Nervous System Infections Among Patients With Febrile Seizure

Nervous System Infections Among Patients With Febrile Seizure : Retrospective Cohort Review of Consecutive Patients Admitted in 7 Pediatric Emergency Departments in Ile-de-France Between 2007 and 2011

Few studies dealing with the risk of infectious of nervous system and the utility of lumbar puncture and of emergent neuroimaging among patients with simple febrile seizure between 3 and 11 months age and with complex seizure has been reported. None of these studies was multicentric. Recommendations about management of these children are heterogeneous.

The investigators aim to study by an observational retrospective multicentric study the rate of infectious of central nervous system among patients with a complex febrile seizure and among patients between 3 and 11 months age with simple febrile seizure.

Study Overview

• Status: Completed
• Conditions: Encephalitis; Meningitis; Seizure; Febrile Seizure

• Study Type: Observational
• Enrollment (Actual): 1200

Contacts and Locations

Study Locations

• France
  • Bondy, France, 93140
    • Hôpital Jean Verdier
  • Creteil, France, 94010
    • Centre Hospitalier Intercommunal de Créteil
  • Lagny-Sur-Marne, France, 77405
    • Centre hospitalier Lagny-Marne la Vallée
  • Le chesnay, France, 78157
    • Centre Hospitalier de Versailles
  • Paris, France, 75019
    • Hôpital Robert Debré
  • Paris, France, 75012
    • Hôpital Armand Trousseau
  • Poissy, France, 78300
    • Centre Hospitalier Intercommunal de Poissy

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 3 months to 5 years (Child)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

This was a retrospective cohort review of consecutive patients admitted in 7 pediatric emergency departments in Ile-de-France between 2007 and 2011. All clinically well-apparent children 3 to 11 months of age with a first simple febrile seizure were included in the study. All children between 3 months and 5 years with a complex febrile seizure were included

Description

Inclusion Criteria:

• febrile (>38°)
• Seizure

Exclusion Criteria:

• previous non febrile seizure
• known trauma
• immunodeficiancy status
• Underlying illness

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Bacterial meningitis	Results of lumbar puncture or meningitis history in charts	7 days after emergency visit
Herpes simplex virus meningitis/encephalitis	Results of lumbar puncture or meningitis history in charts	7 days after emergency visit

Secondary Outcome Measures

Outcome Measure	Time Frame
emergent intracranial processus	7 days after emergency visit

Collaborators and Investigators

• Sponsor: Hôpital Armand Trousseau
• Collaborators: Hopital Universitaire Robert-Debre; Centre Hospitalier Intercommunal Creteil; Versailles Hospital; Hôpital Jean Verdier; Centre hospitalier Lagny Marne la vallée; Centre hospitalier intercommunal de Poissy
• Investigators: Principal Investigator: Ricardo Carbajal, MD, PhD, Hôpital Armand Trousseau, Paris

Study record dates

Study Major Dates

• Study Start: June 1, 2013
• Primary Completion (Actual): March 1, 2014
• Study Completion (Actual): March 1, 2014

Study Registration Dates

• First Submitted: September 24, 2012
• First Submitted That Met QC Criteria: September 24, 2012
• First Posted (Estimate): September 27, 2012

Study Record Updates

• Last Update Posted (Estimate): May 20, 2014
• Last Update Submitted That Met QC Criteria: May 19, 2014
• Last Verified: May 1, 2014

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Neurologic Manifestations; Wounds and Injuries; Body Temperature Changes; Heat Stress Disorders; Encephalitis; Seizures; Hyperthermia; Fever; Meningitis; Seizures, Febrile
• Other Study ID Numbers: febrile seizure and infection