Short-term Effect of Glucose and Sacharose Ingestion on Cognitive Performance and Mood in Elderly

The Short-term Effect of Glucose and Sacharose Ingestion on Cognitive Performance and Mood in Elderly Subjects

The objective of the current study is to determine the acute effect of a glucose drink and a sacharose drink compared to a placebo on cognitive performance in elderly with light memory complaints. The investigators expect that the sugar containing drinks will improve memory and attentional functions. Furthermore, blood glucose response will be measured.

Study Overview

• Status: Completed
• Conditions: Mental Health; Cognition; Attention; Memory
• Intervention / Treatment: Dietary supplement: glucose; Dietary supplement: sacharose; Dietary supplement: Placebo

• Study Type: Interventional
• Enrollment (Actual): 43
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Netherlands
  • Gelderland
    • Wageningen, Gelderland, Netherlands, 6703 HD
      • Wageningen University

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 70 years and older (Older Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• Men and women
• 70 years and older
• Memory complaints

Exclusion Criteria:

• Type I or II diabetes
• Parkinson disease
• MMSE < 25 (to exclude cognitively impaired subjects
• CES-D > 16 (to exclude depressive subjects)
• Pharmacological antidepressives or medication for dementia
• Liver disease

Study Plan

How is the study designed?

Design Details

• Allocation: Randomized
• Interventional Model: Crossover Assignment
• Masking: Double

Number of Arms

3

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Active Comparator: Drink with 50 g glucose; The glucose drink contains 50 g of glucose soluted in 250 ml of water and lemon juice.	Dietary supplement: glucose; The effect of a glucose solution on cognitive performance will be measured.; Other Names: Sucrose, sugar.
Active Comparator: Drink with 100 gram of sacharose; The sacharose drink contains 100 g of sacharose soluted in 250 ml of water and lemon juice.	Dietary supplement: sacharose; The effect of a sacharose solution on cognitive performance will be measured.
Placebo Comparator: Placebo with sweeteners; The placebo contains a mixture of artificial sweeteners in order to have the same sweetness and appearance of the test drinks (the glucose drink and the sacharose drink).	Dietary supplement: Placebo; The effect of a placebo drink with sweeteners on cognitive performance will be measured.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Performance on the paired associate recall test	Cognitive performance will be assessed by several sensitive tests. Power is calculated on the paired associate recall test, but also several other cognitive performance test focusing on memory, attention and reaction time will be performed	cognitive tests will start 15 minutes after ingestion of the intervention product

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Mood	Mood will be measured by the POMS, after consuming the test drink, and after completing the congitive tests.	within 15 minutes after consuming the test drink and after completing the cognitive tests (within 90 minutes after consuming the test drink)
Blood glucose response	Blood glucose will be measured at five time points, at t=0, after 15 minutes, 30, 60 and 90 minutes.	from baseline till 90 minutes after consuming the drink
Plasma insulin levels	One venapunction will be carried out at baseline to measure plasma insulin levels.	At t= -15 minutes, before consuming the test drink

Collaborators and Investigators

• Sponsor: Wageningen University
• Collaborators: Suikerstichting Nederland (Baarn)

Study record dates

Study Major Dates

• Study Start: August 1, 2011
• Primary Completion (Actual): December 1, 2011
• Study Completion (Actual): December 1, 2011

Study Registration Dates

• First Submitted: August 26, 2011
• First Submitted That Met QC Criteria: August 31, 2011
• First Posted (Estimate): September 1, 2011

Study Record Updates

• Last Update Posted (Estimate): March 21, 2012
• Last Update Submitted That Met QC Criteria: March 20, 2012
• Last Verified: March 1, 2012

More Information

Terms related to this study

• Keywords: Elderly; Attention; Memory; Cognitive performance; Glucose; Sacharose; Memory complaints
• Other Study ID Numbers: NL36813.081.11