FMRI in Monitoring Intracerebral Stem Cell Implantation for Chronic Stroke Patients

November 26, 2010 updated by: China Medical University Hospital
A growing number of studies highlight the potential of stem cell transplantation as a novel therapeutic approach for stroke in animal model. But the stem cell therapy for chronic stroke patients has not been well investigated yet. In this study, the investigators will test the hypothesis that intracerebral peripheral blood hematopoietic stem cell (CD34+) (PBSC) transplantation induces neuroplasticity in chronic stroke patients. The remyelination of corticospinal tract in the lesion side, focal increased perfusion and increased cortical activity in the peri-infarcted area will be monitored by the functional MRI after stem cell therapy. The investigators study is aimed to find the potential mechanisms of the functional recovery after stem cell implantation. The investigators also hope to find image surrogate markers for prediction of patient outcome. The possible surrogate markers will be helpful in improving the treatment procedure and patient selection.

Study Overview

Status

Unknown

Conditions

Study Type

Observational

Enrollment (Anticipated)

30

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

35 years to 70 years (Adult, Older Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Sampling Method

Non-Probability Sample

Study Population

University hospital

Description

Inclusion Criteria:

  • Old stroke half an year ~3 year
  • One-sided MCA infarction
  • NIHSS stroke scale: 9-20

Exclusion Criteria:

  • Pacemaker
  • Cerebral aneurysm clips
  • Neurostimulator
  • Metallic heart valves
  • IUD
  • Joint replacement
  • Metal plates
  • Bone or joint pins
  • Vena cava filters
  • Embolization coils
  • Cochlear implants
  • Greenfieid filer
  • Seizures
  • Claustrophobia
  • Bullet/gunshot
  • Prosthesis (non-removeable)
  • Artificial limbs (non-removeable)
  • Surgical slips
  • Metal screws or pins>
  • Shrapnel/metallic fragments
  • Harrington rod
  • Insulin pump
  • Ever had metal removed from in or around the eye
  • Ever been metal worker (i.e., welder, machinist)
  • Non-removeable hearing aids
  • Birdnest or Gianturco filter
  • Pregnant

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Observational Models: Case-Control
  • Time Perspectives: Prospective

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

China Medical University Hospital

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

April 1, 2009

Study Registration Dates

First Submitted

November 25, 2010

First Submitted That Met QC Criteria

November 26, 2010

First Posted (Estimate)

November 29, 2010

Study Record Updates

Last Update Posted (Estimate)

November 29, 2010

Last Update Submitted That Met QC Criteria

November 26, 2010

Last Verified

November 1, 2010

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • DMR98-IRB-031

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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