- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00032500
Evaluation of Echinacea for the Common Cold
August 17, 2006 updated by: National Center for Complementary and Integrative Health (NCCIH)
Evaluation of Echinacea in a Human Rhinovirus Challenge
The purpose of this study is to determine whether three Echinacea preparations with different chemical compositions are effective for prevention or treatment of the common cold.
Study Overview
Detailed Description
Echinacea is a widely used herbal remedy for the common cold.
Previous clinical trials designed to assess the efficacy of Echinacea for prevention or treatment of the common cold have produced inconsistent results.
A variety of different Echinacea products have been used in these clinical trials.
Recent studies indicate that different Echinacea preparations have dramatically different phytochemical profiles.
The available clinical trial data provide no information about the potential role of the different constituents of Echinacea in common cold prevention or treatment.
Our hypothesis is that the variation in reported clinical effectiveness may be due to differences in the phytochemical profile of the Echinacea preparations used.
This study will address the following specific aims: 1) Evaluate the effectiveness of chemically defined extracts of E. angustifolia root which contain alkamides, echinacoside or polysaccharidelglycoprotein for common cold prevention or treatment; 2) Assess the correlation between specific Echinacea metabolites in serum and nasal secretions and efficacy for prevention and treatment of colds; and 3) Determine the effect of different Echinacea preparations on the host response to rhinovirus infection.
Study Type
Interventional
Phase
- Phase 2
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
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Virginia
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Charlottesville, Virginia, United States, 22904
- University of Virginia, Charlottesville
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Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
- Child
- Adult
- Older Adult
Accepts Healthy Volunteers
N/A
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Prevention
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Double
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Investigators
- Principal Investigator: Ronald B. Turner, MD, University of Virginia School of Medicine
- J. David Gangemi, PhD, Clemson University
- Rudolf Bauer, PhD, Karl-Franzens-Universitaet Graz
Publications and helpful links
The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
September 1, 2001
Study Completion
May 1, 2004
Study Registration Dates
First Submitted
March 22, 2002
First Submitted That Met QC Criteria
March 22, 2002
First Posted (Estimate)
March 25, 2002
Study Record Updates
Last Update Posted (Estimate)
August 18, 2006
Last Update Submitted That Met QC Criteria
August 17, 2006
Last Verified
July 1, 2006
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- R01AT001146-01 (U.S. NIH Grant/Contract)
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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NovartisCompletedSore Throat Due to a Common ColdGermany
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Boehringer IngelheimCompleted
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Hormozgan University of Medical SciencesCompletedUpper Respiratory Tract InfectionsIran, Islamic Republic of
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