- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00885131
Effect of Reward on Learning in Motor Cortex
Effects of Reward on Learning in the Motor Cortex
Background:
- Magnetic resonance imaging (MRI) uses a strong magnetic field and radio waves to take pictures of the brain. Some MRI studies suggest that this technique reveals brain differences in patients with a nervous system illness when compared to adults without a nervous system illness.
Objectives:
- To study functional changes in the brain that may be observed in people without any nervous system illness.
- To learn more about which areas of the brain are necessary to perform certain tasks, especially learning simple motor sequences and processing rewards.
Eligibility:
- Healthy volunteers between the ages of 18 and 50 who are right-handed and are native English speakers, and who have no medical conditions that would prevent them from undergoing magnetic imaging.
- Volunteers must not have a history of neurological or psychiatric illnesses.
- Female volunteers must not be pregnant.
Design:
- Volunteers will be asked to undergo different types of magnetic imaging, including functional magnetic resonance imaging (fMRI), magnetic resonance spectroscopy (MRS), and/or transcranial magnetic stimulation (TMS), while participating in either a slot machine simulation or a key sequence learning task.
- Volunteers will participate in one of four possible experiments:
- Experiment 1: MRS/TMS and slot machine (3 visits, 3.5 hours in total).
- Experiment 2: MRS/TMS and key sequence (3 visits, 3.5 hours in total).
- Experiment 3: fMRI and slot machine (2 visits, 3 hours in total).
- Experiment 4: fMRI and key sequence (1 visit, 2 hours in total).
- Experiment types:
- Slot machine: A computer game like a slot machine, where the user presses a button to start the game and watches as the three barrels of the machine spin into place.
- Key sequence: Pressing a series of buttons in response to visual cues.
- Volunteers will also be asked to give a small blood sample for genetic testing.
- Volunteers will be paid a small amount of money (approximately $50 $80) during the experiments in compensation for their participation in the study.
Study Overview
Status
Conditions
Detailed Description
Objective: The role of mesencephalic dopamine neurons in reward processing has been established in primates using electrophysiological techniques and in humans using functional neuroimaging. They have rich projections to both the prefrontal and motor cortices where they synapse on interneurons and cortical pyramidal cells, producing primarily inhibition. Though their function is not fully understood, these projections clearly play an important role in motivation and learning. We recently developed a paradigm to detect reward-related signals in the primary motor cortex, using transcranial magnetic stimulation (TMS), and demonstrated increased inhibition in primary motor cortex under conditions of increased reward expectancy. These results suggest that motor learning, which depends critically on the motor cortex, may be influenced by reward, which may take the form of simple performance feedback in humans. This kind of feedback also allows subjects to predict the outcome of actions. Thus, our present objective is to investigate the influence of reward/feedback/prediction on the activity of primary motor cortex during motor learning and in particular during instances of increased reward expectancy. Further, we will examine the role of a brain derived neurotrophic factor (BDNF) single nucleotide polymorphism on motor learning.
Study Population: The population that we will study will be healthy volunteers between the ages of 18-50, without any significant medical history or contraindication to functional magnetic resonance imaging (fMRI).
Design: All experiments will employ within- or between-subjects fMRI and magnetic resonance spectroscopy (MRS) to measure changes in activations of different cortical areas in response to motor learning and reward.
Outcome Measures: The outcome measures will be (a) graded changes in blood oxygen level-dependent (BOLD) in response to motor learning and reward and (b) variations in GABA concentration in response to motor learning and reward, and c) variations in response time in the behavioral performance of a learning task.
Study Type
Enrollment (Actual)
Contacts and Locations
Study Locations
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Maryland
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Bethesda, Maryland, United States, 20892
- National Institutes of Health Clinical Center, 9000 Rockville Pike
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
- INCLUSION CRITERIA:
- Age 18-50.
- Right handed.
EXCLUSION CRITERIA:
- Significant neurological or psychiatric history
- Habitual consumption of more than two drinks a day, marijuana more than once a week or any other illicit drug use within the last three months
- Use of medication affecting the DA system, such as phenothiazine antihistamines (promethazine), antiemetics or decongestants within the last month
- Significant abnormality on neurological examination
- Metal in the cranial cavity or eye, pacemaker, implanted pumps or stimulators
- Subjects who participate in any one experiment in this protocol may not participate in another experiment in this protocol.
Study Plan
How is the study designed?
Design Details
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
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The outcome measures will be (a) graded changes in blood oxygen level-dependent (BOLD) in response to motor learning and reward and (b) variations in GABA concentration in response to motor learning and reward.
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Secondary Outcome Measures
Outcome Measure |
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The secondary outcome measures will be variations in response time in the behavioral performance of a learning task.
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Collaborators and Investigators
Publications and helpful links
General Publications
- Avanzi M, Uber E, Bonfa F. Pathological gambling in two patients on dopamine replacement therapy for Parkinson's disease. Neurol Sci. 2004 Jun;25(2):98-101. doi: 10.1007/s10072-004-0238-z.
- Ashe J, Lungu OV, Basford AT, Lu X. Cortical control of motor sequences. Curr Opin Neurobiol. 2006 Apr;16(2):213-21. doi: 10.1016/j.conb.2006.03.008. Epub 2006 Mar 24.
- Arancio O, Chao MV. Neurotrophins, synaptic plasticity and dementia. Curr Opin Neurobiol. 2007 Jun;17(3):325-30. doi: 10.1016/j.conb.2007.03.013. Epub 2007 Apr 6.
Study record dates
Study Major Dates
Study Start
Study Completion
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Other Study ID Numbers
- 090124
- 09-N-0124
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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