- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00443144
D3-GHR Polymorphism and Turner Syndrome
D3-Growth Hormone Receptor Polymorphism and Total Effect of Recombinant Human Growth Hormone on Growth in Girls With Turner Syndrome
The protein polymorphism of the growth hormone receptor characterized by the genomic deletion of exon 3 has been linked to the magnitude of the first-year-growth response to growth hormone (GH) in girls with Turner syndrome.
Objective: to study the long-term effect of GH therapy in Turner syndrome in correlation to this GHR polymorphism in a mainly retrospective design (chart-review).
Study Overview
Status
Conditions
Intervention / Treatment
Study Type
Contacts and Locations
Study Locations
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Tübingen, Germany, 72076
- University-Children's Hospital
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- Turner syndrome defined by a structural aberration or lack of the X chromosome.
- Growth velocity less than 2 cm/year at the time of final analysis (= final height).
Exclusion Criteria:
- Age <3.5 or >14 years at start of GH therapy,
- GH peak serum levels < 8 ng/ml in two independent tests,
- Thelarche at start or during the first year of treatment,
- Oxandrolone therapy for any time and a duration of GH therapy less than 2 years.
Study Plan
How is the study designed?
Collaborators and Investigators
Sponsor
Investigators
- Principal Investigator: Gerhard Binder, M.D. PhD, University-Children's Hospital Tübingen
Publications and helpful links
Study record dates
Study Major Dates
Study Start
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
- Pathologic Processes
- Heart Diseases
- Cardiovascular Diseases
- Endocrine System Diseases
- Disease
- Gonadal Disorders
- Disorders of Sex Development
- Urogenital Abnormalities
- Congenital Abnormalities
- Genetic Diseases, Inborn
- Musculoskeletal Diseases
- Bone Diseases
- Heart Defects, Congenital
- Cardiovascular Abnormalities
- Chromosome Disorders
- Bone Diseases, Developmental
- Sex Chromosome Disorders
- Sex Chromosome Disorders of Sex Development
- Syndrome
- Turner Syndrome
- Gonadal Dysgenesis
- Dwarfism
- Physiological Effects of Drugs
- Hormones, Hormone Substitutes, and Hormone Antagonists
- Hormones
Other Study ID Numbers
- TS-TUE-FH1
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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