- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01088503
Treatment With Adenosine Diphosphate (ADP) Receptor Inhibitors: Longitudinal Assessment of Treatment Patterns and Events After Acute Coronary Syndrome (TRANSLATE-ACS)
The TRANSLATE-ACS Study: Treatment With ADP Receptor Inhibitors: Longitudinal Assessment of Treatment Patterns and Events After Acute Coronary Syndrome
The TReatment with ADP receptor iNhibitorS: Longitudinal Assessment of Treatment Patterns and Events after Acute Coronary Syndrome (TRANSLATE-ACS) study is a prospective, observational longitudinal study to evaluate the real world effectiveness and use of prasugrel and other ADP receptor inhibitor therapies among myocardial infarction (MI) participants treated with percutaneous coronary intervention (PCI) during the index hospitalization. Participant management and treatment decisions are at the discretion of the care team per routine clinical practice. Approximately 17,000 participants will be enrolled at approximately 350 sites in the United States. Follow-up will be conducted through 15 months in approximately 15,650 participants.
TRANSLATE-ACS will complement the results of both randomized controlled clinical trials and current registries in addressing the real world treatment patterns and clinical outcomes for MI participants managed with PCI and initiated on ADP receptor inhibitor therapy. In addition to determining the effectiveness of prasugrel in comparison to other ADP receptor inhibitors, the study will also determine factors associated with initial ADP receptor inhibitor selection and longitudinal patterns of use, evaluate the safety, and describe and compare resource use and medical costs associated with ADP receptor inhibitors. Additionally, this study will generate a continuum of information from the inpatient to outpatient settings to provide a comprehensive picture of participant treatment and outcomes not currently available for novel ADP receptor inhibitors.
Study Overview
Status
Conditions
Intervention / Treatment
Study Type
Enrollment (Actual)
Contacts and Locations
Study Locations
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Rio Piedras, Puerto Rico, 00924
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Alabama
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Birmingham, Alabama, United States, 35233
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Mobile, Alabama, United States, 36617
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Alaska
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Anchorage, Alaska, United States, 99508
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Fayetteville, Alaska, United States, 72703
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Arizona
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Gilbert, Arizona, United States, 85297
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Scottsdale, Arizona, United States, 85258
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Tucson, Arizona, United States, 85723
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Arkansas
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Fort Smith, Arkansas, United States, 72901
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Little Rock, Arkansas, United States, 72205
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Rogers, Arkansas, United States, 72758
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California
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Berkeley, California, United States, 94705
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Loma Linda, California, United States, 92354
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Newport Beach, California, United States, 92663
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Northridge, California, United States, 91325
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Roseville, California, United States, 95661
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Sacramento, California, United States, 95819
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Salinas, California, United States, 93901
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Santa Barbara, California, United States, 93105
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Stockton, California, United States, 95204
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Thousand Oaks, California, United States, 91360
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Torrance, California, United States, 90505
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Colorado
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Aurora, Colorado, United States, 80045
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Parker, Colorado, United States, 80138
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Connecticut
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Bridgeport, Connecticut, United States, 06610
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Danbury, Connecticut, United States, 06810
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Farmington, Connecticut, United States, 06030
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Hartford, Connecticut, United States, 06102
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Delaware
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Newark, Delaware, United States, 19718
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District of Columbia
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Washington, District of Columbia, United States, 20010
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Florida
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Atlantis, Florida, United States, 33462
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Brandon, Florida, United States, 33511
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Ft Lauderdale, Florida, United States, 33308
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Gainesville, Florida, United States, 32608
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Hudson, Florida, United States, 34667
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Jacksonville, Florida, United States, 32209
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Lakeland, Florida, United States, 33805
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Melbourne, Florida, United States, 32901
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Miami Beach, Florida, United States, 33140
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Ocala, Florida, United States, 34471
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Orlando, Florida, United States, 32806
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Stuart, Florida, United States, 34996
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Tampa, Florida, United States, 33613
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Vero Beach, Florida, United States, 32960
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Wellington, Florida, United States, 33449
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Winter Haven, Florida, United States, 33881
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Georgia
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Columbus, Georgia, United States, 31904
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Marietta, Georgia, United States, 30060
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Riverdale, Georgia, United States, 30274
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Hawaii
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Honolulu, Hawaii, United States, 96813
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Illinois
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Carbondale, Illinois, United States, 62901
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Chicago, Illinois, United States, 60625
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Geneva, Illinois, United States, 60134
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Hoffman Estates, Illinois, United States, 60169
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Joliet, Illinois, United States, 60435
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Oak Lawn, Illinois, United States, 60453
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Peoria, Illinois, United States, 61614
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Rock Island, Illinois, United States, 61201
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Rockford, Illinois, United States, 61107
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Urbana, Illinois, United States, 61801
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Indiana
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Elkhart, Indiana, United States, 46514
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Ft Wayne, Indiana, United States, 46805
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Hammond, Indiana, United States, 46320
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Indianapolis, Indiana, United States, 46250
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Lafayette, Indiana, United States, 47905
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Muncie, Indiana, United States, 47303
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Iowa
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Davenport, Iowa, United States, 52803
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Kansas
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Kansas City, Kansas, United States, 66160
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Overland Park, Kansas, United States, 66209
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Topeka, Kansas, United States, 66604
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Wichita, Kansas, United States, 67220
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Kentucky
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Crestview Hills, Kentucky, United States, 41017
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Lexington, Kentucky, United States, 40504
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Owensboro, Kentucky, United States, 42303
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Louisiana
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Alexandria, Louisiana, United States, 71301
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Maine
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Lewiston, Maine, United States, 04240
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Maryland
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Annapolis, Maryland, United States, 21401
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Baltimore, Maryland, United States, 21215
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Cumberland, Maryland, United States, 21502
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Hagerstown, Maryland, United States, 21740
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Salisbury, Maryland, United States, 21804
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Takoma Park, Maryland, United States, 20912
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Massachusetts
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Worcester, Massachusetts, United States, 01606
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Michigan
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Ann Arbor, Michigan, United States, 48109
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Bay City, Michigan, United States, 48708
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Dearborn, Michigan, United States, 48124
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Detroit, Michigan, United States, 48202
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Flint, Michigan, United States, 48532
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Grand Blanc, Michigan, United States, 48439
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Marquette, Michigan, United States, 49855
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Mount Clemens, Michigan, United States, 48043
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Saginaw, Michigan, United States, 48602
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Southfield, Michigan, United States, 48075
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St. Joseph, Michigan, United States, 49085
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Troy, Michigan, United States, 48085
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Warren, Michigan, United States, 48093
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Wyoming, Michigan, United States, 49519
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Minnesota
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Coon Rapids, Minnesota, United States, 55433
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Duluth, Minnesota, United States, 55805
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Edina, Minnesota, United States, 55435
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Minneapolis, Minnesota, United States, 55455
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St Cloud, Minnesota, United States, 56303
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Missouri
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Columbia, Missouri, United States, 65212
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Joplin, Missouri, United States, 64804
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Kansas City, Missouri, United States, 64114
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North Kansas City, Missouri, United States, 64116
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Springfield, Missouri, United States, 65804
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St Louis, Missouri, United States, 63141
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Montana
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Bozeman, Montana, United States, 59715
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Kalispell, Montana, United States, 59901
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Nebraska
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Omaha, Nebraska, United States, 68198
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Nevada
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Las Vegas, Nevada, United States, 89102
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Reno, Nevada, United States, 89503
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New Hampshire
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Nashua, New Hampshire, United States, 03060
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New Jersey
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Bridgewater, New Jersey, United States, 08807
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Cherry Hill, New Jersey, United States, 08034
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New Brunswick, New Jersey, United States, 08901
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Newark, New Jersey, United States, 07055
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Ridgewood, New Jersey, United States, 07450
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Summit, New Jersey, United States, 07902
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New Mexico
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Albuquerque, New Mexico, United States, 87131
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New York
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Brooklyn, New York, United States, 11215
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Elmira, New York, United States, 14905
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Johnson City, New York, United States, 13790
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New York, New York, United States, 10075
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Stony Brook, New York, United States, 11794
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Utica, New York, United States, 13501
- For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
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Valhalla, New York, United States, 10595
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North Carolina
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Chapel Hill, North Carolina, United States, 27599
- For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
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Lumberton, North Carolina, United States, 28358
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Raleigh, North Carolina, United States, 27609
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Wilmington, North Carolina, United States, 28402
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Winston-Salem, North Carolina, United States, 27157
- For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
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Ohio
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Canton, Ohio, United States, 44710
- For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
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Cincinnati, Ohio, United States, 45267
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Kettering, Ohio, United States, 45429
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Middleburg Heights, Ohio, United States, 44130
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Toledo, Ohio, United States, 43615
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Youngstown, Ohio, United States, 44501
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Oklahoma
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Oklahoma City, Oklahoma, United States, 73112
- For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
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Oregon
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Bend, Oregon, United States, 97701
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Portland, Oregon, United States, 97225
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Tualatin, Oregon, United States, 97062
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Pennsylvania
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Abington, Pennsylvania, United States, 19001
- For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
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Allentown, Pennsylvania, United States, 18104
- For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
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Bryn Mawr, Pennsylvania, United States, 19010
- For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
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Camp Hill, Pennsylvania, United States, 17011
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Danville, Pennsylvania, United States, 17822
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Darby, Pennsylvania, United States, 19023
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Greensburg, Pennsylvania, United States, 15601
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Harrisburg, Pennsylvania, United States, 17111
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Hershey, Pennsylvania, United States, 17033
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Johnstown, Pennsylvania, United States, 15905
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Lancaster, Pennsylvania, United States, 17602
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Langhorne, Pennsylvania, United States, 19047
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Philadelphia, Pennsylvania, United States, 19140
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Pittsburgh, Pennsylvania, United States, 15240
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Sayre, Pennsylvania, United States, 18840
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Uniontown, Pennsylvania, United States, 15401
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South Carolina
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Anderson, South Carolina, United States, 29621
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Charleston, South Carolina, United States, 29485
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Columbia, South Carolina, United States, 29203
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Tennessee
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Memphis, Tennessee, United States, 38120
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Nashville, Tennessee, United States, 37205
- For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
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Texas
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Dallas, Texas, United States, 75216
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Decatur, Texas, United States, 76234
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Grapevine, Texas, United States, 76051
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Houston, Texas, United States, 77030
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Round Rock, Texas, United States, 78665
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Temple, Texas, United States, 76508
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Virginia
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Charlottesville, Virginia, United States, 22908
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Chesapeake, Virginia, United States, 23320
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Danville, Virginia, United States, 24541
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Newport News, Virginia, United States, 23601
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Norfolk, Virginia, United States, 23507
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Richmond, Virginia, United States, 23320
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Roanoke, Virginia, United States, 24018
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Virginia Beach, Virginia, United States, 23454
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Winchester, Virginia, United States, 22601
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Washington
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Bellevue, Washington, United States, 98004
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Everett, Washington, United States, 98201
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West Virginia
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Huntington, West Virginia, United States, 25701
- For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
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Wisconsin
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Green Bay, Wisconsin, United States, 54308
- For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
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Milwaukee, Wisconsin, United States, 53215
- For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
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Racine, Wisconsin, United States, 53405
- For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
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Waukesha, Wisconsin, United States, 53188
- For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
Description
Inclusion Criteria:
- greater than or equal to 18 years of age
- diagnosed with NSTEMI or STEMI treated with a PCI during the index hospitalization
- initiated (or continued) on ADP receptor inhibitor therapy before discharge
- fully informed and are able to provide written consent for longitudinal follow-up and data collection
Exclusion Criteria:
- simultaneously participating in a research study that directs choice of either an investigational or approved ADP receptor inhibitor within the first 12 months after MI
Study Plan
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
Intervention / Treatment |
---|---|
ADP receptor inhibitor treatment
Participants admitted for non ST elevation myocardial infarction (NSTEMI) or ST elevation myocardial infarction (STEMI) undergoing percutaneous coronary intervention (PCI) and treated with an ADP receptor inhibitor during the index hospitalization.
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Dosage regimen as determined by the treating physician.
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Percentage of Participants With Major Adverse Cardiovascular Events (MACE)
Time Frame: Baseline through 12 months
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MACE is defined as a composite of all-cause death, myocardial infarction (MI), stroke, or unplanned coronary revascularization.
Events that occurred more than 7 days after medication was switched or discontinued were excluded from the analysis.
Observed (unadjusted) percentages of participants with MACE, as well as the statistical analyses adjusted for baseline cohort differences, are presented.
Percentage of participants = (number of participants with events in 12 months/ number of participants treated) * 100.
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Baseline through 12 months
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Factors Associated With Initial Adenosine Diphosphate (ADP) Receptor Inhibitor Selection at Enrollment
Time Frame: Day 0 (study enrollment)
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Factors are drug-eluting stent (DES) vs. bare metal stent (BMS) placement, other (no stent) vs. BMS, STEMI, other race, cardiogenic shock occurred within 24 hours, male, European Quality of Life Questionnaire-5 Dimension Health State Score (EQ-5D) - United States (US) Index =1 vs. <1, married, diabetes, and other vs. BMS placement.
The EQ-5D US index is a participant-rated, health-related, quality-of-life instrument based on US population.
Scores range from -0.11 to 1.0 with 1.0 = perfect health.
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Day 0 (study enrollment)
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Factors Associated With Initial ADP Receptor Inhibitor Selection at Enrollment: Pre-Procedure Hemoglobin
Time Frame: Day 0 (study enrollment)
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Day 0 (study enrollment)
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Factors Associated With Initial ADP Receptor Inhibitor Selection at Enrollment: Duke Coronary Artery Disease (CAD) Index
Time Frame: Day 0 (study enrollment)
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The Duke CAD Index is a validated composite measure of angiographic burden, which assigns prognostic weights 1 through 100.
Higher scores indicate greater angiographic burden and are associated with poorer prognosis.
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Day 0 (study enrollment)
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Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Percentage of Participants With Cumulative Severe or Moderate Bleeding Events
Time Frame: Baseline, 1, 6, 12 and 15 months
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Bleeding events were collected utilizing the Global Utilization of Streptokinase and Tissue Plasminogen Activator for Occluded Coronary Arteries (GUSTO) definition of bleeding.
Non-coronary artery bypass grafting (CABG)-related GUSTO severe or life-threatening bleeding is any intracranial hemorrhage (ICH) OR any bleeding event resulting in substantial hemodynamic compromise requiring treatment.
Non-CABG-related GUSTO moderate bleeding is any bleeding event resulting in the need for transfusion that is not considered a GUSTO severe or life-threatening bleed.
Additional bleeding events are fatal bleeding or ICH, or any non -fatal surgical-related bleeding events leading to ≥4 units of red cell transfusion.
Observed (unadjusted) percentages of participants with bleeding events, as well as the statistical analyses adjusted for baseline cohort differences, are presented.
Percentage of participants = (number of participants with events / number of participants treated) * 100.
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Baseline, 1, 6, 12 and 15 months
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Percentage of Participants With MACE and Who Had No Prior History of Transient Ischemic Attack (TIA)/Stroke, Weigh ≥60 Kilograms (kg), and Are Age <75 Years
Time Frame: Baseline through 12 months
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MACE is defined as a composite of all-cause death, MI, stroke, or unplanned coronary revascularization.
Events that occurred more than 7 days after medication was switched or discontinued were excluded from the analysis.
Observed (unadjusted) percentages of participants with MACE, as well as the statistical analyses adjusted for baseline cohort differences, are presented.
Percentage of participant = (number of participants with events / number of participants treated) * 100.
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Baseline through 12 months
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Percentage of Participants With MACE Over 1, 6 and 15 Months
Time Frame: Baseline through 1, 6 and 15 months
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MACE is defined as a composite of all-cause death, MI, stroke, or unplanned coronary revascularization.
Events that occurred more than 7 days after medication was switched or discontinued were excluded from the analysis.
Observed (unadjusted) percentages of participants with MACE are presented.
Kaplan-Meier analysis was used to estimate the percentage of participants with a MACE event.
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Baseline through 1, 6 and 15 months
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Percentage of Participants With Definite or Probable Stent Thrombosis (ST) Events
Time Frame: Baseline through 15 months
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Academic Research Consortium (ARC) criteria were used to define ST.
Definite ST is angiographic or pathologic confirmation of partial or total thrombotic occlusion within the peri-stent region, and at least 1 of the following additional criteria: acute ischemic symptoms; ischemic electrocardiogram changes; elevated cardiac biomarkers.
Probable ST is any unexplained death within 30 days of stent implantation; any MI, which is related to documented acute ischemia in the territory of the implanted stent without angiographic confirmation of ST and in the absence of any other obvious cause.
Events that occurred more than 7 days after medication was switched or discontinued were excluded from the analysis.
Observed (unadjusted) percentages of participants with ST events are presented.
Kaplan-Meier analysis was used to estimate the percentage of participants with a definite or probable ST event.
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Baseline through 15 months
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Resource Use Patterns, Cumulative Total Medical Costs, and Cost Effectiveness
Time Frame: 15 months
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15 months
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Collaborators and Investigators
Sponsor
Collaborators
Investigators
- Study Director: Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 9 AM - 5 PM Eastern time (UTC/GMT - 5 hours EST), Eli Lilly and Company
Publications and helpful links
General Publications
- Rymer JA, Kaltenbach LA, Doll JA, Messenger JC, Peterson ED, Wang TY. Safety of Dual-Antiplatelet Therapy After Myocardial Infarction Among Patients With Chronic Kidney Disease. J Am Heart Assoc. 2019 May 21;8(10):e012236. doi: 10.1161/JAHA.119.012236.
- Warraich HJ, Kaltenbach LA, Fonarow GC, Peterson ED, Wang TY. Adverse Change in Employment Status After Acute Myocardial Infarction: Analysis From the TRANSLATE-ACS Study. Circ Cardiovasc Qual Outcomes. 2018 Jun;11(6):e004528. doi: 10.1161/CIRCOUTCOMES.117.004528.
- Fanaroff AC, Kaltenbach LA, Peterson ED, Akhter MW, Effron MB, Henry TD, Wang TY. Antiplatelet Therapy Changes for Patients With Myocardial Infarction With Recurrent Ischemic Events: Insights Into Contemporary Practice From the TRANSLATE-ACS (Treatment With ADP Receptor Inhibitors: Longitudinal Assessment of Treatment Patterns and Events After Acute Coronary Syndrome) Study. J Am Heart Assoc. 2018 Feb 8;7(4):e007982. doi: 10.1161/JAHA.117.007982.
- Tisminetzky M, Wang TY, Gurwitz J, Kaltenbach LA, McManus D, Gore J, Peterson E, Goldberg RJ. Magnitude and Characteristics of Patients Who Survived an Acute Myocardial Infarction. J Am Heart Assoc. 2017 Sep 25;6(9):e006373. doi: 10.1161/JAHA.117.006373.
- Guimaraes PO, Krishnamoorthy A, Kaltenbach LA, Anstrom KJ, Effron MB, Mark DB, McCollam PL, Davidson-Ray L, Peterson ED, Wang TY. Accuracy of Medical Claims for Identifying Cardiovascular and Bleeding Events After Myocardial Infarction : A Secondary Analysis of the TRANSLATE-ACS Study. JAMA Cardiol. 2017 Jul 1;2(7):750-757. doi: 10.1001/jamacardio.2017.1460.
- Hess CN, Kaltenbach LA, Doll JA, Cohen DJ, Peterson ED, Wang TY. Race and Sex Differences in Post-Myocardial Infarction Angina Frequency and Risk of 1-Year Unplanned Rehospitalization. Circulation. 2017 Feb 7;135(6):532-543. doi: 10.1161/CIRCULATIONAHA.116.024406.
- Jackson LR 2nd, Peterson ED, McCoy LA, Ju C, Zettler M, Baker BA, Messenger JC, Faries DE, Effron MB, Cohen DJ, Wang TY. Impact of Proton Pump Inhibitor Use on the Comparative Effectiveness and Safety of Prasugrel Versus Clopidogrel: Insights From the Treatment With Adenosine Diphosphate Receptor Inhibitors: Longitudinal Assessment of Treatment Patterns and Events After Acute Coronary Syndrome (TRANSLATE-ACS) Study. J Am Heart Assoc. 2016 Oct 21;5(10):e003824. doi: 10.1161/JAHA.116.003824.
- Fosbol EL, Ju C, Anstrom KJ, Zettler ME, Messenger JC, Waksman R, Effron MB, Baker BA, Cohen DJ, Peterson ED, Wang TY. Early Cessation of Adenosine Diphosphate Receptor Inhibitors Among Acute Myocardial Infarction Patients Treated With Percutaneous Coronary Intervention: Insights From the TRANSLATE-ACS Study (Treatment With Adenosine Diphosphate Receptor Inhibitors: Longitudinal Assessment of Treatment Patterns and Events After Acute Coronary Syndrome). Circ Cardiovasc Interv. 2016 Nov;9(11):e003602. doi: 10.1161/CIRCINTERVENTIONS.115.003602.
- Krishnamoorthy A, Peterson ED, Knight JD, Anstrom KJ, Effron MB, Zettler ME, Davidson-Ray L, Baker BA, McCollam PL, Mark DB, Wang TY. How Reliable are Patient-Reported Rehospitalizations? Implications for the Design of Future Practical Clinical Studies. J Am Heart Assoc. 2016 Jan 25;5(1):e002695. doi: 10.1161/JAHA.115.002695.
- Hess CN, Wang TY, McCoy LA, Messenger JC, Effron MB, Zettler ME, Henry TD, Peterson ED, Fonarow GC. Unplanned Inpatient and Observation Rehospitalizations After Acute Myocardial Infarction: Insights From the Treatment With Adenosine Diphosphate Receptor Inhibitors: Longitudinal Assessment of Treatment Patterns and Events After Acute Coronary Syndrome (TRANSLATE-ACS) Study. Circulation. 2016 Feb 2;133(5):493-501. doi: 10.1161/CIRCULATIONAHA.115.017001. Epub 2015 Dec 17.
- Wang TY, Henry TD, McCoy LA, Berger PB, Cohen DJ, Effron MB, Zettler M, Baker BA, Messenger JC, Peterson ED. Contemporary use of platelet function and pharmacogenomic testing among patients with acute myocardial infarction undergoing percutaneous coronary intervention in the United States. Am Heart J. 2015 Oct;170(4):706-14. doi: 10.1016/j.ahj.2015.06.021. Epub 2015 Jul 2.
- Mathews R, Wang TY, Honeycutt E, Henry TD, Zettler M, Chang M, Fonarow GC, Peterson ED; TRANSLATE-ACS Study Investigators. Persistence with secondary prevention medications after acute myocardial infarction: Insights from the TRANSLATE-ACS study. Am Heart J. 2015 Jul;170(1):62-9. doi: 10.1016/j.ahj.2015.03.019. Epub 2015 Apr 2.
- Mathews R, Peterson ED, Honeycutt E, Chin CT, Effron MB, Zettler M, Fonarow GC, Henry TD, Wang TY. Early Medication Nonadherence After Acute Myocardial Infarction: Insights into Actionable Opportunities From the TReatment with ADP receptor iNhibitorS: Longitudinal Assessment of Treatment Patterns and Events after Acute Coronary Syndrome (TRANSLATE-ACS) Study. Circ Cardiovasc Qual Outcomes. 2015 Jul;8(4):347-56. doi: 10.1161/CIRCOUTCOMES.114.001223. Epub 2015 Jun 2.
- Wang TY, Henry TD, Effron MB, Honeycutt E, Hess CN, Zettler ME, Cohen DJ, Baker BA, Berger PB, Anstrom KJ, Angiolillo DJ, Peterson ED; TRANSLATE-POPS Investigators. Cluster-randomized clinical trial examining the impact of platelet function testing on practice: the treatment with adenosine diphosphate receptor inhibitors: longitudinal assessment of treatment patterns and events after acute coronary syndrome prospective open label antiplatelet therapy study. Circ Cardiovasc Interv. 2015 Jun;8(6):e001712. doi: 10.1161/CIRCINTERVENTIONS.114.001712.
- Xian Y, Wang TY, McCoy LA, Effron MB, Henry TD, Bach RG, Zettler ME, Baker BA, Fonarow GC, Peterson ED. Association of Discharge Aspirin Dose With Outcomes After Acute Myocardial Infarction: Insights From the Treatment with ADP Receptor Inhibitors: Longitudinal Assessment of Treatment Patterns and Events after Acute Coronary Syndrome (TRANSLATE-ACS) Study. Circulation. 2015 Jul 21;132(3):174-81. doi: 10.1161/CIRCULATIONAHA.114.014992. Epub 2015 May 20.
- Bagai A, Peterson ED, Honeycutt E, Effron MB, Cohen DJ, Goodman SG, Anstrom KJ, Gupta A, Messenger JC, Wang TY. In-hospital switching between adenosine diphosphate receptor inhibitors in patients with acute myocardial infarction treated with percutaneous coronary intervention: Insights into contemporary practice from the TRANSLATE-ACS study. Eur Heart J Acute Cardiovasc Care. 2015 Dec;4(6):499-508. doi: 10.1177/2048872614564082. Epub 2014 Dec 16.
- Hess CN, McCoy LA, Duggirala HJ, Tavris DR, O'Callaghan K, Douglas PS, Peterson ED, Wang TY. Sex-based differences in outcomes after percutaneous coronary intervention for acute myocardial infarction: a report from TRANSLATE-ACS. J Am Heart Assoc. 2014 Feb 7;3(1):e000523. doi: 10.1161/JAHA.113.000523.
- Wang TY, McCoy L, Henry TD, Effron MB, Messenger JC, Cohen DJ, Mark DB, Stone GW, Zettler M, Singh M, Fonarow GC, Peterson ED; TRANSLATE-ACS Study Investigators. Early post-discharge bleeding and antiplatelet therapy discontinuation among acute myocardial infarction patients treated with percutaneous coronary intervention. J Am Coll Cardiol. 2014 Apr 29;63(16):1700-2. doi: 10.1016/j.jacc.2013.12.012. Epub 2014 Jan 30. No abstract available.
- Chin CT, Wang TY, Anstrom KJ, Zhu B, Maa JF, Messenger JC, Ryan KA, Davidson-Ray L, Zettler M, Effron MB, Mark DB, Peterson ED. Treatment with adenosine diphosphate receptor inhibitors-longitudinal assessment of treatment patterns and events after acute coronary syndrome (TRANSLATE-ACS) study design: expanding the paradigm of longitudinal observational research. Am Heart J. 2011 Nov;162(5):844-51. doi: 10.1016/j.ahj.2011.08.021.
Study record dates
Study Major Dates
Study Start
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 12549
- H7T-US-B007 (Other Identifier: Eli Lilly and Company)
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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