Improving Adherence to Prescribing Guidelines for Cholesterol Lowering in Hospitalized Diabetic Patients

Assisted Detailing to Improve Guideline Adherence

We hypothesize that when compared to usual care a greater proportion of hospitalized diabetic patients who are candidates for cholesterol lowering will be discharged with a prescription for a statin if their physicians are contacted by a pharmacist to discuss treatment guidelines.

Study Overview

• Status: Completed
• Conditions: Diabetes; Dyslipidemia
• Intervention / Treatment: Other: Academic detailing

• Study Type: Interventional
• Enrollment (Actual): 247
• Phase: Not Applicable

Contacts and Locations

Study Locations

• United States
  • Missouri
    • St. Louis, Missouri, United States, 63110
      • Barnes Jewish Hospital

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• Hospitalized patients with diabetes
• LDL >= 100

Exclusion Criteria:

• Terminal illness
• Pregnancy
• Intolerance or contraindication to statin

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Health Services Research
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: None (Open Label)

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
No Intervention: Usual care
Experimental: Academic detailing of physicians	Other: Academic detailing; Education of physicians by pharmacists regarding indications for statins in diabetic patients

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Statin prescription at hospital discharge	Hospital discharge (avg = 3 days)

Collaborators and Investigators

• Sponsor: Washington University School of Medicine
• Collaborators: National Heart, Lung, and Blood Institute (NHLBI)
• Investigators: Principal Investigator: Thomas C Bailey, MD, Washington University School of Medicine

Publications and helpful links

General Publications

• McKinnon PS, Seaton T, Noirot LA, Reichley RM, Heard KM, Shannon WD, Goldberg AC, Dunagan WC, Bailey TC. Improving adherence to dyslipidemia medication guidelines in hospitalized diabetic patients using a technology-assisted pharmacist intervention. AMIA Annu Symp Proc. 2008 Nov 6:868.
• Reichley R, McKinnon PS, Seaton T, Noirot L, Dunagan WC, Bailey TC. Adherence to dyslipidemia treatment guidelines in diabetic patients. AMIA Annu Symp Proc. 2006;2006:1071.
• Reichley R, Rachmiel E, Seaton T, Noirot L, Longyhore D, Dunagan WC, Bailey TC. Intervention to improve dyslipidemia screening in hospitalized diabetics. AMIA Annu Symp Proc. 2005;2005:1093.
• McKinnon PS, Reichley RM, Noirot LA, Dunagan WC, Bailey TC. Prospective validation of an algorithm to identify hospitalized diabetic patients using administrative data. AMIA Annu Symp Proc. 2006;2006:1029.

Study record dates

Study Major Dates

• Study Start: June 1, 2006
• Primary Completion (Actual): June 1, 2007
• Study Completion (Actual): June 1, 2007

Study Registration Dates

• First Submitted: April 22, 2010
• First Submitted That Met QC Criteria: April 27, 2010
• First Posted (Estimate): April 29, 2010

Study Record Updates

• Last Update Posted (Estimate): April 29, 2010
• Last Update Submitted That Met QC Criteria: April 27, 2010
• Last Verified: April 1, 2010

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Metabolic Diseases; Lipid Metabolism Disorders; Dyslipidemias
• Other Study ID Numbers: 02-1072; R01HL070790 (U.S. NIH Grant/Contract)