Impact of Exercise Training on Cardiac Function in Man

Effects of Exercise Training on Cardiac Function and Lipid Metabolism in Mem 18-22 Year Old

The purpose of this study is to monitor the impact of exercise training on cardiac functions and lipoprotein lipids.

Study Overview

• Status: Completed
• Conditions: Cardiovascular Disease
• Intervention / Treatment: Behavioral: exercise training

Detailed Description

Exercise can increase the mass of left ventricle, which is also called athletic heart. Athletic heart is most frequently encountered as a pathological manifestation of cardiovascular disease, and the early determinants of athelitic remodeling in the general population are largely unknown. We will recruit 45 men aged 18-25 years who will run 5000 meters 2/day for 3 months. caridac function is examined by ECG and echocardiogram, blood pressure, lipoprotein, heart rate, body weight, cardiac troponin will be examined prior to exercise program and 3 months after exercise.

• Study Type: Interventional
• Enrollment (Actual): 46
• Phase: Early Phase 1

Contacts and Locations

Study Locations

• China
  • Henan
    • Luoyang, Henan, China, 471000
      • No. 150 Central hospital of Chinese People's Liberation Army

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 22 years (Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: Male

Description

Inclusion Criteria:

• men
• age 18-25 years
• body mass index (BMI) 18-25 kg/m2
• no regular exercise
• no tobacco use
• no current use of prescribed medications
• no self-report of acute of chronic diseases

Exclusion Criteria:

• conditions that do not meet the inclusion criteria listed.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Health Services Research
• Allocation: N/A
• Interventional Model: Single Group Assignment
• Masking: None (Open Label)

Number of Arms

1

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: experimental 1; men with exercise training for 3 months	Behavioral: exercise training

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
change of cardiac function at baseline to exercise training for 3 months	baseline to 3 months

Secondary Outcome Measures

Outcome Measure	Time Frame
change of lipoprotein at baseline to exercise training for 3 months	baseline to 3 months
change of heart rate at baseline to exercise training for 3 months	baseline to 3 months
Change of body weight at baseline to exercise training for 3 months	baseline to 3 months
change of cardiac troponin frome baseline to exercise training for 3 months	baselin to 3 months
Change of blood pressure from baseline to exercise training for 3 months	baseline to 3 months

Collaborators and Investigators

• Sponsor: No. 150 Central Hospital of the Chinese People Liberation Army
• Investigators: Study Director: Shenxu Wang, MD, No. 150 Central Hospital of PLA

Study record dates

Study Major Dates

• Study Start: December 1, 2012
• Primary Completion (Actual): May 1, 2013
• Study Completion (Actual): May 1, 2013

Study Registration Dates

• First Submitted: June 12, 2013
• First Submitted That Met QC Criteria: June 17, 2013
• First Posted (Estimate): June 19, 2013

Study Record Updates

• Last Update Posted (Estimate): June 19, 2013
• Last Update Submitted That Met QC Criteria: June 17, 2013
• Last Verified: June 1, 2013

More Information

Terms related to this study

• Keywords: Exercise; Lipid; Left ventricular; heart function
• Additional Relevant MeSH Terms: Cardiovascular Diseases
• Other Study ID Numbers: 150CTSX002

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No
• product manufactured in and exported from the U.S.: No