Cancer Biology of Retinoblastoma

Many children with the childhood cancer, Retinoblastoma, have surgery to remove the tumor and sometimes the entire eye. The purpose of this study is to collect the extra tissue from patients who undergo tumor removal for laboratory experiments that will help us understand not only what occurs in retinoblastoma cells but also how cells normally function. Some of these studies will include an evaluation of how cells control the way that genes are expressed, how cells "know" to become retinal cells, how cells remain retinal cells, how cells lose their identity as retinal cells, what changes make retinoblastoma cells different from normal retinal cells, and what changes make some retinoblastomas worse than others.

Study Overview

• Status: Terminated
• Conditions: Retinoblastoma

• Study Type: Observational
• Enrollment (Actual): 8

Contacts and Locations

Study Locations

• Guatemala
  • Guatemala, Guatemala
    • Unidad Nacional De Oncologia Pediatrica
• United States
  • California
    • Stanford, California, United States, 94305
      • Stanford University Cancer Institute

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: No older than 5 years (Child)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

Retinoblastoma patients undergoing surgical removal of part or all of their tumor, with or without the remainder of the eye

Description

Inclusion Criteria:

• Patient must have retinoblastoma
• Patient must be receiving biopsy, partial surgical excision of the tumor, complete excision of the tumor, or enucleation of the eye as part of their standard care.
• Parental consent

Exclusion Criteria:

• Diagnosis other than Retinoblastoma
• No surgical sampling of tumor is planned as part of standard care
• Parental preference to not participate.

Study Plan

How is the study designed?

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort
retinablastoma tumor tissue

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Change in efficiency of reprogramming in cells with "naturally occurring" retinoblastoma mutations	Comparison of number of reprogramming events (defined by colony formation assay and normalized for number of cell plated) as well as the time to reprogramming.	After appropriate time, e.g., 7, 10, 14 days after reprogramming

Collaborators and Investigators

• Sponsor: Stanford University
• Investigators: Principal Investigator: Julien Sage, Stanford University

Study record dates

Study Major Dates

• Study Start: July 1, 2012
• Primary Completion (Actual): December 1, 2015
• Study Completion (Actual): December 1, 2015

Study Registration Dates

• First Submitted: July 11, 2012
• First Submitted That Met QC Criteria: July 12, 2012
• First Posted (Estimate): July 17, 2012

Study Record Updates

• Last Update Posted (Actual): March 6, 2017
• Last Update Submitted That Met QC Criteria: March 2, 2017
• Last Verified: March 1, 2017

More Information

Terms related to this study

• Keywords: retinoblastoma
• Additional Relevant MeSH Terms: Neoplasms by Histologic Type; Neoplasms; Neoplasms by Site; Neoplasms, Glandular and Epithelial; Eye Diseases; Retinal Diseases; Neoplasms, Neuroepithelial; Neuroectodermal Tumors; Neoplasms, Germ Cell and Embryonal; Neoplasms, Nerve Tissue; Eye Diseases, Hereditary; Eye Neoplasms; Retinal Neoplasms; Retinoblastoma
• Other Study ID Numbers: PEDSEYE0002