Comparison of Sub-maximal Voluntary Isometric Training vs Eccentric Training in Management of De Quervain Tenosynovitis

This study is a randomised control trial and the purpose of this study is to compare the effects of Sub-maximal Voluntary Isometric Training vs Eccentric Training in Management of De Quervain Tenosynovitis

Study Overview

• Status: Recruiting
• Conditions: De Quervain Syndrome
• Intervention / Treatment: Procedure: Isometric training of thumb muscles; Procedure: Ultrasound; Procedure: Eccentric training for thumb muscles

Detailed Description

Participants will be recruited into their respective groups using a coin toss method. De Quervain Tenosynovitis will be assessed using the following tests:

1. Wrist hyperflexion and abduction of thumb (WHAT) test
2. Finkelstein's / Eichhoff's test
3. De Quervain Screening Tool

• Study Type: Interventional
• Enrollment (Estimated): 58
• Phase: Not Applicable

Contacts and Locations

• Study Contact: Name: Zahra Nayyer, MS-MSKPT*; Phone Number: 0349-8219386; Email: zahranayyar727@gmail.com

Study Locations

• Pakistan
  • Punjab
    • Rawalpindi, Punjab, Pakistan, 46000
      • Recruiting
      • Foundation University College of Physcial Therapy
      • Contact: Furqan Hassan, OMPT,PHD*; Phone Number: 03334056768; Email: furqan.hassan@fui.edu.pk

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult
• Accepts Healthy Volunteers: No

Description

Inclusion Criteria:

• Patients having history of pain, tenderness in thumb region from 3 weeks or more
• Age 21-50
• Both genders
• Individuals meeting the diagnostic criteria i.e.
• A score of 3 or more out of 7 on De Quervain screening tool.
• Positive Wrist hyperflexion and abduction of thumb (WHAT) test
• Positive Finkelstein's / Eichhoff's test

Exclusion criteria:

• Diagnosed cases of Osteoarthritis of 1st CMC joint and Rheumatoid arthritis
• C6 cervical radiculopathy
• Any systemic inflammatory condition like septic arthritis
• Carpal Tunnel Syndrome
• Complex regional pain syndrome
• Previous surgery impacting the first extensor compartment of the wrist
• Corticosteroid injection in the radial wrist region within 3 months of enrolment into the study
• If patient had undergone isometric thumb exercises or any strengthening protocol lasting greater than 2 weeks for the management of their current episode of de Quervain's syndrome

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: None (Open Label)

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Active Comparator: Sub-maximal Voluntary Isometric training Group; Group A will recieve ultrasound therapy for symptoms management and isometric training of thumb muscles (abducttor pollices longus and extensor pollices brevis) to gain improvement in range of motion and strength	Procedure: Isometric training of thumb muscles; Isometric training for thumb extension, abduction, radial and ulnar deviation will be performed in 3 sessions/ week for 4 weeks. The exercise protocol will begin with training using manual resistance and progress with training against resistance of elastic band and theraband.I; Procedure: Ultrasound; Therapeutic ultrasound for symptom management
Experimental: Eccentric training Group; Group B will receive the ultrasound therapy similar to group A for symptoms management and eccentric training of thumb muscles to gain improvement in range of motion and strength of thumb	Procedure: Ultrasound; Therapeutic ultrasound for symptom management; Procedure: Eccentric training for thumb muscles; In Group B, eccentric training for thumb extension, abduction, radial and ulnar deviation will be performed in 3 sessions/ week for 4 weeks. The exercise protocol will begin with training using unweighted and weighted hammer curls and progress with training using elastic band, dumbbell and theraband.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Grip Strength measurement	Power grip strength will be measured using hand held dynamometer and pinch grip strength will be measured using Modified sphygmomanometer	4 weeks

Collaborators and Investigators

• Sponsor: Foundation University Islamabad

Study record dates

Study Major Dates

• Study Start (Actual): July 18, 2024
• Primary Completion (Estimated): June 1, 2025
• Study Completion (Estimated): June 20, 2025

Study Registration Dates

• First Submitted: February 17, 2025
• First Submitted That Met QC Criteria: February 17, 2025
• First Posted (Actual): March 25, 2025

Study Record Updates

• Last Update Posted (Actual): March 25, 2025
• Last Update Submitted That Met QC Criteria: February 17, 2025
• Last Verified: February 1, 2025

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Musculoskeletal Diseases; Muscular Diseases; Tendinopathy; Tendon Entrapment; Tenosynovitis; De Quervain Disease
• Other Study ID Numbers: FUI/CTR/2025/1

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No