Surgical Resection Lowers Oxidative Stress Markers in Patients With Colorectal Cancer

Study of Oxidative stress Markers (F2 Isoprostanes for lipid peroxidation, Carbonyl groups for protein peroxidation, 3 Nitrotyrosine for damage by nitrogens, and 8-Hydroxyguanosine for RNA peroxidation)in patients with colorectal cancer undergo surgical treatment (preoperatively during the intervention and postoperatively) and controls.

Study Overview

• Status: Completed
• Conditions: Colorectal Cancer; Oxidative Stress; Colon Rectal Resection
• Intervention / Treatment: Procedure: Surgery for colorectal cancer

Detailed Description

Study of the impact of surgery on Lipid peroxidation, Protein peroxidation, damage by nitrogens, and RNA peroxidation, in patients undergo surgical resection for colorectal cancer and compared with controls, and validation of the responsiveness of oxidative stress markers on surgery

• Study Type: Interventional
• Enrollment (Actual): 60
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Greece
  • Epirus
    • Ioannina, Epirus, Greece, 45001
      • G. Hatzikosta General Hospital

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 25 years to 80 years (Adult, Older Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• Patients with colorectal cancer
• Controls

Exclusion Criteria:

• ASA>3
• Metastatic Disease
• Acute bowel obstruction
• Acute bowel perforation
• BMI<30
• Chronic Systemic or Autoimmune Diseases
• Smokers
• Alcohol consumers

Study Plan

How is the study designed?

Design Details

• Allocation: Randomized
• Interventional Model: Factorial Assignment
• Masking: Triple

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Other: Surgery for colorectal cancer; Colorectal cancer patients	Procedure: Surgery for colorectal cancer; Surgical resection of colorectal cancer; Other Names: Open or Laparoscopic resection for colorectal cancer; Low anterior resection; Sigmoidectomy; Left colectomy; Trasverse colectomy; Right colectomy
No Intervention: Controls

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Comparison of Oxidative stress markers in patients with colorectal cancer and controls	Oxidative stress markers variation (8-PGF2α, Protein Carboyls, 3-Nitrotyrosine, 8-OHG) during and after surgery for colorectal cancer, and compare with controls	up to 2 years

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Validation of oxidative stress markers in patients with colorectal cancer undergo surgical resection	Validation of the responsiveness of markers of oxidative stress 8-PGF2α, Protein Carboyls, 3-Nitrotyrosine, 8-OHG)on surgery	up to 2 years

Collaborators and Investigators

• Sponsor: G. Hatzikosta General Hospital
• Collaborators: University of Ioannina
• Investigators: Principal Investigator: George Pappas-Gogos, MD, G. Hatzikosta General Hospital

Study record dates

Study Major Dates

• Study Start: May 1, 2009
• Primary Completion (Actual): October 1, 2010
• Study Completion (Actual): June 1, 2011

Study Registration Dates

• First Submitted: November 5, 2011
• First Submitted That Met QC Criteria: November 10, 2011
• First Posted (Estimate): November 11, 2011

Study Record Updates

• Last Update Posted (Estimate): November 11, 2011
• Last Update Submitted That Met QC Criteria: November 10, 2011
• Last Verified: November 1, 2011

More Information

Terms related to this study

• Keywords: Colorectal cancer; Surgical resection; Controls; Oxidative Stress Markers
• Additional Relevant MeSH Terms: Digestive System Diseases; Neoplasms; Neoplasms by Site; Gastrointestinal Neoplasms; Digestive System Neoplasms; Gastrointestinal Diseases; Colonic Diseases; Intestinal Diseases; Intestinal Neoplasms; Rectal Diseases; Colorectal Neoplasms
• Other Study ID Numbers: GH-1948-08