Fetuin A in Hashimoto Thyroiditis

Fetuin A as a New Marker of Inflammation in Hashimoto Thyroiditis

Fetuin-A levels are reported to be low as a negative acute phase reactant in systemical inflammatory situations. Hashimoto thyroiditis is characterized with inflammation. In this study, we hypothesised that the serum fetuin A levels could be found to be low due to inflammation in patients with Hashimoto thyroiditis

Study Overview

• Status: Completed
• Conditions: Hashimoto Thyroiditis

Detailed Description

Patients ≥ 20 years of age being followed up at the outpatient clinics of the Internal Medicine Department in Medeniyet University Goztepe Training and Research Hospital and fulfilling the eligibility criteria will be included in the study. Approval of the local ethics committee and informed consent of the participants will be received for the study. The study is conducted in accordance with the Declaration of Helsinki. Demographic characteristics, concomitant diseases, smoking and alcohol drinking habits, concomitant medication usage, anthropometric and biochemistry data of the eligible patients will be recorded. Patient group will consist of patients with newly diagnosed Hashimoto thyroiditis and the control group will consist of healthy volunteers.

Groups will be compared according to their demographic, an¬thropometric and biochemistry data and serum fetuin-A levels. In order to detect the relationship between the serum fetuin-A levels and clinical features, correlation analyses will be done.

• Study Type: Observational
• Enrollment (Actual): 97

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 20 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Probability Sample

Study Population

Patients ≥ 20 years of age being followed up at the outpatient clinics of the Internal Medicine Department in Medeniyet University Goztepe Training and Research Hospital and fulfilling the below mentioned criteria were included in the study

Description

Inclusion Criteria:

• patients newly diagnosed with Hashimoto thyroiditis

Exclusion Criteria:

• Acute infection
• Acute or chronic inflammatory disease
• Anti-inflammatory treatment (non-steroidal anti-inflammatory, corticosteroids etc.)
• Hypoxic situations (chronic obstructive pulmonary disease etc.)
• Severe heart, kidney and liver disease
• Pregnancy
• Endocrine disorders
• Malignancy
• Usage of drug that affects thyroid hormone levels

Study Plan

How is the study designed?

Design Details

• Time Perspectives: Cross-Sectional

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort
Group of Hashimoto thyroiditis patients
Healty control group

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Comparison of serum fetuin A levels between patients with Hashimoto thyroiditis and healthy subjects	1 day (The blood samples were obtained on the same day participants arrived to outpatient clinics.)

Collaborators and Investigators

• Sponsor: Istanbul Medeniyet University

Study record dates

Study Major Dates

• Study Start: May 1, 2012
• Primary Completion (Actual): October 1, 2012
• Study Completion (Actual): October 1, 2012

Study Registration Dates

• First Submitted: June 17, 2013
• First Submitted That Met QC Criteria: June 21, 2013
• First Posted (Estimate): June 24, 2013

Study Record Updates

• Last Update Posted (Estimate): June 24, 2013
• Last Update Submitted That Met QC Criteria: June 21, 2013
• Last Verified: June 1, 2013

More Information

Terms related to this study

• Keywords: Acute phase reactant, fetuin A, Hashimoto thyroiditis
• Additional Relevant MeSH Terms: Endocrine System Diseases; Thyroid Diseases; Thyroiditis, Autoimmune; Hashimoto Disease; Thyroiditis
• Other Study ID Numbers: GEAH-1