Effect of Rapid Transfusion With Fluid Management System (FMS) on Plasma Potassium in Liver Transplantation Recipients

Potassium Change in the Fluid Management System (FMS) Reservoir and Its Effect on the Plasma Potassium Concentration During Liver Transplantation Surgery

Rapid infusion of red blood cells is known to result in hyperkalemia in the body. However, potassium concentration in the blood mixture (usually made of RBC, FFP and normal saline) in the reservoir of rapid infusion system and its effect on the plasma potassium change during rapid transfusion are unknown. This study is designed to investigate these changes while massive transfusion is performed during liver transplantation surgery.

Study Overview

• Status: Completed
• Conditions: Condition Requiring Rapid Transfusion During Liver Transplantation Surgery

• Study Type: Observational
• Enrollment (Actual): 10

Contacts and Locations

Study Locations

• Korea, Republic of
  • Seoul, Korea, Republic of
    • Seoul National University Hospital

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 19 years to 80 years (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

adult liver transplantation recipients

Description

Inclusion Criteria:

• preoperative anemia (hemoglobin < 10 g/dl)
• preoperative coagulopathy

Exclusion Criteria:

• children under age 18
• low risk of intraoperative bleeding

Study Plan

How is the study designed?

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort
Potassium concentration; plasma potassium concentrations in the Fluid Management System (FMS) reservoir, arterial blood, and central venous blood

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
potassium concentration in the Fluid Management System (FMS) reservoir	During bolus transfusion (300ml) of blood mixture, blood sample is taken from the side port of infusion line of Fluid Management System (FMS) when 150 ml of blood mixture was transfused. Because the priming volume of the internal circuit is approximately 100 ml, blood sample that was taken after 150 ml transfusion represents the content in the reservoir.	after transfusion of 150 ml of blood mixture

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
plasma potassium of the patient	Just before transfusion starts, blood samples are taken from the central venous catheter and arterial line at the same time to measure baseline values. At the immediate end of transfusion, blood samples are taken again from the same sites to measure the resultant changes.	before and after transfuison of 300 ml of blood mixture

Collaborators and Investigators

• Sponsor: Seoul National University Hospital
• Collaborators: Seoul National University
• Investigators: Principal Investigator: Chul-Woo Jung, MD. PhD, Seoul National University Hospital

Study record dates

Study Major Dates

• Study Start: October 1, 2011
• Primary Completion (Actual): March 1, 2015
• Study Completion (Actual): April 1, 2016

Study Registration Dates

• First Submitted: April 5, 2011
• First Submitted That Met QC Criteria: April 7, 2011
• First Posted (Estimate): April 8, 2011

Study Record Updates

• Last Update Posted (Estimate): July 11, 2016
• Last Update Submitted That Met QC Criteria: July 6, 2016
• Last Verified: July 1, 2016

More Information

Terms related to this study

• Keywords: liver transplantation; transfusion; potassium
• Other Study ID Numbers: FMS_potassium