Ascertainment of Saliva or Blood Samples For Genetic Epidemiology Studies of Cancer and Aging

The purpose of this study is to help us learn more about the roles of genes in cancers. Genes are short pieces of DNA which determine the inherited characteristics that distinguish one individual from another. This study will look at how some genes might raise or lower the chance some people may develop cancer. The sample collection will help generate the materials needed for this study.

Study Overview

• Status: Completed
• Conditions: Non-cancer Affected Volunteers
• Intervention / Treatment: Other: Saliva or Blood samples

Detailed Description

This is a protocol to obtain saliva or blood samples from non-cancer affected volunteers aged 60 years or older, without a history of cancer other than non-melanoma skin cancer. These samples will be used in a genomic approach to elucidate novel pathways of cancer predisposition.

• Study Type: Observational
• Enrollment (Actual): 53

Contacts and Locations

Study Locations

• United States
  • New York
    • New York, New York, United States, 10065
      • Memorial Sloan Kettering Cancer Center

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 60 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

Nursing homes, senior centers, health fairs or other community organizations.

Description

Inclusion Criteria:

• Eligible subjects must be non-cancer affected volunteers of either gender who are 60 years of age or older at the time of saliva/blood donation.
• Subjects will self-identify religion and country of origin of grandparents.
• Volunteers will have (by self report) no history of cancer other than nonmelanoma skin cancer. It is recognized that there may be some errors in self report, however, the literature reports a very low error rate for self reported disease reporting for cancer as assessed by interview.

Exclusion Criteria:

• Subjects with mental impairment will be excluded from this study.

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
obtain saliva or blood from non-cancer volunteers, 60 years or older to carry out anonymous genetic epidemiology studies related to resistance to cancer in elderly.	conclusion of the study

Secondary Outcome Measures

Outcome Measure	Time Frame
samples perform high density genomic scans & candid gene studies carriers specif BRCA found mutat who haven't been affect by breast cancer & old than 60 find genetic cofactor may modify a predispo breast ca confer by germline mutation in BRCA1 & BRCA2.	conclusion of the study

Collaborators and Investigators

• Sponsor: Memorial Sloan Kettering Cancer Center
• Collaborators: Susan G. Komen Breast Cancer Foundation; Jewish Home & Hospital Lifecare System; Metropolitan Jewish Health System; Hebrew Home at Riverdale; Beth Abraham; Gurwin Jewish Nursing & Rehabilitation Center; Margaret Tietz Nursing and Rehabilitation Center; Northern Services Group; Parker Jewish Institute; Lenox Hill Neighborhood House; JASA at Temple Emanuel of Parkchester Senior Center; Van Cortlandt Village Senior Center

Publications and helpful links

Helpful Links

• Memorial Sloan Kettering web site

Study record dates

Study Major Dates

• Study Start (Actual): September 1, 2006
• Primary Completion (Actual): July 1, 2017
• Study Completion (Actual): July 1, 2017

Study Registration Dates

• First Submitted: December 20, 2007
• First Submitted That Met QC Criteria: December 21, 2007
• First Posted (Estimate): December 24, 2007

Study Record Updates

• Last Update Posted (Actual): July 31, 2017
• Last Update Submitted That Met QC Criteria: July 28, 2017
• Last Verified: July 1, 2017

More Information

Terms related to this study

• Keywords: non-cancer affected volunteers; aged 60 years or older
• Other Study ID Numbers: 06-102