Study to Examine the Effect of Betahistine on Body Weight Gain Due to Olanzapine Treatment

A Randomized, Double-Blind, Placebo-Controlled, Multicenter Study to Examine the Effect of Betahistine on Body Weight Gain Due to Olanzapine Treatment

This is a randomized, double-blind, placebo-controlled, multicenter, multinational study. Approximately 78 subjects (39 per treatment group) will be randomized into this 16 week study.

A screening visit will be used to determine subject suitability for inclusion in the trial.

Within 7 days of the screening visit, subjects who meet all inclusion criteria and none of the exclusion criteria will be randomly assigned to 1 of the following 2 treatment groups:

• Olanzapine OD plus betahistine 24 mg BID (48 mg/day total),
• Olanzapine OD plus matching placebo BID.

Double-blind treatment will continue for 16 weeks. During this period, olanzapine dosage will be determined according to the discretion of the treating physician. In addition, 5 study visits (at 2, 4, 8, 12, and 16 weeks) will take place. Study medication (betahistine or matching placebo) will be administered BID (in the morning and together with olanzapine in the evening).

The primary statistical hypothesis to be tested is that the mean change from Baseline to Week 16 will be different between the treatment and placebo groups

Study Overview

• Status: Terminated
• Conditions: Weight Gain
• Intervention / Treatment: Drug: Betahistine

• Study Type: Interventional
• Enrollment (Actual): 36
• Phase: Phase 2

Contacts and Locations

Study Locations

• Canada
  • Alberta
    • Edmonton, Alberta, Canada, T5K 2J5
      • Capital Health, Edmonton Mental Health Clinic
  • British Columbia
    • Penticton, British Columbia, Canada, V2A 4M4
      • Dr. Alexander McIntyre
    • Victoria, British Columbia, Canada, V8R 4Z3
      • Vancouver Island Health Authority
  • Manitoba
    • Winnipeg, Manitoba, Canada, R3K 2E2
      • Dr. Ivan Kowalchuk
  • Nova Scotia
    • Halifax, Nova Scotia, Canada, B3H 2E2
      • Capital District Health Authority
  • Ontario
    • Kingston, Ontario, Canada, K7L 5G2
      • Queen's University
  • Quebec
    • Verdun (Montreal), Quebec, Canada, H4H 1R3
      • Douglas Hospital Research Centre
• Israel
  • Bat Yam, Israel
    • Abarbanel Hospital
  • Petach Tikva, Israel, 49100
    • Geha Psychiatric Hospital
  • Tirat Hacarmel, Israel
    • Lev Hasharon

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 12 years to 41 years (Child, Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• Subject (or legal guardian) is capable and willing to provide signed written informed consent;
• Male or female subjects 16 to 45 years of age;
• Body mass index in the range of 18.5 to 35 kg/m2;
• Diagnosed as having schizophrenia, schizoaffective disorder, schizophreniform disorder or a psychosis disorder that is not otherwise specified (NOS) according to the DSM-IV criteria;
• Maximum of 6 weeks cumulative lifetime exposure to risperidone, OR maximum of 3 weeks cumulative lifetime exposure to any other antipsychotic medication;
• Designated by the managing physician to be appropriate for treatment with olanzapine; and
• If female: is non-lactating, has a negative blood serum pregnancy test result, and does not plan on becoming pregnant during the study, or is not of childbearing potential (hysterectomy or tubal ligation at least 6 months prior to randomization or post-menopausal for 1 year); if of childbearing potential (including peri-menopausal women who have had a menstrual period within one year), must practice and be willing to continue to practice appropriate birth control (such as implants, injectables, oral contraceptives, intrauterine contraceptive devices, sexual abstinence, tubal ligation, or a vasectomized partner) during the entire study duration.

Exclusion Criteria:

• Has obesity of known endocrine origin (e.g., Cushing's disease, Addison's disease, hypothalamic tumor);
• Has a medical history (e.g., morbid childhood obesity) and/or physical characteristics (e.g., polydactyly) suggestive of genetic obesity (e.g., ob/ob genotype) or syndromatic obesity (e.g., Prader-Willi syndrome, Bardet Biedl syndrome);
• Previous surgical procedures for weight loss;
• Has had liposuction within 1 year before screening or is planning to have liposuction during the study;
• Has a clinically significant history or presence of any of the following conditions:
• Active or past history of cardiovascular or cerebrovascular disease including unstable angina, myocardial infarction, transient ischemic attacks/stroke, clinically significant arrhythmia, congestive heart failure, or cardiac valve abnormalities;
• Type 1 diabetes mellitus;
• Type 2 diabetes mellitus with treatment other than metformin monotherapy and/or diet with HbA1c >8%;
• Severe type 2 diabetes with history of ketoacidosis or diabetic ulcers, or presence of retinopathy, neuropathy, or nephropathy;
• Renal insufficiency defined as a serum creatinine >=1.5 mg/dL (133 µmol/L) at screening;
• Malignant disease, other than basal cell carcinoma, within 5 years of screening;
• Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) >2 x ULN;
• Thyroid-stimulating hormone (TSH) outside of the normal range;
• Plans on having any surgery (elective or otherwise) during the course of the study;
• Has uncontrolled hypertension (sitting blood pressure >160/95 mmHg at screening or randomization), uncontrolled hyperlipidemia (triglycerides [TG] >=400 mg/dL or low-density lipoprotein cholesterol [LDL] >160 mg/dL), or uncontrolled diabetes (HbA1c >8%);
• Diagnosis of asthma;
• History of peptic ulcers;
• History of HIV;
• Has a physical examination or electrocardiogram (ECG) with significant abnormalities, as judged by the investigator;
• Chronic antihistamine use or use of antihistamines within 14 days of randomization;
• History of pheochromocytoma
• Requires treatment with any of the following medications but has not been on a stable treatment regimen for a minimum of 90 days prior to screening:
• Hormone replacement therapy;
• Oral contraceptives;
• Antihypertensive agents;
• Metformin;
• Lipid-lowering agents; or
• Thyroid replacement therapy;
• Has been treated over the past 60 days, is currently treated, or is expected to require or undergo treatment with any of the following excluded medications;
• All prescription or over-the-counter agents taken for the purpose of weight reduction, including (but not limited to) the following anti obesity agents:
• Prescription drugs such as orlistat (Xenical), sibutramine (Meridia), and phentermine (Adipex-P, Celltech, Pro-Fast SA, Pro-Fast SR, Fastin, Oby trim, Zantryl, Teramine, Phentride, Phentercot, Obephen, Oby-cap); or
• Over-the-counter antiobesity agents (e.g., herbal supplements or other alternative remedies such as Cortislim, Dexatrim, Acutrim);
• Systemic steroids administered by oral, intravenous, or intramuscular route;
• Drugs that directly affect gastrointestinal motility (e.g., Reglan® and Propulsid®, and chronic [taken for more than 10 days within a 6-month period] macrolide antibiotics such as erythromycin and newer derivatives);
• Anti-depressants or benzodiazepines unless one of the following permitted drugs: escitalopram (Cipralex®), citalopram (Celexa®), clonazepam (Clonapam®), alprazolam (Xanax®), chlordiazepoxide (Librium®), diazepam (Valium®) and lorazepam (Ativan®);
• Calcitonin (e.g., Miacalcin®);
• Insulin;
• Exenatide (Byeta®);
• Sulfonylureas (e.g., Diamicron®, Amaryl®, Glucotrol®, Micronase®); or
• Meglitinides (e.g., Starlix®, Prandin®);
• Receipt of any investigational treatment (drug or device) within 90 days prior to screening; or
• Is an immediate family member of personnel directly affiliated with the study at the investigative sites, or is personally directly affiliated with the study at the investigative sites.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Prevention
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Quadruple

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Placebo Comparator: Placebo	Drug: Betahistine; Betahistine 24mg BID
Experimental: Betahistine 24 mg	Drug: Betahistine; Betahistine 24mg BID

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
The change in body weight from Baseline to Week 16	Week 16

Secondary Outcome Measures

Outcome Measure	Time Frame
Rate of weight change	Week 16
Change in waist circumference from Baseline to Week 16	Week 16
Changes from Baseline to Week 16 in measurements of obesity associated cardiovascular risk factors: sitting systolic and diastolic blood pressure, plasma lipid profile (LDL, non-HDL-C, TG, TC, and HDL-C), HbA1c, and FPG	Week 16
Change in the pharmacokinetic properties of olanzapine due to betahistine co-administration	Week 16
Change in psychiatric condition since randomization	Week 16

Collaborators and Investigators

• Sponsor: OBEcure Ltd.
• Investigators: Study Chair: Yaffa Beck, OBEcure Ltd.

Study record dates

Study Major Dates

• Study Start: March 1, 2007
• Primary Completion (Actual): August 1, 2008
• Study Completion (Actual): December 1, 2008

Study Registration Dates

• First Submitted: January 25, 2007
• First Submitted That Met QC Criteria: January 26, 2007
• First Posted (Estimate): January 29, 2007

Study Record Updates

• Last Update Posted (Estimate): October 15, 2015
• Last Update Submitted That Met QC Criteria: October 13, 2015
• Last Verified: October 1, 2008

More Information

Terms related to this study

• Keywords: Obesity; Betahistine; Schizophrenic disorder; Weight Gain Control; Weight Gain due to Olanzapine Treatment
• Additional Relevant MeSH Terms: Body Weight Changes; Body Weight; Weight Gain; Physiological Effects of Drugs; Neurotransmitter Agents; Molecular Mechanisms of Pharmacological Action; Vasodilator Agents; Histamine Agents; Histamine Agonists; Betahistine
• Other Study ID Numbers: BET202