- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00028197
Comparison of Externally and Self-Initiated Movements
This study will use magnetic resonance imaging (MRI) to investigate how the brain controls voluntary movements triggered by an external stimulus or self-initiated.
Registered HCMS healthy normal volunteers may participate. They will complete a questionnaire and will have a medical history and brief physical examination.
The study consists of two parts: 1) body movement training and 2) magnetic resonance imaging, as follows:
Part 1 - Body movement training
Participants will train to do three different body movements involving the hands and feet. The movements will either be self-initiated or in response to a stimulus, such as a visual or auditory trigger.
Part 2 - Magnetic resonance imaging
Participants will do one or more of the trained movements, with or without a triggering stimulus, during MRI scanning. MRI is a diagnostic procedure that uses a magnetic field and radio waves to produce images of brain structure and activity. For the procedure, the subject lies on a stretcher that is moved into the scanner-a cylinder containing a strong magnet. Earplugs are worn to protect the ears from loud thumping noises that occur with electrical switching of radio frequency circuits. Scanning time varies from 20 minutes to 2 hours, with most examinations lasting 1 to 1-1/2 hours. The subject can communicate with the staff person conducting the test at all times during the scan. A device compatible with magnetic resonance will be used to record the participant's body movements. The participant may be asked to push buttons of the device during the tasks.
Study Overview
Status
Conditions
Detailed Description
Study Type
Enrollment
Contacts and Locations
Study Locations
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Maryland
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Bethesda, Maryland, United States, 20892
- National Institute of Neurological Disorders and Stroke (NINDS)
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
- Child
- Adult
- Older Adult
Accepts Healthy Volunteers
Genders Eligible for Study
Description
INCLUSION CRITERIA:
Normal volunteers will be included. Normal volunteers will be recruited from people who are registered as HMCS Normal Volunteers. All subjects participating in MR studies should have a valid Clinical Center Medical Record Number.
EXCLUSION CRITERIA:
We will not scan pregnant women because safety of high magnetic field to fetus is not established. Therefore, we will administer a urine pregnancy test for any female subjects of childbearing potential prior to functional MRI scan. If the result from a urine pregnancy test is not available for some reason, a medical doctor will judge based on the proper information prior to the scanning.
Study Plan
How is the study designed?
Collaborators and Investigators
Publications and helpful links
General Publications
- Alexander GE, Crutcher MD. Neural representations of the target (goal) of visually guided arm movements in three motor areas of the monkey. J Neurophysiol. 1990 Jul;64(1):164-78. doi: 10.1152/jn.1990.64.1.164.
- Brinkman C, Porter R. Supplementary motor area and premotor area of monkey cerebral cortex: functional organization and activities of single neurons during performance of a learned movement. Adv Neurol. 1983;39:393-420.
- Burbaud P, Doegle C, Gross C, Bioulac B. A quantitative study of neuronal discharge in areas 5, 2, and 4 of the monkey during fast arm movements. J Neurophysiol. 1991 Aug;66(2):429-43. doi: 10.1152/jn.1991.66.2.429.
Study record dates
Study Major Dates
Study Start
Study Completion
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Other Study ID Numbers
- 020068
- 02-N-0068
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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