- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01492764
Ablation of Ventricular Fibrillation by Accurate Targeting of Arrhythmogenic Regions (AVATAR) (AVATAR)
Study Overview
Status
Conditions
Detailed Description
The investigators will enroll patients with documented rapid heart rates from the bottom chambers of the heart (ventricular tachyarrhythmias).
During electrophysiological study, the investigators will map the localized sources of these heart rhythm disorders.
- The 'active' group will prospectively receive brief ablation at localized sources (Focal Impulse and Rotor Modulation, FIRM).
- The control group will be a historical cohort who have received traditional ablation for this disorder.
All patients will be followed for up to 1 year to ensure that they have no recurrent arrhythmias.
Study Type
Enrollment (Actual)
Contacts and Locations
Study Locations
-
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California
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San Diego, California, United States
- University of California, San Diego Medical Center
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San Diego, California, United States
- Veterans Affairs San Diego Medical Center
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
Description
Inclusion Criteria:
- Documented ventricular tachyarrhythmias.
- Undergoing clinically indicated EP study with ablation.
Exclusion Criteria:
1. Unwillingness or inability to provide informed consent.
Study Plan
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
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Active Group
This group will receive brief ablation at localized sources (Focal Impulse and Rotor Modulation, FIRM)
|
Control Group
This group receives traditional ablation for this disorder
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
reduction in ventricular tachyarrhythmias events
Time Frame: 3 months
|
Using careful clinical monitoring, we will compare the burden of VT/VF after ablation (including FIRM) to the burden preceding ablation.
|
3 months
|
safety of ventricular basket mapping in patients undergoing ablation
Time Frame: 1 month
|
To assess the incidence of adverse events arising from ablation using basket mapping in the ventricles.
These include but are not limited to stroke, systemic thromboembolism, MI or acute coronary syndrome, groin complications, or death.
|
1 month
|
Collaborators and Investigators
Investigators
- Principal Investigator: Sanjiv Narayan, MD, PhD, University of California, San Diego
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- AVATAR
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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