- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00600717
Clinical Applications of High-Frequency Oscillations (HFOs)
Localizing Functional Brain Cortices and Epileptogenic Zones With High Frequency Brain Signals
The objective of this study is to use high-frequency brain signals (HFBS) to localize functional brain areas and to characterize HFBS epilepsy, migraine and other brain disorders. We hope to build the world's first high-frequency MEG/MEG/ECoG/SEEG database for the developing brain. HFBS include high-gamma activation/oscillations, high-frequency oscillations (HFOs), ripples, fast ripples, and very high frequency oscillations (VHFOs) in the brain.
To reach the goals, we have developed several new MEG/EEG methods: (1) accumulated spectrogram; (2) accumulated source imaging; (3)frequency encoded source imaging; (4) multi-frequency analysis; (5)artificial intelligence detection of HFOs; (6) Neural network analysis (Graph Theory); and (7) others (e.g. ICA, virtual sensors).
Study Overview
Status
Detailed Description
I. PURPOSE OF STUDY The purpose of this study is to go beyond the conventional analyses of brain signals in a narrow frequency band (typically 1-30 Hz) by measuring brain signals from infraslow to very fast (0.01 - 2800 Hz). Specifically, we propose to study physiological HFOs in sensorimotor, auditory, visual and language evoked magnetic fields and to investigate pathological HFOs in epilepsy, migraine and other disorders. This is clinical very important for many reasons.
For example, There are 400,000 to 600,000 patients with refractory epilepsy in the United States. Since those patients' seizures cannot be controlled by any drugs, epilepsy surgery is one potential cure. Accurate identification of ictogenic zones, the brain areas cause seizures, is essential to ensure a favorable surgical outcome. Unfortunately, the existing method, electrocorticography (ECoG), needs to place electrodes upon the brain surface to capture spikes (typically, 14-70 Hz), which is very risky and costly. The present study is to use magnetoencephalography (MEG) and electroencephalography (EEG) to identification of ictogenic zones noninvasively. To reach the goal, we proposed to detect high frequency (70-2,500 Hz) and low frequency (< 14 Hz) brain signals with advanced signal processing methods. Our central hypothesis is that high frequency brain signals will lead to significantly improved rates of seizure freedom as compared with spikes. This hypothesis is based on recent reports that high frequency brain signals are localized to ictogenic zones.
Building on our unique resources and skills, we plan to address four aims. First, we will quantify the spatial concordance between MEG and ECoG signals in both low and high frequency ranges. We hypothesize that Ictogenic zones determined by invasive ECoG can be non-invasively detected and localized by high frequency MEG signals. Second, we will quantify the occurrence concordance between EEG and ECoG signals in both low and high frequency ranges. We hypothesize that epileptic high frequency signals from the ictogenic zones determined by invasive ECoG can also been non-invasively detected by EEG, although the localization of EEG may be significantly inferior to that of MEG. Third, we will determine whether epilepsy surgery based on multi-frequency signals (low frequency brain signals, spikes, and high frequency brain signals), instead of spikes alone, leads to a better seizure outcome. We hypothesize that epilepsy surgery guided by high frequency brain signals detected with MEG/EEG will significantly improve surgical outcomes. Fourth, we will determine whether multi-frequency analyses provide more information than single frequency analysis for estimating epileptogenic zones for pre-surgical ECoG electrode implantation. We hypothesize that covering all brain areas generating low to high frequency epileptic activity is the prerequisite to localize multiple ictogenic zones for favorable post-surgical outcomes. To yield definitive results, we propose a multi-center study to determine if high frequency brain signals are new biomarkers for significantly improve epilepsy surgery outcomes. According to our pilot data that localization of epileptogenic zones with MEG high frequency signals can increase about 30-40% post-operative seizure freedom, the proposed study should result in millions of intractable epilepsy patients being seizure free. This study also lays a foundation for using low and high frequency brain signals as new biomarkers for diagnosis and treatment of many other disorders (e.g. migraine, autism).
Study Type
Enrollment (Estimated)
Contacts and Locations
Study Locations
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Ohio
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Cincinnati, Ohio, United States, 45229
- MEG
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Sampling Method
Study Population
Description
Inclusion Criteria:
- Healthy and cooperative
- Ages: from 1 day to 69 years (male or female)
- Normal hearing and vision
- Normal hand movement
- No history for neurological or psychiatric disease
- No family history for genetic neurological or psychiatric diseases.
- No metal implants such as pacemaker, neuron-stimulator, cochlear device, etc.
Exclusion Criteria:
- If you are taking any medications for depression, neurologic, or psychiatric condition
- If you do not feel well, have epilepsy or other brain disorders
- If you have had a recent concussion or head injury
- If you have any metal, such as dental braces, in your body that would cause "magnetic noise", you may not be able to be in this study. If you would like, we can do a simple, quick "magnetic noise screening" in the MEG Center, which can tell us whether you can be in the study.
- If you have any electrical or metal implants such as pacemakers, neuro-stimulators, or orthopedic pins or plates. The research nurse will discuss all exclusions with you in further detail before the magnetic resonance imaging (MRI) scan.
- If you could not pass the pre-experimental screening
Study Plan
How is the study designed?
Design Details
- Observational Models: Other
- Time Perspectives: Prospective
Cohorts and Interventions
Group / Cohort |
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Pediatric Patients and Healthy Children
Healthy children without dental works.
Pediatric patients with epilepsy and migraine (headache).
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
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epileptic foci
Time Frame: one year
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Accuracy of localization of epileptic foci
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one year
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Collaborators and Investigators
Collaborators
Investigators
- Study Director: Jing Xiang, Ph.D M.D., Children's Hospital Medical Center, Cincinnati
Publications and helpful links
General Publications
- Wu D, Zhou Y, Xiang J, Tang L, Liu H, Huang S, Wu T, Chen Q, Wang X. Multi-frequency analysis of brain connectivity networks in migraineurs: a magnetoencephalography study. J Headache Pain. 2016;17:38. doi: 10.1186/s10194-016-0636-7. Epub 2016 Apr 18.
- Kotecha R, Xiang J, Wang Y, Huo X, Hemasilpin N, Fujiwara H, Rose D, deGrauw T. Time, frequency and volumetric differences of high-frequency neuromagnetic oscillation between left and right somatosensory cortices. Int J Psychophysiol. 2009 May;72(2):102-10. doi: 10.1016/j.ijpsycho.2008.10.009. Epub 2008 Nov 14.
- Wang Y, Xiang J, Kotecha R, Vannest J, Liu Y, Rose D, Schapiro M, Degrauw T. Spatial and frequency differences of neuromagnetic activities between the perception of open- and closed-class words. Brain Topogr. 2008 Dec;21(2):75-85. doi: 10.1007/s10548-008-0060-7. Epub 2008 Aug 5.
- Liu Y, Xiang J, Wang Y, Vannest JJ, Byars AW, Rose DF. Spatial and frequency differences of neuromagnetic activities in processing concrete and abstract words. Brain Topogr. 2008 Spring;20(3):123-9. doi: 10.1007/s10548-007-0038-x. Epub 2007 Dec 6.
- Xiang J, Xiao Z. Spatiotemporal and frequency signatures of noun and verb processing: a wavelet-based beamformer study. J Clin Exp Neuropsychol. 2009 Aug;31(6):648-57. doi: 10.1080/13803390802448651. Epub 2008 Dec 22.
- Guo X, Xiang J, Mun-Bryce S, Bryce M, Huang S, Huo X, Wang Y, Rose D, Degrauw T, Gartner K, Song T, Schmit J, Vargus-Adams J. Aberrant high-gamma oscillations in the somatosensory cortex of children with cerebral palsy: a meg study. Brain Dev. 2012 Aug;34(7):576-83. doi: 10.1016/j.braindev.2011.09.012. Epub 2011 Oct 21.
- Korostenskaja M, Pardos M, Kujala T, Rose DF, Brown D, Horn P, Wang Y, Fujiwara H, Xiang J, Kabbouche MA, Powers SW, Hershey AD. Impaired auditory information processing during acute migraine: a magnetoencephalography study. Int J Neurosci. 2011 Jul;121(7):355-65. doi: 10.3109/00207454.2011.560312. Epub 2011 Mar 22.
- Zhang R, Wu T, Wang Y, Liu H, Zou Y, Liu W, Xiang J, Xiao C, Yang L, Fu Z. Interictal magnetoencephalographic findings related with surgical outcomes in lesional and nonlesional neocortical epilepsy. Seizure. 2011 Nov;20(9):692-700. doi: 10.1016/j.seizure.2011.06.021. Epub 2011 Jul 22.
- Wang Y, Xiang J, Vannest J, Holroyd T, Narmoneva D, Horn P, Liu Y, Rose D, deGrauw T, Holland S. Neuromagnetic measures of word processing in bilinguals and monolinguals. Clin Neurophysiol. 2011 Sep;122(9):1706-17. doi: 10.1016/j.clinph.2011.02.008. Epub 2011 Mar 16.
- Korostenskaja M, Pardos M, Fujiwara H, Kujala T, Horn P, Rose D, Byars A, Brown D, Seo JH, Wang Y, Vannest J, Xiang J, Degrauw T, Naatanen R, Lee KH. Neuromagnetic evidence of impaired cortical auditory processing in pediatric intractable epilepsy. Epilepsy Res. 2010 Nov;92(1):63-73. doi: 10.1016/j.eplepsyres.2010.08.008. Epub 2010 Sep 21.
- Meng L, Xiang J, Kotecha R, Rose D, Zhao H, Zhao D, Yang J, Degrauw T. White matter abnormalities in children and adolescents with temporal lobe epilepsy. Magn Reson Imaging. 2010 Nov;28(9):1290-8. doi: 10.1016/j.mri.2010.03.046. Epub 2010 Jul 24.
- Huo X, Wang Y, Kotecha R, Kirtman EG, Fujiwara H, Hemasilpin N, Degrauw T, Rose DF, Xiang J. High gamma oscillations of sensorimotor cortex during unilateral movement in the developing brain: a MEG study. Brain Topogr. 2011 Jan;23(4):375-84. doi: 10.1007/s10548-010-0151-0. Epub 2010 Jun 25.
- Wang X, Xiang J, Wang Y, Pardos M, Meng L, Huo X, Korostenskaja M, Powers SW, Kabbouche MA, Hershey AD. Identification of abnormal neuromagnetic signatures in the motor cortex of adolescent migraine. Headache. 2010 Jun;50(6):1005-16. doi: 10.1111/j.1526-4610.2010.01674.x. Epub 2010 May 7.
- Chen Y, Xiang J, Kirtman EG, Wang Y, Kotecha R, Liu Y. Neuromagnetic biomarkers of visuocortical development in healthy children. Clin Neurophysiol. 2010 Sep;121(9):1555-1562. doi: 10.1016/j.clinph.2010.03.029. Epub 2010 Apr 14.
- Huo X, Xiang J, Wang Y, Kirtman EG, Kotecha R, Fujiwara H, Hemasilpin N, Rose DF, Degrauw T. Gamma oscillations in the primary motor cortex studied with MEG. Brain Dev. 2010 Sep;32(8):619-24. doi: 10.1016/j.braindev.2009.09.021.
- Xiang J, Liu Y, Wang Y, Kirtman EG, Kotecha R, Chen Y, Huo X, Fujiwara H, Hemasilpin N, Lee K, Mangano FT, Leach J, Jones B, DeGrauw T, Rose D. Frequency and spatial characteristics of high-frequency neuromagnetic signals in childhood epilepsy. Epileptic Disord. 2009 Jun;11(2):113-25. doi: 10.1684/epd.2009.0253. Epub 2009 May 27.
- Xiang J, Liu Y, Wang Y, Kotecha R, Kirtman EG, Chen Y, Huo X, Fujiwara H, Hemasilpin N, DeGrauw T, Rose D. Neuromagnetic correlates of developmental changes in endogenous high-frequency brain oscillations in children: a wavelet-based beamformer study. Brain Res. 2009 Jun 5;1274:28-39. doi: 10.1016/j.brainres.2009.03.068. Epub 2009 Apr 9.
- Leiken KA, Xiang J, Curry E, Fujiwara H, Rose DF, Allen JR, Kacperski JE, O'Brien HL, Kabbouche MA, Powers SW, Hershey AD. Quantitative neuromagnetic signatures of aberrant cortical excitability in pediatric chronic migraine. J Headache Pain. 2016;17:46. doi: 10.1186/s10194-016-0641-x. Epub 2016 Apr 26.
- Meng L, Xiang J. Frequency specific patterns of resting-state networks development from childhood to adolescence: A magnetoencephalography study. Brain Dev. 2016 Nov;38(10):893-902. doi: 10.1016/j.braindev.2016.05.004. Epub 2016 Jun 7.
- Li F, Xiang J, Wu T, Zhu D, Shi J. Abnormal resting-state brain activity in headache-free migraine patients: A magnetoencephalography study. Clin Neurophysiol. 2016 Aug;127(8):2855-2861. doi: 10.1016/j.clinph.2016.05.015. Epub 2016 May 26.
- Xiang J, Leiken K, Degrauw X, Kay B, Fujiwara H, Rose DF, Allen JR, Kacperski JE, O'Brien HL, Kabbouche MA, Powers SW, Hershey AD. Spatial Heterogeneity of Cortical Excitability in Migraine Revealed by Multifrequency Neuromagnetic Signals. J Pain. 2016 Jun;17(6):694-706. doi: 10.1016/j.jpain.2016.02.009. Epub 2016 Mar 10.
- Tang L, Xiang J, Huang S, Miao A, Ge H, Liu H, Wu D, Guan Q, Wu T, Chen Q, Yang L, Lu X, Hu Z, Wang X. Neuromagnetic high-frequency oscillations correlate with seizure severity in absence epilepsy. Clin Neurophysiol. 2016 Feb;127(2):1120-1129. doi: 10.1016/j.clinph.2015.08.016. Epub 2015 Sep 5.
- Pardos M, Korostenskaja M, Xiang J, Fujiwara H, Lee KH, Horn PS, Byars A, Vannest J, Wang Y, Hemasilpin N, Rose DF. Physical Feature Encoding and Word Recognition Abilities Are Altered in Children with Intractable Epilepsy: Preliminary Neuromagnetic Evidence. Behav Neurol. 2015;2015:237436. doi: 10.1155/2015/237436. Epub 2015 Jun 3.
- Liu H, Ge H, Xiang J, Miao A, Tang L, Wu T, Chen Q, Yang L, Wang X. Resting state brain activity in patients with migraine: a magnetoencephalography study. J Headache Pain. 2015;16:525. doi: 10.1186/s10194-015-0525-5. Epub 2015 May 7.
- Xiang J, Korostenskaja M, Molloy C, deGrauw X, Leiken K, Gilman C, Meinzen-Derr J, Fujiwara H, Rose DF, Mitchell T, Murray DS. Multi-frequency localization of aberrant brain activity in autism spectrum disorder. Brain Dev. 2016 Jan;38(1):82-90. doi: 10.1016/j.braindev.2015.04.007. Epub 2015 Apr 27.
- Leiken K, Xiang J, Zhang F, Shi J, Tang L, Liu H, Wang X. Magnetoencephalography detection of high-frequency oscillations in the developing brain. Front Hum Neurosci. 2014 Dec 12;8:969. doi: 10.3389/fnhum.2014.00969. eCollection 2014.
- Xiang J, Korman A, Samarasinghe KM, Wang X, Zhang F, Qiao H, Sun B, Wang F, Fan HH, Thompson EA. Volumetric imaging of brain activity with spatial-frequency decoding of neuromagnetic signals. J Neurosci Methods. 2015 Jan 15;239:114-28. doi: 10.1016/j.jneumeth.2014.10.007. Epub 2014 Oct 18.
- Xiang J, Tenney JR, Korman AM, Leiken K, Rose DF, Harris E, Yuan W, Horn PS, Holland K, Loring DW, Glauser TA. Quantification of Interictal Neuromagnetic Activity in Absence Epilepsy with Accumulated Source Imaging. Brain Topogr. 2015 Nov;28(6):904-14. doi: 10.1007/s10548-014-0411-5. Epub 2014 Oct 31.
- Tenney JR, Fujiwara H, Horn PS, Vannest J, Xiang J, Glauser TA, Rose DF. Low- and high-frequency oscillations reveal distinct absence seizure networks. Ann Neurol. 2014 Oct;76(4):558-67. doi: 10.1002/ana.24231. Epub 2014 Sep 8.
- Xiang J, Luo Q, Kotecha R, Korman A, Zhang F, Luo H, Fujiwara H, Hemasilpin N, Rose DF. Accumulated source imaging of brain activity with both low and high-frequency neuromagnetic signals. Front Neuroinform. 2014 May 21;8:57. doi: 10.3389/fninf.2014.00057. eCollection 2014.
- Ge HT, Liu HX, Xiang J, Miao AL, Tang L, Guan QS, Wu T, Chen QQ, Yang L, Wang XS. Abnormal cortical activation in females with acute migraine: a magnetoencephalography study. Clin Neurophysiol. 2015 Jan;126(1):170-9. doi: 10.1016/j.clinph.2014.03.033. Epub 2014 Apr 16.
- Miao A, Xiang J, Tang L, Ge H, Liu H, Wu T, Chen Q, Hu Z, Lu X, Wang X. Using ictal high-frequency oscillations (80-500Hz) to localize seizure onset zones in childhood absence epilepsy: a MEG study. Neurosci Lett. 2014 Apr 30;566:21-6. doi: 10.1016/j.neulet.2014.02.038. Epub 2014 Feb 26.
- Miao A, Tang L, Xiang J, Guan Q, Ge H, Liu H, Wu T, Chen Q, Yang L, Lu X, Hu Z, Wang X. Dynamic magnetic source imaging of absence seizure initialization and propagation: a magnetoencephalography study. Epilepsy Res. 2014 Mar;108(3):468-80. doi: 10.1016/j.eplepsyres.2014.01.006. Epub 2014 Jan 29.
- Xiang J, Degrauw X, Korman AM, Allen JR, O'Brien HL, Kabbouche MA, Powers SW, Hershey AD. Neuromagnetic abnormality of motor cortical activation and phases of headache attacks in childhood migraine. PLoS One. 2013 Dec 27;8(12):e83669. doi: 10.1371/journal.pone.0083669. eCollection 2013.
- Xiang J, deGrauw X, Korostenskaja M, Korman AM, O'Brien HL, Kabbouche MA, Powers SW, Hershey AD. Altered cortical activation in adolescents with acute migraine: a magnetoencephalography study. J Pain. 2013 Dec;14(12):1553-63. doi: 10.1016/j.jpain.2013.04.009. Epub 2013 Jun 21.
- Korostenskaja M, Harris E, Giovanetti C, Horn P, Wang Y, Rose D, Fujiwara H, Xiang J. Magnetoencephalography reveals altered auditory information processing in youth with obsessive-compulsive disorder. Psychiatry Res. 2013 May 30;212(2):132-40. doi: 10.1016/j.pscychresns.2012.11.011. Epub 2013 Mar 30.
- Song PP, Xiang J, Jiang L, Chen HS, Liu BK, Hu Y. Dynamic Changes in Spectral and Spatial Signatures of High Frequency Oscillations in Rat Hippocampi during Epileptogenesis in Acute and Chronic Stages. Front Neurol. 2016 Nov 28;7:204. doi: 10.3389/fneur.2016.00204. eCollection 2016.
- Wu C, Xiang J, Sun J, Huang S, Tang L, Miao A, Zhou Y, Chen Q, Hu Z, Wang X. Quantify neuromagnetic network changes from pre-ictal to ictal activities in absence seizures. Neuroscience. 2017 Aug 15;357:134-144. doi: 10.1016/j.neuroscience.2017.05.038. Epub 2017 May 31.
- Wu C, Xiang J, Jiang W, Huang S, Gao Y, Tang L, Zhou Y, Wu D, Chen Q, Hu Z, Wang X. Altered Effective Connectivity Network in Childhood Absence Epilepsy: A Multi-frequency MEG Study. Brain Topogr. 2017 Sep;30(5):673-684. doi: 10.1007/s10548-017-0555-1. Epub 2017 Mar 12.
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- Du, J ; Shan, Y ; Li, L ; Fan, X ; An, Y ; Zhang, X; Xiang, ; Ren, L ; Wang, Y. Dynamic Propagation of Interictal Epileptic Spike of Medial Temporal Lobe Epilepsy Predict Seizure Network: A MEG combined with SEEG Study. Epilepsia, 2017, 58(SI, 5): 871
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- Fan Y, Xiang J, Yang K. Multi-frequency analysis of neuromagnetic activity between eyes-open and eyes-closed in the developing brain. The Journal of Japan Biomagnetism and Bioelectromagnetics Society. 2017 May 20; 30(1):90
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- Liang C, Earl B, Thompson I, Whitaker K, Cahn S, Xiang J, Fu QJ, Zhang F. Musicians Are Better than Non-musicians in Frequency Change Detection: Behavioral and Electrophysiological Evidence. Front Neurosci. 2016 Oct 25;10:464. doi: 10.3389/fnins.2016.00464. eCollection 2016.
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- Liang C, Wenstrup LH, Samy RN, Xiang J, Zhang F. The Effect of Side of Implantation on the Cortical Processing of Frequency Changes in Adult Cochlear Implant Users. Front Neurosci. 2020 Apr 29;14:368. doi: 10.3389/fnins.2020.00368. eCollection 2020.
- Firestone GM, McGuire K, Liang C, Zhang N, Blankenship CM, Xiang J, Zhang F. A Preliminary Study of the Effects of Attentive Music Listening on Cochlear Implant Users' Speech Perception, Quality of Life, and Behavioral and Objective Measures of Frequency Change Detection. Front Hum Neurosci. 2020 Mar 31;14:110. doi: 10.3389/fnhum.2020.00110. eCollection 2020.
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- Xiang J, Maue E, Tong H, Mangano FT, Greiner H, Tenney J. Neuromagnetic high frequency spikes are a new and noninvasive biomarker for localization of epileptogenic zones. Seizure. 2021 Jul;89:30-37. doi: 10.1016/j.seizure.2021.04.024. Epub 2021 May 4.
- Xiang J, Maue E, Fujiwara H, Mangano FT, Greiner H, Tenney J. Delineation of epileptogenic zones with high frequency magnetic source imaging based on kurtosis and skewness. Epilepsy Res. 2021 May;172:106602. doi: 10.1016/j.eplepsyres.2021.106602. Epub 2021 Mar 8.
- Xiang J, Yu X, Bonnette S, Anand M, Riehm CD, Schlink B, Diekfuss JA, Myer GD, Jiang Y. Improved Biomagnetic Signal-To-Noise Ratio and Source Localization Using Optically Pumped Magnetometers with Synthetic Gradiometers. Brain Sci. 2023 Apr 15;13(4):663. doi: 10.3390/brainsci13040663.
- Xiang J, Tong H, Jiang Y, Barnes-Davis ME. Spatial and Frequency Specific Artifact Reduction in Optically Pumped Magnetometer Recordings. J Integr Neurosci. 2022 Aug 16;21(5):145. doi: 10.31083/j.jin2105145.
- Chen D, Liu K, Guo J, Bi L, Xiang J. Editorial: Brain-computer interface and its applications. Front Neurorobot. 2023 Feb 9;17:1140508. doi: 10.3389/fnbot.2023.1140508. eCollection 2023. No abstract available.
- Zhang F, Han JH, Samy R, Xiang J. Editorial: Changes in the auditory brain following deafness, cochlear implantation, and auditory training, volume II. Front Hum Neurosci. 2023 Feb 6;17:1124304. doi: 10.3389/fnhum.2023.1124304. eCollection 2023. No abstract available.
- Xiang J, Ishii R, Yang X. Editorial: High Frequency Brain Signals: From Basic Research to Clinical Application. Front Hum Neurosci. 2022 Mar 30;16:872478. doi: 10.3389/fnhum.2022.872478. eCollection 2022. No abstract available.
- Guo J, Xiao N, Li H, He L, Li Q, Wu T, He X, Chen P, Chen D, Xiang J, Peng X. Transformer-Based High-Frequency Oscillation Signal Detection on Magnetoencephalography From Epileptic Patients. Front Mol Biosci. 2022 Mar 4;9:822810. doi: 10.3389/fmolb.2022.822810. eCollection 2022.
- Sun Y, Li Y, Sun J, Zhang K, Tang L, Wu C, Gao Y, Liu H, Huang S, Hu Z, Xiang J, Wang X. Functional reorganization of brain regions into a network in childhood absence epilepsy: A magnetoencephalography study. Epilepsy Behav. 2021 Sep;122:108117. doi: 10.1016/j.yebeh.2021.108117. Epub 2021 Jul 8.
- Sun K, Yu T, Yang D, Ren Z, Qiao L, Ni D, Wang X, Zhao Y, Chen X, Xiang J, Chen N, Gao R, Yang K, Lin Y, Kober T, Zhang G. Fluid and White Matter Suppression Imaging and Voxel-Based Morphometric Analysis in Conventional Magnetic Resonance Imaging-Negative Epilepsy. Front Neurol. 2021 Apr 29;12:651592. doi: 10.3389/fneur.2021.651592. eCollection 2021.
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Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Estimated)
Study Completion (Estimated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimated)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- IRB 2012-0866; 2018-8108
- 2008-1439 (Other Identifier: CCHMC)
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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