Genotype Influence on Recovery After Traumatic Brain Injury

The Influence of APOE Genotype on Recovery After Traumatic Brain Injury

Genetic differences in response to brain injury may reasonably be expected to play a role in the initial consequences of traumatic brain injury and in the rate of recovery from such injury.

Study Overview

• Status: Completed
• Conditions: Brain Injury

Detailed Description

Polymorphisms in the Apolipoprotein E gene encode functional variants which differentially determine the rate at which neuronal repair can occur, and are associated with differences in expression of neurodegenerative processes, including traumatic brain injury. It is proposed that the accuracy of prediction of outcome after head injury will be significantly increased by inclusion of APOE genotype alone, or in combination with other variables such as severity of head injury, cognitive, electroencephalographic or neuroradiologic measures, or treatment strategies.

• Study Type: Observational

Contacts and Locations

Study Locations

• United States
  • Florida
    • Tampa, Florida, United States, 33612
      • James A. Haley Veterans' Hospital

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 17 years to 55 years (Child, Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Patients enrolled in the DVHIP are subject to the following recruitment criteria:

1. Mild, moderate or severe closed head injury, where the cut off between mild and moderate is defined by GCS<12. PTA>24 hrs or - foca cerebral contusion on CT/MRI or Loss of Consciousness (LOC) > 12 hours.

   Note: the definition of mild, moderate or severe head injury differs widely between centers and is absolutely not critical for the work proposed as we will use continuous measures of severity throughout.

2. Within three months of first assessment. (In practice, patients may be recruited after 3 months. We will deal with this issue by covarying the time from injury to first assessment in our analyses).
3. Rancho Los Amigos cognitive level of 5-7 at first assessment.
4. Volunteer informed consent signed by patient of family.
5. Military or veterans health care beneficiary.
6. Age 17-55

Exclusion Criteria:

1. Unwillingness to participate in rehabilitation program or cooperate with investigators.
2. History of prior severe traumatic brain injury of other severe neurologic or psychiatric condition, such as psychosis, stroke, multiple sclerosis, or spinal cord injury.

Study Plan

How is the study designed?

Collaborators and Investigators

• Sponsor: US Department of Veterans Affairs
• Investigators: Fiona Crawford, Ph.D.; Rodney Vanderploeg, Ph.D.; Robert Thatcher, Ph.D.; Andres Salazar, M.D.

Study record dates

Study Major Dates

• Study Start: October 1, 1998
• Study Completion: October 1, 2001

Study Registration Dates

• First Submitted: July 3, 2001
• First Submitted That Met QC Criteria: July 4, 2001
• First Posted (Estimate): July 5, 2001

Study Record Updates

• Last Update Posted (Estimate): January 21, 2009
• Last Update Submitted That Met QC Criteria: January 20, 2009
• Last Verified: December 1, 2004

More Information

Terms related to this study

• Keywords: Traumatic Brain Injury
• Additional Relevant MeSH Terms: Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Craniocerebral Trauma; Trauma, Nervous System; Brain Injuries; Wounds and Injuries; Brain Injuries, Traumatic
• Other Study ID Numbers: EPID-030-98S