- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01977638
Phase 1 Trial of CXD101 in Patients With Advanced Cancer
October 17, 2022 updated by: Oxford University Hospitals NHS Trust
Phase 1 Study to Assess Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of CXD101 Given Orally (Twice Daily Dosing for 5 Consecutive Days in a 21-day Period) in Patients With Advanced Malignancies Expressing the Biomarker HR23B
The purpose of this study is to determine the highest dose of CXD101 (a novel histone deacetylase inhibitor) that can be safely administered to patients with advanced tumours.
The study will also investigate the use of HR23B expression in tumour as a biomarker of response to treatment with CXD101.
Patients with solid tumours, lymphoma and myeloma can be considered for this study.
Study Overview
Detailed Description
Patients will be treated with CXD101 administered orally starting at 1mg twice a day (ie: 2mg/day).
Dose escalation will proceed according to a standard 3+3 phase 1 scheme.
Adverse experiences will be evaluated according to the NCI Common Terminology Criteria for Adverse Events, version 4.0.
Dose escalation will continue until dose limiting toxicity is encountered in >1/3rd of patients at any dose level.
The dose level below this will be determined to be the maximum tolerated dose.
Patients will be treated, at the discretion of the Principal Investigator, until disease progression, unacceptable toxicity or the withdrawal of consent.
At the maximum tolerated dose a further 20 patients, defined by tumour HR23B expression will be enrolled.
Study Type
Interventional
Enrollment (Actual)
51
Phase
- Phase 1
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
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Oxfordshire
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Oxford, Oxfordshire, United Kingdom, OX3 7LE
- Oxford University Hospitals NHS Trust
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Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years and older (Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
- Age ≥ 18 years.
- Life expectancy of at least 12 weeks.
- ECOG performance score of ≤ 1
- Histologically or cytologically confirmed malignant tumour with the potential to benefit from HDAC inhibitor therapy.
- High HR23B expressing tumour sample on IHC (expansion cohort only).
- Evaluable disease.
- The patient is willing and able to comply with the protocol for the duration of the study, including scheduled follow-up visits and examinations.
- Patients must have recovered from effects of prior treatments, including surgeries (persistent grade 1 toxicities are permitted at the discretion of the Chief Investigator).
- Female patients with reproductive potential must have a negative urine or serum pregnancy test within 14 days prior to start of trial. Both women and men must agree to use a medically acceptable method of contraception throughout the treatment period and for 16 weeks after discontinuation of treatment. Oral contraception and parenteral hormonal contraceptives (patches, injectables and implants) that may be affected by enzyme-inducing drugs should only be used in combination with a barrier method. All males with partners of childbearing potential or whose partners are pregnant must use barrier contraception for the duration of dosing and for 16 weeks post-dosing.
- Able to give written (signed and dated) informed consent.
- Haematological and biochemical indices within acceptable ranges as detailed in study protocol.
Exclusion Criteria:
- Pregnant or breast-feeding women or women of childbearing potential unless effective methods of contraception are used.
- Other psychological, social or medical condition, physical examination finding or a laboratory abnormality that the Investigator considers would make the patient a poor trial candidate or could interfere with protocol compliance or the interpretation of trial results.
- Patients who are known to be serologically positive for Hepatitis B, Hepatitis C or HIV.
- Radiotherapy (except for palliative reasons), endocrine therapy, immunotherapy or use of other investigational agents within 28 days prior to trial entry (or a longer period depending on the defined characteristics of the agents used). Limited field radiotherapy to an isolated lesion in bone or soft tissue must be completed 2 weeks prior to trial entry.
- Patients must not receive any concurrent anti-cancer therapy, including investigational agents, while on-study. Patients may continue the use of bisphosphonates for bone disease or corticosteroids providing the dose is stable before and during the trial.
- Major surgery within 4 weeks of starting the study.
- Co-existing active infection requiring parenteral antibiotics or serious concurrent illness deemed clinically significant.
- Patients with known brain metastases, unless these are shown to be stable (symptomatically and/or radiologically) over a period of 2 months or more.
- History of refractory nausea and vomiting, chronic GI diseases (eg: inflammatory bowel disease) or significant bowel resection that would preclude adequate absorption of oral medication.
- Patients who are unable to swallow oral medication.
- Patients with corrected QT interval >450msec.
- Persistent grade 2 or greater toxicities from any cause.
- Previous treatment with a HDAC inhibitor.
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: N/A
- Interventional Model: Single Group Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: CXD101
Dose escalation study of CXD101 administered orally twice daily for 5 consecutive days in every 21 day cycle.
Starting dose 1mg twice daily (2mg/day).
|
Capsules, administered orally
Other Names:
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
To determine the maximum tolerated dose of CXD101 administered twice daily for 5 consecutive days every 21 days
Time Frame: 18 months
|
18 months
|
Secondary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
To determine the pharmacokinetic (PK) profile of CXD101 following single and multiple dosing
Time Frame: 18 months
|
18 months
|
To enable a preliminary assessment of the anti-tumour activity of CXD101
Time Frame: 24 months
|
24 months
|
To evaluate the tissue expression of the biomarker HR23B
Time Frame: 24 months
|
24 months
|
To assess the pharmacodynamic effect of CXD101
Time Frame: 24 months
|
24 months
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Publications and helpful links
The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
February 14, 2014
Primary Completion (Actual)
October 8, 2019
Study Completion (Actual)
October 14, 2022
Study Registration Dates
First Submitted
November 5, 2013
First Submitted That Met QC Criteria
November 5, 2013
First Posted (Estimate)
November 7, 2013
Study Record Updates
Last Update Posted (Actual)
October 18, 2022
Last Update Submitted That Met QC Criteria
October 17, 2022
Last Verified
October 1, 2021
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- CXD101-0901
- 2009-012743-42 (EudraCT Number)
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
NO
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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