A Clinical Trial to Evaluate the Effects of a Plant-Based Liquid Supplement on Metabolic Health and Overall Well-Being

June 23, 2026 updated by: Biocol Labs
This single-arm clinical trial will evaluate the effects of a plant-based liquid supplement on metabolic health, digestive health, skin health, and overall well-being. Twenty participants aged 40 to 60 years with elevated alanine transaminase (ALT) or aspartate transaminase (AST) levels will use the supplement daily for 90 days. Participants will complete questionnaires, provide body composition and waist circumference measurements, submit photographs, and undergo blood testing throughout the study. Outcomes include changes in metabolic biomarkers, body composition, digestive symptoms, skin health, and overall well-being.

Study Overview

Status

Status

Indicates the current recruitment status or the expanded access status.
Completed

Conditions

Conditions

The disease, disorder, syndrome, illness, or injury that is being studied. On ClinicalTrials.gov, conditions may also include other health-related issues, such as lifespan, quality of life, and health risks.

Intervention / Treatment

Intervention / Treatment

A process or action that is the focus of a clinical study. Interventions include drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available. Interventions can also include noninvasive approaches, such as education or modifying diet and exercise.

Study Type

Study Type

Describes the nature of a clinical study. Study types include interventional studies (also called clinical trials), observational studies (including patient registries), and expanded access.
Interventional

Enrollment (Actual)

Enrollment

The number of participants in a clinical study. The "anticipated" enrollment is the target number of participants that the researchers need for the study.
20

Phase

Phase

The stage of a clinical trial studying a drug or biological product, based on definitions developed by the U.S. Food and Drug Administration (FDA). The phase is based on the study's objective, the number of participants, and other characteristics. There are five phases: Early Phase 1 (formerly listed as Phase 0), Phase 1, Phase 2, Phase 3, and Phase 4. Not Applicable is used to describe trials without FDA-defined phases, including trials of devices or behavioral interventions.
  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • United States
    • Nevada
      • Las Vegas, Nevada, United States, 89118
        • Citruslabs

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Eligibility Criteria

The key requirements that people who want to participate in a clinical study must meet or the characteristics they must have. Eligibility criteria consist of both inclusion criteria (which are required for a person to participate in the study) and exclusion criteria (which prevent a person from participating). Types of eligibility criteria include whether a study accepts healthy volunteers, has age or age group requirements, or is limited by sex.

Ages Eligible for Study

  • Adult

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

  • Age 40 to 60 years
  • Elevated ALT or AST identified during prescreening blood testing
  • Currently experiencing at least two of the following:

Stomach discomfort, Constipation, Diarrhea, Heartburn, Bloating, Gas, Abdominal pain, Skin redness or pimples, Sugar cravings

  • Willing to comply with study requirements
  • Willing to discontinue supplements or herbal remedies targeting detoxification, digestive health, liver function, or skin health during the study
  • Willing to avoid starting new products, medications, or supplements targeting detoxification, digestive health, liver function, or skin health
  • Willing to maintain normal diet, sleep patterns, and activity levels
  • Generally healthy without uncontrolled chronic disease
  • Resides in the United States
  • Not participating in another research study during the study period
  • Has access to a study partner to take study photographs

Exclusion Criteria:

  • Severe digestive disorders including acid reflux, IBS, IBD, Crohn's disease, or gastrointestinal tract surgeries
  • Liver disease
  • Known allergy or hypersensitivity to study product ingredients Chronic conditions that would interfere with study participation, including oncological or psychiatric disorders
  • Known severe allergic reactions
  • Pregnant, breastfeeding, or attempting to conceive
  • Unwilling to follow study procedures
  • Stopped hormonal birth control within the past month
  • History of substance abuse
  • Use of prescription diabetes medications, including GLP-1 receptor agonists such as Ozempic, Wegovy, or Mounjaro

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: N/A
  • Interventional Model: Single Group Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm

Participant Group / Arm

A group or subgroup of participants in a clinical trial that receives a specific intervention/treatment, or no intervention, according to the trial's protocol.
Intervention / Treatment

Intervention / Treatment

A process or action that is the focus of a clinical study. Interventions include drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available. Interventions can also include noninvasive approaches, such as education or modifying diet and exercise.
Experimental: Plant-Based Liquid Supplement
Participants will consume one ampule of the study product diluted in approximately 8 ounces of water before the first meal of the day throughout the study period.
Dietary supplement: Plant-Based Liquid Supplement
A liquid dietary supplement containing choline bitartrate, zinc sulfate, manganese sulfate, artichoke leaf extract, fennel extract, rosemary leaf extract, L-arginine monohydrochloride, inositol, bromelain, papain, sorbitol, glycerin, artificial flavour, and potassium sorbate.

What is the study measuring?

Primary Outcome Measures

Primary Outcome Measures

In a clinical study's protocol, the planned outcome measure that is the most important for evaluating the effect of an intervention/treatment. Most clinical studies have one primary outcome measure, but some have more than one.
Outcome Measure
Measure Description
Time Frame
Change in Body Weight
Time Frame: Baseline, Day 30, Day 60, and Day 90.
Change in body weight measured using a Withings smart scale.
Baseline, Day 30, Day 60, and Day 90.
Change in Waist Circumference
Time Frame: Baseline, Day 7, Day 30, Day 60, and Day 90.
Change in waist circumference measured using a tape measure and recorded in centimeters.
Baseline, Day 7, Day 30, Day 60, and Day 90.
Change in Body Fat Mass
Time Frame: Baseline, Day 7, Day 30, Day 60, and Day 90.
Change in body fat mass measured using a Withings smart scale.
Baseline, Day 7, Day 30, Day 60, and Day 90.
Change in Lean Body Mass
Time Frame: Baseline, Day 7, Day 30, Day 60, and Day 90.
Change in lean body mass measured using a Withings smart scale.
Baseline, Day 7, Day 30, Day 60, and Day 90.
Change in Visceral Fat Index
Time Frame: Baseline, Day 7, Day 30, Day 60, and Day 90.
Change in visceral fat index measured using a Withings smart scale.
Baseline, Day 7, Day 30, Day 60, and Day 90.
Change in Alanine Aminotransferase (ALT)
Time Frame: Baseline, Day 30, Day 60, and Day 90.
Change in serum alanine aminotransferase concentration measured by hepatic function panel.
Baseline, Day 30, Day 60, and Day 90.
Change in Aspartate Aminotransferase (AST)
Time Frame: Baseline, Day 30, Day 60, and Day 90
Change in serum aspartate aminotransferase concentration measured by hepatic function panel.
Baseline, Day 30, Day 60, and Day 90
Change in Alkaline Phosphatase (ALP)
Time Frame: Baseline, Day 30, Day 60, and Day 90.
Change in serum alkaline phosphatase concentration measured by hepatic function panel.
Baseline, Day 30, Day 60, and Day 90.
Change in Total Bilirubin
Time Frame: Baseline, Day 30, Day 60, and Day 90.
Change in serum total bilirubin concentration measured by hepatic function panel.
Baseline, Day 30, Day 60, and Day 90.
Change in Total Cholesterol
Time Frame: Baseline, Day 30, Day 60, and Day 90.
Change in serum total cholesterol concentration measured by lipid panel.
Baseline, Day 30, Day 60, and Day 90.

Secondary Outcome Measures

Secondary Outcome Measures

In a clinical study's protocol, a planned outcome measure that is not as important as the primary outcome measure for evaluating the effect of an intervention but is still of interest. Most clinical studies have more than one secondary outcome measure.
Outcome Measure
Measure Description
Time Frame
Change in Participant-Reported Bloating Severity
Time Frame: Baseline, Day 1, Day 3, Day 7, Day 30, Day 60, and Day 90.
Change in participant-reported bloating severity assessed by study questionnaire.
Baseline, Day 1, Day 3, Day 7, Day 30, Day 60, and Day 90.
Change in Participant-Reported Flatulence Severity
Time Frame: Baseline, Day 1, Day 3, Day 7, Day 30, Day 60, and Day 90.
Change in participant-reported flatulence severity assessed by study questionnaire.
Baseline, Day 1, Day 3, Day 7, Day 30, Day 60, and Day 90.
Change in Participant-Reported Heartburn Severity
Time Frame: Baseline, Day 1, Day 3, Day 7, Day 30, Day 60, and Day 90.
Change in participant-reported heartburn severity assessed by study questionnaire.
Baseline, Day 1, Day 3, Day 7, Day 30, Day 60, and Day 90.
Change in Participant-Reported Digestive Comfort
Time Frame: Baseline, Day 1, Day 3, Day 7, Day 30, Day 60, and Day 90.
Change in participant-reported digestive comfort assessed by study questionnaire.
Baseline, Day 1, Day 3, Day 7, Day 30, Day 60, and Day 90.
Change in Participant-Reported Skin Health
Time Frame: Baseline, Day 1, Day 3, Day 7, Day 30, Day 60, and Day 90.
Change in participant-reported skin health assessed by study questionnaire.
Baseline, Day 1, Day 3, Day 7, Day 30, Day 60, and Day 90.

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Sponsor

The organization or person who initiates the study and who has authority and control over the study.
Biocol Labs

Collaborators

Collaborators

An organization other than the sponsor that provides support for a clinical study. This support may include activities related to funding, design, implementation, data analysis, or reporting.
Citruslabs

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

Study Start

The actual date on which the first participant was enrolled in a clinical study. The "anticipated" study start date is the date that the researchers think will be the study start date.
June 5, 2025

Primary Completion (Actual)

Primary Completion

The date on which the last participant in a clinical study was examined or received an intervention to collect final data for the primary outcome measure. Whether the clinical study ended according to the protocol or was terminated does not affect this date. For clinical studies with more than one primary outcome measure with different completion dates, this term refers to the date on which data collection is completed for all the primary outcome measures. The "anticipated" primary completion date is the date that the researchers think will be the primary completion date for the study.
January 15, 2026

Study Completion (Actual)

Study Completion

The date on which the last participant in a clinical study was examined or received an intervention/treatment to collect final data for the primary outcome measures, secondary outcome measures, and adverse events (that is, the last participant's last visit). The "anticipated" study completion date is the date that the researchers think will be the study completion date.
January 15, 2026

Study Registration Dates

First Submitted

First Submitted

The date on which the study sponsor or investigator first submitted a study record to ClinicalTrials.gov. There is typically a delay of a few days between the first submitted date and the record's availability on ClinicalTrials.gov (the first posted date).
June 23, 2026

First Submitted That Met QC Criteria

First Submitted That Met QC Criteria

The date on which the study sponsor or investigator first submits a study record that is consistent with National Library of Medicine (NLM) quality control (QC) review criteria. The sponsor or investigator may need to revise and submit a study record one or more times before NLM's QC review criteria are met. It is the responsibility of the sponsor or investigator to ensure that the study record is consistent with the NLM QC review criteria.
June 23, 2026

First Posted (Actual)

First Posted

The date on which the study record was first available on ClinicalTrials.gov after National Library of Medicine (NLM) quality control (QC) review has concluded. There is typically a delay of a few days between the date the study sponsor or investigator submitted the study record and the first posted date.
June 29, 2026

Study Record Updates

Last Update Posted (Actual)

Last Update Posted

The most recent date on which changes to a study record were made available on ClinicalTrials.gov. There may be a delay between when the changes were submitted to ClinicalTrials.gov by the study's sponsor or investigator (the last update submitted date) and the last update posted date.
June 29, 2026

Last Update Submitted That Met QC Criteria

Last Update Submitted That Met QC Criteria

The most recent date on which the study sponsor or investigator submitted changes to a study record that are consistent with National Library of Medicine (NLM) quality control (QC) review criteria. It is the responsibility of the sponsor or investigator to ensure that the study record is consistent with the NLM QC review criteria.
June 23, 2026

Last Verified

Last Verified

The most recent date on which the study sponsor or investigator confirmed the information about a clinical study on ClinicalTrials.gov as accurate and current. If a study with a recruitment status of recruiting; not yet recruiting; or active, not recruiting has not been confirmed within the past 2 years, the study's recruitment status is shown as unknown.
June 1, 2026

More Information

Terms related to this study

Other Study ID Numbers

Other Study ID Numbers

Identifiers or ID numbers other than the NCT number that are assigned to a clinical study by the study's sponsor, funders, or others. These numbers may include unique identifiers from other trial registries and National Institutes of Health grant numbers.
  • #20758

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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