Mean Systemic Pressure Measurement During Prone Position Surgery

Study of Hemodynamic Variations During Prone Position Surgery: Measurement of Mean Systemic Pressure and Venous Return Resistance

Venous return is driven by the pressure gradient between mean systemic pressure and right atrial pressure. However, mean systemic pressure is more a physiological concept than an available clinical measurement. Indeed, the mean systemic pressure is the one that would be measured anywhere within the vascular system after cardiac arrest. Recent advances in hemodynamic monitoring have made MSP available to the clinician through beat-by-beat cardiac output measurements during respiratory pauses under mechanical ventilation. In this way, it is possible to calculate MSP, the pressure gradient and the venous return resistances. The investigators aim is to explain the hemodynamic variations and the decrease in cardiac output observed during prone position. The investigators hypothesis is that venous return resistances are increased during prone position probably following an increased intra-abdominal pressure.

Study Overview

• Status: Unknown
• Conditions: Hemodynamic Variation During Surgery

• Study Type: Observational
• Enrollment (Anticipated): 40

Contacts and Locations

Study Locations

• France
  • Strasbourg, France, 67091
    • Recruiting
    • University Hospital of Strasbourg
    • Principal Investigator: Julien POTTECHER, MD

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

Patient scheduled for neurosurgery in the prone position

Description

Inclusion Criteria:

• Prone position neurosurgery
• High-risk neurosurgery

Exclusion Criteria:

• Emergency surgery
• Pregnancy

Study Plan

How is the study designed?

Design Details

• Time Perspectives: Cross-Sectional

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort
prone position; Patient scheduled for surgery in the prone position

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
mean systemic pressure variation	change of mean systemic pressure from supine position to prone position during surgery	during surgery after the patient is put in prone position

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
intrathoracic pressure variation	Change of intrathoracic pressure from supine position to prone position during surgery	during surgery during surgery after the patient is put in prone position
intravesical pressure variation	Change of intravesical pressure from supine position to prone position during surgery	during surgery during surgery after the patient is put in prone position

Collaborators and Investigators

• Sponsor: University Hospital, Strasbourg, France
• Investigators: Principal Investigator: Julien Pottecher, MD, University Hospital of Strasbourg

Study record dates

Study Major Dates

• Study Start: December 1, 2013
• Primary Completion (Anticipated): October 1, 2016
• Study Completion (Anticipated): October 1, 2016

Study Registration Dates

• First Submitted: October 1, 2013
• First Submitted That Met QC Criteria: October 7, 2013
• First Posted (Estimate): October 8, 2013

Study Record Updates

• Last Update Posted (Estimate): September 30, 2015
• Last Update Submitted That Met QC Criteria: September 29, 2015
• Last Verified: September 1, 2015

More Information

Terms related to this study

• Keywords: prone position; hemodynamic variation; mean systemic pressure
• Other Study ID Numbers: 5673