Pilot Study of Lychee Fruit Extract to Promote Cardiovascular Health

Effects of Lychee Fruit Extract on Vascular Function and Inflammation in Postmenopausal Women: a Double-Blind, Crossover Study

Sponsors

Lead Sponsor: University of California, Davis

Source University of California, Davis
Brief Summary

The investigators hypothesize that acute and short term consumption of a lychee fruit extract, particularly rich in low molecular weight dietary flavanols, will improve vascular function and reduce platelet reactivity.

Detailed Description

Several large-scale epidemiologic studies have indicated that chronic consumption of flavonoid-rich foods appear to be associated with decreased risk for several chronic diseases including cancer, diabetes, cardiovascular disease, and stroke. In humans, consumption of several flavonoid-rich foods and beverages, such as berries, teas, cocoa, and grapes have been reported to improve vascular endothelial function and decrease platelet reactivity. Previous work at UC Davis by Dr. Keen and colleagues has helped define the role of flavanols in vascular function, and has used a flavanol-rich cocoa extract as the test material. In this proposed study, we seek to explore the role of a lychee fruit extract rich in flavanols, and its effects of vascular and metabolic parameters.

Overall Status Completed
Start Date April 2009
Completion Date July 2010
Primary Completion Date July 2010
Phase Phase 1
Study Type Interventional
Primary Outcome
Measure Time Frame
Peripheral Arterial Tonometry 0, 2 and 4 hours
Enrollment 44
Condition
Intervention

Intervention Type: Dietary Supplement

Intervention Name: Lychee Fruit Extract

Description: placebo or 100, 200 and 600 mg of lychee fruit extract for 2 weeks with one week washout period between treatments 2000 mg of lychee fruit extract given at a single visit

Eligibility

Criteria:

Inclusion Criteria:

- Female Age 52 to 65 yrs.

- Male Age 18 to 35 yrs.

- Female and male >110 pounds

- Lack of menses in the last year and FSH 23-116.3 mIU/mL

- Subject is willing and able to comply with the study protocols.

- Subject is willing to consume the lychee fruit extract or placebo capsule twice a day.

- BMI 20-35 kg/m2

Exclusion Criteria:

- Physical signs of health impairment

- Weight < 110 pounds

- BMI >35 kg/m2

- Blood Pressure > 140/90 mm Hg

- Diabetes

- Inability to properly place or wear the PAT probes or abnormal measurements on pre-screening PAT

- Abnormal clinical laboratory test (CBC, comprehensive metabolic panel, etc.) if determined to be clinically significant by Dr. M. Eric Gershwin.

- PFA-100 readings 10% outside of normal reference range (normal reference range for ADP-Collagen cartridge: 71-118 sec; Epinephrine-Collagen cartridge: 94-193 sec).

- Inflammatory disorders (e.g. rheumatoid arthritis)

- Malabsorption

- Treatment with corticosteroids, hypolipidemic and anti-inflammatory drugs

- Renal or liver disease

- History of cancer

- Heart disease, which includes cardiovascular events and Stroke

- Cushing's syndrome

- History of psychiatric disorders i.e. schizophrenia or bi-polar or depression treated with antidepressants within the last 1 year.

- Anxiety medications

- Routine use of prescription drugs or over-the counter medications, which may potentially modulate the outcome of this study; including antibiotics, aspirin and aspirin-containing formulations, COX-2 inhibitors, antihistamines, corticosteroids

- Asthma (can be worsened by mild to moderate food allergies)

- Indications of substance or alcohol abuse within the last 3 years

- Multi-vitamin and mineral use other than a general formula, once per day tablet

- Use of herbal or plant-based supplements; omega-3 fatty acids, and fish oils in the past 3-6 months, and unwilling to discontinue use while participating in the study

- Alcohol consumption > 1 oz/day (2 beers/day or 2 glasses of wine/ day, 1 drink of hard liquor/day)

- Allergies to fruit

- Chronic/routine high-intensity exercise

- Smoking or actively in smoking cessation therapy

Gender: All

Minimum Age: 18 Years

Maximum Age: 65 Years

Healthy Volunteers: Accepts Healthy Volunteers

Overall Official
Last Name Role Affiliation
Robert M Hackman, PhD Principal Investigator University of California, Davis
Location
Facility: Ragle Human Nutrition Research Center
Location Countries

United States

Verification Date

August 2010

Responsible Party

Name Title: Robert M Hackman

Organization: Nutrition Department, University of California, Davis

Keywords
Has Expanded Access No
Number Of Arms 4
Arm Group

Label: 100 mg of Lychee fruit extract

Type: Experimental

Label: 200 mg of Lychee fruit extract

Type: Experimental

Label: 600 mg of Lychee fruit extract

Type: Experimental

Label: 2000 mg of Lychee fruit extract

Type: Experimental

Study Design Info

Allocation: Randomized

Intervention Model: Crossover Assignment

Primary Purpose: Basic Science

Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)

Source: ClinicalTrials.gov