Strain-Encoded Magnetic Resonance Imaging in Acute Myocardial Infarction (137-2005)

September 15, 2008 updated by: RWTH Aachen University

Strain-Encoded Magnetic Resonance Imaging for Evaluation of Left Ventricular Function and Acute Myocardial Infarction

The aim of the study was therefore to evaluate whether myocardial deformation imaging performed by SENC allows for quantification of regional left ventricular function and is related to transmurality states of infarcted tissue in patients with acute myocardial infarction (AMI).

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

CMR was performed in 38 consecutive patients with AMI 3±1 days after successful reperfusion using a clinical 1.5 Tesla MR-scanner. Ten healthy volunteers served as controls. SENC is a technique that directly measures peak circumferential strain from long-axis views and peak longitudinal strain from short axis views. Measurements were obtained for each segment in a modified 17 segment model. Wall motion and infarcted tissue were evaluated semi-quantitatively from SSFP cine sequences and contrast-enhanced-MR-images and were then related to myocardial strain. Comparison of peak circumferential strain assessed by SENC and MR-tagging was performed.

Study Type

Observational

Enrollment (Actual)

48

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Germany
      • Heidelberg, Germany, 69120
        • University Hospital Heidelberg

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

30 years to 80 years (Adult, Older Adult)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

All

Sampling Method

Non-Probability Sample

Study Population

  • Consecutive Patients with AMI 3+/-1 days after successful reperfusion
  • Ten healthy volunteers serving as control group

Description

Inclusion Criteria:

  • Patients with AMI after successful reperfusion
  • Healthy volunteers in control group

Exclusion Criteria:

  • No reperfusion

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
1
Patients presenting to hospital with AMI
Procedure: cardiac MRI
cardiac MRI at one time point for group 1 after intervention for group 2 at any time point
Other Names:
  • cardiac resonance magnetic imaging
2
healthy volunteers as control group
Procedure: cardiac MRI
cardiac MRI at one time point for group 1 after intervention for group 2 at any time point
Other Names:
  • cardiac resonance magnetic imaging

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
Left ventricular function
Time Frame: 01.01.2007 until 01.02.2007
01.01.2007 until 01.02.2007

Secondary Outcome Measures

Outcome Measure
Time Frame
Transmurality
Time Frame: 01.01.2007 until 01.02.2007
01.01.2007 until 01.02.2007

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

RWTH Aachen University

Collaborators

Heidelberg University

Investigators

  • Principal Investigator: Mirja Neizel, MD, University Hospital Heidelberg

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

January 1, 2007

Primary Completion (Actual)

January 1, 2008

Study Completion (Actual)

January 1, 2008

Study Registration Dates

First Submitted

September 11, 2008

First Submitted That Met QC Criteria

September 12, 2008

First Posted (Estimate)

September 15, 2008

Study Record Updates

Last Update Posted (Estimate)

September 16, 2008

Last Update Submitted That Met QC Criteria

September 15, 2008

Last Verified

September 1, 2008

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • SENC in AMI

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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