Evaluation of a Non-Implanted Electrical Stimulation Device for Overactive Bladder (OAB) (EVANESCE-II)

February 4, 2026 updated by: FemPulse Corporation

Evaluation of a Non-Implanted Electrical Stimulation Device for Overactive Bladder (OAB) EVANESCE-II

A study to evaluate the safety and effectiveness of FemPulse System

Study Overview

Status

Status

Indicates the current recruitment status or the expanded access status.
Recruiting

Conditions

Conditions

The disease, disorder, syndrome, illness, or injury that is being studied. On ClinicalTrials.gov, conditions may also include other health-related issues, such as lifespan, quality of life, and health risks.

Intervention / Treatment

Intervention / Treatment

A process or action that is the focus of a clinical study. Interventions include drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available. Interventions can also include noninvasive approaches, such as education or modifying diet and exercise.

Study Type

Study Type

Describes the nature of a clinical study. Study types include interventional studies (also called clinical trials), observational studies (including patient registries), and expanded access.
Interventional

Enrollment (Estimated)

Enrollment

The number of participants in a clinical study. The "anticipated" enrollment is the target number of participants that the researchers need for the study.
151

Phase

Phase

The stage of a clinical trial studying a drug or biological product, based on definitions developed by the U.S. Food and Drug Administration (FDA). The phase is based on the study's objective, the number of participants, and other characteristics. There are five phases: Early Phase 1 (formerly listed as Phase 0), Phase 1, Phase 2, Phase 3, and Phase 4. Not Applicable is used to describe trials without FDA-defined phases, including trials of devices or behavioral interventions.
  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Contact

The name and contact information for the person who can answer enrollment questions for a clinical study. Each location where the study is being conducted may also have a specific contact, who may be better able to answer those questions.

Study Locations

  • United States
    • California
      • Beverly Hills, California, United States, 90211
        • Recruiting
        • Cedars Sinai
        • Principal Investigator:
          • Karyn Eilber, MD
        • Contact:
      • Los Angeles, California, United States, 90095
        • Not yet recruiting
        • UCLA
        • Contact:
          • Nassura Richard
          • Phone Number: 310-267-4331
        • Principal Investigator:
          • A Lenore Ackerman, MD
      • Orange, California, United States, 92868
        • Recruiting
        • UC Irvine
        • Contact:
          • Bryan Robles
          • Phone Number: 714-509-6130
        • Principal Investigator:
          • Olivia Chang, MD
      • Palo Alto, California, United States, 94304
        • Recruiting
        • Stanford
        • Principal Investigator:
          • Eric Sokol, MD
        • Contact:
          • Kathryn Batham
          • Phone Number: 650-724-7826
      • San Diego, California, United States, 92037
        • Not yet recruiting
        • USCD
        • Principal Investigator:
          • Yahir Santiago-Lastra, MD
        • Contact:
          • Melissa Saurez
          • Phone Number: 858-249-4447
    • Florida
      • Fort Lauderdale, Florida, United States, 33334
        • Not yet recruiting
        • Holy Cross Medical Group - Women's Center
        • Contact:
          • Judie Corbett
          • Phone Number: 954-542-4841
        • Principal Investigator:
          • Guillermo Davila, MD
    • Illinois
      • Barrington, Illinois, United States, 60010
        • Recruiting
        • Comprehensive Urologic
        • Contact:
          • Sunny Sian
          • Phone Number: 847-852-1777
        • Principal Investigator:
          • Tamra Lewis, MD
    • Kentucky
      • Louisville, Kentucky, United States, 40205
        • Not yet recruiting
        • University of Louisville
        • Principal Investigator:
          • Sean Francis, MD
        • Contact:
          • Decora Whalen
          • Phone Number: 502-588-4412
    • Maryland
      • Owings Mills, Maryland, United States, 21117
        • Recruiting
        • Chesapeake Urology
        • Principal Investigator:
          • Laura Giusto, MD
        • Contact:
          • Seema Shahi
          • Phone Number: 410-616-8431
    • Minnesota
      • Woodbury, Minnesota, United States, 55125
        • Not yet recruiting
        • Minnesota Urology
        • Contact:
          • Carrie McKenzie
          • Phone Number: 651-999-6903
        • Principal Investigator:
          • Jodi Michaels, MD
    • Nebraska
      • Omaha, Nebraska, United States, 68114
        • Recruiting
        • Adult & Pediatric Urology
        • Principal Investigator:
          • Rebecca McCrery, MD
        • Contact:
          • Peyton Schneider
          • Phone Number: 402-399-7898
    • North Carolina
      • Charlotte, North Carolina, United States, 28204
        • Not yet recruiting
        • Atrium Health
        • Principal Investigator:
          • Michael Kennelly, MD
        • Contact:
          • Robbin Clark
          • Phone Number: 704-355-7466
    • South Carolina
      • West Columbia, South Carolina, United States, 29169
        • Recruiting
        • Southern Urogynecology
        • Principal Investigator:
          • Andrea Pezzella, MD
        • Contact:
          • Tina McCready
          • Phone Number: 803-457-7000
    • South Dakota
      • Sioux Falls, South Dakota, United States, 57105
        • Recruiting
        • Sanford Health
        • Principal Investigator:
          • Kevin Benson, MD
        • Contact:
          • Jennifer Pratt
          • Phone Number: 605-328-1391
    • Virginia
      • Falls Church, Virginia, United States, 22042
        • Not yet recruiting
        • Inova
        • Contact:
          • Claudia Lovo-Alvarez
          • Phone Number: 703-776-4600
        • Principal Investigator:
          • Abbas Shobeiri, MD

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Eligibility Criteria

The key requirements that people who want to participate in a clinical study must meet or the characteristics they must have. Eligibility criteria consist of both inclusion criteria (which are required for a person to participate in the study) and exclusion criteria (which prevent a person from participating). Types of eligibility criteria include whether a study accepts healthy volunteers, has age or age group requirements, or is limited by sex.

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Description

Key Inclusion Criteria:

  • Females, defined as a person with a uterus and cervix, ≥21 years old, with a diagnosis of OAB and symptoms for more than 6 months, as confirmed by a physician. OAB is defined by urinary urgency, usually with urinary frequency and nocturia, with or without urgency urinary incontinence with symptoms
  • Willing and able to comply with study required procedures and visits (e.g., maintaining consistent medication use, fluid intake, diary completion).

Key Exclusion Criteria:

  • Systemic condition or disease that may interfere with study participation (e.g., current systemic infection, uncontrolled autoimmune disease, uncontrolled immunodeficiency disease, history of myocardial infarction, etc.) as determined by study investigator.
  • Not an appropriate study candidate as determined by investigator.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm

Participant Group / Arm

A group or subgroup of participants in a clinical trial that receives a specific intervention/treatment, or no intervention, according to the trial's protocol.
Intervention / Treatment

Intervention / Treatment

A process or action that is the focus of a clinical study. Interventions include drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available. Interventions can also include noninvasive approaches, such as education or modifying diet and exercise.
Experimental: Device Group
Subjects receiving the FemPulse System
Device: Device Group
non-implanted, vaginal electrical stimulation device
Other: Medication Group
Subjects receiving medication
Drug: Medication Group
OAB Medication

What is the study measuring?

Primary Outcome Measures

Primary Outcome Measures

In a clinical study's protocol, the planned outcome measure that is the most important for evaluating the effect of an intervention/treatment. Most clinical studies have one primary outcome measure, but some have more than one.
Outcome Measure
Measure Description
Time Frame
Mean Change in Voids per Day
Time Frame: 6 months
Difference in mean change between device and medication groups in number of voids per day (VPD)
6 months

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Sponsor

The organization or person who initiates the study and who has authority and control over the study.
FemPulse Corporation

Collaborators

Collaborators

An organization other than the sponsor that provides support for a clinical study. This support may include activities related to funding, design, implementation, data analysis, or reporting.
Moxie Clinical

Investigators

Investigators

A researcher involved in a clinical study. Related terms include site principal investigator, site sub-investigator, study chair, study director, and study principal investigator.
  • Principal Investigator: Suzette Sutherland, MD, FemPulse Corporation

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

Study Start

The actual date on which the first participant was enrolled in a clinical study. The "anticipated" study start date is the date that the researchers think will be the study start date.
September 30, 2025

Primary Completion (Estimated)

Primary Completion

The date on which the last participant in a clinical study was examined or received an intervention to collect final data for the primary outcome measure. Whether the clinical study ended according to the protocol or was terminated does not affect this date. For clinical studies with more than one primary outcome measure with different completion dates, this term refers to the date on which data collection is completed for all the primary outcome measures. The "anticipated" primary completion date is the date that the researchers think will be the primary completion date for the study.
May 31, 2027

Study Completion (Estimated)

Study Completion

The date on which the last participant in a clinical study was examined or received an intervention/treatment to collect final data for the primary outcome measures, secondary outcome measures, and adverse events (that is, the last participant's last visit). The "anticipated" study completion date is the date that the researchers think will be the study completion date.
December 31, 2027

Study Registration Dates

First Submitted

First Submitted

The date on which the study sponsor or investigator first submitted a study record to ClinicalTrials.gov. There is typically a delay of a few days between the first submitted date and the record's availability on ClinicalTrials.gov (the first posted date).
September 24, 2025

First Submitted That Met QC Criteria

First Submitted That Met QC Criteria

The date on which the study sponsor or investigator first submits a study record that is consistent with National Library of Medicine (NLM) quality control (QC) review criteria. The sponsor or investigator may need to revise and submit a study record one or more times before NLM's QC review criteria are met. It is the responsibility of the sponsor or investigator to ensure that the study record is consistent with the NLM QC review criteria.
September 24, 2025

First Posted (Actual)

First Posted

The date on which the study record was first available on ClinicalTrials.gov after National Library of Medicine (NLM) quality control (QC) review has concluded. There is typically a delay of a few days between the date the study sponsor or investigator submitted the study record and the first posted date.
September 29, 2025

Study Record Updates

Last Update Posted (Actual)

Last Update Posted

The most recent date on which changes to a study record were made available on ClinicalTrials.gov. There may be a delay between when the changes were submitted to ClinicalTrials.gov by the study's sponsor or investigator (the last update submitted date) and the last update posted date.
February 6, 2026

Last Update Submitted That Met QC Criteria

Last Update Submitted That Met QC Criteria

The most recent date on which the study sponsor or investigator submitted changes to a study record that are consistent with National Library of Medicine (NLM) quality control (QC) review criteria. It is the responsibility of the sponsor or investigator to ensure that the study record is consistent with the NLM QC review criteria.
February 4, 2026

Last Verified

Last Verified

The most recent date on which the study sponsor or investigator confirmed the information about a clinical study on ClinicalTrials.gov as accurate and current. If a study with a recruitment status of recruiting; not yet recruiting; or active, not recruiting has not been confirmed within the past 2 years, the study's recruitment status is shown as unknown.
September 1, 2025

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

Other Study ID Numbers

Identifiers or ID numbers other than the NCT number that are assigned to a clinical study by the study's sponsor, funders, or others. These numbers may include unique identifiers from other trial registries and National Institutes of Health grant numbers.
  • CIP012

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

Yes

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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Conditions

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Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations

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