- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01192893
Role of Oxytocin in Post-menopausal Osteoporosis: Evaluation on the Population of the OPUS Cohort
August 13, 2015 updated by: Centre Hospitalier Universitaire de Nice
Oxytocin is a neurohypophysial hormone involved in several central and peripheral functions including parturition, milk let-down reflex and social behaviour.
In vitro and animals studies have shown growing evidence that oxytocin plays a role in bone remodeling and osteoporosis.
The investigators have previously show in a small sample of post-menopausal women with severe osteoporosis (n=20) compare to healthy control (n=16) that oxytocin serum level is significantly decreased, independently of leptin and estradiol, that are known to modulate oxytocin secretion.
Thus, oxytocin appears as a new interesting factor in the osteoporosis pathophysiology.
The aim of the present study is to confirm the relationships between bone status, evaluated by bone mineral density and prevalent fragility fractures, body composition and oxytocin serum levels on a large population.
The investigators will also determine if the relationship between bone mineral density and oxytocin is independent of estradiol and leptin in this population and evaluate the relationships between oxytocin serum level and co-morbidities such as cardiovascular diseases, depression and dementia.
Theses analysis will be done on the serum already available of 1000 women of the international OPUS cohort.
Bone mineral density, body composition analysis by Dual energy X-ray Absorptiometry (DXA), estradiol and clinical data are already available.
The investigators will select women, aged from 55 to 79 y at the time of inclusion.
Study Overview
Status
Completed
Conditions
Study Type
Observational
Enrollment (Actual)
1000
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
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Nice, France, 06200
- Hôpital Archet 1
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Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
55 years to 79 years (Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
Female
Sampling Method
Probability Sample
Study Population
OPUS is a prospective study of postmenopausal women recruited in the general population between April 1999 and April 2001 from five European centers (Aberdeen (UK), Berlin (Germany), Kiel (Germany), Paris (Hôpital Cochin, France), and Sheffield (UK)).
Investigations were approved at each institution according to the Declaration of Helsinki.
Written consent was obtained from all subjects.
Each center recruited approximately 500 postmenopausal women comprising 100 individuals in each 5-yr age band between 55 and 79.
Ninety-nine percent of subjects were of white ethnicity.
Description
Inclusion Criteria:
- post-menopausal women,
- able to undergo bone density,
- without cognitive limitation,
- Age at the time of inclusion: 55 -79y,
- Written consent.
Exclusion Criteria:
- Individuals were excluded because of inability to undergo bone densitometry or perform specified investigations or because of cognitive limitations
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Observational Models: Cohort
- Time Perspectives: Retrospective
Cohorts and Interventions
Group / Cohort |
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OPUS
OPUS is a prospective study of postmenopausal women recruited in the general population between April 1999 and April 2001 from five European centers (Aberdeen (UK), Berlin (Germany), Kiel (Germany), Paris (Hospital Cochin, France), and Sheffield (UK)).
Investigations were approved at each institution according to the Declaration of Helsinki.
Written consent was obtained from all subjects.
Each center recruited approximately 500 postmenopausal women comprising 100 individuals in each 5-yr age band between 55 and 79.
Ninety-nine percent of subjects were of white ethnicity.
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
oxytocin serum levels
Time Frame: at time = 0
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oxytocin serum levels, measured by radio-immuno assay, at the spine and the hip in post-menopausal women
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at time = 0
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bone mineral density
Time Frame: at time = 0
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bone mineral density, measured by dual X ray absorptiometry at the spine and the hip in post-menopausal women
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at time = 0
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Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Estradiol serum level
Time Frame: at time = 0
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Estradiol serum level, body composition (lean mass and fat mass), measured by dual X ray absorptiometry, clinical data (age, age of menopause, previous family history of hip fracture, personal prevalent osteoporotic fractures, prevalent cardiovascular disease, depression and dementia)
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at time = 0
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leptin serum level
Time Frame: at time = 0
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Leptinserum level, body composition (lean mass and fat mass), measured by dual X ray absorptiometry, clinical data (age, age of menopause, previous family history of hip fracture, personal prevalent osteoporotic fractures, prevalent cardiovascular disease, depression and dementia)
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at time = 0
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Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Publications and helpful links
The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.
General Publications
- Breuil V, Fontas E, Chapurlat R, Panaia-Ferrari P, Yahia HB, Faure S, Euller-Ziegler L, Amri EZ, Szulc P. Oxytocin and bone status in men: analysis of the MINOS cohort. Osteoporos Int. 2015 Dec;26(12):2877-82. doi: 10.1007/s00198-015-3201-3. Epub 2015 Jun 25.
- Breuil V, Panaia-Ferrari P, Fontas E, Roux C, Kolta S, Eastell R, Ben Yahia H, Faure S, Gossiel F, Benhamou CL, Euller-Ziegler L, Amri EZ. Oxytocin, a new determinant of bone mineral density in post-menopausal women: analysis of the OPUS cohort. J Clin Endocrinol Metab. 2014 Apr;99(4):E634-41. doi: 10.1210/jc.2013-4126. Epub 2014 Jan 21.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
July 1, 2011
Primary Completion (Actual)
October 1, 2011
Study Completion (Actual)
October 1, 2013
Study Registration Dates
First Submitted
August 31, 2010
First Submitted That Met QC Criteria
August 31, 2010
First Posted (Estimate)
September 1, 2010
Study Record Updates
Last Update Posted (Estimate)
August 14, 2015
Last Update Submitted That Met QC Criteria
August 13, 2015
Last Verified
August 1, 2015
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 10-PP-07
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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