Objective Characterizatoion of Repetitive Behaviors

Actimetric and Electrophysiological Analyses of Repetitive Behaviors (Tics and Compulsions)

Introduction:

Repetitive behaviors (RB) constitute a broad range of symptoms across different psychiatric/neurologic disorders. The most famous are stereotypies (found in autism), compulsions (found in obsessive-compulsive-disorder, OCD) and tics (found in Gilles de la Tourette syndrome, GTS). For some patients, it is sometime difficult to distinguish the nature of the repetitive behaviors presented, however this distinction is crucial in order to chose the appropriate treatment.

Aim:

In our study, the investigators will try to define electrophysiological and accelerometric marker of both OCD and tics to allow objective distinction between both tics and compulsions.

Method:

Subjects: Both OCD and GTS patients will be recruited, 25 patients in each group.

Protocol: our study protocol will involve two step: a step in laboratory, another step at patient home.

• first step: both patients group will be recorded through a high density EEG and a portative EEG while doing a task of symptom provocation. Then they will get an anatomical MRI for source recontruction. Finally, the patients will have to mimic their symptom while wearing an accelerometer (a smartwatch).
• second step: both patient groups will be recorded at home through a portative EEG while tagging their symptom through a smartwatch (also used for accelerometry). After the recording, the patients will keep the smartwatch for 2 weeks, still tagging their sympoms (compulsions or tics).

Study Overview

• Status: Recruiting
• Conditions: OCD; Tic Disorders; Gilles de la Tourette Syndrome
• Intervention / Treatment: Device: EEG; Device: MRI

• Study Type: Interventional
• Enrollment (Estimated): 50
• Phase: Not Applicable

Contacts and Locations

• Study Contact: Name: Luc MALLET, MD; Phone Number: +33157274000; Email: luc.mallet@inserm.fr
• Study Contact Backup: Name: Hugues LAMOTHE, MD; Phone Number: +33149813195; Email: lamothehugues@gmail.com

Study Locations

• France
  • Créteil, France, 94010
    • Recruiting
    • Hôpital Henri Mondor
    • Contact: Luc Mallet
  • Créteil, France, 94000
    • Recruiting
    • Hôpital Albert Chenevier
    • Contact: Hugues Lamothe
  • Paris, France, 75013
    • Recruiting
    • Hopital Pitie Salpetriere
    • Contact: Andreas Hartmann

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Child; Adult; Older Adult
• Accepts Healthy Volunteers: No

Description

Inclusion Criteria:

• To be more of 15 years old or less than 65 years old
• To suffer from OCD and/or GTS (depressive, anxious and attention deficit hyperactivity disorder (ADHD) comorbidities are accepted)
• To be registered to the french social security (or something equivalent)
• To give written consent to participate to the research
• To have contraception for women participants (or to not have any sexual activity)

Exclusion Criteria:

• Patients with any other psychiatric disorders than those mentioned in the inclusion criteria
• Patients with any other neurological disorder than GTS
• Patients who are not able to take decisions for themselves
• Pregnant women
• Patients not allowed to get MRI due to contraindication
• Patients not speaking french

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Basic Science
• Allocation: Non-Randomized
• Interventional Model: Parallel Assignment
• Masking: None (Open Label)

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: GTS group; This arm will be studied to get some electrophysiological marker of tics. The patients will be their own control (periods with symptoms vs. free symptoms periods).	Device: EEG; Recording, from the scalp, the electrophysiological activity of the brain.; Other Names: Electroencephalogram; Device: MRI; Get the anatomical shape of the brain.; Other Names: magnetic resonance imaging
Experimental: OCD group; This arm will be studied to get some electrophysiological marker of compulsions. The patients will be their own control (periods with symptoms vs. free symptoms periods).	Device: EEG; Recording, from the scalp, the electrophysiological activity of the brain.; Other Names: Electroencephalogram; Device: MRI; Get the anatomical shape of the brain.; Other Names: magnetic resonance imaging

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
modification of power (μV2) in EEG frequencies before compulsions in Obsessive-Compulsive Disorder patients	change in the power EEG frequencies in OCD patients before compulsions EEG frequencies come to 0 to 250 Hz, the power is the amplitude of oscillations	one year
modification of power (μV2) in EEG frequencies before tics in Gilles de la Tourette patients	change in the power of EEG frequencies in GTS patients before tics EEG frequencies come to 0 to 250 Hz, the power is the amplitude of oscillations	one year

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Difference in power (μV2) in EEG frequencies between obsessive-compulsive disorder patients and Gilles de la Tourette patients	Difference in the power in the EEG frequencies between obsessive-compulsive disorder patients and Gilles de la Tourette patients EEG frequencies come to 0 to 250 Hz, the power is the amplitude of oscillations	One year and a half
percentage (%) of compulsions and tics detected by accelerometer	percentage of compulsions and tics detected by accelerometer	One year and a half
Correlation of EEG frequency power (arbitrary units) detected before compulsions and scores get with clinical scales (Y-BOCS)	Correlation between power in EEG frequencies and Y-BOCS score get by each individual patients Y-BOCS = Yale-Brown Obsessive-Compulsive Scale; Scores range from 0 to 40 with 40 corresponding to the maximum severity of symptoms	One year and a half
Correlation between number of compulsions detected by accelerometer and Y-BOCS scores get by obsessive-compulsive patients	Correlation between number of compulsions detected by accelerometer and Y-BOCS scores get by obsessive-compulsive patients Y-BOCS = Yale-Brown Obsessive-Compulsive Scale; Scores range from 0 to 40 with 40 corresponding to the maximum severity of symptoms	One year and a half

Collaborators and Investigators

• Sponsor: Institut National de la Santé Et de la Recherche Médicale, France
• Investigators: Principal Investigator: Luc MALLET, MD, Assistance Publique - Hôpitaux de Paris

Study record dates

Study Major Dates

• Study Start (Actual): December 28, 2023
• Primary Completion (Estimated): December 27, 2027
• Study Completion (Estimated): December 27, 2027

Study Registration Dates

• First Submitted: April 28, 2023
• First Submitted That Met QC Criteria: September 15, 2023
• First Posted (Actual): September 22, 2023

Study Record Updates

• Last Update Posted (Actual): February 12, 2026
• Last Update Submitted That Met QC Criteria: February 10, 2026
• Last Verified: February 1, 2026

More Information

Terms related to this study

• Keywords: Biomarker; Electroencephalogram; EEG; Accelerometer; Electrophysiology; Symptom provocation
• Additional Relevant MeSH Terms: Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Mental Disorders; Genetic Diseases, Inborn; Neurodegenerative Diseases; Neurodevelopmental Disorders; Movement Disorders; Heredodegenerative Disorders, Nervous System; Basal Ganglia Diseases; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Tic Disorders; Tourette Syndrome; Diagnostic Techniques and Procedures; Diagnosis; Tomography; Diagnostic Imaging; Diagnostic Techniques, Neurological; Electrodiagnosis; Magnetic Resonance Imaging; Electroencephalography
• Other Study ID Numbers: C21-48; 2022-A01332-41 (Registry Identifier: ID RCB)

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No
• product manufactured in and exported from the U.S.: No