United States, 89086
        • VA Southern Nevada Healthcare System
      • Reno, Nevada, United States, 89511
        • Sierra Nevada Specialty Care
    • New Hampshire
      • Portsmouth, New Hampshire, United States, 03801
        • Seacoast Kidney and Hypertension Specialists
    • New Jersey
      • Bridgewater, New Jersey, United States, 08807
        • Advanced Heart Care, LLC
    • New Mexico
      • Albuquerque, New Mexico, United States, 87106
        • UNM Health Science Center
    • New York
      • New York, New York, United States, 10010-5011
        • VA New York Harbor Healthcare System
    • North Carolina
      • Charlotte, North Carolina, United States, 28208-0014
        • Metrolina Nephrology Associates, PA
      • Charlotte, North Carolina, United States, 28277
        • Metrolina Nephrology Associates, PA
      • Greensboro, North Carolina, United States, 27405-3654
        • Carolina Kidney Associates
      • Winston-Salem, North Carolina, United States, 27103
        • Brookview Hills Research Associates LLC
    • Ohio
      • Cleveland, Ohio, United States, 44106
        • University Hospitals Cleveland Medical Center
    • Pennsylvania
      • Philadelphia, Pennsylvania, United States, 19140
        • Temple University
      • Philadelphia, Pennsylvania, United States, 19114-1028
        • Northeast Endocrine Metabolic Associates
      • Upland, Pennsylvania, United States, 19013
        • Clinical Renal Associates
    • Rhode Island
      • East Providence, Rhode Island, United States, 02914-2641
        • Nephrology Associates, Inc
    • Tennessee
      • Memphis, Tennessee, United States, 38104
        • University of Tennessee
    • Texas
      • Austin, Texas, United States, 78751
        • Research Management, Inc - Austin
      • DeSoto, Texas, United States, 75115-2011
        • Dallas Nephrology Associates Medical Clinic
      • El Paso, Texas, United States, 79935
        • Academy Of Diabetes, Thyroid And Endocrine, PA
      • Lufkin, Texas, United States, 75904
        • P&I Clinical Research, LLC
      • Lufkin, Texas, United States, 75904
        • Texas Institute for Kidney and Endocrine Disorders
      • Pasadena, Texas, United States, 77504-1944
        • Renal Specialists of Houston, PA
      • San Antonio, Texas, United States, 78207
        • University Health
    • Virginia
      • Charlottesville, Virginia, United States, 22903
        • University of Virginia Health System
      • Manassas, Virginia, United States, 20110
        • Kidney and Hypertension Specialists, PLLC
      • Newport News, Virginia, United States, 23606
        • Tidewater Physicians Multispecialty Group
      • Salem, Virginia, United States, 24153
        • Salem VA Medical Center
    • Washington
      • Spokane, Washington, United States, 99204
        • Providence Medical Research Center

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Eligibility Criteria

The key requirements that people who want to participate in a clinical study must meet or the characteristics they must have. Eligibility criteria consist of both inclusion criteria (which are required for a person to participate in the study) and exclusion criteria (which prevent a person from participating). Types of eligibility criteria include whether a study accepts healthy volunteers, has age or age group requirements, or is limited by sex.

Ages Eligible for Study

18 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Description

Key Inclusion Criteria:

  • Evidence of chronic kidney disease (CKD) at risk of kidney disease progression is defined on the basis of local laboratory results recorded at least 3 months before and at the time of the Screening visit, and requires:

    1. Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) eGFR ≥20 <45 mL/min/1.73m² (irrespective of diabetes status); or
    2. No self-reported diabetes: CKD-EPI eGFR ≥45 <90 mL/min/1.73m² with urine albumin-to-creatinine ratio (uACR) ≥150 mg/g (or protein-to-creatinine ratio ≥225 mg/g); or
    3. Self-reported diabetes: CKD-EPI eGFR ≥45 <90 mL/min/1.73m² with uACR ≥30 mg/g (or protein-to-creatinine ratio ≥45 mg/g).

  • Neither requires an Aldosterone Synthase inhibitor (ASi) or Mineralocorticoid Receptor Antagonist (MRA), nor that such treatment is definitely inappropriate.

Key Exclusion Criteria:

  • Blood potassium of >5.2 mmol/L at screening visit
  • Blood Alanine Transaminase (ALT) or Aspartate Transaminase (AST) >3x Upper Limit of Normal (ULN) at Screening visit (only one is required, with ALT preferred)
  • Known liver cirrhosis
  • On dialysis, functioning kidney transplant, or scheduled living donor transplant
  • Treated with new immunosuppression therapy for new (or relapse/flare of pre-existing) kidney disease within the last 60 days
  • Receiving more than one Renin-Angiotensin System (RAS) inhibitor (i.e. on dual therapy with two of an Angiotensin-Converting Enzyme inhibitor (ACEi), Angiotensin Receptor Blocker (ARB) or direct renin inhibitor)
  • Currently treated with an Mineralocorticoid Receptor Antagonist (MRA) (e.g. spironolactone, eplerenone, finerenone)
  • Currently treated with systemic mineralocorticoid replacement therapy (e.g. fludrocortisone) Further exclusion criteria apply.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Quadruple

Arms and Interventions

Participant Group / Arm

Participant Group / Arm

A group or subgroup of participants in a clinical trial that receives a specific intervention/treatment, or no intervention, according to the trial's protocol.
Intervention / Treatment

Intervention / Treatment

A process or action that is the focus of a clinical study. Interventions include drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available. Interventions can also include noninvasive approaches, such as education or modifying diet and exercise.
Experimental: Part 2: Randomized treatment, follow-up period, treatment group
Drug: Empagliflozin

Empagliflozin (called Type E)

Drug: BI 690517

BI 690517 (called Type M randomized treatment)

Other Names:
  • Vicadrostat
Placebo Comparator: Part 2: Follow-up period, placebo group
Drug: Empagliflozin

Empagliflozin (called Type E)

Drug: Placebo matching BI 690517

Placebo matching BI 690517
Other: Part 1: Run-in period (all participants)
  • Participant will receive empagliflozin (called Type E) together with study tablets (called Type F) prior to later randomisation to the main study treatment (Type M).
  • This run-in period allows empagliflozin to be established and have its effects on kidney function before randomisation, and to make sure participant can tolerate empagliflozin long-term. Participants will not routinely know whether type F treatment is active or inactive so that participants can become familiar with taking main study tablet (Type M) after randomization.
Drug: Empagliflozin

Empagliflozin (called Type E)

What is the study measuring?

Primary Outcome Measures

Primary Outcome Measures

In a clinical study's protocol, the planned outcome measure that is the most important for evaluating the effect of an intervention/treatment. Most clinical studies have one primary outcome measure, but some have more than one.
Outcome Measure
Measure Description
Time Frame
Time to first occurrence of the primary composite outcome of: (i) Kidney disease progression*; or (ii) Hospitalization for heart failure; or (iii) Cardiovascular death.
Time Frame: up to 4 years

Kidney disease progression is defined as kidney failure or a sustained decline of ≥40% in estimated Glomerular Filtration Rate (eGFR) from randomization
up to 4 years

Secondary Outcome Measures

Secondary Outcome Measures

In a clinical study's protocol, a planned outcome measure that is not as important as the primary outcome measure for evaluating the effect of an intervention but is still of interest. Most clinical studies have more than one secondary outcome measure.
Outcome Measure
Time Frame
Time to first event of kidney disease progression or cardiovascular death
Time Frame: up to 4 years
up to 4 years
Key secondary outcome: Time to first event of kidney failure, hospitalization for heart failure or cardiovascular death
Time Frame: up to 4 years
up to 4 years
Key secondary outcome: Time to first event of hospitalization for heart failure or cardiovascular death
Time Frame: up to 4 years
up to 4 years
Key secondary outcome: Occurrences of hospitalizations from any cause (first and any subsequent, combined) or death from any cause
Time Frame: up to 4 years
up to 4 years
Key secondary outcome: Time to death from any cause
Time Frame: up to 4 years
up to 4 years
Key secondary outcome: Annual rate of change in eGFR from 1 month until last scheduled visit (i.e. chronic eGFR slope)
Time Frame: up to 4 years
up to 4 years

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Sponsor

The organization or person who initiates the study and who has authority and control over the study.
Boehringer Ingelheim

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

Helpful Links

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

Study Start

The actual date on which the first participant was enrolled in a clinical study. The "anticipated" study start date is the date that the researchers think will be the study start date.
August 30, 2024

Primary Completion (Estimated)

Primary Completion

The date on which the last participant in a clinical study was examined or received an intervention to collect final data for the primary outcome measure. Whether the clinical study ended according to the protocol or was terminated does not affect this date. For clinical studies with more than one primary outcome measure with different completion dates, this term refers to the date on which data collection is completed for all the primary outcome measures. The "anticipated" primary completion date is the date that the researchers think will be the primary completion date for the study.
December 31, 2026

Study Completion (Estimated)

Study Completion

The date on which the last participant in a clinical study was examined or received an intervention/treatment to collect final data for the primary outcome measures, secondary outcome measures, and adverse events (that is, the last participant's last visit). The "anticipated" study completion date is the date that the researchers think will be the study completion date.
December 31, 2026

Study Registration Dates

First Submitted

First Submitted

The date on which the study sponsor or investigator first submitted a study record to ClinicalTrials.gov. There is typically a delay of a few days between the first submitted date and the record's availability on ClinicalTrials.gov (the first posted date).
July 29, 2024

First Submitted That Met QC Criteria

First Submitted That Met QC Criteria

The date on which the study sponsor or investigator first submits a study record that is consistent with National Library of Medicine (NLM) quality control (QC) review criteria. The sponsor or investigator may need to revise and submit a study record one or more times before NLM's QC review criteria are met. It is the responsibility of the sponsor or investigator to ensure that the study record is consistent with the NLM QC review criteria.
July 29, 2024

First Posted (Actual)

First Posted

The date on which the study record was first available on ClinicalTrials.gov after National Library of Medicine (NLM) quality control (QC) review has concluded. There is typically a delay of a few days between the date the study sponsor or investigator submitted the study record and the first posted date.
August 1, 2024

Study Record Updates

Last Update Posted (Actual)

Last Update Posted

The most recent date on which changes to a study record were made available on ClinicalTrials.gov. There may be a delay between when the changes were submitted to ClinicalTrials.gov by the study's sponsor or investigator (the last update submitted date) and the last update posted date.
October 28, 2026

Last Update Submitted That Met QC Criteria

Last Update Submitted That Met QC Criteria

The most recent date on which the study sponsor or investigator submitted changes to a study record that are consistent with National Library of Medicine (NLM) quality control (QC) review criteria. It is the responsibility of the sponsor or investigator to ensure that the study record is consistent with the NLM QC review criteria.
October 27, 2026

Last Verified

Last Verified

The most recent date on which the study sponsor or investigator confirmed the information about a clinical study on ClinicalTrials.gov as accurate and current. If a study with a recruitment status of recruiting; not yet recruiting; or active, not recruiting has not been confirmed within the past 2 years, the study's recruitment status is shown as unknown.
October 1, 2026

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

Other Study ID Numbers

Identifiers or ID numbers other than the NCT number that are assigned to a clinical study by the study's sponsor, funders, or others. These numbers may include unique identifiers from other trial registries and National Institutes of Health grant numbers.
  • 1378-0006
  • 2024-511025-63-00 (Registry Identifier: CTIS)
  • U1111-1306-5049 (Registry Identifier: WHO register (ICTRP))

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

YES

IPD Plan Description

Once the criteria in section "Time Frame" are fulfilled, researchers can use the following link https://www.clinicalstudies.boehringer-ingelheim.com/msw/datasharing to request access to the clinical study documents regarding this study, and upon a signed "Document Sharing Agreement".

Furthermore, researchers can request access to the clinical study data, for this and other listed studies, after the submission of a research proposal and according to the terms outlined in the website.

IPD Sharing Time Frame

One year after the approval has been granted by major Regulatory Authorities and after the primary manuscript has been accepted for publication, or after termination of the development program.

IPD Sharing Access Criteria

For study documents - upon signing of a 'Document Sharing Agreement'. For study data - 1. after the submission and approval of the research proposal (checks will be performed by the sponsor and/or the independent review panel, including checking that the planned analysis does not compete with sponsor's publication plan); 2. and upon signing of a legal agreement.

IPD Sharing Supporting Information Type

  • STUDY_PROTOCOL
  • SAP
  • CSR

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

Yes

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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