An Open Label Extension (OLE) Study (Following Completion of CTQJ230A12301) to Evaluate Long-term Safety and Tolerability of Pelacarsen (TQJ230)

June 8, 2026 updated by: Novartis Pharmaceuticals

A Single Arm, Multicenter, Open-label Extension (OLE) Trial to Evaluate Long-term Safety and Tolerability of Pelacarsen (TQJ230) in Participants Who Completed the Parent Lp(a)HORIZON Trial

This open-label extension study will provide post-trial access to pelacarsen (TQJ230) to participants who have successfully completed the double-blind parent study (CTQJ230A12301).

Study Overview

Status

Status

Indicates the current recruitment status or the expanded access status.
Recruiting

Conditions

Conditions

The disease, disorder, syndrome, illness, or injury that is being studied. On ClinicalTrials.gov, conditions may also include other health-related issues, such as lifespan, quality of life, and health risks.

Intervention / Treatment

Intervention / Treatment

A process or action that is the focus of a clinical study. Interventions include drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available. Interventions can also include noninvasive approaches, such as education or modifying diet and exercise.

Detailed Description

This study will evaluate long-term safety and tolerability of pelacarsen (TQJ230) 80 mg Once a month (QM) in participants with established cardiovascular disease and elevated Lp(a) who completed the parent study (CTQJ230A12301).

Study Type

Study Type

Describes the nature of a clinical study. Study types include interventional studies (also called clinical trials), observational studies (including patient registries), and expanded access.
Interventional

Enrollment (Estimated)

Enrollment

The number of participants in a clinical study. The "anticipated" enrollment is the target number of participants that the researchers need for the study.
5700

Phase

Phase

The stage of a clinical trial studying a drug or biological product, based on definitions developed by the U.S. Food and Drug Administration (FDA). The phase is based on the study's objective, the number of participants, and other characteristics. There are five phases: Early Phase 1 (formerly listed as Phase 0), Phase 1, Phase 2, Phase 3, and Phase 4. Not Applicable is used to describe trials without FDA-defined phases, including trials of devices or behavioral interventions.
  • Phase 3

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Contact

The name and contact information for the person who can answer enrollment questions for a clinical study. Each location where the study is being conducted may also have a specific contact, who may be better able to answer those questions.

Study Contact Backup

  • Name: Novartis Pharmaceuticals
  • Phone Number: +41613241111

Study Locations

  • Argentina
      • Buenos Aires, Argentina, C1280AEB
        • Recruiting
        • Novartis Investigative Site
      • Caba, Argentina, C1427CCL
        • Recruiting
        • Novartis Investigative Site
      • Capital Federal, Argentina, C1023AAB
        • Recruiting
        • Novartis Investigative Site
      • Corrientes, Argentina, W3400CDS
        • Recruiting
        • Novartis Investigative Site
      • Córdoba, Argentina, X5002HWE
        • Active, not recruiting
        • Novartis Investigative Site
      • San Luis, Argentina, D5702JRS
        • Recruiting
        • Novartis Investigative Site
    • Buenos Aires
      • CABA, Buenos Aires, Argentina, C1407FWE
        • Recruiting
        • Novartis Investigative Site
      • Caba, Buenos Aires, Argentina, C1119ACN
        • Recruiting
        • Novartis Investigative Site
      • Mar del Plata, Buenos Aires, Argentina, 7600
        • Recruiting
        • Novartis Investigative Site
      • Mar del Plata, Buenos Aires, Argentina, B7600ENA
        • Recruiting
        • Novartis Investigative Site
      • Ramos Mejía, Buenos Aires, Argentina, B1704ETD
        • Recruiting
        • Novartis Investigative Site
    • Buenos Aires F.D.
      • CABA, Buenos Aires F.D., Argentina, C1426ABP
        • Recruiting
        • Novartis Investigative Site
    • Córdoba Province
      • Córdoba, Córdoba Province, Argentina, 5000
        • Recruiting
        • Novartis Investigative Site
    • San Miguel de Tucuman
      • San Miguel de Tucumán, San Miguel de Tucuman, Argentina, T4000ICL
        • Recruiting
        • Novartis Investigative Site
      • San Miguel de Tucumán, San Miguel de Tucuman, Argentina, T4000AAL
        • Recruiting
        • Novartis Investigative Site
    • Santa Fe Province
      • Rosario, Santa Fe Province, Argentina, S2000CVD
        • Recruiting
        • Novartis Investigative Site
      • Rosario, Santa Fe Province, Argentina, S2000DTB
        • Active, not recruiting
        • Novartis Investigative Site
      • Santa Fe, Santa Fe Province, Argentina, S3000FWO
        • Recruiting
        • Novartis Investigative Site
  • Australia
    • New South Wales
      • Camperdown, New South Wales, Australia, 2050
        • Recruiting
        • Novartis Investigative Site
      • Liverpool, New South Wales, Australia, 2170
        • Recruiting
        • Novartis Investigative Site
    • Queensland
      • Chemside, Queensland, Australia, 4032
        • Recruiting
        • Novartis Investigative Site
      • Woolloongabba, Queensland, Australia, 4102
        • Recruiting
        • Novartis Investigative Site
    • Victoria
      • Clayton, Victoria, Australia, 3168
        • Recruiting
        • Novartis Investigative Site
    • Western Australia
      • Perth, Western Australia, Australia, 6000
        • Recruiting
        • Novartis Investigative Site
  • Austria
      • Graz, Austria, 8036
        • Recruiting
        • Novartis Investigative Site
      • Innsbruck, Austria, 6020
        • Recruiting
        • Novartis Investigative Site
      • Linz, Austria, 4021
        • Recruiting
        • Novartis Investigative Site
      • Salzburg, Austria, 5020
        • Recruiting
        • Novartis Investigative Site
      • Vienna, Austria, 1090
        • Recruiting
        • Novartis Investigative Site
      • Vienna, Austria, 1210
        • Recruiting
        • Novartis Investigative Site
  • Belgium
      • Bruges, Belgium, 8000
        • Recruiting
        • Novartis Investigative Site
      • Dendermonde, Belgium, 9200
        • Recruiting
        • Novartis Investigative Site
      • Huy, Belgium, 4500
        • Recruiting
        • Novartis Investigative Site
      • Mechelen, Belgium, 2800
        • Recruiting
        • Novartis Investigative Site
    • Brussels Capital
      • Brussels, Brussels Capital, Belgium, 1070
        • Recruiting
        • Novartis Investigative Site
    • Limburg
      • Genk, Limburg, Belgium, 3600
        • Recruiting
        • Novartis Investigative Site
    • Oost Vlaanderen
      • Aalst, Oost Vlaanderen, Belgium, 9300
        • Recruiting
        • Novartis Investigative Site
    • West-Vlaanderen
      • Kortrijk, West-Vlaanderen, Belgium, 8500
        • Recruiting
        • Novartis Investigative Site
  • Brazil
      • Rio de Janeiro, Brazil, 20241-180
        • Recruiting
        • Novartis Investigative Site
    • Espírito Santo
      • Vitória, Espírito Santo, Brazil, 29055-450
        • Recruiting
        • Novartis Investigative Site
    • Estado de Bahia
      • Salvador, Estado de Bahia, Brazil, 40170-130
        • Recruiting
        • Novartis Investigative Site
    • Goiás
      • Goiânia, Goiás, Brazil, 74605-020
        • Recruiting
        • Novartis Investigative Site
    • Minas Gerais
      • Belo Horizonte, Minas Gerais, Brazil, 30150-270
        • Recruiting
        • Novartis Investigative Site
      • Belo Horizonte, Minas Gerais, Brazil, 30150-320
        • Recruiting
        • Novartis Investigative Site
      • Juiz de Fora, Minas Gerais, Brazil, 36033-318
        • Recruiting
        • Novartis Investigative Site
      • Uberlândia, Minas Gerais, Brazil, 38400 500
        • Recruiting
        • Novartis Investigative Site
    • Paraná
      • Curitiba, Paraná, Brazil, 80730-150
        • Recruiting
        • Novartis Investigative Site
    • Rio Grande do Sul
      • Canoas, Rio Grande do Sul, Brazil, 92425 900
        • Recruiting
        • Novartis Investigative Site
      • Porto Alegre, Rio Grande do Sul, Brazil, 90880-480
        • Recruiting
        • Novartis Investigative Site
      • Porto Alegre, Rio Grande do Sul, Brazil, 90160-093
        • Recruiting
        • Novartis Investigative Site
    • Santa Catarina
      • Blumenau, Santa Catarina, Brazil, 89020-430
        • Recruiting
        • Novartis Investigative Site
    • Sergipe
      • Aracaju, Sergipe, Brazil, 49055-530
        • Recruiting
        • Novartis Investigative Site
    • São Paulo
      • Campinas, São Paulo, Brazil, 13060 080
        • Recruiting
        • Novartis Investigative Site
      • Campinas, São Paulo, Brazil, 13092133
        • Recruiting
        • Novartis Investigative Site
      • Ribeirão Preto, São Paulo, Brazil, 14026-020
        • Recruiting
        • Novartis Investigative Site
      • Santo André, São Paulo, Brazil, 09090-790
        • Recruiting
        • Novartis Investigative Site
      • Santo André, São Paulo, Brazil, 09060-870
        • Recruiting
        • Novartis Investigative Site
      • Sao Jose Rio Preto, São Paulo, Brazil, 15090 000
        • Recruiting
        • Novartis Investigative Site
      • Sao Jose Rio Preto, São Paulo, Brazil, 15015-750
        • Recruiting
        • Novartis Investigative Site
      • São Paulo, São Paulo, Brazil, 05403 000
        • Recruiting
        • Novartis Investigative Site
      • São Paulo, São Paulo, Brazil, 01323 000
        • Recruiting
        • Novartis Investigative Site
      • São Paulo, São Paulo, Brazil, 04005-003
        • Recruiting
        • Novartis Investigative Site
      • São Paulo, São Paulo, Brazil, 04266 010
        • Recruiting
        • Novartis Investigative Site
      • São Paulo, São Paulo, Brazil, 05403-900
        • Recruiting
        • Novartis Investigative Site
  • Bulgaria
      • Burgas, Bulgaria, 8001
        • Recruiting
        • Novartis Investigative Site
      • Pernik, Bulgaria, 2300
        • Recruiting
        • Novartis Investigative Site
      • Pleven, Bulgaria, 5800
        • Recruiting
        • Novartis Investigative Site
      • Plovdiv, Bulgaria, 4000
        • Recruiting
        • Novartis Investigative Site
      • Rousse, Bulgaria, 7002
        • Recruiting
        • Novartis Investigative Site
      • Sofia, Bulgaria, 1233
        • Recruiting
        • Novartis Investigative Site
  • Canada
    • British Columbia
      • Vancouver, British Columbia, Canada, V5Z 1M9
        • Recruiting
        • Novartis Investigative Site
    • Ontario
      • Oakville, Ontario, Canada, L6K 3W7
        • Recruiting
        • Novartis Investigative Site
      • Toronto, Ontario, Canada, M9V 4B4
        • Recruiting
        • Novartis Investigative Site
    • Quebec
      • Lévis, Quebec, Canada, G6V 4Z5
        • Recruiting
        • Novartis Investigative Site
      • Montreal, Quebec, Canada, H3T 1E2
        • Recruiting
        • Novartis Investigative Site
      • Montreal, Quebec, Canada, H1T 1C8
        • Recruiting
        • Novartis Investigative Site
      • Québec, Quebec, Canada, G1R 2J6
        • Recruiting
        • Novartis Investigative Site
      • Québec, Quebec, Canada, G1V 4W2
        • Recruiting
        • Novartis Investigative Site
  • China
      • Beijing, China, 100730
        • Recruiting
        • Novartis Investigative Site
      • Beijing, China, 100050
        • Recruiting
        • Novartis Investigative Site
      • Beijing, China, 100191
        • Recruiting
        • Novartis Investigative Site
      • Shanghai, China, 200025
        • Recruiting
        • Novartis Investigative Site
      • Shanghai, China, 200040
        • Recruiting
        • Novartis Investigative Site
      • Shanghai, China, 200120
        • Recruiting
        • Novartis Investigative Site
      • Shanghai, China, 200065
        • Recruiting
        • Novartis Investigative Site
      • Tianjin, China, 300052
        • Recruiting
        • Novartis Investigative Site
      • Tianjin, China, 030045
        • Recruiting
        • Novartis Investigative Site
      • Tianjin, China, 300121
        • Recruiting
        • Novartis Investigative Site
      • Xiamen, China, 361004
        • Recruiting
        • Novartis Investigative Site
    • Beijing Municipality
      • Beijing, Beijing Municipality, China, 100013
        • Recruiting
        • Novartis Investigative Site
    • Gansu
      • Lanzhou, Gansu, China, 730030
        • Recruiting
        • Novartis Investigative Site
    • Guangdong
      • Foshan, Guangdong, China, 528000
        • Recruiting
        • Novartis Investigative Site
      • Guangzhou, Guangdong, China, 510080
        • Recruiting
        • Novartis Investigative Site
    • Heilongjiang
      • Harbin, Heilongjiang, China, 150000
        • Recruiting
        • Novartis Investigative Site
    • Hunan
      • Changsha, Hunan, China, 410011
        • Recruiting
        • Novartis Investigative Site
      • Changsha, Hunan, China, 410003
        • Recruiting
        • Novartis Investigative Site
      • Changsha, Hunan, China, 410008
        • Recruiting
        • Novartis Investigative Site
    • Inner Mongolia
      • Baotou, Inner Mongolia, China, 014040
        • Recruiting
        • Novartis Investigative Site
    • Jiangsu
      • Nanjing, Jiangsu, China, 210009
        • Recruiting
        • Novartis Investigative Site
      • Nanjing, Jiangsu, China, 210029
        • Recruiting
        • Novartis Investigative Site
      • Nanjing, Jiangsu, China, 211166
        • Recruiting
        • Novartis Investigative Site
      • Suzhou, Jiangsu, China, 215004
        • Recruiting
        • Novartis Investigative Site
      • Xuzhou, Jiangsu, China, 221003
        • Recruiting
        • Novartis Investigative Site
    • Jilin
      • Changchun, Jilin, China, 130021
        • Recruiting
        • Novartis Investigative Site
    • Liaoning
      • Dalian, Liaoning, China, 116011
        • Recruiting
        • Novartis Investigative Site
      • Shenyang, Liaoning, China, 110016
        • Recruiting
        • Novartis Investigative Site
      • Shenyang, Liaoning, China, 110004
        • Recruiting
        • Novartis Investigative Site
    • Shandong
      • Jinan, Shandong, China, 250013
        • Recruiting
        • Novartis Investigative Site
    • Shanxi
      • Xian, Shanxi, China, 710061
        • Recruiting
        • Novartis Investigative Site
    • Sichuan
      • Chengdu, Sichuan, China, 610041
        • Recruiting
        • Novartis Investigative Site
    • Xinjiang
      • Ürümqi, Xinjiang, China, 830054
        • Recruiting
        • Novartis Investigative Site
    • Zhejiang
      • Hangzhou, Zhejiang, China, 310014
        • Recruiting
        • Novartis Investigative Site
      • Hangzhou, Zhejiang, China, 310016
        • Recruiting
        • Novartis Investigative Site
      • Wenzhou, Zhejiang, China, 325000
        • Recruiting
        • Novartis Investigative Site
  • Colombia
      • Bogotá, Colombia, 111211
        • Recruiting
        • Novartis Investigative Site
      • Medellín, Colombia, 050037
        • Recruiting
        • Novartis Investigative Site
      • San Gil, Colombia, 684031
        • Recruiting
        • Novartis Investigative Site
    • Antioquia
      • Medellín, Antioquia, Colombia, 050001
        • Recruiting
        • Novartis Investigative Site
    • Colombia
      • Barranquilla, Colombia, Colombia, 080020
        • Recruiting
        • Novartis Investigative Site
    • Santander Department
      • Bucaramanga, Santander Department, Colombia, 681017
        • Recruiting
        • Novartis Investigative Site
    • Valle del Cauca Department
      • Cali, Valle del Cauca Department, Colombia, 760032
        • Recruiting
        • Novartis Investigative Site
      • Cali, Valle del Cauca Department, Colombia, 760001
        • Recruiting
        • Novartis Investigative Site
  • Czechia
      • Brandýs nad Labem, Czechia, 250 01
        • Recruiting
        • Novartis Investigative Site
      • Brno, Czechia, 625 00
        • Recruiting
        • Novartis Investigative Site
      • Brno, Czechia, 602 00
        • Recruiting
        • Novartis Investigative Site
      • Broumov, Czechia, 550 01
        • Recruiting
        • Novartis Investigative Site
      • CZE, Czechia, 110 00
        • Recruiting
        • Novartis Investigative Site
      • Hlučín, Czechia, 748 01
        • Recruiting
        • Novartis Investigative Site
      • Hodonín, Czechia, 695 01
        • Recruiting
        • Novartis Investigative Site
      • Jihlava, Czechia, 586 01
        • Recruiting
        • Novartis Investigative Site
      • Kolín, Czechia, 280 20
        • Recruiting
        • Novartis Investigative Site
      • Liberec, Czechia, 460 01
        • Recruiting
        • Novartis Investigative Site
      • Liberec, Czechia, 460 05
        • Recruiting
        • Novartis Investigative Site
      • Mariánské Lázně, Czechia, 353 01
        • Recruiting
        • Novartis Investigative Site
      • Most, Czechia, 434 01
        • Recruiting
        • Novartis Investigative Site
      • Mělník, Czechia, 276 01
        • Recruiting
        • Novartis Investigative Site
      • Olomouc, Czechia, 779 00
        • Recruiting
        • Novartis Investigative Site
      • Ostrava, Czechia, 700 30
        • Recruiting
        • Novartis Investigative Site
      • Pardubice, Czechia, 532 03
        • Recruiting
        • Novartis Investigative Site
      • Polička, Czechia, 57201
        • Recruiting
        • Novartis Investigative Site
      • Prague, Czechia, 128 08
        • Recruiting
        • Novartis Investigative Site
      • Prague, Czechia, 110 00
        • Recruiting
        • Novartis Investigative Site
      • Přerov, Czechia, 751 52
        • Withdrawn
        • Novartis Investigative Site
      • Slaný, Czechia, 274 01
        • Recruiting
        • Novartis Investigative Site
      • Trutnov, Czechia, 460 63
        • Recruiting
        • Novartis Investigative Site
      • Třebíč, Czechia, 674 01
        • Recruiting
        • Novartis Investigative Site
      • Uherské Hradiště, Czechia, 686 01
        • Recruiting
        • Novartis Investigative Site
      • Valašské Meziříčí, Czechia, 75742
        • Recruiting
        • Novartis Investigative Site
      • Zlín, Czechia, 760 01
        • Recruiting
        • Novartis Investigative Site
      • Český Krumlov, Czechia, 381 01
        • Recruiting
        • Novartis Investigative Site
    • Chlumec Nad Cidlinou
      • Chlumec nad Cidlinou, Chlumec Nad Cidlinou, Czechia, 503 51
        • Recruiting
        • Novartis Investigative Site
    • Czech Republic
      • Kroměříž, Czech Republic, Czechia, 767 55
        • Recruiting
        • Novartis Investigative Site
      • Louny, Czech Republic, Czechia, 440 01
        • Recruiting
        • Novartis Investigative Site
      • Ostrava, Czech Republic, Czechia, 725 27
        • Recruiting
        • Novartis Investigative Site
      • Ústí nad Labem, Czech Republic, Czechia, 400 01
        • Recruiting
        • Novartis Investigative Site
    • Zabreh
      • Ostrava, Zabreh, Czechia, 700 30
        • Recruiting
        • Novartis Investigative Site
  • Denmark
      • Aarhus N, Denmark, 8200
        • Recruiting
        • Novartis Investigative Site
      • Copenhagen, Denmark, DK-2100
        • Recruiting
        • Novartis Investigative Site
      • Esbjerg, Denmark, 6700
        • Recruiting
        • Novartis Investigative Site
      • Gistrup, Denmark, 9260
        • Recruiting
        • Novartis Investigative Site
      • Herlev, Denmark, DK-2730
        • Recruiting
        • Novartis Investigative Site
      • Roskilde, Denmark, 4000
        • Recruiting
        • Novartis Investigative Site
      • Viborg, Denmark, 8800
        • Recruiting
        • Novartis Investigative Site
  • France
      • Bron, France, 69677
        • Recruiting
        • Novartis Investigative Site
      • Chambray-lès-Tours, France, 37170
        • Recruiting
        • Novartis Investigative Site
      • Compiègne, France, 60321
        • Recruiting
        • Novartis Investigative Site
      • Grenoble, France, 38043
        • Recruiting
        • Novartis Investigative Site
      • Le Coudray, France, 28630
        • Recruiting
        • Novartis Investigative Site
      • Nantes, France, 44093
        • Recruiting
        • Novartis Investigative Site
      • Paris, France, 75018
        • Recruiting
        • Novartis Investigative Site
      • Toulouse, France, 31054
        • Recruiting
        • Novartis Investigative Site
      • Valenciennes, France, 59300
        • Recruiting
        • Novartis Investigative Site
  • Germany
      • Aachen, Germany, 52074
        • Recruiting
        • Novartis Investigative Site
      • Bad Homburg, Germany, 61348
        • Recruiting
        • Novartis Investigative Site
      • Bad Krozingen, Germany, 79189
        • Recruiting
        • Novartis Investigative Site
      • Bad Oeynhausen, Germany, 32545
        • Recruiting
        • Novartis Investigative Site
      • Bamberg, Germany, 96049
        • Recruiting
        • Novartis Investigative Site
      • Berlin, Germany, 13353
        • Recruiting
        • Novartis Investigative Site
      • Berlin, Germany, 10787
        • Recruiting
        • Novartis Investigative Site
      • Berlin, Germany, 10367
        • Recruiting
        • Novartis Investigative Site
      • Berlin, Germany, 10789
        • Recruiting
        • Novartis Investigative Site
      • Berlin, Germany, 13347
        • Recruiting
        • Novartis Investigative Site
      • Berlin, Germany, 10559
        • Recruiting
        • Novartis Investigative Site
      • Bielefeld, Germany, 33604
        • Recruiting
        • Novartis Investigative Site
      • Dessau, Germany, 06846
        • Recruiting
        • Novartis Investigative Site
      • Dortmund, Germany, 44137
        • Recruiting
        • Novartis Investigative Site
      • Dresden, Germany, 01307
        • Recruiting
        • Novartis Investigative Site
      • Dresden, Germany, 01069
        • Recruiting
        • Novartis Investigative Site
      • Dresden, Germany, 01277
        • Recruiting
        • Novartis Investigative Site
      • Essen, Germany, 45277
        • Recruiting
        • Novartis Investigative Site
      • Essen, Germany, 45355
        • Recruiting
        • Novartis Investigative Site
      • Essen, Germany, 45359
        • Recruiting
        • Novartis Investigative Site
      • Gelnhausen, Germany, 63571
        • Recruiting
        • Novartis Investigative Site
      • Hamburg, Germany, 22041
        • Recruiting
        • Novartis Investigative Site
      • Hamburg, Germany, 22607
        • Recruiting
        • Novartis Investigative Site
      • Kassel, Germany, 34121
        • Recruiting
        • Novartis Investigative Site
      • Lüneburg, Germany, 21339
        • Recruiting
        • Novartis Investigative Site
      • Magdeburg, Germany, 39120
        • Recruiting
        • Novartis Investigative Site
      • Mannheim, Germany, 68165
        • Recruiting
        • Novartis Investigative Site
      • Meissen, Germany, 01662
        • Recruiting
        • Novartis Investigative Site
      • München, Germany, 80636
        • Recruiting
        • Novartis Investigative Site
      • Münster, Germany, 48149
        • Recruiting
        • Novartis Investigative Site
      • Potsdam, Germany, 14471
        • Recruiting
        • Novartis Investigative Site
      • Rüdersdorf, Germany, 15562
        • Recruiting
        • Novartis Investigative Site
      • Ulm, Germany, 89077
        • Recruiting
        • Novartis Investigative Site
      • Warendorf, Germany, 48231
        • Recruiting
        • Novartis Investigative Site
    • Baden-Wurttemberg
      • Mannheim, Baden-Wurttemberg, Germany, 68305
        • Recruiting
        • Novartis Investigative Site
    • Bavaria
      • Muehldorf Am Inn, Bavaria, Germany, 84453
        • Recruiting
        • Novartis Investigative Site
      • Munich, Bavaria, Germany, 81377
        • Recruiting
        • Novartis Investigative Site
      • Weiden in Der Oberpfalz, Bavaria, Germany, 92637
        • Recruiting
        • Novartis Investigative Site
    • Hesse
      • Frankfurt am Main, Hesse, Germany, 60590
        • Recruiting
        • Novartis Investigative Site
      • Frankfurt am Main, Hesse, Germany, 60594
        • Recruiting
        • Novartis Investigative Site
    • Lower Saxony
      • Hanover, Lower Saxony, Germany, 30159
        • Recruiting
        • Novartis Investigative Site
    • North Rhine-Westphalia
      • Cologne, North Rhine-Westphalia, Germany, 50937
        • Recruiting
        • Novartis Investigative Site
      • Cologne, North Rhine-Westphalia, Germany, 50733
        • Recruiting
        • Novartis Investigative Site
      • Essen, North Rhine-Westphalia, Germany, 45355
        • Recruiting
        • Novartis Investigative Site
      • Löhne, North Rhine-Westphalia, Germany, 32584
        • Recruiting
        • Novartis Investigative Site
    • Saarland
      • Saint Ingbert, Saarland, Germany, 66386
        • Recruiting
        • Novartis Investigative Site
    • Saxony
      • Chemnitz, Saxony, Germany, 09113
        • Recruiting
        • Novartis Investigative Site
      • Dresden, Saxony, Germany, 01307
        • Recruiting
        • Novartis Investigative Site
      • Dresden, Saxony, Germany, 01099
        • Recruiting
        • Novartis Investigative Site
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      • Bielsko-Biala, Poland, 43-316
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        • Recruiting
        • Novartis Investigative Site
  • Turkey (Türkiye)
      • Izmir, Turkey (Türkiye), 35100
        • Recruiting
        • Novartis Investigative Site
    • Balcova
      • Izmir, Balcova, Turkey (Türkiye), 35340
        • Recruiting
        • Novartis Investigative Site
    • Bilkent-Cankaya
      • Ankara, Bilkent-Cankaya, Turkey (Türkiye), 06800
        • Recruiting
        • Novartis Investigative Site
    • Fatih
      • Istanbul, Fatih, Turkey (Türkiye), 34098
        • Recruiting
        • Novartis Investigative Site
    • Kadikoy
      • Istanbul, Kadikoy, Turkey (Türkiye), 34668
        • Recruiting
        • Novartis Investigative Site
    • Odunpazari
      • Eskişehir, Odunpazari, Turkey (Türkiye), 26040
        • Recruiting
        • Novartis Investigative Site
    • Samsun
      • Samsun, Samsun, Turkey (Türkiye), 55080
        • Recruiting
        • Novartis Investigative Site
    • Yenisehir
      • Mersin, Yenisehir, Turkey (Türkiye), 33110
        • Recruiting
        • Novartis Investigative Site
  • United Kingdom
      • Birmingham, United Kingdom, B9 5SS
        • Recruiting
        • Novartis Investigative Site
      • Bristol, United Kingdom, BS2 8HW
        • Recruiting
        • Novartis Investigative Site
      • Bromwich, United Kingdom, B71 4HJ
        • Recruiting
        • Novartis Investigative Site
      • Cardiff, United Kingdom, CF64 2XX
        • Recruiting
        • Novartis Investigative Site
      • Chesterfield, United Kingdom, S40 4AA
        • Recruiting
        • Novartis Investigative Site
      • Edinburgh, United Kingdom, EH16 4SA
        • Recruiting
        • Novartis Investigative Site
      • Glasgow, United Kingdom, G20 7BE
        • Recruiting
        • Novartis Investigative Site
      • London, United Kingdom, W12 0HS
        • Recruiting
        • Novartis Investigative Site
      • Londonderry, United Kingdom, BT47 6SB
        • Recruiting
        • Novartis Investigative Site
      • Manchester, United Kingdom, M13 9WL
        • Recruiting
        • Novartis Investigative Site
      • Middlesbrough, United Kingdom, TS4 3BW
        • Recruiting
        • Novartis Investigative Site
      • Middlesex, United Kingdom, UB9 6JH
        • Recruiting
        • Novartis Investigative Site
      • Newport, United Kingdom, NP20 2UB
        • Recruiting
        • Novartis Investigative Site
      • Norwich, United Kingdom, NR4 7UY
        • Recruiting
        • Novartis Investigative Site
      • Plymouth, United Kingdom, PL6 8DH
        • Recruiting
        • Novartis Investigative Site
      • Rhyl, United Kingdom, LL18 5UJ
        • Recruiting
        • Novartis Investigative Site
      • Sheffield, United Kingdom, S5 7AU
        • Recruiting
        • Novartis Investigative Site
      • Tyne and Wear, United Kingdom, NE29 8NH
        • Recruiting
        • Novartis Investigative Site
      • Wiltshire, United Kingdom, SN15 2SB
        • Recruiting
        • Novartis Investigative Site
      • Wrexham, United Kingdom, LL13 7TD
        • Recruiting
        • Novartis Investigative Site
    • Dorset
      • Dorchester, Dorset, United Kingdom, DT1 2JY
        • Recruiting
        • Novartis Investigative Site
    • GBR
      • London, GBR, United Kingdom, EC1M 6BQ
        • Recruiting
        • Novartis Investigative Site
    • Greater London
      • London, Greater London, United Kingdom, EN3 4GS
        • Recruiting
        • Novartis Investigative Site
    • Lancashire
      • Preston, Lancashire, United Kingdom, PR2 9QB
        • Recruiting
        • Novartis Investigative Site
    • Middlesex
      • Harrow, Middlesex, United Kingdom, HA1 3UJ
        • Recruiting
        • Novartis Investigative Site
    • North Manchester
      • Rochdale, North Manchester, United Kingdom, OL11 4AU
        • Recruiting
        • Novartis Investigative Site
    • Nothern Ireland
      • Portadown, Nothern Ireland, United Kingdom, BT63 5QQ
        • Recruiting
        • Novartis Investigative Site
    • Somerset
      • Taunton, Somerset, United Kingdom, TA1 5DA
        • Recruiting
        • Novartis Investigative Site
    • Surrey
      • Chertsey, Surrey, United Kingdom, KT16 0PZ
        • Recruiting
        • Novartis Investigative Site
    • Tyne and Wear
      • Newcastle upon Tyne, Tyne and Wear, United Kingdom, NE7 7DN
        • Recruiting
        • Novartis Investigative Site
      • Sunderland, Tyne and Wear, United Kingdom, SR4 7TP
        • Recruiting
        • Novartis Investigative Site
    • Wales
      • Cardiff, Wales, United Kingdom, CF5 4AD
        • Recruiting
        • Novartis Investigative Site
    • West Sussex
      • Chichester, West Sussex, United Kingdom, PO19 6SE
        • Recruiting
        • Novartis Investigative Site
  • United States
    • Alabama
      • Andalusia, Alabama, United States, 36420
        • Recruiting
        • SEC Clinical Research LLC
        • Principal Investigator:
          • Andreas Muench
        • Contact:
      • Huntsville, Alabama, United States, 35801
        • Recruiting
        • Heart Center Research Llc
        • Principal Investigator:
          • Vernon R Hunter
        • Contact:
      • Mobile, Alabama, United States, 36608
        • Recruiting
        • Mobile Heart Specialists
        • Principal Investigator:
          • Christopher S Brown
        • Contact:
    • Arizona
      • Gilbert, Arizona, United States, 85297
        • Recruiting
        • Mercy Gilbert Medical Center
        • Principal Investigator:
          • Nabil Dib
        • Contact:
      • Sun City West, Arizona, United States, 85375
        • Recruiting
        • Clinical Research Inst of Arizona
        • Principal Investigator:
          • Jalal Abbas
        • Contact:
      • Tucson, Arizona, United States, 85745
        • Recruiting
        • Eclipse Clinical Research
        • Principal Investigator:
          • Eve Shapiro
        • Contact:
    • Arkansas
      • Little Rock, Arkansas, United States, 72204
        • Recruiting
        • Cardiology and Medicine Clinic PA
        • Principal Investigator:
          • Joe L Hargrove
        • Contact:
    • California
      • Beverly Hills, California, United States, 90211
      • Beverly Hills, California, United States, 90210
        • Recruiting
        • Cardiovascular Res Found
        • Principal Investigator:
          • Ronald P Karlsberg
        • Contact:
      • Covina, California, United States, 91723
      • Irvine, California, United States, 92660
        • Recruiting
        • University of Calif Irvine Med Cntr
        • Principal Investigator:
          • Ailin Barseghian El-Farra
        • Contact:
      • Los Angeles, California, United States, 90033
      • Northridge, California, United States, 91325
        • Recruiting
        • Valley Clinical Trials
        • Principal Investigator:
          • Mehrdad Ariani
        • Contact:
      • Palo Alto, California, United States, 94304
        • Recruiting
        • Stanford University Medical Center
        • Principal Investigator:
          • Abha Khandelwal
        • Contact:
      • San Francisco, California, United States, 94115
        • Recruiting
        • UCSF
        • Principal Investigator:
          • Eveline O Stock
        • Contact:
      • Santa Ana, California, United States, 92704
        • Recruiting
        • Helping Hands Medical Associates INC
        • Principal Investigator:
          • Alan Charles Schwartz
        • Contact:
      • Stockton, California, United States, 95204
        • Recruiting
        • Manshadi Heart Institute
        • Contact:
        • Principal Investigator:
          • Ramin Manshadi
      • West Hills, California, United States, 91307
        • Recruiting
        • Interv Cardiology Med Grp
        • Principal Investigator:
          • Farhad Rafii
        • Contact:
    • Colorado
      • Aurora, Colorado, United States, 80045
        • Recruiting
        • Univ Of Color Anschutz Med Center
        • Contact:
        • Principal Investigator:
          • David Saxon
    • Connecticut
      • Bridgeport, Connecticut, United States, 06610
        • Recruiting
        • Bridgeport Hospital
        • Principal Investigator:
          • Adam Schussheim
        • Contact:
      • Hartford, Connecticut, United States, 06102
        • Recruiting
        • Hartford Hospital
        • Principal Investigator:
          • Antonio Fernandez
        • Contact:
      • Waterbury, Connecticut, United States, 06708
        • Recruiting
        • Chase Medical Research LLC
        • Contact:
        • Principal Investigator:
          • Ashish Adlakha
    • Florida
      • Boca Raton, Florida, United States, 33434
        • Recruiting
        • Excel Medical Clinical Trials LLC
        • Principal Investigator:
          • Rasha Youssef
        • Contact:
      • Brandon, Florida, United States, 33511
        • Recruiting
        • Bay Area Cardiology Assoc
        • Principal Investigator:
          • Ranchhod Khant
        • Contact:
      • Jacksonville, Florida, United States, 32216
        • Recruiting
        • Jacksonville Center for Clinical Research
        • Principal Investigator:
          • Michael J Koren
        • Contact:
      • Naples, Florida, United States, 34102
        • Recruiting
        • Advanced Research for Health Improvement LLC
        • Principal Investigator:
          • Julian Javier
        • Contact:
      • Port Charlotte, Florida, United States, 33952
        • Recruiting
        • Peace River Cardiovascular Center
        • Contact:
        • Principal Investigator:
          • David Allan Hotchkiss
      • Port Orange, Florida, United States, 32127
      • Saint Augustine, Florida, United States, 32086
        • Recruiting
        • East Coast Inst for Research LLC
        • Principal Investigator:
          • Ferris George
        • Contact:
      • Wellington, Florida, United States, 33449
        • Recruiting
        • Cardiology Partners Clinical Research Institute
        • Contact:
        • Principal Investigator:
          • Neerav Suresh Shah
    • Georgia
      • Atlanta, Georgia, United States, 30322
        • Recruiting
        • Emory University
        • Principal Investigator:
          • Arshed Quyyumi
        • Contact:
      • Atlanta, Georgia, United States, 30309
        • Recruiting
        • Piedmont Heart Institute
        • Contact:
        • Principal Investigator:
          • Joseph Miller
      • Thomasville, Georgia, United States, 31792
        • Recruiting
        • Cardiovascular Consultants of S GA
        • Contact:
        • Principal Investigator:
          • Christopher Daniels
    • Illinois
      • Chicago, Illinois, United States, 60612
        • Recruiting
        • Rush University Medical Center
        • Contact:
        • Principal Investigator:
          • Annabelle Volgman
    • Indiana
      • Indianapolis, Indiana, United States, 46202 4800
        • Recruiting
        • Krannert Institute of Cardiology
        • Principal Investigator:
          • Julie Clary
        • Contact:
    • Iowa
      • Iowa City, Iowa, United States, 52242
        • Recruiting
        • Uni Of Iowa Hospitals And Clinics
        • Principal Investigator:
          • Marcelo Correia
        • Contact:
    • Kansas
      • Kansas City, Kansas, United States, 66160
        • Recruiting
        • University of Kansas Hospital
        • Contact:
        • Principal Investigator:
          • Patrick M Moriarty
      • Topeka, Kansas, United States, 66606
        • Recruiting
        • Cotton O Neil Clinical Res Center
        • Principal Investigator:
          • Michael Cox
        • Contact:
    • Louisiana
      • Covington, Louisiana, United States, 70433
        • Recruiting
        • Cardiovascular Associates Research
        • Principal Investigator:
          • Dale Presser
        • Contact:
      • Covington, Louisiana, United States, 70433
        • Recruiting
        • Louisiana Heart Center Research
        • Principal Investigator:
          • Bruce J Iteld
        • Contact:
      • Houma, Louisiana, United States, 70360
        • Recruiting
        • CV Institute of the South
        • Principal Investigator:
          • Peter Fail
        • Contact:
      • Lafayette, Louisiana, United States, 70501
        • Recruiting
        • Horizon Research Grp
        • Contact:
        • Principal Investigator:
          • Randall Miller
      • Metairie, Louisiana, United States, 70006
        • Recruiting
        • Omega Clinical Research
        • Principal Investigator:
          • Tuan-Huy Tran
        • Contact:
      • New Orleans, Louisiana, United States, 70112
        • Recruiting
        • Tulane Center for Clinical Research
        • Contact:
        • Principal Investigator:
          • Keith C Ferdinand
      • Opelousas, Louisiana, United States, 70570
        • Recruiting
        • CV Ins of the South
        • Principal Investigator:
          • Siby George Ayalloore
        • Contact:
      • Shreveport, Louisiana, United States, 71105
      • Slidell, Louisiana, United States, 70458
        • Recruiting
        • Louisiana Heart Center Research
        • Principal Investigator:
          • Marc Bernstein
        • Contact:
      • Zachary, Louisiana, United States, 70791
    • Maine
      • Scarborough, Maine, United States, 04074
        • Recruiting
        • Maine Health Cardiology
        • Principal Investigator:
          • Edward Teufel
        • Contact:
    • Maryland
      • Baltimore, Maryland, United States, 21209
        • Recruiting
        • Sinai Ct for Throm Res and Drug Dev
        • Principal Investigator:
          • Paul Gurbel
        • Contact:
      • Baltimore, Maryland, United States, 21287
        • Recruiting
        • Johns Hopkins Univ School of Med
        • Principal Investigator:
          • Thorsten Leucker
        • Contact:
      • Columbia, Maryland, United States, 21044
        • Recruiting
        • Johns Hopkins University
        • Principal Investigator:
          • Daniel Kim
        • Contact:
      • Ft. Washington, Maryland, United States, 20744
      • Rockville, Maryland, United States, 20850
        • Recruiting
        • Adventist HealthCare Shady Grove Medical Center
        • Contact:
        • Principal Investigator:
          • Michael Chen
    • Massachusetts
      • Boston, Massachusetts, United States, 02115
        • Recruiting
        • Brigham and Womens Hosp Harvard Med School
        • Contact:
        • Principal Investigator:
          • Ron Blankstein
      • Boston, Massachusetts, United States, 02114 2696
    • Michigan
      • Detroit, Michigan, United States, 48202
        • Recruiting
        • Henry Ford Hospital
        • Principal Investigator:
          • Khaled Abdul-Nour
        • Contact:
      • Detroit, Michigan, United States, 48201
        • Recruiting
        • Wayne State University
        • Principal Investigator:
          • Brian J O Neil
        • Contact:
      • Flint, Michigan, United States, 48504
        • Recruiting
        • AA Medical Research Center
        • Principal Investigator:
          • Ahmed A Arif
        • Contact:
      • Kalamazoo, Michigan, United States, 49008
        • Recruiting
        • Western Michigan University
        • Principal Investigator:
          • Vishal Gupta
        • Contact:
      • Petoskey, Michigan, United States, 49770
        • Recruiting
        • McLaren Ctr Research Innovation
        • Contact:
        • Principal Investigator:
          • Joel Engel
      • Saginaw, Michigan, United States, 48601
        • Recruiting
        • Central Michigan University
        • Principal Investigator:
          • Peter G Fattal
        • Contact:
      • Wyoming, Michigan, United States, 49519
        • Recruiting
        • Metro Health Univ of MI Health
        • Contact:
        • Principal Investigator:
          • Rony Gorges
    • Minnesota
      • Maplewood, Minnesota, United States, 55109
        • Recruiting
        • Saint Johns Hospital
        • Contact:
        • Principal Investigator:
          • Les B Forgosh
      • Minneapolis, Minnesota, United States, 55407
        • Recruiting
        • Minneapolis Heart Institute
        • Contact:
        • Principal Investigator:
          • Thomas Knickelbine
      • Minneapolis, Minnesota, United States, 55455
        • Recruiting
        • University of Minnesota
        • Principal Investigator:
          • Daniel Duprez
        • Contact:
    • Mississippi
      • Belzoni, Mississippi, United States, 39038
        • Recruiting
        • Belzoni Clinical Research
        • Contact:
        • Principal Investigator:
          • Sidney Carlton Gorton
      • Southaven, Mississippi, United States, 38671
        • Recruiting
        • Stern Cardiovascular Foundation Inc
        • Principal Investigator:
          • Dharmesh Patel
        • Contact:
    • Missouri
      • City of Saint Peters, Missouri, United States, 63303
        • Recruiting
        • StudyMetrix Research
        • Principal Investigator:
          • Timothy Smith
        • Contact:
      • St Louis, Missouri, United States, 63110
        • Recruiting
        • Washington Univ School Of Medicine
        • Principal Investigator:
          • Anne Goldberg
        • Contact:
    • Nebraska
      • Omaha, Nebraska, United States, 68114
        • Recruiting
        • Quality Clinical Research
        • Contact:
        • Principal Investigator:
          • John Hallgren
    • New Hampshire
      • Lebanon, New Hampshire, United States, 03756
        • Recruiting
        • Dartmouth Hitchcock Medical Center
        • Contact:
        • Principal Investigator:
          • Jonathan C Waltman
    • New Jersey
      • Ridgewood, New Jersey, United States, 07450
        • Recruiting
        • The Valley Hospital
        • Contact:
        • Principal Investigator:
          • Joel Landzberg
      • Summit, New Jersey, United States, 07901
    • New York
      • Manhasset, New York, United States, 11030
        • Recruiting
        • Northwell Health
        • Principal Investigator:
          • Bani Azari
        • Contact:
      • New York, New York, United States, 10021
        • Recruiting
        • Weill Cornell Medical Center
        • Principal Investigator:
          • Samuel Kim
        • Contact:
      • New York, New York, United States, 10029
        • Recruiting
        • Icahn School of Med at Mt Sinai
        • Principal Investigator:
          • Robert Rosenson
        • Contact:
      • New York, New York, United States, 43210
        • Recruiting
        • Lenox Hill Hospital
        • Principal Investigator:
          • Eugenia Gianos
        • Contact:
      • Riverhead, New York, United States, 11901
        • Recruiting
        • Northwell Health Physician Peconic
        • Principal Investigator:
          • Sean Donahoe
        • Contact:
    • North Carolina
      • Charlotte, North Carolina, United States, 28204
        • Recruiting
        • Novant Health Heart Vas Inst
        • Principal Investigator:
          • Anish Vani
        • Contact:
      • Greensboro, North Carolina, United States, 27405
        • Recruiting
        • Medication Management LLC
        • Principal Investigator:
          • James Franklin
        • Contact:
      • Raleigh, North Carolina, United States, 27609
        • Recruiting
        • Accellacare US Inc
        • Principal Investigator:
          • John Rubino
        • Contact:
      • Winston-Salem, North Carolina, United States, 27157
        • Recruiting
        • Wake Forest University Baptist Medical Center
        • Principal Investigator:
          • Michael Shapiro
        • Contact:
    • Ohio
      • Canton, Ohio, United States, 44710
        • Recruiting
        • Aultman Hospital
        • Contact:
        • Principal Investigator:
          • Ramana Podugu
      • Cincinnati, Ohio, United States, 45219
        • Recruiting
        • Lindner Ctr At The Christ Hosp
        • Contact:
        • Principal Investigator:
          • Dean J Kereiakes
      • Cleveland, Ohio, United States, 44195
        • Recruiting
        • Cleveland Clinic Foundation
        • Contact:
        • Principal Investigator:
          • Dennis C. Bruemmer
      • Columbus, Ohio, United States, 43210
        • Recruiting
        • Ohio State University
        • Principal Investigator:
          • Wesley Milks
        • Contact:
      • Marion, Ohio, United States, 43302
        • Recruiting
        • Rama Research LLC
        • Principal Investigator:
          • Bhola Rama
        • Contact:
    • Pennsylvania
      • Lancaster, Pennsylvania, United States, 17603
      • Philadelphia, Pennsylvania, United States, 19104
      • Yardley, Pennsylvania, United States, 19067
        • Recruiting
        • Cardiology Consultants of Philadelphia
        • Principal Investigator:
          • Paul Grena
        • Contact:
    • South Dakota
      • Rapid City, South Dakota, United States, 57701
        • Recruiting
        • Monument Health Clinical Research
        • Contact:
        • Principal Investigator:
          • Stephen Wasemiller
    • Tennessee
      • Germantown, Tennessee, United States, 38138
        • Recruiting
        • The Stern Cardiovascular Foundation
        • Principal Investigator:
          • Frank Augustus McGrew
        • Contact:
      • Jackson, Tennessee, United States, 38301
        • Recruiting
        • Apex Cardiology Research Associates of Jackson
        • Principal Investigator:
          • Mohsin Alhaddad
        • Contact:
      • Nashville, Tennessee, United States, 37232
        • Recruiting
        • Vanderbilt Univ Medi Cen
        • Contact:
        • Principal Investigator:
          • MacRae Linton
      • Powell, Tennessee, United States, 37849
        • Recruiting
        • Cardiovascular Res of Knoxville LLC
        • Principal Investigator:
          • Charles B Treasure
        • Contact:
    • Texas
      • Dallas, Texas, United States, 75231
        • Recruiting
        • North Texas Endocrine Center
        • Principal Investigator:
          • Peter Bressler
        • Contact:
      • Dallas, Texas, United States, 75226
        • Recruiting
        • Soltero Cardiovascular Research Center
        • Principal Investigator:
          • Cara East
        • Contact:
      • Dallas, Texas, United States, 75235
        • Recruiting
        • SW Family Medicine Associates
        • Principal Investigator:
          • Chrisette Dharma
        • Contact:
      • Houston, Texas, United States, 77030
        • Recruiting
        • Baylor College of Medicine
        • Contact:
        • Principal Investigator:
          • Christie M Ballantyne
      • Marshall, Texas, United States, 75670
      • Tomball, Texas, United States, 77375
        • Recruiting
        • Northwest Houston Clinical Research PLLC
        • Principal Investigator:
          • Shamaila Aslam
        • Contact:
    • Utah
      • Bountiful, Utah, United States, 84010
      • Murray, Utah, United States, 84107
        • Recruiting
        • Intermountain Medical Center
        • Principal Investigator:
          • Jeffrey Anderson
        • Contact:
      • Salt Lake City, Utah, United States, 84132-0001
        • Recruiting
        • The University of Utah
        • Contact:
        • Principal Investigator:
          • Aaron Shoskes
    • Virginia
      • Falls Church, Virginia, United States, 22042
        • Recruiting
        • Inova Fairfax Hospital
        • Contact:
        • Principal Investigator:
          • Jared Spitz
      • Falls Church, Virginia, United States, 22042
        • Recruiting
        • Virginia Heart
        • Principal Investigator:
          • Tariq Haddad
        • Contact:
      • Manassas, Virginia, United States, 20109
        • Recruiting
        • Carient Heart and Vascular
        • Principal Investigator:
          • Vikram Prasanna
        • Contact:
      • Richmond, Virginia, United States, 23219
        • Recruiting
        • Dominion Medical Associates
        • Principal Investigator:
          • Richard A Jackson
        • Contact:
    • Washington
      • Seattle, Washington, United States, 98104
        • Recruiting
        • Harborview Medical Center
        • Principal Investigator:
          • Francis Kim
        • Contact:
      • Seattle, Washington, United States, 98122
        • Recruiting
        • Swedish Medical Center-Cardiovascular Research
        • Contact:
        • Principal Investigator:
          • John Petersen II
      • Seattle, Washington, United States, 98195
        • Recruiting
        • Univ of Washington Medical Center
        • Principal Investigator:
          • Kelley Branch
        • Contact:
    • West Virginia
      • Morgantown, West Virginia, United States, 26506
        • Recruiting
        • West Virginia University Hospital
        • Principal Investigator:
          • Sudarshan Balla
        • Contact:

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Eligibility Criteria

The key requirements that people who want to participate in a clinical study must meet or the characteristics they must have. Eligibility criteria consist of both inclusion criteria (which are required for a person to participate in the study) and exclusion criteria (which prevent a person from participating). Types of eligibility criteria include whether a study accepts healthy volunteers, has age or age group requirements, or is limited by sex.

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

  • Participants who have provided informed consent prior to initiation of any study-specific activities/procedures.
  • Participants who have completed the parent study EOS visit while still on assigned investigational product.

Exclusion Criteria:

  • Participants who for any reason permanently discontinued or have interrupted the investigational product for continuous 6 months at EOS during the parent study.
  • Participants who have a history or evidence of any clinically significant disorder, condition, or disease that in the opinion of the investigator or Novartis physician (if consulted), would put the participant at risk or interfere with the study participation, including, but not restricted to conditions outlined in Table 6-3 and Table 6-5.
  • Participants are receiving another investigational drug or device before the open-label treatment period.
  • Participants have a known sensitivity to the study drug and are deemed as unsuited for the study by the Investigator at Screening visit.

Other protocol-defined inclusion/exclusion criteria may apply.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: N/A
  • Interventional Model: Single Group Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm

Participant Group / Arm

A group or subgroup of participants in a clinical trial that receives a specific intervention/treatment, or no intervention, according to the trial's protocol.
Intervention / Treatment

Intervention / Treatment

A process or action that is the focus of a clinical study. Interventions include drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available. Interventions can also include noninvasive approaches, such as education or modifying diet and exercise.
Experimental: Pelacarsen (TQJ230)
open-label pelacarsen 80mg
Drug: Pelacarsen (TQJ230)
pelacarsen 80mg s.c. monthly
Other Names:
  • TQJ230

What is the study measuring?

Primary Outcome Measures

Primary Outcome Measures

In a clinical study's protocol, the planned outcome measure that is the most important for evaluating the effect of an intervention/treatment. Most clinical studies have one primary outcome measure, but some have more than one.
Outcome Measure
Measure Description
Time Frame
Number of participants with Adverse events
Time Frame: Up to 36 months
Number of participants with Treatment Emergent Adverse Events (TEAEs), Treatment Emergent Serious Adverse Events (TESAEs), TEAEs of special interest, including abnormal laboratory evaluations and vital signs. Number of participants discontinuing due to treatment emergent adverse events (TEAEs) or treatment emergent serious adverse events (TESAEs) will also be presented.
Up to 36 months

Secondary Outcome Measures

Secondary Outcome Measures

In a clinical study's protocol, a planned outcome measure that is not as important as the primary outcome measure for evaluating the effect of an intervention but is still of interest. Most clinical studies have more than one secondary outcome measure.
Outcome Measure
Measure Description
Time Frame
Time to first occurrence of 4 Point-Major Cardiovascular Event (4P-MACE) from parent study baseline
Time Frame: Up to 36 months
Time to first occurrence of 4P-MACE (cardiovascular death, non-fatal myocardial infarction, non-fatal stroke, or urgent coronary revascularization requiring hospitalization) from the beginning of the parent study will be presented
Up to 36 months
Time to the first occurrence of 4P-MACE from open-label extension (OLE) study baseline
Time Frame: Up to 36 months
Time to first occurrence of 4P-MACE (cardiovascular death, non-fatal myocardial infarction, non-fatal stroke, or urgent coronary revascularization requiring hospitalization) from the beginning of the OLE study will be presented
Up to 36 months
Cumulative number of 4P-MACE over time from OLE study baseline
Time Frame: Up to 36 months
Cumulative number of 4P-MACE (cardiovascular death, non-fatal myocardial infarction, non-fatal stroke, or urgent coronary revascularization requiring hospitalization) over time from the beginning of the OLE study will be presented
Up to 36 months
Cumulative number of 4P-MACE over time from parent study baseline
Time Frame: Up to 36 months
Cumulative number of 4P-MACE (cardiovascular death, non-fatal myocardial infarction, non-fatal stroke, or urgent coronary revascularization requiring hospitalization) over time from the beginning of the parent study will be presented
Up to 36 months
Observed value of Lipoprotein(a) (Lp(a))
Time Frame: Baseline, Month 3, Month 12, Month 24, Month 36
Samples for Lp(a) assessment will be collected at the defined time points, analyzed and values reported.
Baseline, Month 3, Month 12, Month 24, Month 36
Change in Lp(a) compared to baseline of the OLE study
Time Frame: Baseline, Month 3, Month 12, Month 24, Month 36
Samples for Lp(a) assessment will be collected at defined time points and change will be calculated against baseline of the OLE study.
Baseline, Month 3, Month 12, Month 24, Month 36
Change in Lp(a) compared to baseline of the parent study
Time Frame: Baseline, Month 3, Month 12, Month 24, Month 36
Samples for Lp(a) assessment will be collected at defined time points and change will be calculated against baseline of the parent study.
Baseline, Month 3, Month 12, Month 24, Month 36

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Sponsor

The organization or person who initiates the study and who has authority and control over the study.
Novartis Pharmaceuticals

Investigators

Investigators

A researcher involved in a clinical study. Related terms include site principal investigator, site sub-investigator, study chair, study director, and study principal investigator.
  • Study Director: Novartis Pharmaceuticals, Novartis Pharmaceuticals

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

Study Start

The actual date on which the first participant was enrolled in a clinical study. The "anticipated" study start date is the date that the researchers think will be the study start date.
May 11, 2026

Primary Completion (Estimated)

Primary Completion

The date on which the last participant in a clinical study was examined or received an intervention to collect final data for the primary outcome measure. Whether the clinical study ended according to the protocol or was terminated does not affect this date. For clinical studies with more than one primary outcome measure with different completion dates, this term refers to the date on which data collection is completed for all the primary outcome measures. The "anticipated" primary completion date is the date that the researchers think will be the primary completion date for the study.
January 9, 2030

Study Completion (Estimated)

Study Completion

The date on which the last participant in a clinical study was examined or received an intervention/treatment to collect final data for the primary outcome measures, secondary outcome measures, and adverse events (that is, the last participant's last visit). The "anticipated" study completion date is the date that the researchers think will be the study completion date.
January 9, 2030

Study Registration Dates

First Submitted

First Submitted

The date on which the study sponsor or investigator first submitted a study record to ClinicalTrials.gov. There is typically a delay of a few days between the first submitted date and the record's availability on ClinicalTrials.gov (the first posted date).
April 1, 2026

First Submitted That Met QC Criteria

First Submitted That Met QC Criteria

The date on which the study sponsor or investigator first submits a study record that is consistent with National Library of Medicine (NLM) quality control (QC) review criteria. The sponsor or investigator may need to revise and submit a study record one or more times before NLM's QC review criteria are met. It is the responsibility of the sponsor or investigator to ensure that the study record is consistent with the NLM QC review criteria.
April 1, 2026

First Posted (Actual)

First Posted

The date on which the study record was first available on ClinicalTrials.gov after National Library of Medicine (NLM) quality control (QC) review has concluded. There is typically a delay of a few days between the date the study sponsor or investigator submitted the study record and the first posted date.
April 8, 2026

Study Record Updates

Last Update Posted (Actual)

Last Update Posted

The most recent date on which changes to a study record were made available on ClinicalTrials.gov. There may be a delay between when the changes were submitted to ClinicalTrials.gov by the study's sponsor or investigator (the last update submitted date) and the last update posted date.
June 10, 2026

Last Update Submitted That Met QC Criteria

Last Update Submitted That Met QC Criteria

The most recent date on which the study sponsor or investigator submitted changes to a study record that are consistent with National Library of Medicine (NLM) quality control (QC) review criteria. It is the responsibility of the sponsor or investigator to ensure that the study record is consistent with the NLM QC review criteria.
June 8, 2026

Last Verified

Last Verified

The most recent date on which the study sponsor or investigator confirmed the information about a clinical study on ClinicalTrials.gov as accurate and current. If a study with a recruitment status of recruiting; not yet recruiting; or active, not recruiting has not been confirmed within the past 2 years, the study's recruitment status is shown as unknown.
June 1, 2026

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

Other Study ID Numbers

Identifiers or ID numbers other than the NCT number that are assigned to a clinical study by the study's sponsor, funders, or others. These numbers may include unique identifiers from other trial registries and National Institutes of Health grant numbers.
  • CTQJ230A12301E1
  • 2024-519870-38-00 (Other Identifier: EU CT)

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

YES

IPD Plan Description

Novartis is committed to sharing with qualified external researchers, access to patient-level data and supporting clinical documents from eligible studies. These requests are reviewed and approved by an independent review panel on the basis of scientific merit. All data provided is anonymized to respect the privacy of patients who have participated in the trial in line with applicable laws and regulations. This trial data availability is according to the criteria and process described on www.clinicalstudydatarequest.com.

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

Yes

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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Medical Conditions

Drug Interventions

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

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Locations

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